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June 16, 2014

MESSAGE FROM THE DIRECTOR

Stan Gerson, MDStan Gerson, MD
Director, Case CCC

Dear Cancer Center Members:

As you already know, the Cancer Center Annual Scientific Retreat is only a few weeks away. We are working right now to put all the details into place to ensure this two-day event is a success. Now is the time for you to adjust your schedules for July 10-11, and free up the entire Thursday evening through Friday evening to attend.

We already have many people registered, but there are still some members who have not responded. For those people and our new members, I want to remind you of both the value and impact of the retreat. This is a time to showcase our members and their research, to allow for dialogue and discussion, and to plan our next initiatives, recruitments, and expand our focus.

As a consortium center this retreat offers an additional opportunity to meet other members and discuss cancer research with colleagues across the institutions. It is also a chance to meet new members, forge new collaborations, and enhance the quality of science that we produce.

If you have not already done so, please register to attend. Your presence is very important, and your engagement and spirit is what makes our Center work.

Finally, I encourage all students, fellows and postdocs to participate in the poster session on Friday evening. It is always satisfying to witness the excitement of the next generation of cancer researchers. Plus, monetary prizes will be awarded!

I look forward to seeing you all at the retreat!

Agenda Highlights

  • Highlight and introduction of new members, including a new member poster session
  • Keynote Address by Kevin Shannon, MD (UCSF):Preclinical Models to Test Strategies for Targeting Oncogenic Ras
  • Full line-up of scientific talks by Cancer Center members followed by panel Q&A: Emerging Topics and Trends; Cancer Signaling and Drug Resistance; Cancer Genomics & Population Sciences; Experimental Therapeutics; Highlight on Innovative Awards
  • Mid-day scientific program breakouts to discuss new initiatives, collaborations, and requests for Cancer Center support through research pilot project and core resources
  • Students, postdoc and fellow poster competition. Submit abstracts by June 27. Monetary prizes will be awarded.

Retreat Homepage


CASE CCC IN THE NEWS

Oral cancer study underway at CWRU, University Hospitals; new diagnostic test being researched
The Plain Dealer - June 13, 2014
A test being developed at Case Western Reserve University may someday be able to predict if someone will get oral cancer, as well as detect the disease much earlier...The notion of hBD-3 being part of a family of proteins was being pursued in the early 2000s by different research groups across the country, who discovered it in different parts of the body. CWRU researchers discovered it in the oral cavity, in saliva, the lining of the mouth and in pre-cancerous tissues there, said Dr. Aaron Weinberg, associate dean and chair of the Department of Biological Sciences at the dental school. Weinberg, the study's lead investigator, is working with Dr. Chad Zender, a head and neck surgeon at UH's Ear, Nose & Throat Institute. Head and neck cancer patients are getting younger, said Zender, who treats benign and cancerous lesions of the mouth and throat.

RESEARCH HIGHLIGHTS/MEMBER NEWS

Peter de Blank Inaugural Winner of Francis S. Collins Scholar Award

Peter de Blank, MDPeter de Blank, MD is one of two early career physician-scientists named inaugural winners of the Francis S. Collins Scholars Program in Neurofibromatosis Clinical and Translational Research, sponsored by the Neurofibromatosis Therapeutic Acceleration Program (NTAP) at Johns Hopkins University. The program will create a community of expert clinician-scientists and groom them to be leaders in neurofibromatosis type 1 (NF1) research and clinical care. The awards were presented at a ceremony last week at the Whittemore House in Washington, D.C.

 

Cancer Drug Boosts Levels of Vascular-Protective Gene, KLF2

 Case Western Reserve University researchers have discovered that an existing drug used to help cancer patients has the potential to protect thousands of others from the often-deadly impact of vascular clots.

In 2008, the Food and Drug Administration approved bortezomib (Velcade) to treat multiple myeloma, which is a type of bone cancer and mantle cell lymphoma – a particularly aggressive form of non-Hodgkin lymphoma. In addition to attacking cancer cells, the drug has been shown to help prevent clot development common to many forms of the disease.

As hematologist Lalitha Nayak, MD, an assistant professor of medicine, reports in the June 12 edition of the journal "Blood," the anti-thrombotic effects of bortezomib are determined by KLF2, part of a family of Kruppel-like factors – master regulators of vascular health.

"We thought that if we could figure out how bortezomib protects against thrombosis," Nayak explained, "we might be closer to understanding why our patients develop blood clots and what could be done to help them."

She is also a member of the Mukesh Jain, MD, Laboratory at Case Western Reserve University, so she was also well aware of the laboratory's work in Kruppel-like factors. KLF2 specifically is a protein in the Kruppel-like gene family of transcription factors that prevents clot formation in the body's major blood vessels. (Transcription factor is a protein that controls the flow of genetic information that provides instructions to our bodies on how to function.)

"Work from our laboratory during the past decade has established Kruppel-like factors as nodal regulators of vascular health," said Jain, cardiologist and professor of medicine. "It was a good educated guess by Dr. Nayak that bortezomib's positive effect on vascular function was linked to a member of this family."


FUNDING OPPORTUNITIES

Limited Submission: Gabrielle's Angel Foundation

Gabrielle's Angel Foundation has invited the Case CCC to submit two applications (1 conventional and 1 integrative) for its annual Medical Research Awards. Eligible candidates must have their MD or PhD degree and currently hold a junior faculty position at a 501(c)(3) teaching research institution. Applicants must also currently be an Assistant Professor, hold a tenure track position, and have spent no more than five years in their current position.

Interested candidates should submit a one-page LOI to Kristin Waite (kristin.waite@case.edu) by Wednesday, June 25, 2014.
Internal LOI Deadline: June 25
External Application Deadline: August 15

AIDS and Cancer Specimen Resource

The AIDS and Cancer Specimen Resource (ACSR) is pleased to announce the ACSR Young Investigator Pilot Award. The ACSR Young Investigator Pilot Award is targeted toward junior investigators and faculty with innovative ideas for clinical and/or behavioral-epidemiological HIV-related research that utilizes ACSR's annotated biospecimens. Awards are intended for pilot work to show feasibility and/or to generate preliminary data that will support efforts for future funding of larger projects. 
Deadline: August 1

Lymphoma Research Foundation

The Lymphoma Research Foundation (LRF) seeks proposals for the following opportunities:

  • Adolescent/Young Adult Cooperative Group Correlative Studies Grant: Applications to this initiative must be an adjunct to a major NCI cooperative group research project in lymphoma. Projects should also relate to work in the clinical setting and/or involve primary lymphoma patient samples. All principal investigators holding an academic faculty appointment at non-profit organizations or public or private institutions such as universities, colleges, hospitals, and laboratories, may apply.

    Deadline: September 3

  • The LRF Clinical Investigator Career Development Grant Program is designed to support physician investigators at the level of advanced fellow or junior faculty member who will contribute to the development of new lymphoma therapies and diagnostic tools. Eligible investigators must have no greater than five years of experience beyond completion of their fellowship or post-doctoral training (the five year limit may be non-sequential in cases of interruptions for pregnancy or illness).

    Deadline: September 3

  • The Lymphoma Research Foundation Lymphoma Clinical Research Mentoring Program (LCRMP) is an education and mentoring program for fellows and junior faculty with a focus in clinical research in the field of non-Hodgkin and Hodgkin lymphoma. The program is two years in length and offers a broad education on clinical research and career development as well as managing career and quality of life issues.

    Deadline: September 3

  • The LRF Postdoctoral Fellowship Grant is designed to support investigators at the level of advanced fellow, postdoctoral researcher, or junior faculty member in laboratory or clinic based research with results and conclusions that must be clearly relevant to the treatment, diagnosis or prevention of Hodgkin and/or non-Hodgkin lymphoma.

    Deadline: September 3

AACR Scholar-in-Training Awards: Other Conferences and Meetings

The AACR offers Scholar-in-Training Awards to enhance the education and training of early career scientists by providing financial support for their attendance at AACR conferences and meetings. These awards are provided to offset a portion of the registration, travel and subsistence expenses incurred in attending these programs. The number of awards available, award amounts and application requirements vary by conference.


MARK YOUR CALENDARS

Call for Abstracts: Case CCC Annual Scientific Retreat

There is still time to register to attend this year's Annual Case CCC Scientific Retreat, July 10-11, 2014. On Thursday, July 10 keynote speaker Kevin Shannon, MD from UCSF will kick-off the event with his presentation, Preclinical Models to Test Strategies for Targeting Oncogenic Ras. New this year, there will be discussion of new members and their research, including poster presentations during a cocktail reception reception.

The retreat will continue Friday, July 11 at Corporate College East. We have a full scientific line-up of talks from Cancer Center members: Emerging Topics and Trends; Cancer Signaling and Drug Resistance; Cancer Genomics & Population Sciences; Experimental Therapeutics; Highlight on Innovative Awards.

A mid-day breakout for each scientific program to discuss new initiatives, collaborations, and requests for Cancer Center support through research pilot project and core resources will be one of the highlights of the day.

Core directors will also be available during breaks to meet with you to discuss how they can help you further your research.

Finally, we will once again have judged poster presentations by the next generation of cancer researchers. All trainees, fellows and students are encouraged to submit abstracts. Monetary prizes will be awarded.

Pre-registration to attend the retreat is required. The retreat is open to Cancer Center members, Core Facility Directors/Managers, and students, fellows or postdocs who present posters. See the retreat webpage for more information.

NCRM Cancer Stem Cell Conference

The first CWRU: National Center for Regenerative Medicine Cancer Stem Cell Conference will be held in Cleveland, August 17-20, 2014. This conference is guaranteed to have incredible research from a variety of backgrounds in the Cancer Stem Cell field, and will feature keynote speakers from over 25 different institutions from around the world.

Cleveland Clinic 2014 Medical Innovation Summit

Save the date for the 2014 Medical Innovation Summit: Cancer Treatment and Personalized MedicineOctober 27-29, 2014. The Medical Innovation Summit provides an unrivaled perspective on the newest medical innovations and the financial drivers behind those innovations. The conference is recognized for providing singular insights, networking opportunities and actionable take away for all participants.

PREVIOUSLY ANNOUNCED OPPORTUNITIES

Lung Cancer Research Foundation
Deadline: June 16

Limited Submission: Edward Mallinckrodt, Jr. Foundation
Internal Deadline: June 16
External Deadline: August 1

Pew Scholars Program in the Biomedical Sciences
Internal Deadline: June 16
External Deadline: November 3

DoD Prostate Cancer Research Program Biomarker Development Award
Pre-Application (Preproposal) Deadline: June 18
Application Deadline: September 24

2014 AACR Distinguished Lecture on the Science of Cancer Health Disparities, funded by Susan G. Komen®
Nomination deadline: June 18

2014 AACR Award for Outstanding Achievement in Cancer Prevention Research
Nomination deadline: June 18

DoD Prostate Cancer Research Program Exploration–Hypothesis Development Award
Pre-Application Deadline: June 25
Application Deadline: July 9

Patient-Centered Outcomes Research Institute
LOI Deadline: June 27

Damon Runyon-Rachleff Innovation Award
Deadline: July 1

DoD Prostate Cancer Research Program Prostate Cancer Pathology Resource Network Award
Pre-Application Deadline: July 23
Application Deadline: October 29

DoD Prostate Cancer Research Program Health Disparity Research Award
Pre-Application Deadline: July 23
Application Deadline: September 24

DoD Prostate Cancer Research Program Laboratory–Clinical Transition Award
Pre-Application Deadline: July 23
Application Deadline: October 29

DoD Prostate Cancer Research Program Population Science Impact Award
Pre-Application Deadline: July 23
Application Deadline: October 29

DoD Prostate Cancer Research Program Clinical Exploration Award
Pre-Application Deadline: July 23
Application Deadline: October 29

Stand Up To Cancer (SU2C)-Cancer Research UK Translational Research Fellowship
Deadline: July 28

DoD Lung Cancer Research Program Concept Award
LOI Deadline: July 29
Application Deadline: August 12

Linda K. Arena Endowed Scholarship Award For Lung Cancer Education 
Deadline: July 28

American Cancer Society Clinical Research Professor
LOI Deadline: August 1
Application Deadline: October 15

Uniting Against Lung Cancer
Deadline: August 13

Damon Runyon Cancer Research Foundation Fellowship Awards
Deadline: August 15

Harrington Prize for Innovation in Medicine
Deadline: August 15

DoD Breast Cancer Research Program Breast Cancer Innovator Award
Deadline: August 15

DoD Breast Cancer Research Program Era of Hope Scholar Award
Deadline: August 15

Harrington Prize for Innovation in Medicine
Deadline: August 15

DoD Prostate Cancer Research Program Physician Research Training Award
Pre-Application Deadline: August 27
Confidential Letters of Recommendation: September 10
Application Deadline: September 10

DoD Prostate Cancer Research Program Collaborative Undergraduate Historically Black Colleges and Universities (HBCU) Student Summer Training Program Award
Pre-Application Deadline: August 27
Application Deadline: September 10

DoD Prostate Cancer Research Program Postdoctoral Training Award
Pre-Application Deadline: August 27
Confidential Letters of Recommendation: September 10
Application Deadline: September 10

DoD Bone Marrow Failure Idea Development Award 
Deadline: August 28

R. Robert & Sally Funderburg Research Award in Gastric Cancer
Deadline: August 29

Elsa U. Pardee Foundation
Deadline: Oct 1; Feb 1; June 1

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Molecular and Cellular Characterization of Screen-Detected Lesions (U01)(RFA-CA-14-010)


HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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EVENTS

calendar

Mon, June 16

Genomic Medicine Institute Seminar
Jessica Mester, MS, LGC
Genetic Medicine Institute
Cleveland Clinic
Topic: Developing a Multidisciplinary Clinic for Patients with PTEN Hamartoma Tumor Syndrome: Benefits and Barriers
12:30 pm NE1-205 Cleveland Clinic


Tues, June 17

Radiation Oncology Grand Rounds
Samuel Chao, MD
Assistant Professor, Brain Tumor and Neuro-oncology, Radiation Oncology
Cleveland Clinic
Topic: Advances & Challenges in the Management of Brain and Spinal Metastasis
8:10 am Lerner B-151

Molecular Genetics Departmental Seminar
Melissa Mullen Davis, PhD
Postdoctoral Fellow, Luse lab, Molecular Genetics
Cleveland Clinic
Topic: Competition between RNA polymerase II-interacting proteins Gdown1 and TFIIF at different stages of transcription
9:30 am NE1-205 Cleveland Clinic

Translational Hematology and Oncology Research (THOR) Lecture Series
Babal Jha, PhD
Project Scientist, Cancer Biology
Cleveland Clinic
Topic: Enhancing Ligand Specificity and Affinity by Molecular Docking and Rationale Design
1 pm R3-002 Cleveland Clinic


Wed, June 18

Hematology and Oncology Division Research Conference
Rami Manochakian, MD 
Assistant Professor, Div. of Hem/Onc
CWRU/UH
Topic: Improving Veteran Access to Lung Cancer Care
8 am Lerner B-151

Immunology Faculty Research in Progress Series
Shiguang Qian, MD
Associate Staff, Immunology
Cleveland Clinic
Topic: Graft Mediated Control of Host Immunity: A Mechanism in Operational Tolerance
12 pm NC1-202

Skeletal Research Center
Scott P. Bruder MD 
Chief Medical and Scientific Officer
Stryker Corporation
Adjunct Professor, Biomedical Engineering
CWRU
Topic: Creating a Sustainable Innovation Portfolio in the Evolving Medical Device Sector
1 pm Clapp 108

Molecular Biology & Microbiology Seminar
Chris Marks
Pall ForteBio Corp
Topic: Bio-Layer Interferometry (BLI) for Rapid, Label-Free, Biomolecular Kinetics and Quantification
1 pm Rottman Seminar Room W203


Thurs, June 19


Fri, June 20

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Jame Abraham, MD
Nathan Pennell, MD
Halle Moore, MD
Cleveland Clinic
Topic: ASCO Presentations
8 am R3/002-003 Cleveland Clinic

Tumor Immunology Group
Julian Kim, MD, MS
Professor and Chief, Surgical Oncology
CWRU/UH
Topic: Development of Adoptive T Cell Therapy from Mouse to Human
1 pm NA1-142 Cleveland Clinic

Cancer Center Research In Progress Seminar
Agne Petrosiute, MD
Instructor, Pediatrics
CWRU/UH
AND
Francesca Scrimieri, PhD
Postdoctoral Fellow, Huang lab, Pediatrics
CWRU/UH
Topic: Combating Tumor Immune Evasion on Two Fronts: Immune Check-point Control and Modulation of Adhesion Molecules
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East
Details

Cancer Stem Cell Conference
August 17-20, 2014
Cleveland, OH
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

ASCO Review
June 26
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH
Details

American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine
October 12-15
Cleveland, OH
Details

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas
Details