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September 8, 2014

CASE CCC IN THE NEWS

Avon's Sunflower Mile Becomes Weapon Against a Rare Childhood Cancer
The Plain Dealer - September 6, 2014
The latest manifestation is a crowd-gathering mile of sunflowers along Interstate 90 in Avon. It commemorates 7-year-old Maria McNamara of Avon Lake and shines a light on the private nonprofit that bears her name: the Prayers from Maria Foundation...Megan McNamara, Maria's mother, said today that the foundation is announcing a $250,000 grant to underwrite research by Dr. James P. Basilion, associate professor of radiology and biomedical engineering and member of the Case Comprehensive Cancer Center at Case Western Reserve University...Since their daughter's death, the couple has raised funds through various campaigns that include marathons and wine festivals. In 2010, they gave Dr. Bingcheng Wang, a Case Western Reserve University researcher working at MetroHealth Medical Center and member of the Case Comprehensive Cancer Center, the first grant of $100,000.

Cutting-edge Cancer Treatment Uses Laser to Zap Brain Tumors
Fox News - September 4, 2014
Meghan Schultz was 25 weeks pregnant when she started having seizures in the kitchen as she was preparing dinner in 2011...Schultz knew she would need another surgery, so in the fall of 2013, she opted for a new kind of laser treatment called Neuroblate. "A laser which is a couple millimeters in size is directed into the tumor, and then the neurosurgeon controls the laser with a [magnetic resonance imaging] MRI," said Dr. Manmeet Ahluwalia, a medical oncologist and associate director of clinical trials operations at the Cleveland Clinic and Case Comprehensive Cancer Center member. "We heat the tumors to kill the tumor cells."

Discovery of a Single Genetic Mutation in Castration-Resistant Prostate Cancer Could Lead to New Biomarkers and Targeted Therapies
Department of Defense 2014 Prostate Cancer Highlights - September 2, 2014
The mechanisms that enhance DHT production from DHEA and promote abiraterone resistance in CRPC remain poorly understood. With this in mind and support from FY08 Physician Training Award, Case Comprehensive Cancer Center member Dr. Nima Sharifi and his multidisciplinary team of researchers at the University of Texas Southwestern Medical Center discovered a mutant version of the 3β hydroxysteroid dehydrogenase type 1 enzyme (3βHSD1), that was present in a subset of CRPCs. This mutation, N367T, prevents the enzyme from being ubiquitinated, a key part of the degradation process. By blocking ubiquitination, the 3βHSD1 is not degraded, and remains present in cancer cells much longer than the wild type version...Dr. Sharifi and his team, now located at the Cleveland Clinic Foundation, are working toward the identification of a small molecular inhibitor of this enzyme that may be used for prostate cancer therapy. The added potential for using the N367T mutation as a biomarker for CRPC further emphasizes the significance of this finding and its potential for impact in prostate cancer patients.

Genome Editing Edges to the Clinic
Genetic Engineering & Biotechnology News - September 1, 2014
Sigma has formed a partnership with Cleveland Clinic's Molecular Screening Core to develop a CRISPR [clustered regularly interspaced short palindromic repeats] core. This new core is part of the Case Comprehensive Cancer Center at Case Western Reserve University and is open for researchers at Cleveland Clinic and other biomedical research centers in the Cleveland area. One of core's first users, Paul Tesar, PhD, associate professor, department of genetics and genome sciences, Case Western Reserve University School of Medicine and Case Comprehensive Cancer Center member, uses gene-editing technology to study neurogenic and neurodevelopment disorders. Dr. Tesar's group focuses on areas of the brain that impact oligodendrocytes, which make myelin.


MARK YOUR CALENDARS

Fall 2014 Case CCC Clinical Research Retreat

The Case CCC will be holding a Clinical Research Retreat on October 7 in the Wolstein Research Building. A reception will be held from 5-5:30 pm, followed by presentations from 5:30-7 pm.

The agenda will focus on the theme of Immunotherapy:

James Finke, PhDStrategies to Reduce Immune Suppression as a Means to Improve Immunotherapy: A laboratory perspective

Joseph Baar, MDRecent Advances in the Immunotherapy of Cancer

Shaveta Vinayak, MDTumor Infiltrating Lymphocytes Predict for Response to Therapy in Triple-negative Breast Cancer

Mitchell Machtay, MDNational Clinical Trials Network/Cooperative Groups (NCTN) Update

Pre-registration is required. Please contact Dr. Smitha Krishnamurthi (smitha.krishnamurthi@UHhospitals.org) with any questions. We hope everyone interested in clinical trials can attend!

2014 Adolescent and Young Adult Cancers Symposium

The 2014 Adolescent and Young Adult (AYA) Cancers Symposium will be held October 30-31, 2014 in the Wolstein Research Building. The focus of this two-day symposium will be on advancing AYA-related research, increasing federal funding, and exploration of scientific, clinical and psychological considerations in the AYA population.

Program highlights include a keynote address by Clifton Leaf, Deputy Managing Editor of Fortune Magazine and author of The Truth in Small Doses Why We're Losing the War on Cancer – And How to Win It.

Registration and program details soon to follow! For additional information or questions, please emailAYASYM2014@UHhospitals.org.


FUNDING OPPORTUNITIES

DoD Breast Cancer Research Program

Applications to the Fiscal Year 2014 (FY14) Breast Cancer Research Program (BCRP) are being solicited for the Assistant Secretary of Defense for Health Affairs, Defense Health Program (DHP), by the U.S. Army Medical Research Acquisition Activity (USAMRAA). The intent of the Breakthrough Awards are to support promising research that has high potential to lead to or make breakthroughs in breast cancer. The following are general descriptions, although not all-inclusive, of the scope of research projects that would be appropriate to propose under each funding level:

Funding Level 1: Innovative, high-risk/high-reward research that is in the earliest stages of idea development. Research with potential to yield new avenues of investigation. Proof of concept. No preliminary data required.

Funding Level 2: Research that is already supported by preliminary data and has potential to make significant advancements toward clinical translation. Demonstration of efficacy in in vivo models, as applicable.

Pre-Application/LOI Deadline: December 3
Application Deadline: December 17

Funding Level 3: Advanced translational studies that have potential for near-term clinical investigation. Small-scale clinical trials may apply.

Funding Level 4: Large-scale projects that will transform and revolutionize the clinical management and/or prevention of breast cancer. Near-term clinical impact is expected. PIs are expected to have experience in successfully leading large-scale projects.

Pre-Application (Preproposal) Deadline: October 22
Invited Application Deadline: January 29, 2015

Worldwide Cancer Research

Worldwide Cancer Research is accepting applications for research funding. The goal of the organization is to fund scientific research that may, in future, help reduce the incidence of cancer or improve cancer survival. The organization offers funding to support basic or translational research into the causes, mechanisms, diagnosis, treatment or prevention of cancer. 
Deadline: October 31, 2014; April 24, 2015

Cancer Research Institute

The Cancer Research Institute (CRI) offers its Clinic and Laboratory Integration Program (CLIP) Grants to qualified scientists who are working to explore clinically relevant questions aimed at improving the effectiveness of cancer immunotherapies. The program supports basic, pre-clinical, and translational research that can be directly applied to optimizing cancer immunotherapy in the clinic. Candidates for a CLIP Grant must hold a faculty appointment as a tenure-track assistant professor (or higher rank) at the time of award activation. CRI has no citizenship restrictions, and research supported by the award may be conducted at medical schools and research centers in the United States or abroad.
Deadline: November 1

Free to Breathe

Free to Breathe has a new funding opportunity solely focused on research to prevent or stop lung cancer metastasis. We seek to support high-impact and innovative lung cancer research within this area of emphasis that will result in clinical translation (e.g. clinical trial) by the end of the 3-year award period. Our ultimate goal is to fund research that will result in treatments for lung cancer patients and increase survival. At the time of application, the PIs must hold a doctoral degree (MD, PhD, DO, DrPH, or equivalent), and be independent investigators at or above the level of Assistant Professor (or equivalent).
Deadline: November 7

Melanoma Research Alliance

The Melanoma Research Alliance (MRA) announces its eighth annual Request for Proposals (RFP), soliciting translational research grant applications from scientists and clinicians around the world. The RFP calls for ideas that could lead to high impact near-term clinical application in melanoma detection, prevention, diagnosis, staging, or treatment. An investigator may serve as PI on only one proposal submitted to the MRA under any of the mechanisms in this cycle. This includes PIs on team science awards.

Full descriptions of each opportunity, including eligibility criteria and deadlines can be found here.

Deadlines for Young Investigator Award (including Dermatology Young Investigators), Established Investigator Award (including BMS-MRA Established Investigators), and Pilot Award (including SITC-MRA Pilot Award): November 11:

Deadlines for All Academic-Industry Partnership Award (for Established Investigators and Teams) and BMS-MRA Team Science Award: November 21

PREVIOUSLY ANNOUNCED OPPORTUNITIES

Pezcoller Foundation-AACR International Award for Cancer Research
Deadline: September 10

AAAS Marion Milligan Mason Award for Women in the Chemical Sciences
Deadline: September 15

Prostate Cancer Foundation Global Treatment Sciences Challenge Award for Lethal Prostate Cancer
Deadline: September 22

AACR Princess Takamatsu Memorial Lectureship
Deadline: September 17

AACR-American Cancer Society Award for Research Excellence in Cancer Epidemiology and Prevention
Deadline: September 17

Limited Submission: NSF Partnerships for International Research and Education (PIRE)
Internal LOI Deadline: September 19
External Deadline: October 21

AACR Award for Lifetime Achievement in Cancer Research
Deadline: September 24

AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Deadline: September 24

Szent-Györgyi Prize
Deadline: September 30

AACR Award for Outstanding Achievement in Cancer Research
Deadline: October 1

AACR G.H.A. Clowes Memorial Award
Deadline: October 1

Elsa U. Pardee Foundation
Deadline: October 1; February 1; June 1

AACR Richard and Hinda Rosenthal Memorial Award
Deadline: October 8

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Deadline: October 8

AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship
Deadline: October 15

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Deadline: October 15

AACR Award for Outstanding Achievement in Chemistry in Cancer Research
Deadline: October 15

American Cancer Society RFA: Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Application Deadline: October 15

American Cancer Society RFA: The Role of Health Policy and Health Insurance in Improving Access to and Performance of Cancer Prevention, Early Detection, and Treatment Services
Deadline: October 15

American Cancer Society RFA: Pilot and Exploratory Studies Using Community-Based Participatory Research (CBPR) to Achieve Cancer Health Equity
Deadline: October 15

American Cancer Society Research Scholar Grants
Deadline: October 15

American Cancer Society Postdoctoral Fellowships
Deadline: October 15

American Cancer Society Mentored Research Scholar Grant
Deadline: October 15

American Skin Association Research Scholar Awards
Deadline: October 18

American Skin Association Research Scholar Awards for Melanoma/Non-Melanoma Skin Cancer
Deadline: October 18

American Skin Association Research Grants
Deadline: October 18

American Skin Association Medical Student Grants Targeting Melanoma and Skin Cancer
Deadline: October 18

CTSC KL2 Training Program
Deadline: October 27

Center for Cancer Research Clinical Investigator Development Program
Deadline: October 31

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: December 1

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

Collaborative Activity Awards
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Pediatric Preclinical Testing Consortium: Research Programs (U01)(RFA-CA-14-018)

Pediatric Preclinical Testing Consortium: Coordinating Center(U01)(RFA-CA-14-019)

Limited Competition: International Agency for Research on Cancer (IARC) Monographs Program (U01)(RFA-CA-14-503)

NIH Support for Conferences and Scientific Meetings (Parent R13/U13)(PA-13-347)

Advancing Interventions to Improve Medication Adherence (R01)(PA-14-334)

Advancing Interventions to Improve Medication Adherence (R21)(PA-14-335)

 

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

EVENTS

calendar

Mon, September 8

Frontiers in Digestive Health Lecture Series
Jerrold Turner, MD, PhD
Associate Chair, Pathology
University of Chicago
Topic: Plasticity and Epithelial Barriers: Mechanisms and Therapeutic Opportunities
1 pm BRB 105

DBP Seminar
Emmanoulis "Manolis" Doxastakis, PhD, MSc
Assistant Materials Scientist, Materials Science Division
Argonne National Laboratory
Topic: Protein Association in Lipid Membranes
4 pm SOM Robbins Building, E-501

Pathology Research Seminar Series
Klaus Ley, PhD
Division Head and Professor, Div. of Inflammatory Biology
La Jolla Institute for Allergy & Immunology
Topic: Integrin Activation during Neutrophil Rolling and Arrest
4 pm WRB 5-136


Tues, September 9

Immunology Research Seminar Series
Thomas Ferguson, PhD
Professor, Ophthalmology and Visual Sciences
Washington University in St. Louis
Topic: Autophagy: Preserving Vision through Healthy (Self)-Eating
12 pm WRB 1-413

Pharmacology Seminar Series
Scott Welford, PhD
Assistant Professor, Radiation Oncology
CWRU
Topic: TBD
12 pm Wood W331

THOR Lecture Series
Samir Parekh, MD
Senior Faculty, Hematology & Medical Oncology
Mount Sinai
Topic: Genomics in B Cell Malignancies
1 pm R3-027 Cleveland Clinic

Cancer Biology Faculty Candidate
Jianjun Zhao, MD, PhD
Instructor, Medical Oncology
Harvard University/Dana-Farber Cancer Institute
Topic: Genetic Lesions in Multiple Myeloma Initiation and MicroRNAs Based Therapeutic Approaches
2 pm NC1-202 Cleveland Clinic

DNA Damage/Repair Meeting
Scott Welford, PhD
Assistant Professor, Radiation Oncology
CWRU
Topic: The Polyamine Catabolic Enzyme SAT1 Modulates Tumorigenesis and Radiation Response in GBM
4 pm WRB 3-136


Wed, September 10

Hematology and Oncology Division Research Conference
Topic: Arena Scholarship–Lung Cancer talk 
8 am Lerner B-151

Immunology Seminar
Stephen Miller, PhD
Penn State University
Topic: Nanoparticle Approaches for the Targeting of T Cells and Monocytes for the Treatment of Neuroinflammatory Disorders
12 pm NC1-202 Cleveland Clinic

PRCHN Seminar
Kimberly Bess, PhD
Assistant Professor, Human and Organizational Development
Vanderbilt University
Topic: Social Network Analysis: Building Community Health and Relational Well-being
12 pm BioEnterprise Building ground floor


Thurs, September 11

Leaders in AIDS Research Seminar
Jerome Zack, PhD
Professor, Medicine, Microbiology, Immunology & Molecular Genetics
Director, Mouse/Human Chimera
Associate Director, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
UCLA
Topic: Novel Strategies to Combat HIV Disease
1 pm Rottman Seminar Rm. W203

Prostate Cancer Working Group Seminar Series & Journal Club
Brett Carver, MD
Associate Attending, Memorial Sloan Kettering Cancer Center
Topic: PI3K-AR Reciprocal Feed-back Regulation: Response, Resistance, Complexity
2 pm NE1-205 Cleveland Clinic


Fri, September 12

Hem/Onc Fellows
Obayo Siraji, MD
CWRU/UH
Topic: TBD
8 am Wearn 137/Breen Conf Rm.

TCI Grand Rounds
Angelika Erwin, MD
Genomic Medicine
Cleveland Clinic
Topic: The Porphyrias–Shedding Light on the Chaos
8 am R3/002-003 Cleveland Clinic

BME - Joint Appointment Seminar
Andrew Godley, DPhil
Associate Staff, Radiation Oncology
Cleveland Clinic
Topic: 20 to 21st Century Radiation Therapy
11 am NE1-205 Cleveland Clinic

Cancer Center Seminar Series
Qing Yi, MD, PhD
Betsy B. de Windt Endowed Chair in Cancer Biology
Department of Cancer Biology, Lerner Research Institute
Cleveland Clinic
Topic: Immunotherapy in Multiple Myeloma: Pushing Forward
12 pm Frohring Auditorium - BRB 105

Cancer Center Research In Progress Seminar Series
Xia Liu, PhD
Research Associate, Liu Lab, Pathology
CWRU
Topic: Breast Cancer Stem Cells and Cancer Dissemination Patterns
4 pm WRB 3-136


Mon, September 15

Pathology Research Seminar Series
Zhigang Xiong, MD, PhD
Professor, Neurobiology
Morehouse School of Medicine
Topic: Acid Sensing Ion Channels and Ischemic Brain Injury
12 pm WRB 1-413

GMI Seminar
Kyle Logue
Serre lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Unbiased Characterization of Anopheles Mosquito Bloodmeals by Targeted High-thoughput Sequencing of 16S rRNA Genes
12:30 pm NE1-205 Cleveland Clinic


Tues, September 16

Immunology Research Seminar Series
Neetu Gupta, PhD
Assistant Professor, Immunology
Cleveland Clinic
Topic: Protective and Pathogenic B cell Activation at the Membrane-cytoskeletal Interface
12 pm WRB 1-413

Pharmacology Seminar Series
Laliltha Nayak, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: TBD
12 pm Wood W331/Webster Conf. Rm.

THOR Seminar
David Chafin
Ventana Medical Systems
Topic: Conquering Pre-analytics: Two-Temperature Tissue Fixation to Enable Phospho-Marker Assay Development
1 pm R3-027 Cleveland Clinic Cleveland Clinic

Cancer Biology Seminar
Janet Houghton, PhD
Professor, Cancer Biology
Cleveland Clinic
Topic: Targeting GLI-Dependent Transcription in Colon Cancer
2 pm NC1-202 Cleveland Clinic


Wed, September 17

Hematology and Oncology Division Research Conference
Neal Meropol, MD
Professor and Chief, Div. of Hem/Onc
CWRU/UH
Topic: Intro to Clinical Research
8 am Lerner B-151


Thurs, September 18

Molecular Genetics Seminar
George R. Stark, PhD
Distinguished Scientist and Professor, Molecular Genetics
CWRU/Cleveland Clinic
Topic: Current studies on NFκB and STATs 1-3
9:30 am NE1-205 Cleveland Clinic

Cancer Trainee Seminar
Research Speaker: Lisa Bauer
Topic: Magnetic Nanoparticles: Applications in cancer drug delivery and imaging
AND
Clinical Speaker: TBD
12 pm WRB 3-136

Skeletal Research Center
Jeffrey M. Karp, PhD
Associate Professor, Medicine 
Brigham and Women's Hospital
Harvard Medical School
Topic: Next-Gen Bio-inspired Tissue Adhesive Technologies
4:15 pm DeGrace, Rm 312


Fri, September 19

Hematology/Oncology Fellows
Topic: Cancer Biology Series 
8 am Breen Conf Ctr

Cellular and Molecular Seminar Series
Steven D. Mittelman, MD, PhD
Department of Endocrinology
University of Southern California
Topic: Obesity and Cancer: Time To Consider The Tumor Macroenvironment?
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Adrian Lee, PhD
Professor, Pharmacology & Chemical Biology and Human Genetics
University of Pittsburgh
Director of the Women's Cancer Research Center
University of Pittsburgh Cancer Institute and Magee-Women's Research Institute
Topic: Genomic and Transcriptomic Changes in Metastatic Breast Cancer
12 pm Frohring Auditorium - BRB 105

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

ASTRO Review
November 15, 2014
Crowne Plaza, Independence, OH
Registration

14th Annual Multidisciplinary Genitourinary Oncology Course
November 20, 2014
InterContinental Hotel & Bank of America Conference Center
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

Biomedical and Health Informatics Workshop: Strides, Stumbles, and Grand Challenges
September 16-17, 2014
Tinkham Veale University Center
Details

American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine
October 12-15
Cleveland, OH
Details

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas
Details