Case CCC Leads Way with Reporting of Clinical Trials Results
Reporting results of clinical trials in ClinicalTrials.gov
is a federal mandate. At the Case Comprehensive Cancer Center, this activity is coordinated by the Clinical Research Office, under the direction of Kat Karelus and Dr. Smitha Krishnamurthi, with project team April Firstencel and Jan Hanson. Until recently, little was known about investigator compliance with this federal regulation. A study led by Dr. Harlan Krumholz from Yale School of Medicine that was published two weeks ago in The BMJ
(Ruijun C. et al. BMJ 2016; 352:i637
) presented data showing compliance of leading academic medical centers in the U.S. with the requirements of reporting clinical trials results. The Case CCC ranked third among our peers in sharing our clinical trials outcomes.
Using data from ClinicalTrials.gov through the Aggregate Analysis of ClinicalTrials.gov database, the researchers identified 51 centers with at least 40 interventional trials registered in ClinicalTrials.gov and with primary completion dates from October 2007 to September 2010. The researchers looked at the proportion of trials that either published results in peer-reviewed journals or reported them in ClinicalTrials.gov within 24 months of study completion.
Overall, the results of 2892 (66.5%) of the trials had been disseminated (published or reported inClinicalTrials.gov) as of July 2014, with the findings of 1560 trials (35.9%) disseminated within 24 months of completion. In 25.7% of cases, more than 24 months had elapsed from completion to dissemination. Across institutions, the proportion of trials that disseminated results (in ClinicalTrials.gov or published)within 24 months ranged from 16.2% to 55.3%. The rate for CWRU was 48.5 % which placed CWRU and Case CCC in the third place out of 51 centers.
Kudos to the Case CCC Clinical Research Office staff who work closely with investigators to assure accurate and prompt reporting of clinical trials results to comply with ethical obligations and statutory requirements to enable advances in cancer care!
"Report to the Nation on the Status of Cancer" Shows Overall Decline in Cancer Deaths, but Increase in Liver Cancer Deaths
Earlier this week the National Cancer Institute released The Report to the Nation on the Status of Cancer (1975-2012). While this report shows a continuing trend of decline of mortality for most cancers for both men and women, thanks largely to progress in prevention and early detection, it also highlights a dismal picture for liver cancer, showing a steady annual increase of incidence and mortality and substantial racial and ethnic disparities. This calls for concerted and targeted efforts to reverse this trend and reduce the disparities by: 1) increasing uptake of hepatitis screening and vaccination and early treatment; 2) maintaining healthy body weight; and 3) reducing excessive alcohol use.