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January 26, 2015


Dr. Stan GersonStan Gerson, MD
Director, Case CCC

Case CCC Featured at City Club Cleveland Event This Friday

The Case Comprehensive Cancer Center will be featured in a forum discussion at this week's City Club Forum, this Friday, January 30 at noon.

Ruth Keri, Brian Bolwell, Neal Meropol and I will discuss critical issues for our community to appreciate about all of the exceptional work that you do, and we will advocate for the importance of cross-institutional efforts in medical research, especially in cancer, and the positive impact that it has on our efforts, our institutions, and our community. It is a terrific story and we need community recognition and support!

Some of the topics we plan to cover include:

  • We will explain what the Case CCC is – a collaborative cancer research effort across Case Western Reserve University, Cleveland Clinic and University Hospitals, with involvement of researchers at the Louis Stokes Cleveland VA Medical Center, and MetroHealth.
  • We will highlight examples of how cancer researchers across Cleveland come together in breast cancer, prostate cancer, leukemias, clinical trials, and drug development.
  • We will discuss how we can test new drugs in our hospitals with National Cancer Institute and drug company support, with over 1,100 patients enrolled in a drug study every year who can  receive new drugs that they cannot receive anywhere else.
  • We will also highlight and raise awareness of national issues in cancer research and cancer care, such as:
    • Prevention and detection are the best way to cure cancer.
    • Early detection is better than the best treatment for advanced disease.
    • How to make treatments more cost effective and how to manage the reduction in cancer research funding from the NIH.
    • New treatments are needed if we cannot cure the disease - this requires participation in clinical trials.

Throughout the discussion, we will give examples of your work and discoveries and we will mention members from each of our institutions in our remarks. This is terrific exposure for all of the good work that you do. We are proud to represent our incredible Cancer Center.

For those that would like attend, tickets are $18 for City Club members and $30 for nonmembers. Please visit the City Club of Cleveland website for more information and to purchase tickets.


Coroner Investigates Death of Girl Who Refused Chemotherapy
ABC News - Jan 22, 2015
The death of an 11-year-old girl who sparked headlines after her family agreed to let her stop chemotherapy will be investigated by a local coroner. Makayla Sault, a member of the First Nations tribe in Canada, died after suffering a stroke on Sunday, according to a family statement...Dr. John Letterio, chief of pediatric hematology and oncology at University Hospitals Rainbow Babies & Children's Hospital and member of the Case Comprehensive Cancer Center in Cleveland, said it was unlikely that chemotherapy drugs could have caused a stroke months after Makayla stopped treatment. "The drugs we use, literally thousands of patients have had these," said Letterio, who did not treat Makayla. "One of the chemotherapy agents we use has the risk for some heart problems [but] it's so very, very rare."

Initial Prostate Biopsies May be More Accurate at Academic Centers
Global Post- Jan 15, 2015
Men may get more accurate prostate cancer biopsies at an academic medical center than at a community hospital, say Canadian researchers. The study focused on men diagnosed with low-risk prostate cancer based on the results of initial biopsies. These men are typically monitored by doctors but don't get treatment right away because their tumors are usually small and slow-growing...If it's at all possible, men should travel to an academic medical center for a biopsy, especially if they have already found an abnormal result at a community hospital closer to home, said Dr. Jay Ciezki at the Cleveland Clinic's Taussig Cancer Institute and Case Comprehensive Cancer Center in Ohio. Even though the study was done at a single site in Toronto, the findings should be applicable in the U.S. because the difference in expertise between academic medical centers and local hospitals is widespread, said Ciezki, who was not involved in the research.


Tesar Recognized with International Stem Cell Award

Dr. Paul TesarThe International Society for Stem Cell Research (ISSCR) has named Paul Tesar, PhD of Case Western Reserve University and the Case Comprehensive Cancer Center theOutstanding Young Investigator for 2015. The award "recognizes the exceptional achievements of an investigator in the early part of his or her independent career in stem cell research who will be honored with the award at the ISSCR Annual Meeting in Stockholm, Sweden in June 2015."

Madabhushi to Serve on Computer Science Journal Editorial Board

Dr. Anant MadabhushiDr. Anant Madabhushi, Professor of Biomedical Engineering and Director of the Center for Computational Imaging and Personalized Diagnostics at Case Western Reserve University, has been invited to serve as associate editor for the Journal of Medical Image Analysis (MedIA), one of the top international journals in computer science. Dr. Madabhushi is also a member of the Case Comprehensive Cancer Center.

Mark Your Calendars

Social Network Analysis and Health Mini-Series: Workshop Scholarships Available

The Social Network Analysis and Health Mini-Series, held May 6-7, 2015 at CWRU, is a forum to enhance our understanding of social network theory and methods and their application within the field of health research. Social network analysis is increasingly used by scientists across the prevention-to-treatment continuum to understand relational dynamics of complex health issues. The goals of the mini-series are to introduce this method through case examples that include applications related to a range of chronic and infectious diseases among adult and youth populations. The public lecture will orient faculty, fellows, students, clinicians, and the broader Cleveland community to applications of social network theory and methods.

The Mini-Series has to components: a lecture and workshop. A free lecture on Social Networks and Health will take place Wednesday, May 6 from 12:30-2:00 pm in BRB 105. A workshop, A Hands-On Introduction to Social Network Analysis and its Applications, will be held Thursday, May 7 from 9:00 am-4:00 pm in Kelvin Smith Library, Room LL06. The workshop will provide a broader overview of social network analysis and an opportunity for participants to explore analytic software including UCINET, NETDRAW, Exponential Random Graph Models, and SIENA. Trial versions of the software will be available to participants for use during the workshop. There is a $50 fee to attend, and spaces are limited to 30 registrants. A small number of workshop scholarships are available to support graduate students and non-faculty trainees/post-doctoral fellows. Applications are due by February 15. Regular workshop registration will open March 2.

Graft versus Host Disease National Symposium

Registration is now open for the Graft versus Host Disease (GvHD) National SymposiumFriday, April 24, at the Embassy Suites Cleveland. This conference is intended to raise awareness about the signs and symptoms of GvHD, review cutting edge approaches to prevention and treatment, and highlight and promote research to further our understanding of its cause.

The symposium will have two tracks: a scientifically rigorous one for physicians and practitioners, and a survivor track that will focus on challenges faced by BMT recipients and their families. The survivor track is intended to provide both education and the opportunity for individuals to interact with national leaders in the GvHD field. The afternoon "Meet the Expert" uniquely interactive breakout sessions will provide an opportunity for the physicians, survivors and their families to come closely together during the program. Continuing Medical Education credits will be offered.

Case CCC Annual Scientific Retreat

The Case CCC Annual Scientific Retreat will be held July 9-10, 2015. The agenda is still being planned, but we hope you will set aside time to attend this important event! More details will be posted in future newsletters.

Cultural Competency Series

Cultural Competency and the Research Process

This week, we continue the Cultural Competency Series with discussion of Cultural Competency and the Research Process.

We encourage you to view this week's entry where we will introduce the following definitions and concepts:

  • Cultural competency in research;
  • Roles cultural competency plays in research; and
  • Importance of cultural competency in research.

The feature also provides steps and suggestions to start your cultural competency journey. Visit the Cancer Center website to view the January 26 edition of the Cultural Competency Series.

Want to Learn More? 
View Cultural Competency in Research, presented Katrice D. Cain, MA and Mary Ellen Lawless, MA, RN from the Center for Reducing Health Disparities at a May 2013 Case CCC Continuing Education Session. This presentation provides an introduction to cultural competency in research and overview of the importance of considering culture throughout the research process.

Viewing the slide presentation and taking an online quiz will allow you to receive 3 Continuing Research Education Credits (CRECs). The slides from the presentation are available at: (Cultural Competency in Research: Katrice Cain and Mary Ellen Lawless's Powerpoint Handout).


Clinical Oncology Research Career Development Program

The Case Case Comprehensive Cancer Center is accepting applications for the Clinical Oncology Research Career Development Program (CORP). The purpose of this program is to provide interdisciplinary training in clinical and translational oncology research for clinical oncology junior faculty physicians who are interested in pursuing academic research careers as physician scientists. This training addresses the need for clinician investigators to translate fundamental cancer research discoveries into medical care of cancer patients. Eligible candidates are physicians (MD, DO or MD/PhD) with a clinical training background in one of a number of oncology disciplines, including medical, surgical, pediatric, dermatological, gynecological and radiation oncology.

This career development program is supported by robust interdisciplinary clinical and translational research programs in the Case Comprehensive Cancer Center that provide Paul Calabresi Scholars the opportunity to select one of three areas of concentration:

  • Mechanism Based Therapeutics and Clinical Trials
  • Stem Cell Biology and Hematopoietic Malignancy Clinical Trials
  • Prevention, Aging and Cancer Genetics and Clinical Trials

Deadline: April 17


American Institute for Cancer Research Investigator-Initiated Grants
Deadline: January 26, 2015

AACR-Triple Negative Breast Cancer Foundation Career Development Award for Clinical/Translational Research
Deadline: January 27, 2015

Debbie's Dream Foundation-AACR Gastric Cancer Research Fellowships
Deadline: January 27, 2015

American Brain Tumor Association Medical Student Summer Fellowships
Deadline: January 28, 2015

National Center for Accelerated Innovations (NCAI-CC)
Deadline: February 10

Leukemia & Lymphoma Society Translational Research Program (TRP)
LOI Deadline: February 15, 2015
Application Deadline: March 1, 2015

Lila and Murray Gruber Memorial Cancer Research Award
Deadline: February 28, 2015

Ohio Cancer Research Associates
Deadline: February 28, 2015

Myeloma Research Foundation
Deadline: March 1, 2015

Bladder Cancer Advocacy Network 2015 Young Investigator Awards
Deadline: March 4, 2015

Taub Foundation Grants Program for Myelodysplastic Syndromes (MDS) Research
Initial Proposal Deadline: March 17
Invited Proposal Deadline: August 14

Limited Submission: National Science Foundation Collections in Support of Biological Research (CSBR)
Internal Deadline: March 23, 2015
External Deadline: July 13, 2015

Worldwide Cancer Research
Deadline: April 24, 2015

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

Collaborative Activity Awards
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at


Tues, Jan 27

Molecular Genetics Departmental Research Seminar Series
Sudip Bandyopadhyay, PhD
Project Staff, Molecular Genetics, Sen Lab
Cleveland Clinic
Topic: The Compound AGN226554 Blocks Inflammasome Activation Triggered by Oxidative Stress
9:30 am NE1-205 Cleveland Clinic

Pathobiology Department Seminar Series
Ciarán Fealy, BSc, PhD Candidate
Pathobiology, Kirwan Lab
Cleveland Clinic
Topic: CrossFit Exercise Training for the Treatment of Type 2 Diabetes: Promising results from a pilot study
11:30 am NE1-205 Cleveland Clinic

Immunology Seminar Series
James Ignatz-Hoover
Wald Lab, Immunology
Topic: Nuclear GSK3b Promotes NF-κB Activation in AML
12 pm WRB 1-413

Cancer Biology Seminar Series
Arie Horowitz, PhD
Assistant Staff, Molecular Cardiology
Cleveland Clinic
Topic: Exploiting Membrane Trafficking to Inhibit Angiogenesis
2 pm NC1-202 Cleveland Clinic

Wed, Jan 28

Hematology/Oncology Grand Rounds
Afshin Dowlati, MD
Professor, Div. of Hem/Onc
Topic: Discovering New Therapies in Thoracic Cancers
8 am Lerner B-151

Pathology Grand Rounds
Julian Kim, MD
Professor, Surgical Oncology
Topic: Immunotherapy
8 am Institute of Pathology Auditorium

Immunology Faculty Candidate
Joseph Barbi, PhD
Postdoctoral Fellow, Immunology
Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center
Topic: Neuritin: An unexpected immune response modulator and a regulator of regulators
11 am WRB 5-136

Immunology Seminar
Craig Morrell, DVM, PhD
University of Rochester
Topic: Platelets as Mediators of Immune and Tissue Injury Responses
12 pm NC1-202 Cleveland Clinic

Academic Drug Development Seminar
Monica Montano, PhD
Associate Professor, Pharmacology 
Topic: Targeting Hormone Resistant and Metastatic Breast Cancer
4 pm Global Cardiovascular Innovations Center (GCIC) Room 1-102

Thurs, Jan 29

Immunology Journal Club 
Elizabeth Akinbiyi
Dept. of Immunology
Topic: Antigen Recognition in the Islets Changes with Progression of Autoimmune Islet Infiltration
12 pm WRB 5-136

Neurosciences Seminar 
Marthe Howard, PhD
University of Toledo
Topic: Molecular Mechanisms of Autonomic Neuron Development
12:10pm in BRB 105

Molecular Biology and Microbiology Seminar
Piet de Boer, PhD
Professor, Molecular Biology and Microbiology
Bing Liu
de Boer lab, Molecular Biology and Microbiology
Topic: Septal Peptidoglycan Synthesis and Outer-membrane Invagination during Cell Fission in E.coli
1 pm Rottman Seminar Room W203

Fri, Jan 30

Hematology/Oncology Fellows Seminar
8 am Wearn 137

TCI Grand Rounds
Keith McCrae, MD; Aaron Gerds, MD; Yogen Saunthararajah MD; Alok Khorana MD
Cleveland Clinic
Topic: ASH Update – Oral Presentations
8 am R3/002-003 Cleveland Clinic

City Club Cleveland Panel Discussion
Stan Gerson, MD; Brian Bolwell, MD; Ruth Keri, PhD; Neal Meropol, MD
Case Comprehensive Cancer Center Executive Committee
Topic: From Science to Cancer Cures: How the Case Comprehensive Cancer Center Makes the City of Cleveland Better
12 pm City Club Cleveland
Tickets and More Information

Cancer Center Research In Progress Seminar
Edward Greenberg, MD
Trainee in Physician Scientist Track
Distelhorst Lab, Div. of Hem/Onc
Topic: Synergistic Killing of Small Cell Lung Cancer Cells by the BH3-mimetic ABT-263 and the Bcl-2-IP3 Receptor Disruptor BIRD-2
4 pm WRB 3-136

Mon, Feb 2

Tumor Immunology and Immunotherapy Focus Group Meeting
4 pm NA1-139 Cleveland Clinic

Skeletal Research Center
Veronique Lefebvre, PhD
Professor, Cellular & Molecular Medicine, Orthopaedic and Rheumatologic Research Center
Cleveland Clinic
Topic: Actions and Regulation of the Master Chondrogenic SOX5/6/9 Trio
4 pm Millis 123

Tues, Feb 3

Translational Hematology & Oncology Research
Andrew Feldman, MD
Associate Professor, Laboratory Medicine and Pathology
Mayo Clinic
Topic: Pathology of Anaplastic Large Cell Lymphoma
1 pm R3-027 Cleveland Clinic

Wed, Feb 4

Hem/Onc Division Research Conference
8 am Lerner B-151

Immunology Seminar
Laura Davison 
Jorgensen Lab, Immunology
Cleveland Clinic
Topic: SiglecH+ Plasmacytoid Dendritic Cells Drive Disease in Lupus-Prone B6.Nba2 Mice
Miwa Morita
Lu/Qian Lab, Immunology
Cleveland Clinic
Topic: Rejection Triggers Liver Transplant Tolerance: Involvement of Mesenchyme-Mediated Immune Control Mechanisms
12 pm NC1-202 Cleveland Clinic

Thurs, Feb 5

Molecular Biology and Microbiology Seminar
Ming Luo
University of Alabama at Birmingham
Topic: Nucleocapsid of Negative Strand RNA Virus
1 pm Rottman Seminar Room W203

Fri, Feb 6

Hem/Onc Fellows
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Colleen Delaney, MD
Associate Professor, Div. of Pediatric Hematology/Oncology
University of Washington/Fred Hutchinson Cancer Research Center
Topic: Development of a Universal Ex Vivo Expanded Cord Blood Progenitor Cell Product for Clinical Application
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Martin G. Pomper, MD, PhD
William R. Brody Professor of Radiology
Johns Hopkins University 
Topic: Forays into Molecular Imaging
12 pm BRB 105

Mirko Paiardini
Emory University
Immune-based Interventions for HIV cure: Role of nonhuman primate
1 pm BRB 105

Cancer Center Research In Progress Seminar
4 pm WRB 3-136


Case CCC Calendar

LRI Calendar


Best of San Antonio Breast Cancer Symposium
February 4, 2015

Multidisciplinary Head and Neck Cancer Update
Weston, FL
March 6-7, 2015

Graft Versus Host Disease Symposium 2015
April 24, 2015
Embassy Suites Cleveland - Rockside

Advances in Lung Cancer: A Multidisciplinary Approach
April 25, 2015
Marriott Hotel at Key Center

ASCO Review
June 26, 2015
InterContinental Hotel


Symposium on Global Cancer Research
March 25, 2015
Boston Sheraton Hotel