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September 2, 2014

MESSAGE FROM THE DIRECTOR

Stan Gerson, MD

Stan Gerson, MD
Director, Case CCC

 

Cancer Center Seminar Series 2014-2015

flyer‌The Cancer Center Seminar Series for the academic year kicks off at noon this Friday, September 5, in Frohring Auditorium (BRB 105), and will feature a presentation by Anant Madabhushi, PhD.

In the short time since his arrival, Anant has forged remarkable collaborative projects around the exciting technology of complex imaging assessments of tumors. Starting with histologic sections and combining efforts with visual imaging, gene expression and radiographic imaging, he is able to construct much more powerful assessments of tumors and to link these to invasiveness, prognosis and stage.

Please don't miss the talk –you need to see it to appreciate the technology and its potential!


CASE CCC IN THE NEWS

In Sickness and in Health
NY Times - Aug 28, 2014
Mikkael Sekeres, MD, Director of the leukemia program at the Cleveland Clinic.


RESEARCH HIGHLIGHTS/MEMBER NEWS

Cancer Center Members Daly and Stange Recognized as Distinguished University Professors

Cancer Center members Barbara Daly, PhD, MSN, FAANand Kurt Stange, MD, PhD were recognized by CWRU as Distinguished University Professors - the university's highest faculty honor - at the Fall Convocation last week.

Dr. Barbara DalyDr. Barbara Daly is the Gertrude Oliva Perkins Professor of Oncology Nursing at the Frances Payne Bolton School of Nursing, and Director of Clinical Ethics at University Hospitals Case Medical Center. Read more about her accomplishments here.

 

Dr. Kurt StangeDr. Kurt Stange is the Gertrude Donnelly Hess, MD Professor of Oncology Research and Professor of Family Medicine, Epidemiology & Biostatistics, Oncology and Sociology. Read more about his accomplishments here.

Madabhushi Awarded Two-year NIH Grant on Predicting Aggressive Head & Neck Cancers from Digital Pathology

Anant Madabhushi, PhDAnant Madabhushi, PhD, Professor of Biomedical Engineering and Director of the Center for Computational Imaging and Personalized Diagnostics, has been awarded an R21 grant from the National Cancer Institute for his project, Histologic Image-based Aggressiveness Prediction in p16+ Oropharyngeal Carcinoma. The focus of this two-year $386,000 project will be to develop computerized image analysis tools for identifying patterns connecting to aggressive behavior from digitized tissue slides images of p16+.


MARK YOUR CALENDARS

Fall 2014 Case CCC Clinical Research Retreat

The Case CCC will be holding a Clinical Research Retreat on October 7 in the Wolstein Research Building. A reception will be held from 5-5:30 pm, followed by presentations from 5:30-7 pm.

The agenda will focus on the theme of Immunotherapy:

James Finke, PhDStrategies to Reduce Immune Suppression as a Means to Improve Immunotherapy: A laboratory perspective

Joseph Baar, MDRecent Advances in the Immunotherapy of Cancer

Shaveta Vinayak, MDTumor Infiltrating Lymphocytes Predict for Response to Therapy in Triple-negative Breast Cancer

Mitchell Machtay, MDNational Clinical Trials Network/Cooperative Groups (NCTN) Update

Pre-registration is required. Please contact Dr. Smitha Krishnamurthi (smitha.krishnamurthi@UHhospitals.org) with any questions. We hope everyone interested in clinical trials can attend!

2014 Adolescent and Young Adult Cancers Symposium

The 2014 Adolescent and Young Adult (AYA) Cancers Symposium will be held October 30-31, 2014 in the Wolstein Research Building. The focus of this two-day symposium will be on advancing AYA-related research, increasing federal funding, and exploration of scientific, clinical and psychological considerations in the AYA population.

Program highlights include a keynote address by Clifton Leaf, Deputy Managing Editor of Fortune Magazine and author of The Truth in Small Doses Why We're Losing the War on Cancer – And How to Win It.

Registration and program details soon to follow! For additional information or questions, please emailAYASYM2014@UHhospitals.org.


FUNDING OPPORTUNITIES

Limited Submission: NSF Partnerships for International Research and Education (PIRE)

Partnerships for International Research and Education (PIRE)is an NSF-wide program that supports international activities across all NSF supported disciplines. The primary goal of PIRE is to support high quality projects in which advances in research and education could not occur without international collaboration. PIRE seeks to catalyze a higher level of international engagement in the U.S. science and engineering community.

International partnerships are essential to addressing critical science and engineering problems. In the global context, U.S. researchers and educators must be able to operate effectively in teams with partners from different national environments and cultural backgrounds. PIRE promotes excellence in science and engineering through international collaboration and facilitates development of a diverse, globally-engaged, U.S. science and engineering workforce. This PIRE competition will be open to all areas of science and engineering research which are supported by the NSF.

A single organization may submit one preliminary proposal as the lead institution. Full proposals will be accepted by invitation only.
Internal LOI Deadline: September 19
External Deadline: October 21

American Cancer Society

The American Cancer Society is accepting applications for the following opportunities, all with a deadline of October 15:

RFA: The Role of Health Policy and Health Insurance in Improving Access to and Performance of Cancer Prevention, Early Detection, and Treatment Services: call for research that evaluates the impact of the many changes now occurring in the healthcare system with a particular focus on cancer prevention, control, and treatment. Efforts focusing on improving access to care may also impact inequities that contribute to health disparities. New health public policy initiatives such as the new federal and state marketplaces that have expanded insurance coverage, as well as Medicaid expansion in some states, create natural experiments ripe for evaluation. Research to be funded by this RFA should focus on the changes in national, state, and/or local policy and the response to these changes by healthcare systems, insurers, payers, communities, practices, and patients.

RFA: Pilot and Exploratory Studies Using Community-Based Participatory Research (CBPR) to Achieve Cancer Health Equity: The purpose of this RFA is to stimulate research on effective interventions to reduce cancer health disparities (at any stage of the cancer continuum) and achieve cancer health equity using community-based participatory research (CBPR). This request for applications (RFA) aligns with the American Cancer Society's commitment to reducing disparities in the cancer burden among population groups and to achieving health equity through its programmatic, research and advocacy strategies.

Studies funded by this RFA must:

  • Focus on addressing cancer health disparities and other strategies to contribute to achieving health equity
  • Use CBPR as the research method or propose strategies to generate preliminary data critical to the development of a CBPR research study
  • Demonstrate clear evidence of how this pilot data will be used to develop a larger independently funded study (e.g., NIH R21 or RO1, Patient Centered Outcomes Research Institute (PCORI) grant or ACS Research Scholar Grant).

Research Scholar Grants support investigator-initiated projects across the cancer research continuum. Awards are for up to four years and for up to $165,000 per year (direct costs), plus 20% allowable indirect costs. Independent investigators in the first six years of an independent research career or faculty appointment are eligible to apply. There are exceptions to this, however. Exceptions: 1) RSG applicants to the Cancer Control and Prevention Research Program ONLY may be at any career stage provided the focus of their project is either: a) health policy/health services research or b) cancer disparity reduction; 2) Psychosocial or behavioral studies that are population based (5 years of funding are permitted) where a budget of $400,000 per year (direct costs), plus 20% allowable indirect costs is permitted.

Postdoctoral Fellowships support the training of researchers who have received a doctoral degree to provide initial funding leading to an independent career in cancer research (including basic, preclinical, clinical, cancer control, psychosocial, behavioral, epidemiology, health services and health policy research).

Mentored Research Scholar Grant support for mentored research and training to full-time junior faculty, typically within the initial four years of their first independent appointment. The goal is for these beginning investigators to become independent researchers as either clinician scientists or cancer control and prevention researchers.

American Skin Association

The American Skin Association is accepting applications for the following opportunities, all with a deadline of October 18.*A Chair can endorse only one Scholar Award (either category) and one research grant each year.

Research Scholar Awards support basic science and clinical research by investigators in the early phases of their careers, working at the level of instructor through associate professor in the field of dermatology or cutaneous biology. The aim of the program is to provide bridge support for young investigators. Special consideration will be given to individuals without significant prior support.

Research Scholar Awards for Melanoma/Non-Melanoma Skin Cancer fosters the career development of a young investigator working at the level of instructor through associate professor in the field of dermatology or cutaneous biology. The aim of the program is to provide bridge support for young investigators. Special consideration will be given to individuals without significant prior support.

Research Grants underwrite new and ongoing clinical investigations in five areas – melanoma/skin cancer, psoriasis/inflammatory diseases, vitiligo/pigment cell biology, childhood diseases, and quality of life/health services/outcome studies. There is no age requirement. However, applicants without prior funding, who are in a formative stage of their career, or who are undergoing a mid-career research change will be given preference.

Medical Student Grants Targeting Melanoma and Skin Cancer supports medical students to do research in the area of melanoma and non-melanoma skin cancer.

PREVIOUSLY ANNOUNCED OPPORTUNITIES

AACR Team Science Award
Deadline: September 3

AACR-CRI Lloyd J. Old Award in Cancer Immunology
Deadline: September 3

Lymphoma Research Foundation Clinical Investigator Career Development Grant Program
Deadline: September 3

Lymphoma Research Foundation Lymphoma Clinical Research Mentoring Program (LCRMP)
Deadline: September 3

Lymphoma Research Foundation Postdoctoral Fellowship Grant 
Deadline: September 3

Lymphoma Research Foundation Adolescent/Young Adult Cooperative Group Correlative Studies Grant
Deadline: September 3

2014 AICR Conference Scholarship
Deadline: September 5

Pezcoller Foundation-AACR International Award for Cancer Research
Deadline: September 10

AAAS Marion Milligan Mason Award for Women in the Chemical Sciences
Deadline: September 15

Prostate Cancer Foundation Global Treatment Sciences Challenge Award for Lethal Prostate Cancer
Deadline: September 22

AACR Princess Takamatsu Memorial Lectureship
Deadline: September 17

AACR-American Cancer Society Award for Research Excellence in Cancer Epidemiology and Prevention
Deadline: September 17

AACR Award for Lifetime Achievement in Cancer Research
Deadline: September 24

AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Deadline: September 24

Szent-Györgyi Prize
Deadline: September 30

AACR Award for Outstanding Achievement in Cancer Research
Deadline: October 1

AACR G.H.A. Clowes Memorial Award
Deadline: October 1

Elsa U. Pardee Foundation
Deadline: October 1; February 1; June 1

AACR Richard and Hinda Rosenthal Memorial Award
Deadline: October 8

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Deadline: October 8

AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship
Deadline: October 15

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Deadline: October 15

AACR Award for Outstanding Achievement in Chemistry in Cancer Research
Deadline: October 15

American Cancer Society RFA: Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Application Deadline: October 15

CTSC KL2 Training Program
Deadline: October 27

Center for Cancer Research Clinical Investigator Development Program
Deadline: October 31

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: December 1

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

Collaborative Activity Awards
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Capacity Building Through Training and Mentoring for Treatment, Care and Support, Including PMTCT, TB/HIV, Laboratory, Informatics, and Cervical Cancer in Botswana Under the President's Emergency Plan for AIDS Relief (PEPFAR)

Implementation of the NIH Genomic Data Sharing Policy for NIH Grant Applications and Awards (NOT-OD-14-111)

NIH Genomic Data Sharing Policy (NOT-OD-14-124)

Public Comments on Proposed Guidance Regarding Significant Changes to Ongoing Animal Activities (NOT-OD-14-125)

Guidance on Significant Changes to Animal Activities (NOT-OD-14-126)

Request for Information (RFI): Input on Information Resources for Data-Related Standards Widely Used in Biomedical Science (NOT-CA-14-054)

Training Modules to Enhance Data Reproducibility (R25)(RFA-GM-15-006)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

EVENTS

calendar

Wed, September 3

Hematology and Oncology Division Research Conference
Elizabeth Weinstein, MD, MS
Medical Director, Supportive Oncology
Assistant Professor, Div. of Hem/Onc
CWRU/UH
Topic: Fellowship Curriculum Series: Pain Management
8 am Lerner B-151

Cancer Imaging Program Meeting
Jason W. Sohn, PhD
Associate Professor, Radiation Oncology
CWRU/UH
Topic: TBD
12 pm WRB 3-136


Thurs, September 4

Second Annual Genetics Education Symposium: Genetics and Genomics: Roadmap for Clinical Practice, The Journey Continues
7:30 am InterContinental Hotel & Bank of America Conference Center
Pre-registration required

Cancer Center Seminar
Jianwen Que, MD, PhD
Assistant Professor, Biomedical Genetics
University of Rochester
Topic: Modeling Esophageal Diseases with Stem Cells and Mouse Genetics
11 am WRB 3-136


Fri, September 5

Taussig Cancer Institute Grand Rounds
Edith Mitchell, MD
Professor, Medical Oncology
Director, Center to Eliminate Cancer Disparities
Kimmel Cancer Center at Thomas Jefferson University
Topic: Navigating the Complex World of Cancer Diagnosis and Care: Minimizing Disparities
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar Series
H. Alex Brown, PhD
Professor, Pharmacology
Vanderbilt University
Topic: Mass Spectrometry-Based Metabolomics in Target Discovery and Therapeutics for Cancer & Infectious Disease
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Anant Madabhushi, PhD
Professor & Director, Center for Computational Imaging & Personalized Diagnostics
Departments of Biomedical Engineering, Urology, Pathology, Radiology, General Medical Sciences, Electrical Engineering & Computer Science
Topic: Computational Image Mining and its Role in Personalized Medicine: Use cases in breast, Prostate, Lung, Brain and colorectal cancers
12 pm BRB 105


Mon, September 8

Immunology Seminar Series
Betty Diamond, MD
Feinstein Institute for Medical Research
Topic: The Impact of SLE Susceptibility Genes
11 am NC1-202 Cleveland Clinic

Frontiers in Digestive Health Lecture Series
Jerrold Turner, MD, PhD
Associate Chair, Pathology
University of Chicago
Topic: Plasticity and Epithelial Barriers: Mechanisms and Therapeutic Opportunities
1 pm BRB 105

Pathology Research Seminar Series
Klaus Ley, PhD
La Jolla Institute for Allergy & Immunology
Topic: Implications of New Prion Adaptation and Evolution Paradigm for Human Neurodegenerative Diseases
4 pm WRB 5-136


Tues, September 9

Immunology Research Seminar Series
Thomas Ferguson, PhD
Professor, Ophthalmology and Visual Sciences
Washington University in St. Louis
Topic: Autophagy: Preserving Vision through Healthy (Self)-Eating
12 pm WRB 1-413

Pharmacology Seminar Series
Scott Welford, PhD
Assistant Professor, Radiation Oncology
CWRU
Topic: TBD
12 pm Wood W331

THOR Lecture Series
Samir Parekh, MD
Senior Faculty, Hematology & Medical Oncology
Mount Sinai
Topic: Genomics in B Cell Malignancies
1 pm R3-027 Cleveland Clinic

Cancer Biology Faculty Candidate
Jianjun Zhao, MD, PhD
Instructor, Medical Oncology
Harvard University/Dana-Farber Cancer Institute
Topic: Genetic Lesions in Multiple Myeloma Initiation and MicroRNAs Based Therapeutic Approaches
2 pm NC1-202 Cleveland Clinic

DNA Damage/Repair Meeting
Scott Welford, PhD
Assistant Professor, Radiation Oncology
CWRU
Topic: The Polyamine Catabolic Enzyme SAT1 Modulates Tumorigenesis and Radiation Response in GBM
4 pm WRB 3-136


Wed, September 10

Hematology and Oncology Division Research Conference
Topic: Arena Scholarship–Lung Cancer talk 
8 am Lerner B-151

Immunology Seminar
Stephen Miller, PhD
Penn State University
Topic: Nanoparticle Approaches for the Targeting of T Cells and Monocytes for the Treatment of Neuroinflammatory Disorders
12 pm NC1-202 Cleveland Clinic

PRCHN Seminar
Kimberly Bess, PhD
Assistant Professor, Human and Organizational Development
Vanderbilt University
Topic: Social Network Analysis: Building Community Health and Relational Well-being
12 pm BioEnterprise Building ground floor


Thurs, September 11

Leaders in AIDS Research Seminar
Jerome Zack, PhD
Professor, Medicine, Microbiology, Immunology & Molecular Genetics
Director, Mouse/Human Chimera
Associate Director, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
UCLA
Topic: Novel Strategies to Combat HIV Disease
1 pm Rottman Seminar Rm. W203

Prostate Cancer Working Group Seminar Series & Journal Club
Brett Carver, MD
Associate Attending, Memorial Sloan Kettering Cancer Center
Topic: PI3K-AR Reciprocal Feed-back Regulation: Response, Resistance, Complexity
2 pm NE1-205 Cleveland Clinic


Fri, September 12

Hem/Onc Fellows
Obayo Siraji, MD
CWRU/UH
Topic: TBD
8 am Wearn 137/Breen Conf Rm.

TCI Grand Rounds
Angelika Erwin, MD
Genomic Medicine
Cleveland Clinic
Topic: The Porphyrias–Shedding Light on the Chaos
8 am R3/002-003 Cleveland Clinic

BME - Joint Appointment Seminar
Andrew Godley, DPhil
Associate Staff, Radiation Oncology
Cleveland Clinic
Topic: 20 to 21st Century Radiation Therapy
11 am NE1-205 Cleveland Clinic

Cancer Center Seminar Series
Qing Yi, MD, PhD
Betsy B. de Windt Endowed Chair in Cancer Biology
Department of Cancer Biology, Lerner Research Institute
Cleveland Clinic
Topic: Immunotherapy in Multiple Myeloma: Pushing Forward
12 pm Frohring Auditorium - BRB 105

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Second Annual Genetics Education Symposium: Genetics and Genomics: Roadmap for Clinical Practice, The Journey Continues
September 4, 2014
InterContinental Hotel & Bank of America Conference Center
Details

ASTRO Review
November 15, 2014
Crowne Plaza, Independence, OH
Registration

14th Annual Multidisciplinary Genitourinary Oncology Course
November 20, 2014
InterContinental Hotel & Bank of America Conference Center
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

Biomedical and Health Informatics Workshop: Strides, Stumbles, and Grand Challenges
September 16-17, 2014
Tinkham Veale University Center
Details

American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine
October 12-15
Cleveland, OH
Details

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas
Details