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October 6, 2014

MESSAGE FROM THE DIRECTOR

Dr. Stan GersonStan Gerson, MD
Director, Case CCC

I was stimulated by the October 2 New York Times op ed titled Young, Brilliant and Underfunded to write the following letter to the editor:

The provocative words of Congressman Andy Harris reflects both his experience as an NIH funded investigator and his frustration with the future of the high quality discovery research by our current, and the next, generation of scientists coming of age in the US. Yet, his imperative to emphasize support for younger investigators need not undermine support for senior scientists and their younger colleagues' mentors. Indeed, these very "seniors" provide incredible support and scientific leadership for aspiring investigators. I agree that more funds need to be set aside to encourage the next generation. However, losing this group will block the US out of the field for a generation. But the answer is to reconsider the stranglehold on NIH funding that is a hinder to health research now, and will have a negative impact for decades. Now is the time to increase the budget for NIH supported research.

But the overall message is critical - we need to find ways to improve funding and academic independence of younger investigators and do so more quickly then we currently have funds to do so. Also, we need to improve the research climate for all of our younger investigators.


CASE CCC IN THE NEWS

Burning Away Brain Tumors
ABC12 - Oct 1, 2014
After baby Liam was born, Meghan had major brain surgery – doctors cut into her skull to remove her tumor. A year later, the tumor came back – and Cleveland Clinic surgeons told Meghan about a new option. "I think it's the next, next big thing in brain tumor surgery," said Dr. Gene Barnett, a Cleveland Clinic Neurosurgeon and member of the Case Comprehensive Cancer Center. Instead of cutting, doctors use heat to destroy the tumor. They heat a thin laser probe up to 130 degrees, then insert it through a tiny hole, and essentially burn the tumor. "It works by heating the tissue around it to the point where it cooks, just like you're cooking a hard boiled egg," explained Dr. Barnett.


MEMBER & RESEARCH HIGHLIGHTS

Scientists Wield Plant Viruses Against Deadly Human Disease

Dr. Nicole SteinmetzCase Western Reserve University researchers hope to take a healthy salad up a level by growing a vaccine for an aggressive form of breast cancer in leafy greens.

"In the long run, one could think about administering the vaccine either by eating the salad or making a pill from the plant tissue," said Dr. Nicole Steinmetz, assistant professor of biomedical engineering at Case Western Reserve School of Medicine, member of the Case Comprehensive Cancer Center, and leader of the project. She is working with Case Western Reserve School of Medicine's Ruth Keri, professor of pharmacology; Alan Levine, professor of medicine, and Julian Kim, professor of surgery and Chief, Division of Surgical Oncology, Seidman Cancer Center. They plan to develop and test the vaccine in preclinical studies. The Susan G. Komen breast cancer organization is funding the research with a three-year, $450,000 grant.

Steinmetz also received a $144,000 grant from the American Heart Association for a separate project: developing a transporter to deliver clot-busting drugs to the site of blood clots before they trigger heart attacks or strokes.

In both projects, researchers will manipulate plant viruses the size of nanoparticles to deliver protection from these killer diseases–but in very different ways. [more]


MARK YOUR CALENDARS

Affymetrix Workshop

The Gene Expression & Genotyping Facility (GEGF) is sponsoring an Affymetrix Workshop focused on their new Mouse Transcriptome Array. The Workshop will be held in the Wolstein Research Building on Wednesday, October 8, and will provide a comprehensive review of this new expression array. The morning session will concentrate on describing what type of information the array can provide and how this product can enhance your research efforts. This session will also discuss sample preparation for the array, sample quantity needed & sample types that will work with this technology.

The afternoon session will provide a more in-depth discussion of software and data analysis. The afternoon session will be much smaller, more hands-o, and will be applicable to investigators using either the Mouse or the Human Transcriptome Array. Improvements have been made to the Transcriptome Analysis Console Software and these will be highlighted.

Finally, Affymetrix is running a promotion on both the Human and the Mouse Transcriptome arrays through December 15. Purchase of the bundled arrays and reagents can results in a 20% savings. Contact the GEGF for specific pricing or a project cost estimate.

2014 Adolescent and Young Adult Cancers Symposium

Registration is open for the first Adolescent and Young Adult (AYA) cancer conference hosted by the Case Comprehensive Cancer Center is being held October 30-31 at the Wolstein Research Building. This collaborative symposium is organized by the Angie Fowler Adolescent & Young Adult Cancer Institute at University Hospitals Rainbow Babies & Children's Hospital, UH Seidman Cancer Center, Case Comprehensive Cancer Center, and the Oregon Health & Science University Knight Cancer Institute. The focus of this two-day symposium is on advancement of AYA-related cancer research, including exploration of scientific, clinical and psychological considerations in adolescent and young adult cancer patients.

We are excited to feature two key speakers from University Hospitals Case Medical Center, Dr. Henry Koon, Disease Team Leader of Melanoma and Dr. Cheryl Kingsberg, Division Chief Ob/GYN Behavioral Medicine, CWRU Obstetrics and Gynecology, University Hospitals MacDonald Women's Hospital.

We hope that you will join us this year for our first AYA cancer conference, and we hope that we can help you connect to an international community of researchers and advocates for the AYA cancer community. Register today! Continuing Medical Education credits are available.


FUNDING OPPORTUNITIES

Limited Submission Reminder: NSF Major Research Instrumentation Program

The Major Research Instrumentation Program (MRI) serves to increase access to shared scientific and engineering instruments for research and research training in our Nation's institutions of higher education, and not-for-profit museums, science centers and scientific/engineering research organizations. This program especially seeks to improve the quality and expand the scope of research and research training in science and engineering, by supporting proposals for shared instrumentation that fosters the integration of research and education in research-intensive learning environments. Each MRI proposal may request support for the acquisition (Track 1) or development (Track 2) of a single research instrument for shared inter- and/or intra-organizational use; development efforts that leverage the strengths of private sector partners to build instrument development capacity at MRI submission-eligible organizations are encouraged.

Instrument acquisition or development proposals that request funds from NSF in the range $100,000-$4 million may be accepted from any MRI-eligible organization. Proposals that request funds from NSF less than $100,000 may also be accepted from any MRI-eligible organization for the disciplines of mathematics or social, behavioral and economic sciences and from non-Ph.D.-granting institutions of higher education for all NSF-supported disciplines.

Cost-sharing of precisely 30% of the total project cost is required for PhD-granting institutions of higher education and for non-degree-granting organizations. Non-Ph.D.-granting institutions of higher education are exempt from cost-sharing and cannot include it. National Science Board policy is that voluntary committed cost sharing is prohibited. 
CWRU Internal Deadline: October 10
Tentative External Deadline: January 26, 2015

Support of Case CCC Scientific Program Projects

Proposals are requested from the Case CCC Scientific Programs addressing unique research opportunities, innovative ideas or areas identified as strategically important to the program. Proposals must be for projects that are aligned with the goals described in the Cancer Center Strategic Plan. They may build on the institutional investments in genomics and informatics, drug screening and discovery, promote the development and use of new technologies, foster new collaborations or strengthen existing research teams through the development of new research areas aligned with the scientific program strategic plan. Attention to catchment area related research is preferred. Proposals should be multi-investigator in nature, with inclusion of translational or clinical research projects.

Each program is asked to submit one response to this RFA. Program leaders must be engaged in identifying potential areas or recommending topics and proposals for the program. Proposals must be reviewed by a committee within the program that is convened specifically for this purpose before being submitted to the Cancer Center Executive Committee. The Executive Committee will make the final determination for funding after evaluating proposals and reviews. It is expected that the research projects will lead to nationally competitive grant proposals from multi-investigator teams.
Deadline for Submission to Program Leaders: November 7 
Deadline for Submission of priority proposals to Executive Committee: December 15

Alex's Lemonade Stand Foundation Epidemiology Grants

Alex's Lemonade Stand Foundation Epidemiology Grants are expected to provide funds that will support investigators pursuing epidemiological research aimed at improving our understanding of childhood cancer. This grant mechanism is designed to support hypothesis-driven research that focuses on the epidemiology, early detection and prevention of childhood cancer or comparative effectiveness and outcomes research related to detection, prevention and treatment. 
Deadline: December 15

Support of Multi-investigator Initiatives in the Case CCC

The Case CCC will provide two modes of support to new research teams that plan to submit large multi-investigator grant applications (usually non-R support mechanisms).

  • Administrative support and funding for travel are available to encourage team member meetings and meetings with external advisors.
  • Pilot project funding for research teams with an established track record of collaborative research is available to support key research initiatives that are necessary to generate competitive multi-investigator proposals.

Requests are competitive. The research team must demonstrate the active engagement of members, clearly articulate the significance and innovation of the project, and provide a roadmap for acquisition of external funding. Advocacy and support of the specific program leaders interacting with the team is required. Discussion with Ruth Keri, PhD, Associate Director for Basic Research, is strongly encouraged before developing an application.

Deadline: Open 

PREVIOUSLY ANNOUNCED OPPORTUNITIES

Limited Submission: Blavatnik Awards for Young Scientists
CWRU LOI Deadline: October 6
External Deadline: November 25

American Brain Tumor Association Discovery Grant Funding Program
Deadline: October 8

Pancreatic Cancer Action Network-AACR Research Acceleration Network (RAN) Grant
LOI Deadline: October 8

AACR Richard and Hinda Rosenthal Memorial Award
Deadline: October 8

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Deadline: October 8

AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship
Deadline: October 15

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Deadline: October 15

AACR Award for Outstanding Achievement in Chemistry in Cancer Research
Deadline: October 15

American Cancer Society RFA: Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Application Deadline: October 15

American Cancer Society RFA: The Role of Health Policy and Health Insurance in Improving Access to and Performance of Cancer Prevention, Early Detection, and Treatment Services
Deadline: October 15

American Cancer Society RFA: Pilot and Exploratory Studies Using Community-Based Participatory Research (CBPR) to Achieve Cancer Health Equity
Deadline: October 15

American Cancer Society Research Scholar Grants
Deadline: October 15

American Cancer Society Postdoctoral Fellowships
Deadline: October 15

American Cancer Society Mentored Research Scholar Grant
Deadline: October 15

American Skin Association Research Scholar Awards
Deadline: October 18

American Skin Association Research Scholar Awards for Melanoma/Non-Melanoma Skin Cancer
Deadline: October 18

American Skin Association Research Grants
Deadline: October 18

American Skin Association Medical Student Grants Targeting Melanoma and Skin Cancer
Deadline: October 18

DoD BCRP Breakthrough Award Funding Level 3 and 4
Pre-Application (Preproposal) Deadline: October 22
Invited Application Deadline: January 29, 2015

CTSC KL2 Training Program
Deadline: October 27

Doris Duke Clinical Scientist Development Award
Deadline: October 31

Center for Cancer Research Clinical Investigator Development Program
Deadline: October 31

Worldwide Cancer Research
Deadline: October 31; April 24, 2015

Cancer Research Institute Clinic and Laboratory Integration Program (CLIP) Grants
Deadline: November 1

5th Annual DeGregorio Foundation Award for Cancers of the Esophagus and Stomach
Deadline: November 3

Free to Breathe
Deadline: November 7

Melanoma Research Alliance Young Investigator Award (including Dermatology Young Investigators), Established Investigator Award (including BMS-MRA Established Investigators), and Pilot Award (including SITC-MRA Pilot Award)
Deadline: November 11

Carcinogenesis SS Graduate Student Award/Dharm V. Singh Carcinogenesis Endowment Award
Deadline: November 16

Melanoma Research Alliance Academic-Industry Partnership Award (for Established Investigators and Teams) and BMS-MRA Team Science Award
Deadline: November 21

Friends For An Earlier Breast Cancer Test®
Deadline: December 1

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: December 1

Alex's Lemonade Stand Foundation Innovation Grant
LOI Deadline: December 3

DoD BCRP Breakthrough Award Funding Level 1 and 2
Pre-Application/LOI Deadline: December 3
Application Deadline: December 17

Worldwide Cancer Research
Deadline: October 31, 2014; April 24, 2015

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

Collaborative Activity Awards
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)(RFA-RM-14-013)

Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (R21)(RFA-RM-14-014)

Facile Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (U01)(RFA-RM-14-015)

Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2015 and 2016 (P50)(PAR-14-353)

4D Nucleome Network Organizational Hub (U01)(RFA-RM-14-010)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

EVENTS

calendar

Mon, Oct 6

Biochemistry Student Seminar
Dongyin Guan
Student, Biochemistry
CWRU
Topic: The Tumor Suppressor Protein PML – A potential therapeutic target
12 pm Wood W428

Pathology Research Seminar Series
Huiping Liu, MD, PhD
Department of Pathology
CWRU
Topic: TBD
12 pm 1-413

GMI Seminar
Bin Zhang, PhD
Associate Staff, Genomic Medicine Institute
Cleveland Clinic
Topic: Trafficking COPs in Controlling Collagen Secretion
12:30 pm NE1-205 Cleveland Clinic

Physiology & Biophysics Seminar
Arun Anantharam, PhD
Assistant Professor, Biological Sciences
Wayne State University
Topic: The Regulation of Secretory Granule Fusion and Fusion Modes in the Adrenal Chromaffin Cell
4 pm Robbins Building, E-501


Tues, Oct 7

Immunology Research Seminar Series
Robert Maitta, MD, PhD
Department of Pathology
CWRU
Topic: Alpha-synuclein in Hematopoiesis and Lymphopoiesis, it is Not Just a Parkinson's Pathologic Mediator
12:00 pm Wolstein Research Bldg 1-413

Pharmacology/Chemistry Joint Seminar
Lawrence Que, Jr.
University of Minnesota
Topic: TBD
12 pm Wood W331/Webster Conf. Rm.

Cancer Biology Invited Speaker
Arindam Chakrabarti, PhD
Research Associate, Pathobiology
Cleveland Clinic
Topic: RNase L Activates the NLRP3 Inflammasome During Viral Infections
2 pm NC1-202 Cleveland Clinic

Case CCC Clinical Research Retreat 
5-7 pm WRB 1-413
Pre-registration required


Wed, Oct 8

Affymetrix Workshop
Ryan Estep
Field Application Scientist, Affymetrix
Topic: Dive deep into the Mouse Transcriptome: Genes, Exons, lincRNA, Isomers, microRNA and SNPs
11 am WRB 1-413

Affymetrix Transcriptome Analysis Console (TAC) Software Workshop
12:30-2:00 pm WRB 3-136
RSVP Susan_Vigilante@affymetrix.com

Cancer Imaging Program Meeting/Imaging Center Seminar Series
Andrew Sloan, MD
Associate Professor, Neurological Surgery
CWRU/UH
AND
Susann Brady-Kalnay, PhD
Professor, Molecular Biology & Microbiology
CWRU
Topic: Resection and Molecular Imaging of Brain Tumors
12:30 pm Frohring Auditorium - BRB 105

Early Phase Therapeutics Opportunity Meeting
Topic: "RET" as a Target
5 pm WRB 2-136


Thurs, Oct 9

Chemistry Special Seminar
John Cadwell
President & CEO FiberCell Systems
Topic: Hollow Fiber Cell Culture: Cell Culture in 3 Dimensions
10:30am - 12:00 pm Clapp Hall 405
RSVP to rgs@case.edu

Neurosciences Seminar
Jose Luis Perez Velazquez, PhD
Professor, Pediatrics
University of Toronto
Topic: Noise and Fluctuations in Brain Activity, or How to Control Brain and Behavior with Minimal Effort
12:10 pm BRB 105

Molecular Biology and Microbiology Seminar
David Alvarez and Yoelvis Garcia
Karn Lab, Molecular Biology and Microbiology
CWRU
Topic: TBA
1 pm Rottman Seminar Room W203


Fri, Oct 10

Taussig Cancer Institute Grand Rounds
Ramaswamy Govindan, MD
Washington University
Topic: Genomics of Lung Cancer: Clinical Implications
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Scott Welford, PhD
Assistant, Radiation Oncology
CWRU
Topic: Topic: The Polyamine Catabolic Enzyme SAT1 Modulates Tumorigenesis and Radiation Response in GBM
12 pm BRB 105

Cancer Center Research in Progress
James W. Jacobberger, PhD
Professor, Div. of General Medical Sciences (Oncology)
CWRU
Topic: A Pharmacodynamic Assay For Azacytidine /Decitabine Therapy
4 pm WRB 3-136


Mon, Oct 13

Frontier Lecture
Mien-Chie Hung, PhD
Vice President of Basic Research
Chair, Department of Molecular and Cellular Oncology
Director, Breast Cancer Basic Research Program
University of Texas MD Anderson Cancer Center
Topic: Novel Cross Talk Signaling Pathways in Cancer Cells and Development of Targeted Therapy
12 pm BRB 105

Genomic Medicine Institute Integrative and Translational Seminar Series
Salah M Blaih, PhD, RPh, FRSC
Professor, Chemistry and Biochemistry
Kent State University
Topic: Pharmacogenomics of Classical vs. New Oral Anticoagulant Therapy: A Personalized Healthcare Approach to Patient Safety
12:30 pm NE1-205 Cleveland Clinic


Tues, Oct 14

Immunology Research Seminar Series
Kyle McKenna, PhD
Department of Ophthalmology
Franciscan University
Topic: Consequences of Immune Privilege: Impaired Immunosurveillance of Intraocular Tumors
12 pm WRB 1-413

DNA Damage/Repair Meeting
Shigemi Matsuyama, PhD
Associate Professor, Div. of Hem/Onc
CWRU/UH
Topic: TBD
4 pm WRB 3-136


Wed, Oct 15


Thurs, Oct 16

Annual Nathan S. Greenfield Family Pharmacology Lecture
Raymond Stevens, PhD
Provost Professor of Chemistry and Biology
University of Southern California
Topic: The Amazing Diversity of G-protein Coupled Receptors
10 am WRB 1-413

Molecular Biology and Microbiology
Angel Reyes-Rodriguez and Jennifer Cenker
McDonald lab, Molecular Biology and Microbiology
CWRU
Topic: TBD
1 pm Rottman Seminar Room W203


Fri, Oct 17

Taussig Cancer Institute Grand Rounds
Jing Ai, MD
Cleveland Clinic
Topic: Clinical Applications of Single Nucleotide Polymorphism Array & Somatic Mutation Studies in Myeloid Neoplasms
8 am R3/002-003 Cleveland Clinic

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Adolescent and Young Adult (AYA) Cancer Conference
October 30-31, 2014
Wolstein Research Building, CWRU campus
Details and Registration

ASTRO Review
November 15, 2014
Crowne Plaza, Independence, OH
Details and Registration

14th Annual Multidisciplinary Genitourinary Oncology Course
November 20, 2014
InterContinental Hotel & Bank of America Conference Center
Details and Registration

ADDITIONAL UPCOMING SEMINARS & EVENTS

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas