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November 24, 2014


Dr. Stan Gerson

Stan Gerson, MD
Director, Case CCC

Case CCC 2014 High Impact Publications

The External Advisory Board to the Cancer Center noted the uptick in high impact papers from our members. Congratulations!

In the past year (Sept 2013-Sept 2014) 27 of our members co-authored a high impact paper, representing 7 of our Scientific Programs. The list is remarkable for its breadth– from novel MR imaging to cancer prevention to early detection, with basic mechanisms thrown in! We have compiled a full list with links to these remarkable observations. For those with a paper in press, we will list and congratulate you next year. For those thinking about their next publication, AIM HIGH!

ASH Annual Meeting

The American Society of Hematology (ASH) Annual Meeting will be held December 6-9 in San Francisco. The Case CCC is pleased to have many members participating, presenting, and leading sessions. Please support your colleagues if you are attending the meeting. Congratulations to everyone!

In addition, the Seidman Cancer Center invites all Cancer Center members to attend an hors d'oeuvres and cocktail reception, co-hosted by myself, Hillard Lazarus, Clark Distelhorst, and Jane Little. We hope you will join us on Saturday, December 6 at 7:30 pm at the Intercontinental Hotel, The Living Room – Lobby Level near Luce (888 Howard Street, San Francisco, CA). Please RSVP to Shelly Parkhurst at Shelly.Parkhurst@UHhospitals.orgor 216.767.8567.


MMA's Impact on Chemotherapy Prescribing Less Than Assumed
Medscape- Nov 20, 2104
Changes in reimbursement for outpatient prescription drugs as stipulated by the Medicare Modernization Act (MMA) of 2003 may have had less of an impact on prescribing patterns of chemotherapy than previously assumed. According to a new article in the Journal of Clinical Oncology, the introduction of new drugs and clinical evidence, as well as other factors, appear to be the strong drivers of new prescribing patterns...But as Lowell E. Schnipper, MD, from Beth Israel Deaconess Medical Center, Boston, Massachusetts, and Neal J. Meropol, MD, University Hospitals Case Medical Center Seidman Cancer Center and Case Comprehensive Cancer Center, Cleveland, Ohio, note, the decision as to whether chemotherapy should be administered and which drugs to prescribe ideally should not be influenced by financial incentive. "Rather, oncologists would be reimbursed for the care they provide and would base their recommendations solely on evidence regarding treatment value in the context of individual patient preferences," they say, adding that financial incentives could be aligned with the clinical outcome of a therapy. Basically, it is time for a change in how oncologists are paid. "The current payment system misaligns incentives among physicians, drug makers, payers, and patients for providing high-quality cancer care," the editorialists write. "Although there are historical reasons that led to the development of the present system, the time is ripe to develop, test, and implement a prescription for change."

MetroHealth Offers 3D Ultrasound Cancer Screening for Women with Dense Breasts
The Plain Dealer - Nov 19, 2014
With Ohio on the verge to be the latest state to pass a breast density notification law, the MetroHealth System is now offering women an additional breast cancer screening tool. MetroHealth is the first hospital in Northeast Ohio with 3-dimensional breast ultrasound. The Invenia ABUS system, made by GE Healthcare, was approved by the Food and Drug Administration last June to be used as a screening tool, along with mammography, for women with dense breast tissue...University Hospitals will begin using ultrasound as a breast cancer screening tool next year, but for now there are no immediate plans to acquire an ABUS system, said Dr. Donna Plecha, director of breast imaging at UH Case Medical Center and member of the Case Comprehensive Cancer Center. "We will use handheld right now," she said. "There are a lot more studies with handheld ultrasound than with automated."

Deep Sedation for Colonoscopy Might not be Safe
Consumer Reports - Nov 19, 2014
Getting knocked out during a colonoscopy might seem like a good idea. After all, being awake as your doctor uses a long, flexible tube to get an inside view of your lower intestines doesn't sound very appealing. To avoid that problem, many doctors now routinely use the drug propofol (Diprivan) during colonoscopy to cause deep sedation in their patients...For example, propofol increases your risk of aspiration pneumonia (caused by inhaling particles such as vomit, mucus, or saliva) by almost 50 percent, according to a study by Gregory Cooper, MD, in the journal JAMA Internal Medicine. And it can cause a host of other side effects, including confusion, seizures, irregular heart beats, and potentially deadly allergic reactions.

Should Transplant Centers Use a Specific Age Cutoff for Transplanting Elderly Patients?
MedPage Today - Nov 17, 2014 (video)
For the month of November, MedPage Today has invited hematologists from leading medical institutions to "deconstruct" multiple myeloma diagnosis and treatment. In this installment we asked, "Should transplant centers use a specific age cutoff for transplanting elderly patients?" Our participants are: Matt Kalaycio, MD, of the Cleveland Clinic, and Hillard Lazarus, MD, of University Hospitals Case Medical Center in Cleveland. Both are members of the Case Comprehensive Cancer Center.

Curcumin and Tackling Mesothelioma: An interview with Dr. Afshin Dowlati
News-Medical.Net - Nov 17, 2014
THOUGHT LEADERS SERIES...insight from the world's leading experts, featuring Dr. Afshin Dowlati of the Case Comprehensive Cancer Center and UH Seidman Cancer Center.

Charis Eng, AB'82, PhD'86, MD'88, Discovers Key Genetic Markers Linking Cancer and Autism
University of Chicago Magazine - Nov/Dec 2014
Some people have trophies; geneticist Charis Eng, AB'82, PhD'86, MD'88, has empty wine bottles arranged on a high shelf in her office at Cleveland Clinic's Lerner Research Institute. The budget-minded Seaview Brut and Roeder Estate hark back to the late 1990s, when Eng and her colleagues at Dana-Farber Cancer Institute toasted her discoveries around PTEN, a gene linked to a tumor-causing disease called Cowden syndrome. "We were poor then," says Eng, the chair and founding director of the Cleveland Clinic's Genomic Medicine Institute and member of the Case Comprehensive Cancer Center, with a twinkle behind her silver-rimmed glasses.

Texture Analysis Shows Level of Invasion of Ground-glass Lung Nodules
AuntMinnie- Nov 10, 2014
In this talk, researchers from Case Western Reserve University will share how textural analysis techniques may be able to decrease the number of unnecessary biopsies in ground-glass non-small cell lung nodules. Improved imaging methods are needed to distinguish benign confounding disease (fibrosis) from ground-glass nodules with no or minimal invasion and those with frank invasion to guide clinicians toward surveillance or surgical resection. Studies have shown that up to 25% of surgically resected ground-glass nodules are benign, resulting in significant overtreatment for patients who don't have lung cancer, according to senior author Anant Madabhushi, PhD,member of the Case Comprehensive Cancer Center and director of the Center of Computational Imaging and Personalized Diagnostics at Case Western Reserve University.


CWRU #GivingTuesday to Benefit the Case Comprehensive Cancer Center

The Tuesday after Thanksgiving, Black Friday and Cyber Monday, is nationally recognized as "#GivingTuesday," a movement to create a day of giving to kick-off the giving season.

This year, #GivingTuesday falls on December 2. The Case Comprehensive Cancer Center has been selected by CWRU as one of several campus organizations to benefit from donations given on this day. If you are going to participate in #GivingTuesday, please consider donating locally and supporting the great work being done right here at home at the Cancer Center. We also hope you will encourage your friends and family join in this national movement.

Additional information will be provided via email and on ourFacebook and Twitter pages later this week. Please visit theCWRU #GivingTuesday webpage for details.


$50,000 Childhood Cancer Research Grant Awarded to Case Western Reserve University

Dr. Alex HuangThe St. Baldrick's Foundation, a volunteer-driven and donor-centered charity dedicated to raising money for childhood cancer research, is proud to award a one-year, $50,000 grant to the Case Western Reserve University. This grant is one of 40 infrastructure grants awarded as part of the Foundation's fall grant cycle, totaling more than $2.5 million and surpassing last year's total awarded during this same period.

"This grant will help us improve the next generation of immunotherapy for childhood and adolescent cancer patients," said Alex Huang, MD, PhD, associate professor of Pediatrics and Pathology at Case Western Reserve University, and a member of the Case Comprehensive Cancer Center. "With such limited funding for childhood and adolescent cancer research, we are very appreciative to the St. Baldrick's Foundation for their support."


Colon Cancer Alliance-AACR Fellowship in Young-Onset Colorectal Cancer Research

The Colon Cancer Alliance-AACR Fellowship in Young-Onset Colorectal Cancer Research represents a joint effort to encourage and support a postdoctoral or clinical research fellow to conduct colorectal cancer research focusing on reducing colorectal cancer incidence and mortality as well as targeted treatments among the young-onset population and to establish a successful career path in this field. The research proposed for funding may be basic, translational, clinical or epidemiological in nature and must have direct applicability and relevance to young-onset colorectal cancer.
Deadline: December 9

International Association of the Study of Lung Cancer

The purpose of International Association of the Study of Lung Cancer (IASLC) is to promote the study of the etiology, the epidemiology, the prevention, the diagnosis, the treatment and all other aspects of lung cancer and to disseminate information about lung cancer to the members of the Association to the medical community at large, and to the public. The IASLC provides fellowship and young investigator awards in all aspects of lung cancer research.
Deadline: January 15, 2015

GI SPORE: Request for Project Proposals

All Faculty members are invited to submit concept proposals for five-year Projects to compete for incorporation as a full project proposal in the upcoming GI SPORE competing renewal application that will be prepared starting in January 2015 for submission in September 2015.

All proposals must be directed towards translational research of a GI malignancy, with at least one specific aim that involves direct study of patients or of human tissues. Proposals must include two project leaders: one Basic Science leader and one Clinical leader. Previously submitted SPORE pilot applications are welcome to be resubmitted as full projects, and may be updated with any new progress. 
Deadline: January 16, 2015


Friends For An Earlier Breast Cancer Test®
Deadline: December 1

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: December 1

Kure It-AACR Research Grant for Immunotherapy in Kidney Cancer
Deadline: December 2

Alex's Lemonade Stand Foundation Innovation Grant
LOI Deadline: December 3

DoD BCRP Breakthrough Award Funding Level 1 and 2
Pre-Application/LOI Deadline: December 3
Application Deadline: December 17

Sidney Kimmel Foundation for Cancer Research Kimmel Scholar Award
Deadline: December 3

Sidney Kimmel Foundation for Cancer Research Kimmel Translational Science Award
Deadline: December 3

Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research
Deadline: December 9

Alex's Lemonade Stand Foundation Epidemiology Grants Epidemiology Grants
Deadline: December 15

Doris Duke Clinical Research Mentorship Program
Deadline: January 13, 2015

Radiological Society of North America
Deadline: January 15, 2015

Lila and Murray Gruber Memorial Cancer Research Award
Deadline: February 28, 2015

Worldwide Cancer Research
Deadline: April 24, 2015

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

Collaborative Activity Awards
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

National Cancer Institute Program Project Applications (P01)(PAR-15-023)

Environmental Influences During Windows of Susceptibility in Breast Cancer Risk (U01)(RFA-ES-14-012)

NIH Request for Public Comments on the Draft NIH Policy on Dissemination of NIH-Funded Clinical Trial Information (NOT-OD-15-019)

Notice of Pre-application Teleconference for RFA-CA-14-014, RFA-CA-14-015, RFA-CA-14-016, and RFA-CA-14-017 for The "Early Detection Research Network" Program (NOT-CA-15-002)

Notice of Change in Application Due Date for RFA-CA-14-014 "The Early Detection Research Network: Biomarker Developmental Laboratories (U01)" (NOT-CA-15-003)

Notice of Change in Application Due Date for RFA-CA-14-015 "The Early Detection Research Network: Clinical Validation Centers (U01)" (NOT-CA-15-004)

Notice of Change in Application Due Date for RFA-CA-14-016 "The Early Detection Research Network: Biomarker Developmental Laboratories (U01)" (NOT-CA-15-005)

Notice of Change in Application Due Date for RFA-CA-14-017 "The Early Detection Research Network: Data Management and Coordinating Center (U24)" (NOT-CA-15-006)

Research Aimed at Novel Behavioral Targets to Improve Adolescent Substance Abuse Treatment and Prevention Interventions (R34)(PA-15-035)

Administrative Supplements for Tobacco Regulatory Research on the Public Display of Harmful and Potentially Harmful Constituents (HPHC) Information (Admin Supp)(PA-15-046)

Systems Science and Health in the Behavioral and Social Sciences (R21)(PAR-15-047)

Systems Science and Health in the Behavioral and Social Sciences (R01)(PAR-15-048)


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at


Tues, Nov 25

Molecular Genetics Departmental Research Seminar Series
Jarnail Singh, PhD
Project Staff, Padgett Lab, Molecular Genetics
Cleveland Clinic
Topic: Inherited and Somatic Mutations in RNA Helicase Gene DDX41 in MDS and Myeloid Neoplasms
9:30 am NE1-205 Cleveland Clinic

Pharmacology Seminar Series
Girish Shukla, PhD
Associate Professor, Biology, Geology, Environmental Science
Cleveland State University
Topic: TBD
12 pm Wood W331/Webster Conference room

THOR Meeting
Valeria Visconte, PhD
Department of Translational Hematology and Oncology Research
Cleveland Clinic
Topic: Genetics of Myelodysplastic Syndromes
1 pm R3-027 Cleveland Clinic

Mon, Dec 1

Pathology Research Seminar Series
Bryan Benson
Ransohoff Lab, Pathology
Topic: Modeling the Cerebral Microvasculature
Grant Zimmerman
Zhou Lab, Pathology
Topic: Zimmerman: Dysregulated Selectin Ligands Drive Leukemic Progression
12 pm WRB 1-413

GMI Seminar
Amanda Shalkhauser
Genomic Medicine Institute, Serre Lab
Cleveland Clinic
Topic: De Novo Transcriptome Assembly from Individual Anopheles Mosquitoes: Genes, SNPs and More
12:30 pm NE1-205 Cleveland Clinic

Molecular Oncology Program Tumor Immunology and Immunotherapy Focus Group Meeting
4 pm NA1-139 Cleveland Clinic

Tues, Dec 2

Immunology Research Seminar Series
Pamela Wearsch, PhD
Department of Pathology
Topic: TBD
Wolstein Research Bldg 1-413

Pharmacology/Ophthalmology Joint Seminar
W. Daniel Stamer, PhD
Duke Eye Center
Topic: TBD
Wood W331/Webster Conference room

THOR Meeting
Mark Brown, PhD
Assistant Staff, Cellular & Molecular Medicine
Cleveland Clinic
Topic: Targeting Glycerophospholipid Metabolism for Treatment of Hepatocelluar Carcinoma and Glioblastoma
1 pm R3-027 Cleveland Clinic

Special Cancer Center Seminar Series
Etty (Tika) Benveniste, PhD
Professor and Chair, Cell, Developmental and Integrative Biology
University of Alabama at Birmingham School of Medicine
Topic: The Role of Protein Kinase CK2 in Glioblastoma
1:30 pm BRB 105

Wed, Dec 3

Cancer Center Faculty Candidate
Wenge Zhu, PhD
Assistant Professor, Biochemistry and Molecular Biology
George Washington University Medical Center
Topic: Maintenance Of Genomic Stability In Human Cell
11 am BRB 105

Thurs, Dec 4

Molecular Biology & Microbiology Seminar
Rojas Lab, Molecular Biology & Microbiology
Topic: TBD
1 pm Rottman Seminar Room W203

Fri, Dec 5

Taussig Cancer Institute Grand Rounds
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar
Jan Jensen, PhD
Associate Professor, Stem Cell Biology and Regenerative Medicine
Cleveland Clinic
Topic: Towards Developmental Systems Biology: Creation of a technology platform addressing cellular differentiation using multi-dimensional perturbation experimental designs
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Paul Fox, PhD
Professor, Cellular and Molecular Medicine
CWRU/Cleveland Clinic
Topic: VEGF-Ax, a Novel, Anti-angiogenic Factor Generated by Programmed Translational Readthrough of VEGFA mRNA
12 pm BRB 105


Case CCC Calendar

LRI Calendar


ASH Review
January 21, 2015

Best of San Antonio Breast Cancer Symposium
February 4, 2015

Multidisciplinary Head and Neck Cancer Update
Weston, FL
March 6-7, 2015

Lung Cancer Course
April 25, 2015


Symposium on Global Cancer Research
March 25, 2015
Boston Sheraton Hotel