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October 13, 2014

MESSAGE FROM THE DIRECTOR

Dr. Stan GersonStan Gerson, MD
Director, Case CCC

Case Comprehensive Cancer Center Cancer Education Committee

Dear members of the Cancer Center community:

I am excited to share a new initiative with you, aimed at improving cancer training and education throughout our institutions.

We currently have a multitude of training environments, many of which are not coordinated with each other and do not take full advantage of the superb training environment that our location can provide. We believe we have a unique opportunity to take the lead in not only improving the coordinated effort of these cancer activities throughout our training programs, but also to enhance the quality of training, and improve support for these activities through internal sources, philanthropy and grant efforts.

To accomplish these objectives, we have developed the Cancer Education Committee, a group of cancer training leaders throughout our institutions, to start the dialogue about how we can best coordinate activities, consolidate training and expand horizons in cancer in cancer education and research.

Please join me in welcoming this committee and in support of their efforts to improve the reach of the cancer center community in cancer research and education.

Cancer Education Committee
Stanton L. Gerson, MD: Committee Chair; Director, Clinical Oncology Research Career Development Program (K12)
Mark W. Jackson, PhD: Associate Director for Training and Education, Case Comprehensive Cancer Center; Cancer Biology Training Grant (T32)
Robert C. Elston, PhD: Director, Computational Genomic Epidemiology of Cancer (R25)
Li Li, MD, PhD: Associate Director for Prevention Research, Case Comprehensive Cancer Center; Associate Director, Computational Genomic Epidemiology of Cancer (R25)
Noa Noy, PhD: Director, Cancer Pharmacology Training Grant (R25); Cancer Pharmacology Training Program (CPTP)
Joseph A. Bokar, MD, PhD: Associate Professor, Medicine- Hematology and Oncology, CWRU SOM
Smitha S. Krishnamurthi, MD: Associate Professor, Medicine- Hematology and Oncology, CWRU SOM
Siran M. Koroukian, PhD: Associate Professor, Epidemiology & Biostatistics, CWRU
Rachel Egler, MD: Assistant Professor, Pediatric Hematology/Oncology, CWRU SOM
David Mansur, MD: Associate Professor, Radiation Oncology, CWRU SOM
Timothy D. Gilligan, MD, MS: Director, Cleveland Clinic Hematology/Medical Oncology Fellowship Program
Jennifer Eads, MD (Trainee Representative): Clinical Oncology Research Career Development Program (K12) Scholar


IN THE NEWS

Cleveland Clinic Research on Rare Type of Autism Linked to PTEN Gene Reveals Potential Clues to the Brain Disorder
The Plain Dealer - Oct 7, 2014
Researchers at the Cleveland Clinic have been studying the link between a small percentage of children with autism who have mutations in a particular gene, called PTEN, for more than a decade...The PTEN gene, or phosphatase and tensin homolog, was first discovered in 1997 by Clinic cancer geneticist Dr. Charis Eng, who was then working at Dana-Farber Cancer Institute. PTEN provides instructions for making a protein that is found in almost all tissues in the body and acts as a tumor suppressor, helping to regulate the cycle of cell division by keeping cells from growing and dividing too rapidly.

Ohio State University Opens Country's First Fully Integrated Cancer Emergency Department
The Plain Dealer - Oct 6, 2014
To address the complex health needs of cancer patients during and after their treatment, Ohio State University has opened up a new emergency department dedicated solely to those patients, staffed by oncologists and emergency medicine physicians who have been trained in the same treatment protocols and care guidelines...It's not just patient satisfaction that is the driving force behind more specialized emergency care for cancer patients. "The James will save money if patients are diverted from [regular] emergency room to somewhere else," said Dr. Matt Kalaycio, chair of the Cleveland Clinic's department of hematology and medical oncology....With that in mind, the Clinic's Taussig Cancer Institute several months ago launched a low acuity clinic that mimics the care that cancer patients would receive at an emergency department without having to go there...University Hospitals Seidman Cancer Center also offers similar acute care services. In late 2008 it opened the Fast Track Clinic to provide treatment for sickle cell patients at the first signs of a crisis. Because the fields of hematology (blood disorders) and oncology (cancer) often overlap, sickle cell patients are treated at Seidman.


MEMBER & RESEARCH HIGHLIGHTS

Xu Receives Prestigious NIH Director's New Innovator Award

Dr. Rong XuCongratulations to Dr. Rong Xu, who is one of 50 researchers nationwide to receive the 2014 NIH Director's New Innovator Award from the National Institutes of Health. Dr. Xu will receive $2.4 million to support her research of initiating computational analysis of thousands of drugs and their effects. Her goal is to determine whether current drugs can be used in new ways to treat other diseases.

Dr. Xu is an assistant professor in the Division of Medical Informatics at CWRU, and is also a fellow in the Case Comprehensive Cancer Center's Computational Genomic Epidemiology of Cancer (CoGEC) training program. She is mentored by Dr. Li Li, Associate Director of CoGEC. "Her funded research is truly innovative and cutting edge, integrating novel computational bioinformatics methodology with large electronic health record data from a local health system to repurpose commonly used therapeutics for treating diseases, " said Li. "The proposed research could have broad impact in drug development and move the field fast forward."

Previous CWRU faculty who have received this award include 2013 awardee Dr. Derek Taylor, and Drs. Erin Lavik and Brian Cobb.


MARK YOUR CALENDARS

2014 Adolescent and Young Adult Cancers Symposium

There is still time to register for the first Adolescent and Young Adult (AYA) cancer conference hosted by the Case Comprehensive Cancer Center is being held October 30-31 at the Wolstein Research Building. This collaborative symposium is organized by the Angie Fowler Adolescent & Young Adult Cancer Institute at University Hospitals Rainbow Babies & Children's Hospital, UH Seidman Cancer Center, Case Comprehensive Cancer Center, and the Oregon Health & Science University Knight Cancer Institute. The focus of this two-day symposium is on advancement of AYA-related cancer research, including exploration of scientific, clinical and psychological considerations in adolescent and young adult cancer patients.

We are excited to feature two key speakers from University Hospitals Case Medical Center, Dr. Henry Koon, Disease Team Leader of Melanoma and Dr. Cheryl Kingsberg, Division Chief Ob/GYN Behavioral Medicine, CWRU Obstetrics and Gynecology, University Hospitals MacDonald Women's Hospital.

We hope that you will join us this year for our first AYA cancer conference, and we hope that we can help you connect to an international community of researchers and advocates for the AYA cancer community. Register today! Continuing Medical Education credits are available.


FUNDING OPPORTUNITIES

Sidney Kimmel Foundation for Cancer Research

The Sidney Kimmel Foundation for Cancer Research is accepting applications for the following funding opportunities with a deadline of December 3:

  • Kimmel Scholar Award: The Kimmel Foundation is seeking accomplished young investigators dedicated to a career in cancer research. Qualified applicants must hold an MD, PhD or equivalent graduate degree and must perform research in an American not-for-profit institution during the period of Kimmel Foundation support. Applications are limited to those who achieved the equivalent rank of Assistant Professor on or after July, 2011. However, physicians who have both clinical and research responsibility are eligible if appointed on or after July, 2010. These awards are designed for researchers who do not yet have their own R01 funding.
  • Kimmel Translational Science Award: The Foundation provides up to five additional awards specifically for physicians engaged in translational science. Eligibility includes those with MD or equivalent degrees, who have achieved the rank of Assistant Professor on or after July, 2010. Candidates must not hold R01 funding for the laboratory component of their cancer research. Applicants must demonstrate a significant personal involvement in the laboratory component of the translational project described. The translational research may involve primarily animal studies but must include reasonable application to subsequent human investigation.

Support of Case CCC Scientific Program Projects

Proposals are requested from the Case CCC Scientific Programsaddressing unique research opportunities, innovative ideas or areas identified as strategically important to the program. Proposals must be for projects that are aligned with the goals described in the Cancer Center Strategic Plan. They may build on the institutional investments in genomics and informatics, drug screening and discovery, promote the development and use of new technologies, foster new collaborations or strengthen existing research teams through the development of new research areas aligned with the scientific program strategic plan. Attention to catchment area related research is preferred. Proposals should be multi-investigator in nature, with inclusion of translational or clinical research projects.

Each program is asked to submit one response to this RFA.Program leaders must be engaged in identifying potential areas or recommending topics and proposals for the program. Proposals must be reviewed by a committee within the program that is convened specifically for this purpose before being submitted to the Cancer Center Executive Committee. The Executive Committee will make the final determination for funding after evaluating proposals and reviews. It is expected that the research projects will lead to nationally competitive grant proposals from multi-investigator teams.
Deadline for Submission to Program Leaders: November 7 
Deadline for Submission of priority proposals to Executive Committee: December 15

Support of Multi-investigator Initiatives in the Case CCC

The Case CCC will provide two modes of support to new research teams that plan to submit large multi-investigator grant applications (usually non-R support mechanisms).

  • Administrative support and funding for travel are available to encourage team member meetings and meetings with external advisors.
  • Pilot project funding for research teams with an established track record of collaborative research is available to support key research initiatives that are necessary to generate competitive multi-investigator proposals.

Requests are competitive. The research team must demonstrate the active engagement of members, clearly articulate the significance and innovation of the project, and provide a roadmap for acquisition of external funding. Advocacy and support of the specific program leadersinteracting with the team is required. Discussion with Ruth Keri, PhD, Associate Director for Basic Research, is strongly encouraged before developing an application.

Deadline: Open

 

PREVIOUSLY ANNOUNCED OPPORTUNITIES

AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship
Deadline: October 15

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Deadline: October 15

AACR Award for Outstanding Achievement in Chemistry in Cancer Research
Deadline: October 15

American Cancer Society RFA: Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Application Deadline: October 15

American Cancer Society RFA: The Role of Health Policy and Health Insurance in Improving Access to and Performance of Cancer Prevention, Early Detection, and Treatment Services
Deadline: October 15

American Cancer Society RFA: Pilot and Exploratory Studies Using Community-Based Participatory Research (CBPR) to Achieve Cancer Health Equity
Deadline: October 15

American Cancer Society Research Scholar Grants
Deadline: October 15

American Cancer Society Postdoctoral Fellowships
Deadline: October 15

American Cancer Society Mentored Research Scholar Grant
Deadline: October 15

American Skin Association Research Scholar Awards
Deadline: October 18

American Skin Association Research Scholar Awards for Melanoma/Non-Melanoma Skin Cancer
Deadline: October 18

American Skin Association Research Grants
Deadline: October 18

American Skin Association Medical Student Grants Targeting Melanoma and Skin Cancer
Deadline: October 18

DoD BCRP Breakthrough Award Funding Level 3 and 4
Pre-Application (Preproposal) Deadline: October 22
Invited Application Deadline: January 29, 2015

CTSC KL2 Training Program
Deadline: October 27

Doris Duke Clinical Scientist Development Award
Deadline: October 31

Center for Cancer Research Clinical Investigator Development Program
Deadline: October 31

Worldwide Cancer Research
Deadline: October 31; April 24, 2015

Cancer Research Institute Clinic and Laboratory Integration Program (CLIP) Grants
Deadline: November 1

5th Annual DeGregorio Foundation Award for Cancers of the Esophagus and Stomach
Deadline: November 3

Free to Breathe
Deadline: November 7

Melanoma Research Alliance Young Investigator Award (including Dermatology Young Investigators), Established Investigator Award (including BMS-MRA Established Investigators), and Pilot Award (including SITC-MRA Pilot Award)
Deadline: November 11

Carcinogenesis SS Graduate Student Award/Dharm V. Singh Carcinogenesis Endowment Award
Deadline: November 16

Melanoma Research Alliance Academic-Industry Partnership Award (for Established Investigators and Teams) and BMS-MRA Team Science Award
Deadline: November 21

Friends For An Earlier Breast Cancer Test®
Deadline: December 1

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: December 1

Alex's Lemonade Stand Foundation Innovation Grant
LOI Deadline: December 3

DoD BCRP Breakthrough Award Funding Level 1 and 2
Pre-Application/LOI Deadline: December 3
Application Deadline: December 17

Alex's Lemonade Stand Foundation Epidemiology Grants Epidemiology Grants
Deadline: December 15

Worldwide Cancer Research
Deadline: October 31, 2014; April 24, 2015

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

Collaborative Activity Awards
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Spatial Uncertainty: Data, Modeling, and Communication (R21)(PA-15-009)

Spatial Uncertainty: Data, Modeling, and Communication (R01)(PA-15-010)

Spatial Uncertainty: Data, Modeling, and Communication (R03)(PA-15-011)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

EVENTS

Tues, Oct 14

Genetics and Genome Sciences Seminar
Yan Li, PhD
Postdoctoral Fellow, Ludwig Institute for Cancer Research
University of California, San Diego
Topic: Elucidating 3D Regulome in Signal-Dependent Transcription and Stem Cell Differentiation
10 am BRB 105

Immunology Research Seminar Series
Kyle McKenna, PhD
Department of Ophthalmology
Franciscan University
Topic: Consequences of Immune Privilege: Impaired Immunosurveillance of Intraocular Tumors
12 pm WRB 1-413

Cancer Biology Seminar Series
Monica Venere, PhD
Project Staff, Rosenfeld Lab, Cancer Biology
Cleveland Clinic
Topic: Targeting Proliferation and Invasion in Glioblastoma via Mitotic Kinesins
2 pm NC1-202 Cleveland Clinic

DNA Damage/Repair Meeting
Shigemi Matsuyama, PhD
Associate Professor, Div. of Hem/Onc
CWRU/UH
Topic: Possible Role of NHEJ DNA Repair in Preventing Age-dependent Degenerative Diseases
4 pm WRB 3-136


Wed, Oct 15

Hematology and Oncology Division Research Conference
Lisa Rogers, MD 
Medical Director, Neuro-oncology Program
Professor, The Neurological Institute
CWRU/UH
Topic: Fellowship Curriculum Series: Radiation Necrosis
8 am Lerner B-151


Thurs, Oct 16

Annual Nathan S. Greenfield Family Pharmacology Lecture
Raymond Stevens, PhD
Provost Professor of Chemistry and Biology
University of Southern California
Topic: The Amazing Diversity of G-protein Coupled Receptors
10 am WRB 1-413

Cancer Trainee Seminar 
Research Speaker: Tessianna Misko
Dealwis Lab, Pharmacology
CWRU Topic: A Structural and Cellular Approach to Understanding Ribonucleotide Reductase Inhibition
AND 
Clinical Speaker: Yuraj Choudhary
Clinical Topic: TBA
12 pm WRB 3-136

Molecular Biology and Microbiology
Angel Reyes-Rodriguez and Jennifer Cenker
McDonald lab, Molecular Biology and Microbiology
CWRU
Topic: Dendritic Cells Preferentially Enhance HIV Infection of Effector Memory CD4 T Cells in Human Lymphoid Tissues
1 pm Rottman Seminar Room W203

Prostate Cancer Working Group Seminar Series & Journal Club
David Danielpour, PhD
Professor, Div. of General Medical Sciences - Oncology and Pharmacology
CWRU
Topic: Mechanistic Insights on Therapeutic Targets of Prostate Cancer
3 pm NE1-205 Cleveland Clinic


Fri, Oct 17

Taussig Cancer Institute Grand Rounds
Jing Ai, MD
Cleveland Clinic
Topic: Clinical Applications of Single Nucleotide Polymorphism Array & Somatic Mutation Studies in Myeloid Neoplasms
8 am R3/002-003 Cleveland Clinic


Mon, Oct 20

Pathology Research Seminar Series
Mukesh Jain, MD
Professor, Cardiology
CWRU/UH
Topic: TBD
12 pm

GMI Seminar
Pauline Funchain, MD
Eng Lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Microbial Communities in Head and Neck Squamous Cell Carcinoma: Species-Level and Whole Community Comparisons
12:30 pm NE1-205 Cleveland Clinic


Tues, Oct 21

Immunology Research Seminar Series
Elane Reyes
Anthony Lab, Immunology
CWRU
Topic: Characterization of B Cells Subsets in Chronic Hepatitis C Infection
12 pm WRB 1-413

Pharmacology Seminar Series
Anton Komar, PhD
Department of Biology, Geology, Environmental Science
Cleveland State University
Topic: TBD
12 pm Wood W331/Webster Conference room

THOR Lecture Series
Raed Dweik, MD
Director, Pulmonary Vascular Program
Cleveland Clinic
Topic: Research Misconduct
1 pm R3-027 Cleveland Clinic

Cancer Biology Seminar
Yong Lu, PhD
Research Fellow, Yi Lab, Cancer Biology
Cleveland Clinic
Topic: T-Helper 9 Cells: New T Cell Subset for Cancer Adoptive Cell Therapy
2 pm NC1-202 Cleveland Clinic


Wed, Oct 22


Thurs, Oct 23


Fri, Oct 24

Cancer Center Seminar Series
Angela H. Ting, PhD
Associate Staff, Genomic Medicine Institute, Lerner Research Institute
Cleveland Clinic
Topic: DNA Methylation in Cancer: Location, Function, and Intervention
12 pm BRB 105

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Adolescent and Young Adult (AYA) Cancer Conference
October 30-31, 2014
Wolstein Research Building, CWRU campus
Details and Registration

ASTRO Review
November 15, 2014
Crowne Plaza, Independence, OH
Details and Registration

14th Annual Multidisciplinary Genitourinary Oncology Course
November 20, 2014
InterContinental Hotel & Bank of America Conference Center
Details and Registration

ASH Review
January 21, 2015

Best of San Antonio Breast Cancer Symposium
February 4, 2015

Multidisciplinary Head and Neck Cancer Update
Weston, FL
March 6-7, 2015

Lung Cancer Course
April 25, 2015

ADDITIONAL UPCOMING SEMINARS & EVENTS

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas
Details