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May 27, 2014

MESSAGE FROM THE DIRECTORStan Gerson, MD

Stan Gerson, MD
Director, Case CCC

Cell Line Gender

In a recent editorial in Nature Francis Collins, NIH Director, described the need for new policies evaluating research conducted through the NIH for its inclusion of gender analysis in the research subject matter. This will require, in soon to be released guidelines, that all investigators consider using cell lines of both genders as well as defining how they will include and monitor subjects and samples from individuals of both sexes. I suspect that many of you may not know the gender of the cell lines that you are using. While some are most likely obvious, as in prostate cancer, breast cancer and ovarian cancer, others are not. I will instruct Cancer Center core facilities to identify the gender of the cell lines and xenografts that they are utilizing. I encourage you to do the same and to consider and anticipate these new guidelines.

CASE CCC IN THE NEWS

Yes, You Need to Wear Sunscreen Everywhere. Here's How
Time - May 23, 2014
"Signs of sun damage show up here early in life, perhaps because the area is more sensitive and often exposed," says Kevin Cooper, MD, chair of the department of dermatology at University Hospitals Case Medical Center in Cleveland. Cover the entire region with sunscreen, including the sides of your neck.

lab chat: why the heck does drug development take so long?
freshwater cleveland - May 22, 2014
Welcome to the latest round of Lab Chat, in which we try to demystify the often complex and mysterious field of biomedical research. Today, our conversant and well informed writer takes on commercial drug development – specifically, why the heck does it take so long for prescription drugs to move from a scientist at a lab bench to the pharmacy at our local CVS?...Amar Desai is a Post-Doctoral Research Associate in the Department of Hematology/Oncology at Case Western Reserve University. He works in the field of adult stem cells and regenerative medicine with the goal of developing novel therapeutics for hematological diseases in hopes of one day popping his own bottle of Moet.

Double Mastectomy not necessary for most breast cancer patients who choose it, study shows
The Plain Dealer - May 22, 2014
The study confirms what many breast surgeons have been dealing with for years, said Dr. Robert Shenk, medical director of the Breast Center at University Hospitals Case Medical Center and associate professor of surgery at Case Western Reserve University School of Medicine. "The concern is, they don't want to have to deal with [another diagnosis] again. I can understand that," he said. "But it's a lot more surgery and the complications are a lot higher. "Simply having an MRI increases the rate of mastectomy," Shenk said. "You find something on the MRI and it hasn't even been biopsied and a patient will want to have that [healthy] breast removed."

Protect Yourself from Melanoma
Newswise - May 21, 2014
With May being Melanoma Awareness Month, Kevin Cooper, MD, Chairman of the Department of Dermatology at University Hospitals (UH) Case Medical Center in Cleveland, Ohio, offers tips on how to help lower our risk for skin cancer...

Early Detection, Trial Participation Keys to Improved Outcomes in Pancreatic Cancer
Helio/HemOnc Today - May 10, 2014
New report concludes trial participation is the key to improved outcomes in pancreatic cancer. Dr. Davendra Sohal comments.

RESEARCH HIGHLIGHTS/MEMBER NEWS

Anant Madabhushi to Serve on Editorial Board for New IEEE "Journal of Translational Engineering in Health and Medicine"

Dr. Anant Madabhushi, Associate Professor of Biomedical Engineering and Director of the Center for Computational Imaging and Personalized Diagnostics at CWRU, has been invited to serve as member of the Editorial Board and associate editor for the new "Journal of Translational Engineering in Health and Medicine," a scientific publication journal offered through the Institute of Electronic and Electrical Engineering (IEEE).
The "Journal of Translational Engineering in Health and Medicine" will publish high-quality peer-reviewed and articles in healthcare innovations and translational engineering in health and medicine. The journal will serve as a community hub for researchers, clinicians, and developers who are addressing challenges in technology development, commercialization, and deployment for better global healthcare. The ultimate goal is to improve the practice of engineering in translational medicine and to serve as a focal point for the nascent community.

Cancer Stem Cell News Highlights High-Impact Member Research

Two publications by Cancer Center members were highlighted in the most recent issue of Cancer Stem Cell News.

Phage Display Discovery of Novel Molecular Targets in Glioblastoma-Initiating Cells
Targeting VAV3 by ribonucleic acid interference decreased glioma-initiating cell growth, migration, invasion and in vivo tumorigenesis (Cell Death Differ 16 May 2014). James Liu, Daniel Lubelski, David Schonberg, Qiulian Wu, James Hale, William Flavahan, Erin Mulkearns-Hubert, Jianghong Man,Anita Hjelmeland, Jennifer Yu, Justin Lathia and Jeremy Rich

The Zinc Finger Transcription Factor ZFX Is Required for Maintaining the Tumorigenic Potential of Glioblastoma Stem Cells
Scientists demonstrate that the zinc finger and X-linked transcription factor (ZFX) maintains glioma stem cell self-renewal and tumorigenic potential by up-regulating c-Myc expression. (Stem Cells 16 May 2014 online) Xiaoguang Fang, Zhi Huang, Wenchao Zhou, Qiulian Wu, Andrew E. Sloan, Gaoliang Ouyang, Roger E. McLendon, Jennifer Yu, Jeremy N. Rich and Shideng Bao.

FUNDING OPPORTUNITIES

Limited Submission Reminder: W.M. Keck Foundation

The W.M. Keck Foundation strives to fund endeavors that are distinctive and novel in their approach. It encourages projects that are high-risk with the potential for transformative impact. "High-risk" comprises a number of factors, including questions that push the edge of the field, present unconventional approaches to intractable problems, or challenge the prevailing paradigm. By funding the high-risk/high-impact work of leading researchers, the Keck Foundation seeks to lay the groundwork for new paradigms, technologies and discoveries that will save lives, provide innovative solutions, and add to our understanding of the world. Both Senior and Early Career investigators are encouraged to apply. 
Internal Deadline: June 9
External Deadline: November 1

Patient-Centered Outcomes Research Institute

Patient-Centered Outcomes Research Institute (PCORI) is now accepting LOIs through its second call for proposals to conduct large pragmatic clinical studies. PCORI will provide up to $90 million to fund approximately nine such studies, which are designed to address important questions faced by typical patients and clinicians. 
LOI Deadline: June 27

DoD Lung Cancer Research Program

Applications to the Fiscal Year 2014 Lung Cancer Research Program (LCRP) are being solicited for the Assistant Secretary of Defense for Health Affairs, Defense Health Program, by the U.S. Army Medical Research Acquisitions Activity for the Concept Award. This award supports the exploration of a highly innovative new concept or untested theory that addresses an important problem relevant to lung cancer. The Concept Award is not intended to support an incremental progression of an already established research project but, instead, allows PIs the opportunity to pursue serendipitous observations. This award mechanism supports high-risk studies that have the potential to reveal entirely new avenues for investigation. Applications must describe how the new idea will enhance the existing knowledge of lung cancer or create an entirely new avenue for investigation. Submissions from and partnerships with investigators at Military Treatment Facilities (MTFs), military labs, the Department of Veterans Affairs (VA) Medical Centers and research laboratories are strongly encouraged. Research completed through a Concept Award may generate sufficient preliminary data to enable the PI to prepare an application for future research.
LOI Deadline: July 29
Application Deadline: August 12

ANNOUNCEMENTS

Join Our Team - Race for the Place

Walk or run with the Case Comprehensive Cancer Center team at the Race for the Place, June 1, 2014. This great event helps The Gathering Place to offer services to anyone touched by cancer, no matter their economic situation. Anyone is welcome to join our team. If you can't make the Race in person, please consider making a donation to support our efforts. Click here to view our team page.

MARK YOUR CALENDARS

Case CCC Clinical Research Retreat

The 2014 Case CCC Clinical Research Retreat will take place Tuesday, October 7, from 5-7 pm in the Wolstein Research Building Auditorium. The Retreat theme will be Immunotherapy. Please contact Dr. Smitha Krishnamurthi (smitha.krishnamurthi@UHhospitals.org) with any questions.

Call for Abstracts: Case CCC Annual Scientific Retreat

The Annual Case CCC Scientific Retreat will be held July 10-11, 2014. We will kick-off the retreat in late afternoon on Thursday, July 10 at the Wolstein Research Building with a keynote presentation by Kevin Shannon, MD from UCSF, on Preclinical Models to Test Strategies for Targeting Oncogenic Ras. A cocktail reception with heavy hors d'oeuvres will follow, allowing you the chance to network with your colleagues. New this year, there will be discussion of new members and their research, including poster presentations during the reception.

The retreat will continue Friday, July 11 at Corporate College East. We have a full scientific line-up of talks from Cancer Center members: Emerging Topics and Trends; Cancer Signaling and Drug Resistance; Cancer Genomics & Population Sciences; Experimental Therapeutics; Highlight on Innovative Awards.

A mid-day breakout for each scientific program to discuss new initiatives, collaborations, and requests for Cancer Center support through research pilot project and core resources will be one of the highlights of the day.

Finally, we will once again have poster presentations by the next generation of cancer researchers. All trainees, fellows and students are encouraged to submit an abstract. Monetary prizes will be awarded.

Pre-registration to attend the retreat is required. The retreat is open to Cancer Center members, Core Facility Directors/Managers, and students, fellows or postdocs who present posters. See the retreat webpage for more information.

NCRM Cancer Stem Cell Conference

The first CWRU: National Center for Regenerative Medicine Cancer Stem Cell Conference will be held in Cleveland, August 17-20, 2014. This conference is guaranteed to have incredible research from a variety of backgrounds in the Cancer Stem Cell field, and will feature keynote speakers from over 25 different institutions from around the world.

Attendees are invited to submit abstracts of original investigation for consideration in the conference poster session and possible short talk podium presentations. Accepted abstracts will be published online on the conference website and the conference program. Abstract submission deadline is June 1.

In addition, the conference will offer Cancer Stem Cell Conference Abstract Awards that are sponsored by the CWRU School of Medicine Dean's Office. Six outstanding graduate students will be chosen to receive free registration to attend this conference and present their abstracts. This opportunity is open to all graduate students interested in attending this conference. Contact Lyn Haselton (lyn.haselton@case.edu; 216.844.5375) for more information.

DoD BCRP Breast Cancer Breakthrough Award Levels 1 and 2 
Deadline: May 28

DoD BCRP Breast Cancer Breakthrough Award Levels 3 and 4
Deadline: May 28

Alex's Lemonade Stand Foundation Reach Award
Deadline: May 30

Doctors Cancer Foundation
Deadline: May 31

Elsa U. Pardee Foundation
Deadline: June 1; Oct 1; Feb 1

Lasker Clinical Research Scholars Program
Request for Letter of Support Deadline: June 2
Full Application Deadline: July 29

HHMI Investigator Program National Competition
Deadline: June 3

DoD OCRP Clinical Translational Leverage Award
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): August 27

DoD OCRP Investigator-Initiated Research Award 
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): August 27

DoD Ovarian Cancer Academy Dean and Assistant Dean (Leadership) Award
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): August 20

DoD Ovarian Cancer Academy Award – Early-Career Investigator
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): August 27

DoD LCRP Career Development Award
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): September 17

DoD LCRP Clinical Exploration Award (CEA)
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): September 17

DoD LCRP Idea Development Award
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): September 17

Individual and/or Cross Barrett's Esophagus Translational Research Network (BETRNet) pilot projects
Deadline: June 6

Limited Submission: Hartwell Foundation - Individual Biomedical Research Awards
Internal LOI Deadline: June 9
Internal Application Deadline: July 11
Sponsor Deadline: September 15

Vilcek Prizes For Creative Promise in Biomedical Science
Deadline: June 10

DoD Prostate Cancer Research Program Idea Development Award
Pre-Application (Preproposal) Deadline: June 12
Application Deadline: September 24

DoD Prostate Cancer Research Program Synergistic Idea Development Award
Pre-Application (Preproposal) Deadline: June 12
Application Deadline: September 24

DoD Prostate Cancer Research Program PCRP Biomarker Development Award
Pre-Application (Preproposal) Deadline: June 18
Application Deadline: September 24

Alex's Lemonade Stand Foundation Bio-Therapeutics Impact award
Deadline: June 12

Lung Cancer Research Foundation
Deadline: June 16

Limited Submission: Edward Mallinckrodt, Jr. Foundation
Internal Deadline: June 16
External Deadline: August 1

Pew Scholars Program in the Biomedical Sciences
Internal Deadline: June 16
External Deadline: November 3

2014 AACR Distinguished Lecture on the Science of Cancer Health Disparities, funded by Susan G. Komen®
Nomination deadline: June 18

2014 AACR Award for Outstanding Achievement in Cancer Prevention Research
Nomination deadline: June 18

Damon Runyon-Rachleff Innovation Award
Deadline: July 1

Stand Up To Cancer (SU2C)-Cancer Research UK Translational Research Fellowship
Deadline: July 28

American Cancer Society Clinical Research Professor
LOI Deadline: August 1
Application Deadline: October 15

Uniting Against Lung Cancer
Deadline: August 13

Damon Runyon Cancer Research Foundation Fellowship Awards
Deadline: August 15

Harrington Prize for Innovation in Medicine
Deadline: August 15

DoD BCRP Breast Cancer Innovator Award
Deadline: August 15

DoD BCRP Breast Cancer Era of Hope Scholar Award
Deadline: August 15

DoD BMFRP Idea Development Award 
Deadline: August 28

DoD PRCRP Idea Award with Special Focus
Pre-Application Deadline: June 10
Application Deadline (Invite Only): September 17

DoD PRCRP Career Development Award
Pre-Application Deadline: June 10
Application Deadline (Invite Only): September 17

Elsa U. Pardee Foundation
Deadline: Feb 1; June 1; Oct 1

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Change in Expiration Date of PAR-14-116, "Quantitative Imaging for Evaluation of Response to Cancer Therapies (U01)" (NOT-CA-14-044)

Notice of Clarification Regarding the Additional Educational Information Required for PA-14-147 "Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)" (NOT-OD-14-094)

Notice of Clarification Regarding the Additional Educational Information Required for PA-14-148 "Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Div)" (NOT-OD-14-095)

Notice of Clarification Regarding the Additional Educational Information Required for PA-14-149 "Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)" (NOT-OD-14-096)

Announcement of National Longitudinal Study of Neurodevelopmental Consequences of Substance Use (NOT-DA-14-011)

Notice of Clarification and Correction to PAR-14-207 "Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01)" (NOT-HG-14-028)

Development of an Integrated Mathematical Model for Comparative Characterization of Complex Molecules (U01) (RFA-FD-14-082)

Development of Process Simulation and Modeling Tools for Integrated Pharmaceutical Manufacturing Processes (U01) (RFA-FD-14-083)

Exploratory Studies of Smoking Cessation Interventions for People with Schizophrenia (R21/R33) (PAR-14-230)

Exploratory Studies of Smoking Cessation Interventions for People with Schizophrenia (R33)(PAR-14-231)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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EVENTS

calendar

Mon, May 26

Happy Memorial Day!

Tues, May 27

Pharmacology Seminar
Jeffrey Benovic, PhD
Professor and Chairman, Biochemistry & Molecular Biology 
Thomas Jefferson University/Kimmel Cancer Center
Topic: The Ins and Outs of G-protein-coupled Receptor Signaling
12 pm SOM W331

Pathology Thesis Defense
Charles Su
Pathology
CWRU
Topic: Endogenous Memory CD8 T Cells in Cardiac Allograft Rejection
1:30pm WRB 5-136

Cancer Biology Seminar Series
Candece Gladson, MD
Professor, Cancer Biology
Cleveland Clinic
Topic: Positive and Negative Regulators of Angiogenesis in Glioblastoma
2 pm NC1-202 Cleveland Clinic

Molecular Genetics Seminar
Elise Holvey-Bates
Senior Research Technologist, Stark Lab, Molecular Genetics
Cleveland Clinic
Topic: Which IRDS/U-ISGF3-induced Protein(s) Promote Resistance to DNA Damage in Cancer Cells? A Clue from 1984!
9:30 am NE1-205 Cleveland Clinic

Wed, May 28

Hematology and Oncology Division Research Conference
Topic: TBD
8 am Lerner B-151

Pathology Grand Rounds 
David Hicks, MD
Director of Surgical Pathology
University of Rochester 
Topic: Breast Cancer Predictive Factor Testing (ER, PR & HER2); Bridging the Gap Between Diagnosis and Clinical Management
8 am Pathology Amphitheatre

Thurs, May 29

Cancer Center Special Seminar
Chong Chen, PhD
Research Fellow, Lowe lab
Memorial Sloan-Kettering Cancer Center
Topic: Epigenetic Regulators & Therapeutic Susceptibility In Acute Myeloid Leukemia
10 am WRB 3-136

Molecular Biology & Microbiology Seminar
Polly Phillips-Mason, PhD
Brady-Kalnay lab, Molecular Biology & Microbiology
Topic: Should I Stay or Should I Go? Proteolytic Processing of PTPμ in Cancer
1 pm Rottman Seminar Room W203

Fri, May 30

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Wearn 137

Cellular and Molecular Medicine Seminar Series
Jonathan D. Smith, PhD
Staff, Lerner Research Institute
Cleveland Clinic
Topic: HDL Biogenesis and Making "Good Cholesterol" Better
10 am NC1-202 Cleveland Clinic

Mon, June 2

Molecular Biology and Microbiology Thesis Presentation
Kenneth Yan
Rich lab
Cleveland Clinic
Topic: Instructional Cues for Hierarchy Maintenance in Glioblastoma
1 pm Rottman Seminar Room W203

Case CCC Calendar

LRI Calendar

UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Drug Development at Case Comprehensive Cancer Center
June 6
4:30 – 6:00 pm
Wolstein Research Bldg

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East
Details

Cancer Stem Cell Conference
August 17-20, 2014
Cleveland, OH
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

ASCO Review
June 26
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH
Details

American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine
October 12-15
Cleveland, OH
Details

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas
Details