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August 4, 2014

Stan Gerson, MDMESSAGE FROM THE DIRECTOR

Stan Gerson, MD
Director, Case CCC

NCRM Cancer Stem Cell Conference: Updated Program

Dear Cancer Center Members:

As a reminder, the Case Comprehensive Cancer Center and National Center for Regenerative Medicine (NCRM) are hosting the Cancer Stem Cell Conference (CSC 2014), August 17-20, 2014 at the Cleveland Convention Center.

This four-day conference has already attracted an impressive array of attendees; so far we have over 250 registrants from 15 countries and 25 states.

The program agenda has been carefully planned to include a wide breadth of topics that will appeal to a diverse audience, from those with a long-standing stem cell research background, to researchers who have a newfound interest in the field. The program agenda is organized around scientific session on Genetics, Brain Tumors, Tumor Microenvironment, Metabolism and Inflammation, Epithelial Tumors, Metastasis, DNA and Genomics, Therapeutic Resistance, Epigenetics and RNA, Development and Tumor Evolution.

In addition, I want to point out that the program faculty boasts an assembly of world-class experts, including Irving Weissman (Stanford University), Luis Parada (UT Southwestern), M. Celeste Simon (University of Pennsylvania), John Condeelis (Albert Einstein College of Medicine), and Bradley Bernstein (Massachusetts General Hospital), just to name a few.

I encourage you to view the updated program agenda, view the impressive group of presenters being brought together at this forum, and register to attend this inaugural Cancer Stem Cell Conference.


CASE CCC IN THE NEWS

The Pill Linked to Breast Cancer Risk
MedPage Today - Aug 1, 2014
Recent use of some oral contraceptives is associated with an increased risk of breast cancer, researchers reported...But the risk varied with formulation of the contraceptives; some types – notably those with low-dose estrogen – were not associated with cancer, Beaber and colleagues reported in the Aug. 1 issue of Cancer Research. Many women ask about oral contraceptives and breast cancer and the benefits and risks need to be clearly understood, commented Holly Pederson, MD, of the Cleveland Clinic.

CWRU Gets $1.6 Million Grant for Nursing Program to Increase Patient Participation in Clinical Cancer Trials
The Plain Dealer - Jul 30, 2014
The National Cancer Institute is giving Case Western Reserve University researchers $1.6 million over five years to develop and nationally test a program designed to help oncology nurses educate cancer patients about clinical trials. The researchers, from CWRU's School of Medicine and Frances Payne Bolton School of Nursing, will be testing two components: educational materials in the form of texts, and a web-based program called Oncology Nurse IMPACT. They will see how effective each is, and which has the most impact in increasing the number of qualified cancer patients who participate in clinical trials. "Patients have fears about trials and researchers in general," Barbara Daly, an oncology nursing professor at CWRU and clinical ethics director at University Hospitals Case Medical Center, told The Plain Dealer...To that end, Daly and Dr. Neal Meropol, chief of the division of hematology/oncology at UH and CWRU and associate director for clinical programs at UH Seidman Cancer Center, are leading a team of researchers who are developing a program to educate nurses on how to approach patients and discuss clinical trials as a routine treatment option...


RESEARCH HIGHLIGHTS/MEMBER NEWS

CORRECTION: Ahluwalia Elected As Chair of ASCO Committee

‌Dr. Manmeet AhluwaliaDr. Manmeet Ahluwalia, Associate Director of Clinical Trials, Operations and Section Head of NeuroOncology Outcomes in the Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center of the Cleveland Clinic Neurological Institute, and member of the Case Comprehensive Cancer Center, has been elected as Chair of the ASCO Cancer Education Committee on the Central Nervous System Tumors Track.


NEWS FROM THE NCI

NCI Community Oncology Research Program (NCORP)

The National Cancer Institute (NCI) is pleased to announce the official launch of the new NCI Community Oncology Research Program (NCORP). NCORP is a national network of investigators, cancer care providers, academic institutions, and other organizations that provide care to diverse populations in community-based healthcare practices across the United States. This effort is a collaboration between NCI's Divisions of Cancer Prevention, Cancer Control and Population Sciences, Cancer Treatment and Diagnosis, and Center to Reduce Cancer Health Disparities.

NCORP will design and conduct trials to improve cancer prevention, cancer control, screening, and post-treatment management. Additionally, a new focus for NCI community-based research will be care delivery and comparative effectiveness research that will focus on the factors that affect access to and quality of care in the community. NCORP is particularly committed to increasing access to NCI research for minority, rural, and other underserved patient populations.

NCORP replaces two previous NCI community-based clinical research programs: the NCI Community Clinical Oncology Program (CCOP), made up of the Community Clinical Oncology Programs, Minority-Based Clinical Oncology Programs, and Research Bases, and the NCI Community Cancer Centers Program (NCCCP).


FUNDING OPPORTUNITIES

PILOT PROJECT GRANTS: American Cancer Society IRG Awards

The Case Comprehensive Cancer Center, with funds from its American Cancer Society Institutional Research Grant (IRG), will provide seed money to foster cancer research by junior faculty who have no current national grant support of their own. Investigators in the CWRU School of Medicine and Cleveland Clinic Lerner College of Medicine as well as in other schools and colleges in the University are eligible. Grants, not to exceed $30,000, will be awarded to investigators who intend to gather preliminary data to be used in seeking future and independently funded programs.

IRG pilot project grants are intended to support independent, self-directed investigators early in their careers (assistant professor or equivalent). Applicants for the pilot project grants should be within six years of their first independent research or faculty appointment and eligible to apply for an independent national competitive research grant, but cannot currently hold such a grant. Recipients of IRG pilot project grants must be, at the time of the application, citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.
LOI Deadline: August 15
Application Deadline: August 27

James S. McDonnell Foundation

The James S. McDonnell Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems. In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas:

Deadline: Open


MARK YOUR CALENDARS

SOM Institutional Scientific Core Facility Retreat

The Second Annual SOM Institutional Scientific Core Facility Retreat is scheduled for August 25. Retreat participation is by invitation only and is primarily for Core Facility Directors and Managers, as well as Administrative/Clerical Staff. However, there will be limited additional seating available. If you would like to attend, please follow this link to request an invitation.


PREVIOUSLY ANNOUNCED OPPORTUNITIES

Mesothelioma Applied Research Foundation Research Grant Program
Deadline: August 8

Uniting Against Lung Cancer
Deadline: August 13

Damon Runyon Cancer Research Foundation Fellowship Awards
Deadline: August 15

DoD Breast Cancer Research Program Breast Cancer Innovator Award
Deadline: August 15

DoD Breast Cancer Research Program Era of Hope Scholar Award
Deadline: August 15

Harrington Prize for Innovation in Medicine
Deadline: August 15

American Society of Cytopathology Foundation Patient Advocacy Grant
Deadline: August 15

DoD Prostate Cancer Research Program Physician Research Training Award
Pre-Application Deadline: August 27
Confidential Letters of Recommendation: September 10
Application Deadline: September 10

DoD Prostate Cancer Research Program Collaborative Undergraduate Historically Black Colleges and Universities (HBCU) Student Summer Training Program Award
Pre-Application Deadline: August 27
Application Deadline: September 10

DoD Prostate Cancer Research Program Postdoctoral Training Award
Pre-Application Deadline: August 27
Confidential Letters of Recommendation: September 10
Application Deadline: September 10

DoD Bone Marrow Failure Idea Development Award 
Deadline: August 28

R. Robert & Sally Funderburg Research Award in Gastric Cancer
Deadline: August 29

Center for Global Health Short-Term Scientist Exchange Program
Deadline: September 1; December 1; March 1; June 1

Lymphoma Research Foundation Adolescent/Young Adult Cooperative Group Correlative Studies Grant
Deadline: September 3

Lymphoma Research Foundation Clinical Investigator Career Development Grant Program
Deadline: September 3

Lymphoma Research Foundation Lymphoma Clinical Research Mentoring Program (LCRMP)
Deadline: September 3

Lymphoma Research Foundation Postdoctoral Fellowship Grant 
Deadline: September 3

2014 AICR Conference Scholarship
Deadline: September 5

AAAS Marion Milligan Mason Award for Women in the Chemical Sciences
Deadline: September 15

Prostate Cancer Foundation Global Treatment Sciences Challenge Award for Lethal Prostate Cancer
Deadline: September 22

Elsa U. Pardee Foundation
Deadline: October 1; February 1; June 1

CTSC KL2 Training Program
Deadline: October 27

Center for Cancer Research Clinical Investigator Development Program
Deadline: October 31

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: December 1

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Support of Multi-investigator Initiatives in the Case CCC
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Modification of Allowable Budgets for Data Deposition in PA-14-154 "Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R43/R44)" (NOT-GM-14-123)

Notice of Modification of Allowable Budgets for Data Deposition in PA-14-156 "Extended Development, Hardening and Dissemination of Technologies in Biomedical Computing, Informatics and Big Data Science (R01)" (NOT-GM-14-125)

Notice of Modification of Allowable Budgets for Data Deposition in PA-14-157 "Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R41/R42)" (NOT-GM-14-126)

Notice of Modification of Allowable Budgets for Data Deposition in PA-14-155 "Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R01)" (NOT-GM-14-127)

Pilot Studies in Pancreatic Cancer (R21)(PA-11-297)

Examination of Survivorship Care Planning Efficacy and Impact (R21)(PA-12-274)

Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21)(PA-13-288)

Physical activity and weight control interventions among cancer survivors: Effects on biomarkers of prognosis and survival (R21)(PAR-12-229)

Cancer Intervention and Surveillance Modeling Network (CISNET)(U01)(RFA-CA-14-012)


HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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EVENTS

calendar

Mon, August 4

Genomic Medicine Institute
Zhigang Liu, PhD
Zhang lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Nuclear Beta-catenin is Associated with Higher Expression of AMACR in Colon Cancer
12:30 pm NC1-202 Cleveland Clinic

Cancer Biology Staff Candidate
James Jackson, PhD
Instructor, Genetics
University of Texas M.D. Anderson Cancer Center 
Topic: Mutant p53: Breast Cancer's Vulnerability?
1:30 pm NC1-202 Cleveland Clinic


Tues, August 5

Infectious Diseases Seminar
Oliver Hartley, PhD
Assistant Professor, Pathology and Immunology
Faculty of Medicine, University of Geneva
Co-founder and Chief Scientific Officer, Mintaka Foundation for Medical Research
Geneva, Switzerland
Topic: HIV Entry Inhibition: The Ins and Outs of CCR5 Blockade
12 pm BRB 10th Fl. Conference Rm.

THOR Seminar
Clemens Burda, PhD
Professor, Chemistry, Materials Science & Engineering
CWRU
Topic: Design and Control of Gold Nanoparticles for Drug Delivery Applications
1 pm R3-027 Cleveland Clinic


Wed, August 6

Special Hematology and Oncology Division Research Conference
Ramon Tiu, MD
Assistant Professor, Molecular Medicine
Departments of Translational Hematology & Oncology Research and Hematologic Oncology & Blood Disorders
CWRU/Cleveland Clinic
Topic: Molecular Pathogenesis of Myelodysplastic Syndromes and Myeloproliferative Neoplasms
8 am Wearn 137


Thurs, August 7

Cancer Center Faculty Candidate
Chong Chen, PhD
Research Fellow, Scott Lowe laboratory
Memorial Sloan-Kettering Cancer Center
Topic: Deciphering Chromosomal Alterations in Acute Myeloid Leukemia
12 pm BRB 105

Prostate Cancer Working Group Seminar Series and Journal Club
Joshua Lang, MD, MS
Assistant Professor, Medicine
University of Wisconsin Carbone Cancer Center
Topic: Circulating Biomarkers: Technology, Translation and Clinical Integration
3 pm NE1-205 Cleveland Clinic


Fri, August 8

Hem/Onc Fellows
Jennifer Eads, MD and Evi Stavrou, MD
Fellows, Div. of Hem/Onc
CWRU/UH
Topic: Developing a Research Plan During Fellowship
8 am Wearn 137/Breen Conf Rm.


Mon, August 11

Genomic Medicine Institute
Tony Wynshaw-Boris, PhD
Professor and Chair, Genetics and Genome Sciences
CWRU
Topic: Investigating the Pathophysiology of Neurogenetic Disease in Mouse and Induced Pluripotent Stem Cell Models
12:30 pm NE1-205 Cleveland Clinic


Tues, August 12

Pharmacology Final Dissertation Defense
I-Ju Yeh
Montano Lab, Pharmacology
CWRU
Topic: HEXIM1 is an Inhibitor of Two Transcription Factors Critical in Cancer: The Androgen Receptor and Hypoxia Inducible Factor-1 Alpha
12 pm Webster Conference Room, W331


Wed, August 13

Hematology and Oncology Division Research Conference
Charles Nock, MD
Assistant Professor, Div. of Hem/Onc
CWRU/VA
Topic: Brain Cancer
8 am Lerner B-151


Thurs, August 14

Molecular Genetics Guest Speaker
Lynn Enquist, PhD
Department of Molecular Biology
Princeton University
Topic: Alpha Herpesvirus Infection of the Nervous System
9:30 am NE1-205 Cleveland Clinic

Special Seminar
Dr. Irit Sagi
Department of Biological Regulation
Weizmann Institute of Science
Topic: Controlling Extracellular Remodeling as a Strategy to Fight Inflammatory Diseases and Cancer
12 pm BRB 105


Mon, August 18

Cordgenics' Presentation
Topic: ChemoID®
10 am WRB 3-136

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Cancer Stem Cell Conference
August 17-20, 2014
Cleveland Convention Center
Details

ASTRO Review
November 15, 2014
Crowne Plaza, Independence, OH
Registration

14th Annual Multidisciplinary Genitourinary Oncology Course
November 20, 2014
InterContinental Hotel & Bank of America Conference Center
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine
October 12-15
Cleveland, OH
Details

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas
Details