MESSAGE FROM THE DIRECTOR
Stan Gerson, MD
Director, Case CCC
Adolescent and Young Adult Cancer Research Awards
We are delighted to announce the first recipients of the Adolescent and Young Adult (AYA) Cancer Research Awards. These one-year awards, made possible through the Fowler family's generous support of AYA cancer research at the Case Comprehensive Cancer Center, are granted to members of the AYA Cancer Research Initiative, led by John Letterio and Stan Gerson. The objective of these awards is to broaden and deepen research focus on AYA cancers and to engage members across the Center in this important area. We will present a scientific symposium on these projects in September.
The project awards are:
Use of a Novel Radiographic Biomarker to Characterize Low Grade Glioma and Treatment Effect in Adolescent and Young Adults
PI: Peter de Blank; Co-Investigators: Mark Griswold, Andrew Sloan
Targeting Adolescent and Young Adult Cancer Using NK Cell Therapy
PI: Marcos de Lima; Co-Investigators: David Wald, Alex Huang
Disrupting Macrophage Interaction with Tumor-associated VCAM-1 Signaling in Pulmonary Metastasis of Osteosarcoma
PI: Alex Huang; Co-Investigators: Nicole Steinmetz, Ed Greenfield, San Xiao
A Novel Role for Cdk5 in Melanoma Biology and Metastasis
PI: John Letterio; Co-Investigators: Seong-Jin Kim, Patrick Leahy, Tej Kumar Pareek, Seughwan Lim, Marcus Rosenberg, Barbara Bedogni
Adolescent and Young Adult Cancer Database and Biorepository
PI: Paolo Caimi, Yousif Matloub, Robin Norris; Co-Investigators: Sanjay Ahuja, Amelia Baffa, Rachel Egler, Meg Gerstenblith, Henry Koon, David Mansur, John Pink
The Cancer Stem Cell Gamble
The January 16 edition of "Science" featured an article on cancer stem cells and clinical trials, The Cancer Stem Cell Gamble. Many in our field have strong feelings about cancer stem cells, and much research still needs to be done. The article is an interesting read and covers both sides of this hot issue.
Dr. Jeremy Rich, Co-Director for the National Center for Regenerative Medicine and Professor, Stem Cell Biology and Regenerative Medicine, "got the last word" on the topic when he was quoted at the very end of the article: "For now, cancer patients, researchers and physicians, and investors in companies such as Verastem will anxiously wait for data to roll in from the clinical trials. For those with a stake in treatments, the results could bring hope. For researchers debating the reality of cancer stem cells, though, they may not bring resolution. Says Jeremy Rich of the Cleveland Clinic in Ohio, who is studying stem cells in brain cancer, 'Even if we're wildly successful, which I don't think we will be, I don't think there will be a black-and-white answer.' "
Groundbreaking Study Sheds Light on Treating Blood Cancers
In a new study, researchers explored ways to treat life-threatening blood cancers in a less toxic way. They worked to wipe out cancer cells in the blood without destroying healthy surrounding cells. Yogen Saunthararajah, MD, who treats cancer patients at Cleveland Clinic, led the study. Dr. Saunthararajah, Co-leader of the Developmental Therapeutics Program and Professor, Hematologic Oncology and Blood Disorders, explains how the new approach works by comparing it to a popular arcade game.
"The way the medicine works is like the game Whac-a-Mole™. You have a mallet and you're only getting the moles that happen to be in a particular phase of their growth cycle. You don't want a huge mallet because you're just going to damage the golf green. You want a little mallet and you want to keep on whacking regularly," Dr. Saunthararajah says.
In the same way, the new treatment involves using an existing drug but in a more targeted, repetitive way. The idea is to use more and smaller doses, as though the drug were the mallet you use to strike the cancer cells. More>
Social Network Analysis and Health Mini-Series: Workshop Scholarships Available
The Social Network Analysis and Health Mini-Series, held May 6-7, 2015 at CWRU, is a forum to enhance our understanding of social network theory and methods and their application within the field of health research. Social network analysis is increasingly used by scientists across the prevention-to-treatment continuum to understand relational dynamics of complex health issues. The goals of the mini-series are to introduce this method through case examples that include applications related to a range of chronic and infectious diseases among adult and youth populations. The public lecture will orient faculty, fellows, students, clinicians, and the broader Cleveland community to applications of social network theory and methods.
The Mini-Series has to components: a lecture and workshop. A free lecture on Social Networks and Health will take place Wednesday, May 6 from 12:30-2:00 pm in BRB 105. A workshop, A Hands-On Introduction to Social Network Analysis and its Applications, will be held Thursday, May 7 from 9:00 am-4:00 pm in Kelvin Smith Library, Room LL06. The workshop will provide a broader overview of social network analysis and an opportunity for participants to explore analytic software including UCINET, NETDRAW, Exponential Random Graph Models, and SIENA. Trial versions of the software will be available to participants for use during the workshop. There is a $50 fee to attend, and spaces are limited to 30 registrants. A small number of workshop scholarships are available to support graduate students and non-faculty trainees/post-doctoral fellows. Applications are due by February 15. Regular workshop registration will open March 2.
Graft versus Host Disease National Symposium
Registration is now open for the Graft versus Host Disease (GvHD) National Symposium, Friday, April 24, at the Embassy Suites Cleveland. This conference is intended to raise awareness about the signs and symptoms of GvHD, review cutting edge approaches to prevention and treatment, and highlight and promote research to further our understanding of its cause.
The symposium will have two tracks: a scientifically rigorous one for physicians and practitioners, and a survivor track that will focus on challenges faced by BMT recipients and their families. The survivor track is intended to provide both education and the opportunity for individuals to interact with national leaders in the GvHD field. The afternoon "Meet the Expert" uniquely interactive breakout sessions will provide an opportunity for the physicians, survivors and their families to come closely together during the program. Continuing Medical Education credits will be offered.
Case CCC Annual Scientific Retreat
The Case CCC Annual Scientific Retreat will be held July 9-10, 2015. The agenda is still being planned, but we hope you will set aside time to attend this important event! More details will be posted in future newsletters.
SAGES Capstone Resource Grant
The SAGES capstone resource grant is funding specifically for resources to aid CWRU students in carrying out their capstone projects. We are especially interested in allowing students to be more ambitious and creative in designing and completing these projects. Resources are defined broadly to include supplies, travel support, admissions for museums, etc. The SAGES capstone resource grant does NOT allow stipend support.
Deadline: February 6
Case-Coulter Translational Research Partnership (CCTRP)
This is the fourth year of the second phase of the Case-Coulter Translational Research Partnership (CCTRP) to support collaborative translational research projects that address unmet or poorly met clinical needs. The CCTRP seeks to reduce the market risk of promising new clinical products arising from the research programs of BME and other Case faculty. Successful projects will thus often focus on the development of prototype products, building relationships with companies, performing clinical feasibility studies, obtaining regulatory approval, and other activities that companies or business experts indicate are the essential last steps before a license can be negotiated or a startup launched. An overarching goal of the program is to foster research and development work likely leading to commercially relevant translational technologies within a three- to five-year horizon. Because the goals of all Coulter projects are to reduce market risk, all proposals are expected to reflect genuine business input, and all projects must include a "business advisor" as an important member of the decision making team.
LOI Deadline: February 13
CWRU Skin Diseases Research Center (SDRC)
The Skin Diseases Research Center is funded by a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. The goal of the Center is to foster translational and basic research in cutaneous biology and skin diseases. The SDRC sponsors innovative research through its Pilot and Feasibility (P&F) Program and plans to support three new P&F projects for funding for one year with an annual budget of $25,000 (direct costs). Projects are supported with the understanding that the PI will subsequently apply for NIH or equivalent funding using preliminary data acquired during the P&F project period.
Deadline: February 27
Multiple Myeloma Research Grants
Significant advances in our understanding of the pathophysiology and molecular biology involved in multiple myeloma have identified numerous putative molecular targets for therapeutic intervention. The MMRF welcomes proposals on any and all multiple myeloma related topics to the traditional Research Grant Award programs. Applications are accepted from non-profit institutions and universities in the United States and internationally.
- Senior Research Awards are for established investigators who hold an MD, PhD or equivalent degree who have documented experience in blood cancer research or in research areas that are pertinent to multiple myeloma. The goal of this initiative is to accelerate the development of therapeutic approaches for myeloma and may include proposals in basic science, validation, or clinical research. Applicants may request up to $100,000 per year for 2 years, or $200,000 total.
Deadline: March 17
- Research Fellow Awards are for researchers who hold an MD, PhD or equivalent degree at the post-doctorate, clinical fellow or assistant professor levels who are beginning studies in the multiple myeloma field under the supervision of a research mentor or sponsor. Applicants may request up to $75,000 for one year.
Deadline: April 21
American Cancer Society: The Role of Health Policy and Health Insurance in Improving Access to and Performance of Cancer Prevention, Early Detection, and Treatment Services
The American Cancer Society has released a Request for Applications (RFA): The Role of Health Policy and Health Insurance in Improving Access to and Performance of Cancer Prevention, Early Detection, and Treatment Services. This RFA is a call for research that evaluates the impact of the many changes now occurring in the healthcare system with a particular focus on cancer prevention, control, and treatment. Efforts focusing on improving access to care may also impact inequities that contribute to health disparities. New health public policy initiatives such as the new federal and state marketplaces that have expanded insurance coverage, as well as Medicaid expansion in some states, create natural experiments ripe for evaluation. Research to be funded by this RFA should focus on the changes in national, state, and/or local policy and the response to these changes by healthcare systems, insurers, payers, communities, practices, and patients.
Applications may be submitted by not-for-profit institutions located within the United States, its territories and the Commonwealth of Puerto Rico. Independent investigators at all stages of their career are eligible to apply. The usual ACS restriction to investigators within the first six years of their initial independent research appointment for the Research Scholar grant applicants does not apply to this RFA.
Deadline: April 1, 2015
National Center for Accelerated Innovations (NCAI-CC)
Leukemia & Lymphoma Society Translational Research Program (TRP)
Lila and Murray Gruber Memorial Cancer Research Award
Ohio Cancer Research Associates
Myeloma Research Foundation
Bladder Cancer Advocacy Network 2015 Young Investigator Awards
Taub Foundation Grants Program for Myelodysplastic Syndromes (MDS) Research
Limited Submission: National Science Foundation Collections in Support of Biological Research (CSBR)
Worldwide Cancer Research
International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Solving Kids' Cancer Therapeutic Development Initiative
Support of Multi-investigator Initiatives in the Case CCC
Collaborative Activity Awards
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