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June 9, 2014

CASE CCC IN THE NEWS

Second Thoughts from Sekeres: Of God and Cancer
Oncology Times - June 10, 2014
Case Comprehensive Cancer Center member Mikkael Sekeres, MD, MS writes about a recent trip to Jerusalem.

Fish, Exercise may help Thwart Colon Cancer's Return, Study Says
Medical Xpress- June 3, 2014
It also might be that people who eat more fish end up eating less red meat and processed foods, which other studies have linked to increased colon cancer risk, said Dr. Smitha Krishnamurthi, an ASCO spokeswoman, associate professor at Case Western Reserve University School of Medicine, and member of the Case Comprehensive Cancer Center in Cleveland. "In the United States, there are people who include fish as part of their diet intentionally to be healthier. It's not a standard part of our diet, like it is in other parts of the world," Krishnamurthi said.

Chemotherapy: How Cancer Drugs Impact the Body Long-term
Fox News - June 2, 2014
"All major cancer centers now have informed consent to alert patients to the immediate and long-term consequences of chemo," Dr. Stan Gerson, director of the Case Comprehensive Cancer Center and UH Seidman Cancer Center in Cleveland, told FoxNews.com. "Hardly any of these medicines are benign. The intensity and complexity of side effects both have to do with the age of the patient, and whether there are sequential treatments. It's a complex test to foretell what they're [going to experience]."


RESEARCH HIGHLIGHTS/MEMBER NEWS

Stem Cells Hold Keys to Body's Plan

Dr. Paul TesarDr. Peter ScacheriCase Comprehensive Cancer Center researchers have discovered landmarks within pluripotent stem cells that guide how they develop to serve different purposes within the body. This breakthrough offers promise that scientists eventually will be able to direct stem cells in ways that prevent disease or repair damage from injury or illness. The study and its results appear in the June 5 edition of the journal "Cell Stem Cell".

Pluripotent stem cells are so named because they can evolve into any of the cell types that exist within the body. Their immense potential captured the attention of two accomplished faculty with complementary areas of expertise.

"We had a unique opportunity to bring together two interdisciplinary groups," said co-senior author Paul Tesar, PhD, Assistant Professor of Genetics and Genome Sciences at CWRU School of Medicine and the Dr. Donald and Ruth Weber Goodman Professor.

"We have exploited the Tesar lab's expertise in stem cell biology and my lab's expertise in genomics to uncover a new class of genetic switches, which we call seed enhancers," said co-senior author Peter Scacheri, PhD, Associate Professor of Genetics and Genome Sciences at CWRU School of Medicine. "Seed enhancers give us new clues to how cells morph from one cell type to another during development."


FUNDING OPPORTUNITIES

Limited Submission: Gabrielle's Angel Foundation

Gabrielle's Angel Foundation has invited the Case CCC to submit two applications (1 conventional and 1 integrative)for its annual Medical Research Awards. Eligible candidates must have their MD or PhD degree and currently hold a junior faculty position at a 501(c)(3) teaching research institution. Applicants must also currently be an Assistant Professor, hold a tenure track position, and have spent no more than five years in their current position.

Interested candidates should submit a one-page LOI to Kristin Waite (kristin.waite@case.edu) by Wednesday, June 25, 2014.
Internal LOI Deadline: June 25
External Application Deadline: August 15

DoD Prostate Cancer Research Program

Applications to the Fiscal Year 2014 Prostate Cancer Research Program (PCRP) are being solicited for the Assistant Secretary of Defense for Health Affairs, Defense Health Program, by the U.S. Army Medical Research Acquisitions Activity.

  • The Health Disparity Research Award supports new ideas based on innovative concepts or methodologies for health disparity research with the potential to make an important contribution toward eliminating death from prostate cancer and enhancing the well-being of men impacted by the disease. Applicants for this award must explicitly state how the proposed research is related to an area of prostate cancer health disparity.
    Pre-Application Deadline: July 23
    Application Deadline: September 24
  • The Laboratory–Clinical Transition Award supports product-driven preclinical studies of promising lead agents or medical devices that have the potential to revolutionize prostate cancer clinical care.
    Pre-Application Deadline: July 23
    Application Deadline: October 29
  • The Population Science Impact Award supports high-impact, population science approaches to prostate cancer research. Applications should clearly demonstrate the potential of the study to contribute significantly to the elimination of death from prostate cancer and/or enhancing the well-being of men experiencing the impact of the disease. 
    Pre-Application Deadline: July 23
    Application Deadline: October 29
  • The Clinical Exploration Award supports early-phase, proof-of-principle clinical trials and correlative studies to investigate hypothesis-based, innovative interventions and/or avenues of research that have the potential to resolve current clinical barriers and result in a profound impact on the management of prostate cancer.
    Pre-Application Deadline: July 23
    Application Deadline: October 29
  • The Exploration–Hypothesis Development Award supports the exploration of highly innovative, untested, potentially high-gain concepts, theories, paradigms, and/or methods that address an important problem in prostate cancer. This award is designed to provide investigators the opportunity to pursue serendipitous observations that may reveal entirely new avenues for investigation.
    Pre-Application Deadline: June 25
    Application Deadline: July 9
  • The Prostate Cancer Pathology Resource Network Award is currently supporting four organizations that together form the Prostate Cancer Biorepository Network (PCBN). The PCRP provides infrastructure support to these awardees for the development and maintenance of a prostate cancer biorepository that will facilitate the collection, processing, annotation, storage, and distribution of high-quality human prostate cancer biospecimens to be distributed to the prostate cancer research community. The intent of the PCBRSA is to expand the PCBN by adding Resource Sites that will enhance the biorepository's utility to prostate cancer researchers through the provision of biospecimens that are unique and/or in limited supply. Both U.S. and international organizations are encouraged to apply to this Program Announcement/Funding Opportunity.
    Pre-Application Deadline: July 23
    Application Deadline: October 29
  • The Physician Research Training Award supports a mentored training experience to prepare physicians with clinical duties and/or responsibilities for productive careers in prostate cancer research. This award emphasizes equally the quality of both the research and the training proposed.
    Pre-Application Deadline: August 27
    Confidential Letters of Recommendation: September 10
    Application Deadline: September 10
  • The Postdoctoral Training Award supports prostate cancer research training opportunities for recent doctoral graduates. These awards primarily provide salary support for the Principal Investigator (PI); the postdoctoral trainee is considered the PI of the application.
    Pre-Application Deadline: August 27
    Confidential Letters of Recommendation: September 10
    Application Deadline: September 10
  • The Collaborative Undergraduate Historically Black Colleges and Universities (HBCU) Student Summer Training Program Award supports the training of the next generation of prostate cancer researchers. This award funds new or existing summer training programs in prostate cancer research for undergraduate students from HBCU at host institutions with ongoing prostate cancer research.
    Pre-Application Deadline: August 27
    Application Deadline: September 10

Linda K. Arena Endowed Scholarship Award For Lung Cancer Education

University Hospitals Seidman Cancer Center is seeking applications for the annual Linda Arena Scholarship Award (in the amount of $4,400) designated toward lung cancer education or symptom management in lung cancer. All disciplines are encouraged to apply including students, residents, fellows, attending physicians, and nurses. The criteria for selection include 1) demonstrable interest in lung cancer treatment or prevention; and 2) intent to apply knowledge to care of lung cancer patients. Return completed applications to marybeth.lipka@uhhospitals.org.
Deadline: July 28

Harrington Prize

The Harrington Prize, presented by the American Society for Clinical Investigation (ASCI) and the Harrington Discovery Institute at University Hospitals Case Medical Center, honors a physician-scientist who has moved science forward with achievements notable for innovation, creativity and potential for clinical application. Applicants must hold an MD or equivalent degree, and do not need to be a member of ASCI.
Deadline: August 15

R. Robert & Sally Funderburg Research Award in Gastric Cancer

The American Gastroenterological Association is accepting applications for the R. Robert & Sally Funderburg Research Award in Gastric Cancer. The overall objective of this award is to support an established investigator in the field of gastric biology whose research will enhance the fundamental understanding of gastric cancer pathobiology in order to ultimately prevent or develop a cure for the disease. Applications that do not denote a gastric biology focus and are not responsive to this announcement will not be submitted for review.
Deadline: August 29


MARK YOUR CALENDARS

Call for Abstracts: Case CCC Annual Scientific Retreat

There is still time to register to attend this year's Annual Case CCC Scientific Retreat, July 10-11, 2014. On Thursday, July 10 keynote speaker Kevin Shannon, MD from UCSF will kick-off the event with his presentation, Preclinical Models to Test Strategies for Targeting Oncogenic Ras. New this year, there will be discussion of new members and their research, including poster presentations during a cocktail reception reception.

The retreat will continue Friday, July 11 at Corporate College East. We have a full scientific line-up of talks from Cancer Center members: Emerging Topics and Trends; Cancer Signaling and Drug Resistance; Cancer Genomics & Population Sciences; Experimental Therapeutics; Highlight on Innovative Awards.

A mid-day breakout for each scientific program to discuss new initiatives, collaborations, and requests for Cancer Center support through research pilot project and core resources will be one of the highlights of the day.

Core directors will also be available during breaks to meet with you to discuss how they can help you further your research.

Finally, we will once again have judged poster presentations by the next generation of cancer researchers. All trainees, fellows and students are encouraged to submit abstracts. Monetary prizes will be awarded.

Pre-registration to attend the retreat is required. The retreat is open to Cancer Center members, Core Facility Directors/Managers, and students, fellows or postdocs who present posters. See the retreat webpage for more information.

NCRM Cancer Stem Cell Conference

The first CWRU: National Center for Regenerative Medicine Cancer Stem Cell Conference will be held in Cleveland, August 17-20, 2014. This conference is guaranteed to have incredible research from a variety of backgrounds in the Cancer Stem Cell field, and will feature keynote speakers from over 25 different institutions from around the world.

Cleveland Clinic 2014 Medical Innovation Summit

Save the date for the 2014 Medical Innovation Summit: Cancer Treatment and Personalized MedicineOctober 27-29, 2014. The Medical Innovation Summit provides an unrivaled perspective on the newest medical innovations and the financial drivers behind those innovations. The conference is recognized for providing singular insights, networking opportunities and actionable take away for all participants.


PREVIOUSLY ANNOUNCED OPPORTUNITIES

Limited Submission: Hartwell Foundation - Individual Biomedical Research Awards
Internal LOI Deadline: June 9
Internal Application Deadline: July 11
Sponsor Deadline: September 15

Limited Submission Reminder: W.M. Keck Foundation 
Internal Deadline: June 9
External Deadline: November 1

Vilcek Prizes For Creative Promise in Biomedical Science
Deadline: June 10

NCI Office of Acquisitions: Systematic Review to Inform Research and Treatment for Multi-Morbidities
Deadline: June 11

DoD Prostate Cancer Research Program Idea Development Award
Pre-Application (Preproposal) Deadline: June 12
Application Deadline: September 24

DoD Prostate Cancer Research Program Synergistic Idea Development Award
Pre-Application (Preproposal) Deadline: June 12
Application Deadline: September 24

DoD Prostate Cancer Research Program Biomarker Development Award
Pre-Application (Preproposal) Deadline: June 18
Application Deadline: September 24

Alex's Lemonade Stand Foundation Bio-Therapeutics Impact award
Deadline: June 12

Lung Cancer Research Foundation
Deadline: June 16

Limited Submission: Edward Mallinckrodt, Jr. Foundation
Internal Deadline: June 16
External Deadline: August 1

Pew Scholars Program in the Biomedical Sciences
Internal Deadline: June 16
External Deadline: November 3

2014 AACR Distinguished Lecture on the Science of Cancer Health Disparities, funded by Susan G. Komen®
Nomination deadline: June 18

2014 AACR Award for Outstanding Achievement in Cancer Prevention Research
Nomination deadline: June 18

Patient-Centered Outcomes Research Institute
LOI Deadline: June 27

Damon Runyon-Rachleff Innovation Award
Deadline: July 1

Stand Up To Cancer (SU2C)-Cancer Research UK Translational Research Fellowship
Deadline: July 28

DoD Lung Cancer Research Program Concept Award
LOI Deadline: July 29
Application Deadline: August 12

American Cancer Society Clinical Research Professor
LOI Deadline: August 1
Application Deadline: October 15

Uniting Against Lung Cancer
Deadline: August 13

Damon Runyon Cancer Research Foundation Fellowship Awards
Deadline: August 15

Harrington Prize for Innovation in Medicine
Deadline: August 15

DoD Breast Cancer Research Program Breast Cancer Innovator Award
Deadline: August 15

DoD Breast Cancer Research Program Era of Hope Scholar Award
Deadline: August 15

DoD Bone Marrow Failure Idea Development Award 
Deadline: August 28

DoD Peer Reviewed Cancer Research Program Idea Award with Special Focus
Pre-Application Deadline: June 10
Application Deadline (Invite Only): September 17

DoD Peer Reviewed Cancer Research Program Career Development Award
Pre-Application Deadline: June 10
Application Deadline (Invite Only): September 17

Elsa U. Pardee Foundation
Deadline: Oct 1; Feb 1; June 1

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Correction to PAR-14-242 "Role of the Microflora in the Etiology of Gastro-Intestinal Cancer (R01)"(NOT-CA-14-045)

Notice of National Cancer Institute (NCI) and National Heart, Lung, and Blood Institute (NHLBI) Participation in PAR-14-212 "Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3)"(NOT-TR-14-004)

Notice of National Cancer Institute (NCI) and National Heart, Lung, and Blood Institute (NHLBI) Participation in PAR-14-210 "Limited Competition for NIH-Industry Program: Discovering Pediatric New Therapeutic Uses for Existing Molecules (UH2/UH3)"(NOT-TR-14-005)

Notice of National Cancer Institute (NCI) and National Heart, Lung, and Blood Institute (NHLBI) Participation in PAR-14-211 "Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH3)" (NOT-TR-14-006)

Notice of National Cancer Institute (NCI) and National Heart, Lung, and Blood Institute (NHLBI) Participation in PAR-14-213 "Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02)" (NOT-TR-14-007)

Identifying Non-Coding RNA Targets for Early Detection of Cancer (R01)(PA-12-213)

Identifying Non-Coding RNA Targets for Early Detection of Cancer (R21)(PA-12-214)

NCI Small Grants Program for Cancer Research (NCI Omnibus R03)(PAR-14-007)

Role of the Microflora in the Etiology of Gastro-Intestinal Cancer (R01)(PAR-14-242)

Molecular and Cellular Characterization of Screen-Detected Lesions - Coordinating Center and Data Management Group (U01)(RFA-CA-14-011)

Limited Competition: Biospecimen Banks to Support NCI-Clinical Trials Network (NCTN) (U24)(RFA-CA-14-501)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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EVENTS

calendar

Mon, June 9

Genomic Medicine Institute Seminar
Alvaro Monteiro, PhD
Moffitt Cancer Center
Topic: Searching for Mechanisms Underlying Cancer Predispositions Loci: Dreaming in Genetic Space
12:30 pm NE1-205 Cleveland Clinic

Molecular Biology and Microbiology Special Seminar
Jean Pieters, PhD
Professor, Biochemistry, Biozentrum
University of Basel, Switzerland
Topic: Regulation of Pathogen Survival and Immune Responses through Coronin 1-Mediated Signaling
1 pm Rottman Seminar Rm, W203

Pathology Thesis Defense
Ling Wu
Li Lab, Pathology
Cleveland Clinic
Topic: A hyper-TH17 Response Connects the Psoriasis-associated ACT1 Variant to Skin Inflammation
1 pm WRB 5-136


Tues, June 10

Molecular Genetics Departmental Seminar
Andrew Schuster
Technologist, Longworth Lab, Molecular Genetics
Cleveland Clinic
Topic: Examining the antimicrobial functions of CAP-D3
9:30 am NE1-205 Cleveland Clinic

Cancer Biology Staff Candidate Seminar
Mamta Gupta, PhD
Assistant Professor, Div. of Hematology
Mayo Clinic
Topic: Molecular Targets in Non Hodgkin Lymphoma
11 am NE1-205 Cleveland Clinic


Wed, June 11

Hematology and Oncology Division Research Conference
Basem William, MD 
Assistant Professor, Div. of Hem/Onc
CWRU/UH
Topic: Oral Azacitidine Maintenance After Allogeneic Stem Cell Transplantation
8 am Lerner B-151

PRCHN Seminar Series
Amy Sheon, PhD, MPH
Executive Director, Urban Health Initiative
CWRU
Topic: Wearable Computing and Sensor Technology: What's all the fuss?
12 pm Bioenterprise Bldg - PCHRN Ground Fl Conf Rm


Thurs, June 12

Cancer Center Faculty Candidate Seminar
Jose Javier Bravo-Cordero, PhD
Associate, Anatomy & Structural Biology
Yeshiva University
Topic: Shedding Light on RhoGTPase Signaling During Metastasis
1 pm in WRB 3-136

Molecular Biology & Microbiology Seminar
Marie McCausland
Lederman lab, Molecular Biology & Microbiology
CWRU
Topic: Microbial Translocation from the Gut and the Unique Monocyte Phenotype in HIV Disease
1 pm Rottman Seminar Room W203

Prostate Cancer Working Group and Journal Club Seminar
Bingcheng Wang, PhD
Professor, Div. of Nephrology
CWRU/MetroHealth
Topic: EphA2-ephrinA1 Bi-directional Signaling in Malignant Progression of Prostate Cancer
3 pm NE1-205 Cleveland Clinic


Fri, June 13

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
James Kochenderfer, MD
Investigator, Experimental Transplantation and Immunology Branch
Center for Cancer Research, National Cancer Institute
National Institutes of Health
Topic: Treating Hematological Malignancies with Chimeric Antigen Receptors
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar Series
William Schiemann, PhD
Associate Professor, General Medical Sciences-Oncology
CWRU
Topic: Oncogenic TGF-b Signaling and EMT Programs in Metastatic Breast Cancer
10 am NC1-202 Cleveland Clinic

Biomedical Engineering
Ferdinand Hui, MD
Staff, Cerebrovascular Center, Neurological Institute
Cleveland Clinic
Topic: Frontiers in Neurointervention: A Classification of Pathologies, and an Overview of Treatment Paradigms
11 am NE1-205 Cleveland Clinic

Cancer Center Research In Progress Seminar
David Callejas, PhD
Research Associate, Narla Lab, Medicine and Transformative Molecular Medicine
CWRU/UH
Topic: Small Molecule PP2A Activators Target the Androgen Receptor for Degradation
4 pm WRB 3-136


Mon, June 16

Genomic Medicine Institute Seminar
Jessica Mester, MS, LGC
Genetic Medicine Institute
Cleveland Clinic
Topic: Developing a Multidisciplinary Clinic for Patients with PTEN Hamartoma Tumor Syndrome: Benefits and Barriers
12:30 pm NE1-205 Cleveland Clinic

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East
Details

Cancer Stem Cell Conference
August 17-20, 2014
Cleveland, OH
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

ASCO Review
June 26
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH
Details

American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine
October 12-15
Cleveland, OH
Details

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas
Details