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February 23, 2015


Fowler Family Ensures Young Adults with Cancer Diagnosis get Specialized Care
Currents News - Feb 20, 2015
Survivorship rates for childhood cancers are very high, and great strides have been made in adult cancer survival rates. However, other facts are sobering. Outcomes for adolescents and young adults with cancer – the AYA community – are no better than they were in 1975, according to Dr. John Letterio, professor of pediatrics at CWRU, chief of the division of pediatric hematology/oncology at UH Rainbow Babies & Children's Hospital, and member of the Case Comprehensive Cancer Center. For these people, between the ages of 15 and 30, one out of 210 will get cancer. "We have to do better for patients in this demographic," said Dr. Letterio.

What Oncologists Think about the Oncology Care Model
Oncology Times- Feb 18, 2015
While waiting for the February 19 webinar from the Centers for Medicare and Medicaid Innovation Center (12 noon Eastern) introducing CMS's Oncology Care Model (OCM) as a new way to pay for cancer care, I asked several people I respect to share their initial impressions...Neal J. Meropol, MD, Chief, Division of Hematology and Oncology, University Hospitals Case Medical Center & Case Western Reserve University, Cleveland and Associate Director for Clinical Research at the Case Comprehensive Cancer Center: "The time is ripe for payment reforms that reward coordination of care and better align financial incentives with high quality care and patient outcomes. The CMS program is an initial step in the right direction, but there is a long way to go to optimize how we pay for oncology care in the United States."

Cancer Experience Triggers Thoughts of Healthy Lifestyle Changes in Both Survivors and their Family Members, Case Western Reserve Researchers Conclude
Health Canal - Feb 18, 2015
After studying cancer survivors and their family caregivers, researchers at Case Western Reserve University conclude that the period between the final cancer treatment and first post-treatment checkup may be an ideal time for the entire household to jumpstart a healthy lifestyle. "A window of opportunity exists during the post-treatment transition period for oncology clinicians to reach out to patients and their caregivers who want to have a healthy start on life after cancer," said Susan Mazanec, PhD, RN, AOCN, assistant professor at Case Western Reserve's Frances Payne Bolton School of Nursing and member of the Case Comprehensive Cancer Center. Mazanec, also a nurse scientist at University Hospitals Case Medical Center's Seidman Cancer Center, was lead investigator of the study, "Health Behaviors in Family Members of Patients Completing Cancer Treatment," recently reported in Oncology Nursing Forum.

CWRU Wins $6 Million Grant to Establish Cleveland Digestive Diseases Research Core Center - Feb 12, 2015
Case Western Reserve University has won a $6 million grant from the National Institutes of Health to establish Cleveland as a Digestive Diseases Research Core Center, one of only 17 in the country. CWRU, which will act as administrator for the site, will collaborate with the Cleveland Clinic and University Hospitals in research on digestive inflammation, gastrointestinal cancer and liver and metabolic diseases..."Last year, the Clinic was ranked No. 2 and UH Case was ranked No. 14 on U.S. News and World Report's Best Hospitals for adult gastroenterology and GI surgery," said Dr. Fabio Cominelli, the center's program director and the grant's principal investigator. Dr. Cominelli is also a member of the Case Comprehensive Cancer Center.


NCI Office of Cancer Centers Launches New and Improved Website

The National Cancer Institute Office of Cancer Centers (OCC) has launched a new website! The website is more user friendly. Highlights include a more modern look and an exportable list of Cancer Centers, director names and contact information.

Mark Your Calendars

Case CCC Clinical Research Retreat

The Case Comprehensive Cancer Center Spring Clinical Research Retreat will take place on March 5 from 5-7 pm in the Wolstein Research Building Auditorium and Atrium. The agenda will focus on the Phase 0/I trials theme, and will offer 1.5 CME Category 2 hours. Pre-registration is required. Please contact Dr. Michael Gibson at with any questions.

St. Baldrick's "Shave It Off!" Event

On Friday, March 13, a special St. Baldrick's "Shave It Off!" event will be held at Rainbow Babies & Children's Hospital from 10 am - 2 pm. Over 50 people will shave their heads in solidarity with children who have cancer and typically lose their hair during treatment, while raising critical funds for childhood cancer research!

Even if you are not planning to shave your head, all are invited to attend the event in honor of all the patients and families at Rainbow Babies & Children's Hospital who are fighting the fight of their lives! For more information, please visit the UH Rainbow event page.

Great Lakes Breast Cancer Symposium

Together with the University of Pittsburgh Cancer Institute, partner with University of Pittsburgh Medical Center (UPMC) CancerCenter, and The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute, the Case Comprehensive Cancer Center is pleased to announce the inaugural Great Lakes Breast Cancer Symposium to be held June 4-6, 2015, on the campus of Case Western Reserve University in Cleveland, Ohio. These three organizations are located less than 200 miles from one another and have complementary strengths in basic, translational, and clinical breast cancer research. Thus, this symposium was developed with the goal of providing an avenue for networking and building cross-disciplinary collaborations across the region occupied by our Centers.

Agenda Highlights:

  • Key note address by breast cancer luminary Dr. Douglas Yee, Director of the University of Minnesota Masonic Cancer Center
  • Overview of breast cancer research at Case Comprehensive Cancer Center, Ohio State's Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute, and University of Pittsburgh Cancer Institute
  • Short talks on current research by faculty at each participating site
  • Poster presentations by trainees and additional faculty
  • Opportunities for networking with outstanding breast cancer investigators in the region

All individuals interested in breast cancer research, spanning from basic mechanisms to clinical trials and population-based research, are encouraged to attend. Individuals who are not associated with the three organizing centers are also encouraged to participate.

Registration information will be available soon.


AAAS Martin and Rose Wachtel Cancer Research Award

The American Association for the Advancement of Science (AAAS) Martin and Rose Wachtel Cancer Research Awardhonors an early-career investigator who has performed outstanding work in the field of cancer research and who has the potential to contribute substantially to future progress in the treatment of cancer. The winner will present an associated lecture and receive $25,000. The award winning Essay will be published as a Focus article in Science Translational Medicine. 
Deadline Extended: March 15

Bladder Cancer Advocacy Network John Quale Travel Fellowships

The John Quale Travel Fellowship Program is a special opportunity for early career investigators interested in bladder cancer research to attend the annual Bladder Cancer Think Tank Meeting. The $1,700 travel fellowships awarded each year are intended to defray travel-related costs for attending the meeting. Hosted by the Bladder Cancer Advocacy Network (BCAN), the primary mission of this meeting is to enhance collaboration among physicians and researchers who are dedicated to the prevention, diagnosis, and treatment of bladder cancer. This is a unique opportunity to meet and learn from leaders in the field. The Travel Fellowship Program seeks to engage more early-career individuals with interests related to bladder cancer including basic scientists, urologists, oncologists, and pathologists. 
Deadline: March 18

Cancer Center Summer Training Program for Medical Students

The Case Comprehensive Cancer Center is looking for medical students interested in summer research opportunities.

There are 8 openings available, with 4 supported by the Brian Werbel Memorial Fund sponsored through University Hospitals Seidman Cancer Center and 4 by the Case Comprehensive Cancer Center.


  • Completed application and reference letter due by: Friday, March 27, 2015
  • Awardees must be conducting cancer research with a Case Comprehensive Cancer Center member at Case Western Reserve University, Cleveland Clinic and University Hospitals Case Medical Center.
  • Those receiving the Brian Werbel Memorial Fund awards must attend the Annual golf outing on June 25, 2015.

For more details and an application, please contact Megan Kilbane at

Case CCC Funding for Pilot/Phase I Clinical Trials

The Case Comprehensive Cancer Center is accepting Letters of Intent (LOIs) for Early Phase Clinical Research Support (EPCRS) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Priority will be given to trials which are developed jointly between University Hospitals and Cleveland Clinic with planned accrual at both institutions.

Letters of Intent should include a maximum of three-page project narrative including the following information: background, objectives, eligibility, methods, endpoints/statistics, and assessment of feasibility. Submit materials to Katarzyna Karelus, Case CCC Clinical Research Office,, 216.844.4176.
Deadline: April 15


Revised Treatment Protocol Template

The Case Comprehensive Cancer Center Clinical Research Office has revised the old biomedical templates into one new treatment protocol template with guidance documents. The guidance documents can be reached via links in the protocol. This template is mandatory for investigator-initiated treatment studies for immediate use. Please contact April Firstencel at with any questions.


CWRU Skin Diseases Research Center Pilot and Feasibility Program
Deadline: February 27

Lila and Murray Gruber Memorial Cancer Research Award
Deadline: February 28

Ohio Cancer Research Associates
Deadline: February 28

Myeloma Research Foundation
Deadline: March 1

Bladder Cancer Advocacy Network 2015 Young Investigator Awards
Deadline: March 4

Patient-Centered Outcomes Research Institute - Improving Healthcare Systems
LOI Deadline: March 6

Multiple Myeloma Senior Research Grants
Deadline: March 17

Taub Foundation Grants Program for Myelodysplastic Syndromes (MDS) Research
Initial Proposal Deadline: March 17
Invited Proposal Deadline: August 14

Limited Submission: National Science Foundation Collections in Support of Biological Research (CSBR)
Internal Deadline: March 23
External Deadline: July 13

ASTRO Residents/Fellows in Radiation Oncology Research Seed Grants
Deadline: March 27

Limited Submission: National Science Foundation Collections in Support of Biological Research (CSBR)
Internal Deadline: March 23, 2015
External Deadline: July 13, 2015

ASTRO Residents/Fellows in Radiation Oncology Research Seed Grants
Deadline: March 27

American Cancer Society The Role of Health Policy and Health Insurance in Improving Access to and Performance of Cancer Prevention, Early Detection, and Treatment Services
Deadline: April 1

American Cancer Society Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Deadline: April 1 and October 1

Multiple Myeloma Research Fellow Awards
Deadline: April 21

Worldwide Cancer Research
Deadline: April 24

American Cancer Society Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Deadline: April 1 and October 1

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

Collaborative Activity Awards
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at


Tues, Feb 24

Immunology Seminar
James Morrow, Scacheri Lab
Topic: Metastatic Variant Enhancer Loci Modulate Pro-metastatic Transcriptional Programs May Identify Metastasis Dependencies in Osteosarcoma
12 pm WRB Auditorium

Translational Hematology & Oncology Research
Quteba Ebrahem, PhD
Translational Hematology & Oncology Research
Cleveland Clinic
Topic: Mechanism-based Solutions for 5-azacytidine/decitabine Resistance
1 pm R3-027 Cleveland Clinic

Cancer Biology Seminar Series
Chris Hubert, PhD
Research Fellow, Stem Cell Biology and Regenerative Medicine
Cleveland Clinic
Topic: Identification Cancer-Specific RNA Splicing Sensitivity in Glioblastoma and Development of Glioblastoma Organoid Cultures
2 pm NC1-202 Cleveland Clinic

Pharmacology Seminar
Kristina Baker, PhD
Department of Pharmacology
3 pm Webster Conference Room W331

Wed, Feb 25

Hem/Onc Division Research Conference
Hillard Lazarus, MD
Professor, Div. of Hem/Onc
Topic: Novel Cell Therapy at UHCMC 
8 am Lerner B-151

Immunology Faculty Candidate
Byron Au-Yeung, PhD
University of California San Francisco
Topic: Titration of T Cell Antigen Receptor Signal Strength Reveals Thresholds for T Cell Responses
10 am in WRB 5-136

Immunology Seminar
Michael I. Nishimura, PhD
Associate Director, Oncology Institute
Associate Director, Cancer Center Translations Research
Loyola University
Topic: Antigen Recognition by TCR Transduced T Cells
12 pm NC1-202 Cleveland Clinic

Thurs, Feb 26

Immunology Journal Club
Michael Katsnelson 
Student, Immunology
Topic: Immune Dysregulation in Human Subjects with Heterozygous Mutations in CTLA4
12 pm WRB 5-136

Molecular Biology and Microbiology Seminar
Marisa Winkler and Laura Rojas Coy
Bonomo lab, Molecular Biology and Microbiology
1 pm Rottman Seminar Room W203

Stem Cell Biology Guest Presentation
Jianwen Qu, MD, PhD
Assistant Professor, Biomedical Genetics
University of Rochester Rochester
Topic: Basal Stem Cells in Development and Disease of the Esophagus
1 pm NE1-205 Cleveland Clinic

PHRM 511 Journal Club
Darcie D. Seachrist 
Department of Pharmacology
3 pm Webster Conference Room W331

Fri, Feb 27

Hem/Onc Fellows
Evi Stavrou, MD
Assistant Professor, Div. Hem/Onc
Topic: Coagulation 
8 am Breen Conference Room

Taussig Cancer Institute Grand Rounds
Thierry LeChevalier, MD
Institut Gustave-Roussy
Topic: Adjuvant/ Neoadjuvant Chemotherapy for Early Stage NSCLC, and the Use of Biomarkers to Optimize It
8 am R3/002-003 Cleveland Clinic

CWRU Basic Science Research Seminar
Alfredo Garcia, PhD
Seattle Children's Research Institute for Integrative Brain Research
Topic: Neuronal Chemosensitivity: An avenue for vulnerability and adaption in cardio-respiratory control
9 am BRB 832

Cancer Center Seminar Series
Michael Goggins, MD
Professor, Pathology, Medicine and Oncology
Director, Early Detection Research Laboratory Sol Goldman Pancreatic Cancer Research Center
Johns Hopkins Medical Institutions
Topic: The Early Detection of Pancreatic Cancer
12 pm BRB 105

Cancer Center Seminar Series
Matthew Knarr
Pharmacology Graduate Student, DiFeo Lab, General Medical Sciences (Oncology)
Topic: Feeding the Beast: The effects of a miRNA on mesenchymal stem cells and their implications for the ovarian tumor niche
4 pm WRB 3-136

Mon, Mar 2

Biochemistry Student Seminar
Ying-Hsin Chen
Department of Biochemistry
12 pm SOM W428

Genomic Medicine Institute Research Seminar
Huan Zhang
Eng Lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Metagenomic Profiling of Mobile Squamous Cell Carcinoma
12:30pm NE1-205 Cleveland Clinic

Tumor Immunology and Immunotherapy Focus Group meeting of the Case CCC Molecular Oncology Program
Kurt Lu, MD
Assistant Professor, Dermatology
4 pm Wearn 137

Tues, Mar 3

Translational Hematology & Oncology Research
Xiaorong Gu, PhD
Translational Hematology & Oncology Research
Cleveland Clinic
1 pm R3-027 Cleveland Clinic

Cancer Biology Seminar Series
Jianfei Qian, PhD
Project Scientist, Yi Lab, Cancer Biology
Cleveland Clinic 
Topic: Targeting DKK1 for Immunotherapy in Multiple Myeloma
2 pm NC1-202 Cleveland Clinic

Wed, Mar 4

Hem/Onc Division Research Conference
8 am Lerner B-151

Thurs, Mar 5

Molecular Biology and Microbiology Seminar
Gwen Fewell
Chief Commercial Officer, transOMIC Technologies
Topic: Sensor-based shRNA design for more effective RNAi screens
1 pm Rottman W203

PHRM 511 Journal Club
Ryan William Clinton
Department of Pharmacology
3pm Webster Conference Room W331

Fri, Mar 6

Hem/Onc Fellows
8 am Breen Conference Room

Taussig Cancer Institute Grand Rounds
Qing Yi, MD, PhD
Chair, Cancer Biology
Cleveland Clinic
Topic: Targeting the Microenvironment for Cancer Therapy: Insights from Myeloma
8 am R3/002-003 Cleveland Clinic

Cellular & Molecular Medicine
Ofer Reizes, PhD
Assistant Professor, Cell Biology & Molecular Medicine, Lerner Research Institute
CWRU/Cleveland Clinic
Topic: Leptin Receptor Integrates Metabolic Cues in Breast Cancer Stem Cells
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Patricia S. Steeg, PhD
Deputy Chief, Women's Malignancies Branch
Center for Cancer Research, National Cancer Institute
Deputy Editor, Clinical Cancer Research
12 pm BRB 105

Cancer Center Seminar Series
Andrew Blum, MD
Gastroenterology Fellow, Guda Lab, General Medical Sciences (Oncology)
Topic: Transcriptome Sequencing Identifies JUN and TGF-β Pathways as Critical Mediators of Barrett's Carcinogenesis
4 pm WRB 3-136


Case CCC Calendar

LRI Calendar


Multidisciplinary Head and Neck Cancer Update
March 6-7, 2015
Weston, FL

Graft Versus Host Disease Symposium 2015
April 24, 2015
Embassy Suites Cleveland - Rockside

Advances in Lung Cancer: A Multidisciplinary Approach
April 25, 2015
Marriott Hotel at Key Center

Great Lakes Breast Cancer Symposium
June 4-6, 2015
Tinkham Veale University Center

ASCO Review
June 26, 2015
InterContinental Hotel


Symposium on Global Cancer Research
March 25, 2015
Boston Sheraton Hotel