MESSAGE FROM THE DIRECTOR
Stan Gerson, MD
Academic Drug Development Seminar
As cancer researchers, we are often frustrated when our insight into cancer biology cannot be translated into saving lives due to lack necessary tools or drugs. The Developmental Therapeutics Program is interested in helping to alleviate this problem by hosting the Academic Drug Development Seminar, a monthly forum to discuss the process of creating your own therapeutic agent.
The importance and potential of academic drug development has been recognized by federal and foundation funding agencies, however, to obtain such support or the interest of pharma, certain pieces must be in place. The Academic Drug Development Seminar, held the fourth Wednesday of every month at 4 pm in the Global Cardiovascular Innovation Center at 10000 Cedar, is one forum where your colleagues will offer insight into the process by sharing lessons learned.
The next seminar will be held July 23, where Zhenghe John Wang, PhD will discuss his novel approach to targeting the Akt pathway. Details will be sent out soon.
To be added to the seminar mailing list or for more information on this effort, please contact Yogen Saunthararajah (email@example.com) or John Pellecchia (firstname.lastname@example.org).
Symposium: Drug Development at Case Comprehensive Cancer Center
Related to the topic of drug discovery, I want to remind you that this Friday, June 6, the UH Harrington Discovery Institute will host a symposium, Drug Development at Case Comprehensive Cancer Center, from 4:30-6 pm in the Wolstein Research Bldg Auditorium. I will give the Introduction and Overview, and set the stage for the following presentations:
Goutham Narla, MD, PhD: Small Molecule Activators of Tumor Suppressor Genes
I hope you will join us for this event to hear about this timely and exciting topic.
NCI Specimen Resource Locator
Researchers are encouraged to participate in the Specimen Resource Locator (SRL), which is a biospecimen resource database designed to help researchers locate resources that may have the samples needed for their investigational use. This publicly searchable database includes information about biospecimen banks and sample procurement services. The specimens and samples come from non-commercial, either NCI or non-NCI-funded resources. Investigators can search the database and gain access to thousands of specimens of various tumor, organ, and preservation methods.
In the event you are unsuccessful in finding the appropriate specimen resource you may contact the NCI Tissue Expediter, a scientist, who can further assist you. The Tissue Expediter can also assist researchers to identify potential collaborators when needed.
The SRL is also helpful for those of you wanting to publicize the availability of your specimens and lead cancer research investigators directly to your resource. Please note that you should include only the specimens that you would like to advertise and distribute. You may indicate if specimens are available for a fee or available only through collaboration. The SRL will help you operate your resource more efficiently by directly matching investigator to resource and reducing the number of inappropriate requests.
CASE CCC IN THE NEWS
Expensive Drugs Forcing Cancer Doctors to Weigh Price
New Drug Helps Prevent Infertility in Breast Cancer Patients
New Way to Predict Response to Chemotherapy in Triple-negative Breast Cancer
Life Beyond the Cancer Clinic
Cleveland Clinic to Participate in WellPoint Program Aimed at Cutting Cancer Care Costs
Study Finds Disconcerting Trends in NSCLC Trials
Running 26 Miles Through Slush and Snow? Count Me In!
Should You Have Chemotherapy Before Surgery for Breast Cancer?
RESEARCH HIGHLIGHTS/MEMBER NEWS
Cancer Center Members Receive CTSC/Coulter Grant
Cancer Center members Anant Madabhushi, PhD, Associate Professor of Biomedical Engineering, Lyndsay Harris, MD, Professor of Hematology/Oncology, and Hannah Gilmore, MD, Assistant Professor of Pathology, were awarded a one-year Clinical and Translational Science Collaborative and Case Coulter Translational Research Partnership grant for their proposal titled, Computerized Histologic Image-based predictor of recurrence in breast cancers following treatment. The goal of this $50,000 pilot project is to develop a histologic image based predictor of treatment response in estrogen receptor positive breast cancers using advanced computer vision and machine learning tools to quantitatively extract patterns of tumor morphology, vascular density, proliferation index from immunohistochemistry and hematoxylin and eosin digitized histological images of biopsy specimens.
Limited Submission: NIH Research Evaluation and Commercialization Hub (REACH) Awards
The NIH Research Evaluation and Commercialization Hub (REACH) program will support proof-of-concept centers (Hubs) that facilitate and accelerate the translation of biomedical innovations into commercial products that improve patient care and enhance health. The REACH Hubs will provide qualified institutions with the initial investment and resources to nurture innovators to develop high priority early-stage technologies within the NIH’s mission by providing: (1) infrastructure for identifying the most promising technologies, (2) funding for product definition studies (e.g. feasibility studies, prototype development, or proof-of-concept studies), (3) coordinated access to expertise in areas required for early stage technology development (including scientific, regulatory, reimbursement, business, legal, and project management), and (4) skills development and hands-on experience in entrepreneurism. Establishing public-private partnerships and providing additional non-federal funds will be critical for success.
NCI Office of Acquisitions: Systematic Review to Inform Research and Treatment for Multi-Morbidities
Leidos Biomedical Research, Inc. (Leidos Biomed), on behalf of the Behavioral Research Program is soliciting proposals to conduct a systematic review of the representation of individuals with multiple chronic conditions in randomized controlled trials (RCTs) of behavioral and psychosocial interventions. This project is inspired by a recent systematic review of the representation of patients with multiple chronic conditions in RTCs published in high-impact general medical and specialized journals (Jadad, To, Emara, & Jones, 2011). The goal is to conduct a systematic review to assess the frequency with which research participants with multiple chronic conditions are represented in all or a representative subset of RCTs of behavioral and psychosocial interventions published in general medical and specialized journals, published within the last decade or decade and a half, that focus on behavioral medicine and behavioral science, health psychology, social science, and public health.
Limited Submission: Gabrielle's Angel Foundation
Gabrielle's Angel Foundation has invited the Case CCC to submit two applications (1 conventional and 1 integrative)for its annual Medical Research Awards. Eligible candidates must have their MD or PhD degree and currently hold a junior faculty position at a 501(c)(3) teaching research institution. Applicants must also currently be an Assistant Professor, hold a tenure track position, and have spent no more than five years in their current position.
Interested candidates should submit a one-page LOI to Kristin Waite by Wednesday, June 25, 2014.
MARK YOUR CALENDARSCall for Abstracts: Case CCC Annual Scientific Retreat
Thet will be held July 10-11, 2014. We will kick-off the retreat in late afternoon on Thursday, July 10 at the Wolstein Research Building with a keynote presentation by Kevin Shannon, MD from UCSF, on Preclinical Models to Test Strategies for Targeting Oncogenic Ras. A cocktail reception with heavy hors d'oeuvres will follow, allowing you the chance to network with your colleagues. New this year, there will be discussion of new members and their research, including poster presentations during the reception.
The retreat will continue Friday, July 11 at Corporate College East. We have a full scientific line-up of talks from Cancer Center members: Emerging Topics and Trends; Cancer Signaling and Drug Resistance; Cancer Genomics & Population Sciences; Experimental Therapeutics; Highlight on Innovative Awards.
A mid-day breakout for each scientific program to discuss new initiatives, collaborations, and requests for Cancer Center support through research pilot project and core resources will be one of the highlights of the day.
Finally, we will once again have poster presentations by the next generation of cancer researchers. All trainees, fellows and students are encouraged to submit an abstract. Monetary prizes will be awarded.
Pre-registration to attend the retreat is required. The retreat is open to Cancer Center members, Core Facility Directors/Managers, and students, fellows or postdocs who present posters. See the retreat webpage for more information.
NCRM Cancer Stem Cell Conference
The first CWRU: National Center for Regenerative Medicine Cancer Stem Cell Conference will be held in Cleveland, August 17-20, 2014. This conference is guaranteed to have incredible research from a variety of backgrounds in the Cancer Stem Cell field, and will feature keynote speakers from over 25 different institutions from around the world.
Attendees are invited to submit abstracts of original investigation for consideration in the conference poster session and possible short talk podium presentations. Accepted abstracts will be published online on the conference website and the conference program. Abstract submission deadline is June 1.
In addition, the conference will offer Cancer Stem Cell Conference Abstract Awards that are sponsored by the CWRU School of Medicine Dean's Office. Six outstanding graduate students will be chosen to receive free registration to attend this conference and present their abstracts. This opportunity is open to all graduate students interested in attending this conference. Contact Lyn Haselton (email@example.com; 216.844.5375) for more information.
PREVIOUSLY ANNOUNCED OPPORTUNITIES
Lasker Clinical Research Scholars Program
2014 AACR Award for Outstanding Achievement in Cancer Prevention Research
NIH BULLETIN – Notices and Funding Opportunities
Oncology Models Forum (U24)(PAR-14-239)
Collaborative Research Projects to Enhance Applicability of Mouse Models for Translational Research (Collaborative R01)(PAR-14-240)
Research Projects to Enhance Applicability of Mouse Models for Translational Research (R01)(PAR-14-241)
Revision Applications to P01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P01)(PAR-13-317)
Revision Applications to P50 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P50)(PAR-13-318)
HELP US HELP YOU!
If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at firstname.lastname@example.org.