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November 17, 2014

CASE CCC IN THE NEWS

Clinic's VeloSano Cycling Event Brings in More than $1.95 Million for Cancer Research
Crain's Business Cleveland - Nov 14, 2014
Cleveland Clinic announced its inaugural VeloSano cycling event raised more than $1.95 million to support cancer research at the health system..."We are extremely grateful to all who supported and participated in VeloSano's inaugural year," said Dr. Brian J. Bolwell, chairman of Clinic's Taussig Cancer Institute, in a release.

Multidisciplinary Teams in NSCLC Important for Optimal Patient Care
Targeted Oncology- Nov 13, 2014
Increasing knowledge of the diverse pathologic and molecular phenotypes in non-small cell lung cancer (NSCLC) has driven a more complex treatment algorithm in recent years. This complexity emphasizes the need for a multidisciplinary approach to better manage comprehensive, personalized patient care...Mutations in the epidermal growth factor receptor (EGFR) gene and translocations in the anaplastic lymphoma kinase (ALK)-tyrosine kinase receptor are 2 of the most common genetic abnormalities for which targeted treatments are available. Patrick C. Ma, MD, MS, from the Cleveland Clinic Taussig Cancer Institute and Case Comprehensive Cancer Center, added that "a timely, multiplexed genomic profiling determination…is already becoming a new standard."

Coverage of Lung Cancer Screening Proposed by Medicare; Local Hospitals Praise the Move
The Plain Dealer - Nov 11, 2014
A proposal by the Centers for Medicare & Medicaid Services to cover the cost of lung cancer screening for a specific group of Medicare recipients is being welcomed by local hospitals that for years have been providing the service at a greatly reduced cost...The fact that Medicare is willing to cover the cost of a visit to talk specifically about lung cancer screening is significant, said Dr. Peter Mazzone, a Cleveland Clinic pulmonologist and member of the Case Comprehensive Cancer Center who has conducted extensive research on potential early lung cancer detection tools. "We all want to do that for every one of our patients, but traditionally there has been no support for that," he said. "To have 10 or 15 minutes in a [doctor's] office to talk about smoking cessation, blood pressure, exercise and to pay the appropriate amount of time to discuss the harms and benefits of screening is somewhat unrealistic."

Exploradio: Cleveland's growing stem cell scene
WKSU- Nov 10, 2014
The project is the brain-child of Stan Gerson, head of the National Center for Regenerative Medicine and Case Comprehensive Cancer Center. About the name of his center – he says, "it's not really regenerative exactly, it's cell therapy – it's restoration with cells rather than with drugs." He and his colleagues at Case were among the first to treat people using stem cells. But Gerson says that, despite the deep academic know-how here in Ohio, the East and West Coasts are where the stem-cell industry is taking root. "We don't have enough financial risk takers that are willing to take the same risks here that they might take on the coasts, and yet we know we're as competitive and as strong intellectually as anybody on the coasts are, so we need more investments," according to Gerson.

Case Western Reserve Center Wins Second Round of CDC Funding for Urban Public Health Research
The Plain Dealer - Nov 5, 2014
For the past five years, a large group of Cleveland's public health experts, headed up by the Prevention Research Center for Healthy Neighborhoods (PRCHN) at Case Western Reserve University, have been working together to tackle some of the biggest problems facing the city's urban neighborhoods...Last week, the center received a five-year $4.35 million grant from the Centers for Disease Control and Prevention to renew its operation, and another $2.97 million to fund ongoing projects focused on smoking cessation, living with epilepsy, and coping with chronic disease and dementia. "We've just brought in a ton of money, but it's not money that the university keeps – we're trying to build public health practice," said Elaine Borawski, the PRCHN's director and principal investigator and member of the Case Comprehensive Cancer Center. "We're not a traditional research center – our entire being is based on a community partnership, so it's a very different model for research."


NATIONAL DAY OF GIVING

CWRU #GivingTuesday to Benefit the Case Comprehensive Cancer Center

The Tuesday after Thanksgiving, Black Friday and Cyber Monday, is nationally recognized as "#GivingTuesday," a movement to create a day of giving to kick-off the giving season.

This year, #GivingTuesday falls on December 2. The Case Comprehensive Cancer Center has been selected by CWRU as one of several campus organizations to benefit from donations given on this day. If you are going to participate in #GivingTuesday, please consider donating locally and supporting the great work being done right here at home at the Cancer Center. We also hope you will encourage your friends and family join in this national movement.

Additional information will be provided via email and on ourFacebook and Twitter pages later this week. Please visit theCWRU #GivingTuesday webpage for details.


AMERICAN ASSOCIATION FOR CANCER RESEARCH

AACR Annual Meeting 2015: Call for Clinical Trials Abstracts

The AACR Annual Meeting will be held April 18-22, 2015 in Philadelphia. AACR is encouraging attendees to submit clinical trials for presentation at the AACR Annual Meeting 2015 to facilitate the continued growth of the invaluable clinical content of this meeting. There will be at least 38 opportunities for the oral presentation of clinical trials at the Annual Meeting, including the presentation in the Opening Plenary Session of an outstanding clinical trial that holds promise for changing clinical practice and approaches. We also offer four marquee Clinical Trials Symposia which will feature tandem presentations of the trial data and the science informing the trial. Please keep in mind that there are also many poster sessions, including one focusing on highly informative "Trials in Progress."

Clinical trial abstracts that are available by the Wednesday, Dec. 3, 2014 deadline should be submitted to the appropriate Clinical Trial (CT) category. Late-breaking and placeholder abstracts should be submitted by Tuesday, Jan. 27, 2015. If a placeholder abstract is submitted, completed abstracts must be submitted no later than Friday, Feb. 27, 2015. Full instructions and guidelines for submitting clinical trials are available Annual Meeting website. Abstracts selected for presentation will be embargoed in accordance with AACR guidelines.


FUNDING OPPORTUNITIES

Call for Applications: Computational Genomic Epidemiology of Cancer (CoGEC) Training Program

The Case Comprehensive Cancer Center invites applications to its funded program for research associates, for a start date of August 1, 2015. This program combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum.

This program is designed to prepare research associates for careers as: Independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics, and computer science. Cancer researchers obtaining training will have the skills vital to decipher the complex pathways compromised of genetic and environmental risk factors for disease, and will ultimately be able to provide clinicians and their patients with valuable information for the prevention and treatment of cancer. Salary and research supply funds are highly competitive.

Requirements:

  • US citizenship or permanent residency.
  • Terminal degree (PhD, MD or MD/PhD).
  • Demonstrated skills in quantitative analysis and an interest in a career in cancer genetics research.

For more information about the program and application materials, please visit the Cancer Center website OR contact Lyn Haselton at lmh92@case.edu.

Limited Submission: Damon Runyon Clinical Investigator Award

The Damon Runyon Clinical Investigator Award supports independent young physician-scientists conducting disease-oriented research that demonstrates a high level of innovation and creativity. The goal is to support the best young physician-scientists doing work aimed at improving the practice of cancer medicine. The awardee will receive financial support for three years, as well as assistance with certain research costs such as the purchase of equipment. The Foundation will also retire up to $100,000 of any medical school debt still owed by the awardee. Visit the Cancer Center website for application information.
LOI Due to Cancer Center: November 17
Application Due to Sponsor: February 17, 2015

Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research

The Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research was established to recognize the outstanding achievement of a junior faculty-level scientist working in the field of cancer prevention, and support his or her novel and innovative research that, if successful, will have the potential for high impact in the cancer prevention field. The goal of the grant program is to encourage junior faculty, who have completed their most recent doctoral degree or medical residency within the past 11 years at the start of the grant term, to pursue novel, high-risk, high-reward cancer prevention research. Travel support is included to help foster interactions and collaborations among cancer scientists studying various aspects of cancer biology and to disseminate scientific knowledge about cancer prevention research within the field. 
Deadline: December 9

PREVIOUSLY ANNOUNCED OPPORTUNITIES

Limited Submission: Rita Allen Foundation Scholars Program
CWRU LOI Deadline: November 17
External Application Deadline: December 12

Melanoma Research Alliance Academic-Industry Partnership Award (for Established Investigators and Teams) and BMS-MRA Team Science Award
Deadline: November 21

Limited Submission: NIH Director's Early Independence Award
CWRU LOI Deadline: December 1
NIH LOI Deadline: December 30
NIH Application Deadline: January 30, 2015

Friends For An Earlier Breast Cancer Test®
Deadline: December 1

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: December 1

Kure It-AACR Research Grant for Immunotherapy in Kidney Cancer
Deadline: December 2

Alex's Lemonade Stand Foundation Innovation Grant
LOI Deadline: December 3

DoD BCRP Breakthrough Award Funding Level 1 and 2
Pre-Application/LOI Deadline: December 3
Application Deadline: December 17

Sidney Kimmel Foundation for Cancer Research Kimmel Scholar Award
Deadline: December 3

Sidney Kimmel Foundation for Cancer Research Kimmel Translational Science Award
Deadline: December 3

Alex's Lemonade Stand Foundation Epidemiology Grants Epidemiology Grants
Deadline: December 15

Doris Duke Clinical Research Mentorship Program
Deadline: January 13, 2015

Radiological Society of North America
Deadline: January 15, 2015

Lila and Murray Gruber Memorial Cancer Research Award
Deadline: February 28, 2015

Worldwide Cancer Research
Deadline: April 24, 2015

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

Collaborative Activity Awards
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Administrative Supplements for Research on Sex/Gender Differences (Admin Supp)(PA-15-034)

National Cancer Institute Program Project Applications (P01)(PAR-15-023)

Cancer Prevention, Control, Behavioral Sciences, and Population Sciences Career Development Award (K07)(PAR-15-033)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

EVENTS

Mon, Nov 17

Pathology Research Seminar Series
Andrew Lavik
Distelhorst L ab, Div. of Hem/Onc
CWRU/UH
Topic: The Role of IP3 Receptor-Interacting Proteins in Regulating Calcium Signals and Cell Survival
12 pm WRB 1-143

Genomic Medicine Institute Seminar
Madhav Sankunny
Eng Lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Maintenance of Pericentromeric H3K9 Trimethylation in Association with KLLN is Essential for Safeguarding Genomic Stability
12:30 pm NE1-205 Cleveland Clinic

Physiology & Biophysics Seminar
Peter J. Thomas, PhD
Associate Professor, Mathematics, Applied Mathematics and Statistics
Departments of Biology and Cognitive Science
CWRU
Topic: Measuring Edge Importance: a quantitative analysis of the stochastic shielding approximation for random processes on graphs
4 pm SOM/Robbins E-501


Tues, Nov 18

Radiation Oncology Grand Rounds
Ravi Patel, MD
Radiation Oncology
CWRU/UH
Topic: Automated Prostate Segmentation for Pelvic Radiotherapy: Preliminary Results and Future Directions
8:10 am Lerner Tower B-151

Immunology Research Seminar Series
Michael Katsnelson
Dubyak Lab, Immunology
CWRU
Topic: Calcium-Independent Activation of the NLRP3 Inflammasome in Response to the Potassium Ionophore Nigericin and Extracellular ATP/P2X7
12 pm WRB 1-413

THOR Meeting
Remco Molenaar
MD/PhD Candidate, Cell Biology and Histology
University of Amsterdam
Topic: IDH 1/2 Mutations in Solid Tumors and Leukemias: Friends and foes
1 pm R3-027 Cleveland Clinic


Wed, Nov 19

Hematology/Oncology Special Presentation
Leland Metheny, MD
Chief Fellow, Hematology and Oncology
CWRU/UH
Topic: Mesenchymal Stromal Cells and Allogeneic Transplantation
8 am Lerner 151


Thurs, Nov 20

Cancer Trainee Seminar
Research Speaker: Karin Lee
Topic: A Long-circulating PVX-based Nanoparticle for Enhanced Tumor Homing and Therapeutic Payload Deliver
AND
Clinical Speaker: Carlos Silva
Clinical Topic: Diagnosis and Treatment of Leukemia
12 pm WRB 3-136

Pharmacology Seminar
Linda Hshieh-Wilson, PhD
Professor, Chemistry
Investigator, Howard Hughes Medical Institute
California Institute of Technology
Topic: The Sweeter Side of Cellular Signaling: Roles of Carbohydrates from Neuroregeneration to Metabolism
12 pm Wood W331/Webster Conference room

Molecular Biology & Microbiology Seminar
Yotam Blech-Hermoni
Ladd lab, Molecular Biology and Microbiology
CWRU
Topic: Thesis Defense
1 pm Rottman Seminar Room W203


Fri, Nov 21

Taussig Cancer Institute Grand Rounds
Bo Zhao, MD
Cleveland Clinic
Topic: Opportunities in the Changing Landscape of Hormonal Therapy in Prostate Cancer
8 am R3/002-003 Cleveland Clinic

World Health Interest Group Seminar
Peter A. Zimmerman, PhD
Professor, International Health, Biology and Genetics
CWRU
Topic: Vivax Malaria in Madagascar
9 am BRB 433

Cancer Center Seminar Series
Kishore Guda, DVM, PhD
Assistant Professor, General Medical Sciences-Oncology
Case Comprehensive Cancer Center
CWRU
Topic: Molecular Genetics of Gastrointestinal Cancers
12 pm BRB 105

Cancer Center Research in Progress
Duncan Stearns, MD
Assistant Professor, Pediatrics
CWRU/UH
Topic: Matrix Reloaded: An update on the role of type III collagen in medulloblastoma tumorigenesis
4 pm WRB 3-136


Mon, Nov 24

Genomic Medicine Institute Seminar
Angela Ting, PhD
Associate Staff, Genomic Medicine Institute
Assistant Professor, Molecular Medicine
CWRU/Cleveland Clinic
Topic: Lab Updates: DNA methylation in many contexts
12:30 pm NE1-205 Cleveland Clinic

Breast Cancer Program Focus Group Meeting
Topic: Transcription and Gene Expression 
4 pm WRB 3-136


Tues, Nov 25

Pharmacology Seminar Series
Girish Shukla, PhD
Associate Professor, Biology, Geology, Environmental Science
Cleveland State University
Topic: TBD
12 pm Wood W331/Webster Conference room

THOR Meeting
Valeria Visconte, PhD
Department of Translational Hematology and Oncology Research
Cleveland Clinic
Topic: Genetics of Myelodysplastic Syndromes
1 pm R3-027 Cleveland Clinic

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

14th Annual Multidisciplinary Genitourinary Oncology Course
November 20, 2014
InterContinental Hotel & Bank of America Conference Center
Details and Registration

ASH Review
January 21, 2015

Best of San Antonio Breast Cancer Symposium
February 4, 2015

Multidisciplinary Head and Neck Cancer Update
Weston, FL
March 6-7, 2015

Lung Cancer Course
April 25, 2015

ADDITIONAL UPCOMING SEMINARS & EVENTS

Symposium on Global Cancer Research
March 25, 2015
Boston Sheraton Hotel
Details