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May 5, 2014

CASE CCC IN THE NEWS

Student at Cleveland's University School Conducts Research on Causes and Effects of Colon Inflammation
Digital Journal - May 2, 2014 
University School junior William Xin has learned a lot about the value of patience when it comes to working in a medical research lab. "Lab work requires quite a bit of repetitive work to get enough data for comprehensive results," he said. "We also need to wait for the mice to react to any chemicals we've administered, or during certain processes, like centrifuging." For the past year, William has been conducting research in the lab of Case Comprehensive Cancer Center member Dr. Lan Zhou at Case Western Reserve University's School of Medicine studying the causes and effects of inflammation in the colon...On May 3, William will travel to Chicago to present his research at the American Gastroenterological Association's (AGA) Digestive Disease Week, a leading conference in the digestive disease field.

Cleveland Clinic Tests New Tool to Fight Breast Cancer
19 Action News - May 2, 2014
Cleveland Clinic is one of 16 centers testing a new technology that could reduce the number of unnecessary biopsies...Doctors say this device feels similar to an ultrasound and works with optoacustics, an imaging technology based on sound and light, to determine if a mass is cancerous or benign. The procedure requires no radiation, pain or risk, which means unnecessary biopsies may be avoided by as much as 40%.

Poor Kidney Function May Boost Cancer Risk
Nephrology News & Issues - Apr 29, 2014
People with kidney disease may be at increased risk of cancer, according to new findings presented here at the National Kidney Foundation's 2014 Spring Clinical Meetings. Men and women with stage 3 chronic kidney disease were significantly more likely to be diagnosed with cancer during a five-year follow-up period than their peers with normally functioning kidneys. The research was conducted by Dhruti P. Chen, MD and her colleagues at University Hospitals, Case Western Reserve University School of Medicine, in Cleveland.

New Drug to Treat Stomach Cancer Approved by FDA: Cyramza expected to be available in a few weeks
The Plain Dealer - Apr 24, 2014
The Food and Drug Administration has approved Cyramza for patients with advanced or metastatic stomach cancer or a type of cancer called gastroesophageal junction cancer, found in the lower part of the esophagus that connects to the stomach...Although the number of stomach cancer cases is declining, the subset of GE junction cancers is going up substantially, said Dr. Alok Khorana, director of the Gastrointestinal Malignancies Program at the Cleveland Clinic and member of the Case Comprehensive Cancer Center. The reasons for the increase are unknown, but physicians suspect that reflux disease is a contributing factor, he said.

The Best Medical Team for Advanced Prostate Cancer Treatment
Everyday Health - Apr 7, 2014
A good prostate cancer medical team can improve a patient's treatment success. "This doesn't [necessarily] mean they will live longer, but their medical management is likely to be smoother, with the care team anticipating problems and mitigating them earlier," said Robert Dreicer, MD, chair of the solid tumor oncology department at the Cleveland Clinic and Deputy Associate Director for Clinical Research at the Case Comprehensive Cancer Center.


RESEARCH HIGHLIGHTS/MEMBER NEWS

Mohamed Abazeed Receives Seed Grant for Lung Cancer Research

‌Mohamed Abazeed, MD, PhDMohamed Abazeed, MD, PhD, Associate Staff Physician in the Cleveland Clinic Department of Radiation Oncology, is the recipient of a Radiological Society of North America (RSNA) Research and Education Foundation Seed Grant for his project Integrative Radiogenomics and Precision Therapy in Squamous Cell Lung Cancer. The Research Seed Grants enable investigators to gain experience in defining objectives and testing hypotheses in preparation for major grant applications to corporations, foundations and governmental agencies.

Case CCC Researchers Discover Kindlin-3 Plays Major Role in Formation and Spread of Breast Cancer

A protein believed to be limited to the hematopoietic system, called Kindlin-3, has been identified as a major player in both the formation and spread of breast cancer to other organs. This discovery, published in the May 2014 issue of "The FASEB Journal", could open the door to an entirely new class of breast cancer drugs that targets this protein's newly found activity.

The manuscript was also featured as the cover story for the May issue of "The FASEB Journal".

Drs. Khalid Sossey-Alaoui, Elzbieta Pluskota, Gangarao Davuluri, Katarzyna Bialkowska, Mitali Das, Dorota Szpak,Daniel J. Lindner, Erinn Downs-Kelly, Cheryl L. Thompson, and Edward F. Plow contributed to this research.

Cancer Imaging Program Pilot Funds Unique TAM Research; Results in Publication

Last year, the Cancer Imaging Program awarded pilot funding to members with promising research. That funding has now resulted in a publication by Case Comprehensive Cancer Center members Drs. Mei Zhang and Julian Kim and their colleagues that was recently published in the journal "Materials Research Express".

According to Dr. Zhenghong Lee, co-leader of the Cancer Imaging Program, the research publication, Development of Y-shaped peptide for constructing nanoparticle systems targeting tumor-associated macrophages in vitro and in vivo, is unique for three reasons: Tumor-associated macrophage (TAM) is gaining attention due to its role in tumor progression and metastasis; TAM has become a target for treatment and imaging, which is what this project attempts to do; and L-shaped peptide specifically targeting TAM is novel, and further grafting with a nanotube with an imaging agent is unique.

Northern Ohio Golf Charities Foundation Enables Purchase of Specialized Microscope

Huiping Liu, MD, PhDFunds provided by the Northern Ohio Golf Charities Foundation will enable the purchase of an Incucyte Kinetic Imaging system under the leadership of Huiping Liu, MD, PhD. With this specialized microscope, the Liu lab hopes to develop next generation nanoparticles to target harmful cancer stem cells, leading to the development of new treatment drugs. The Incucyte system is available for use by Cancer Center members. Please contact Dr. Huiping Liu (hxl494@case.edu) for more information.

FUNDING OPPORTUNITIES

Limited Submission: Hartwell Foundation - Individual Biomedical Research Awards

Because Case Western Reserve University earned an at-large bid in The Hartwell Foundation's Individual Biomedical Research Awards program, CWRU is eligible to nominate two faculty members for proposal submission this year. In 2011, both of CWRUs applicants were selected for awards. In 2012 and 2013, one of CWRU's two applicants were selected. The foundation funds 10 Hartwell Investigators annually for their innovative, early-stage, cutting-edge biomedical research that has the potential to benefit children. These awards provide funding to individual researchers in the U.S. for three years, at $100,000 direct cost per year.
Internal LOI Deadline: June 9
Internal Application Deadline: July 11
Sponsor Deadline: September 15


ANNOUNCEMENTS

Help Us Improve the Case CCC Website: Please take a short survey

The Case Comprehensive Cancer Center is in the process of improving its website: cancer.case.edu. As someone in the Cancer Center community, we ask that you complete a short survey that will better help us tailor our website to user needs: http://bit.ly/1kwvki4

We at the Case Comprehensive Cancer Center thank you for your time, and hope we can better serve your web needs.

Post Cultural Competency Retreat Thoughts

The organizers of the Cultural Competency Retreat would like to thank all speakers and attendees who participated in the event in early March. The retreat was a great success in raising awareness about the dynamic variety of people and communities the Case CCC serves, and in providing the Case CCC clinical research staff with a unique learning experience and skills to conduct culturally competent research.

The keynote presentation, break-out sessions, and panel discussion provided an important forum for sharing ideas and discussion of often difficult topics. Over 100 people attended the retreat and provided a valuable feedback for developing subsequent cultural competency education and training activities. Videos of the keynote presentation and panel discussion will be available online soon. An announcement will be posted in the newsletter when available. Contact Katarzyna Karelus (katarzyna.karelus@case.edu or 216.844.4176) with any questions.

Join Our Team - Race for the Place

Walk or run with the Case Comprehensive Cancer Center team at the Race for the Place, June 1, 2014. This great event helps The Gathering Place to offer services to anyone touched by cancer, no matter their economic situation. Anyone is welcome to join our team. If you can't make the Race in person, please consider making a donation to support our efforts. Click here to view our team page.


MARK YOUR CALENDARS

ImageIQ Seeks Beta-testers for New Online Image Analysis Technology

ImageIQ is a Cleveland company specializing in imaging, image analysis and software engineering. They are looking for individuals to be beta-testers for their new online image analysis technology for preclinical research, ImageQuantify.com. Participants will receive limitless use of the new service for a six-month period following its launch, and can use of any data that is analyzed during the beta test period in their research. After that, the technology may be added to the CWRU software center if it is appropriate.

Informational webinars:

Wednesday, May 7 from 1:05-1:25 pm 
Register

Thursday, May 8 from 11:05-11:25 am
Register

CME Event - Screening for Cancer in Women: 2014

Registration is open for Screening for Cancer in Women: 2014Wednesday, May 21 from 8 am - 3:35 pm at the Embassy Suites Hotel in Independence.

This conference will feature speakers from health centers across Northeast Ohio working together to fight cancer, who will offer expert insight, updates, and advice on screening for cancer in women.

KEYNOTE ADDRESS: Cancer Screening and Prevention in High-Risk Women
Allison Kurian, MD, MSc, Assistant Professor, Medicine (Oncology) and Health Research & Policy, Associate Director, Stanford Program in Clinical Cancer Genetics, Physician Leader, Stanford Women's Cancer Genetics Clinic, Stanford University

PRESENTERS AND PANELISTS
Stan Gerson, MD: Welcome
Holly Marshall, MD: Breast Cancer Screening
Jeff Marks, MD: Update on Colon Cancer Screening in Women
Brian Bolwell, MD: Affordable Care Act
Allison Vidimos, MD: Skin Cancer Screening in Women
Phyllis Nsiah-Kumi, MD, MPH: Cancer Disparities
Allison Kurian, MD, MSc; Andrea Sikon, MD, FACP; Shaveta Vinayak, MD; Cindy Zelis, MD: Panel Discussion
Charles Lau, MD, MBA: Lung Screening
Kim Gecsi, MD: Gynecologic Cancer Screening
Paula Silverman, MD: Closing Remarks

PLANNING COMMITTEE
Donna Plecha, MD, Activity Director
Paula Silverman, MD, Chair
Lyndsay N. Harris, MD
Halle Moore, MD

Primary care physicians, hematologists, medical oncologists, and nurses should attend this course.

CME credit will be offered. Visit the conference website for more details and registration information.

Call for Abstracts: Case CCC Annual Scientific Retreat

The Annual Case CCC Scientific Retreat will be held July 10-11, 2014. We will kick-off the retreat in late afternoon on Thursday, July 10 at the Wolstein Research Building with a keynote presentation by Kevin Shannon, MD from UCSF, an expert in Myc and RAS in cancer. A cocktail reception with heavy hors d'oeuvres will follow, allowing you the chance to network with your colleagues. New this year, there will be discussion of new members and their research, including poster presentations during the reception.

The retreat will continue Friday, July 11 at Corporate College East. We have a full scientific line-up of talks from Cancer Center members. A mid-day breakout for each scientific program to discuss new initiatives, collaborations, and requests for Cancer Center support through research pilot project and core resources will be one of the highlights of the day.

Finally, we will once again have poster presentations by the next generation of cancer researchers. All trainees, fellows and students are encouraged to submit an abstract. Monetary prizes will be awarded.

Pre-registration to attend the retreat is required. The retreat is open to Cancer Center members, Core Facility Directors/Managers, and students, fellows or postdocs who present posters. See the retreat webpage for more information.

NCRM Cancer Stem Cell Conference

The first CWRU: National Center for Regenerative Medicine Cancer Stem Cell Conference will be held in Cleveland,August 17-20, 2014. This conference is guaranteed to have incredible research from a variety of backgrounds in the Cancer Stem Cell field, and will feature keynote speakers from over 25 different institutions from around the world.

Attendees are invited to submit abstracts of original investigation for consideration in the conference poster session and possible short talk podium presentations. Accepted abstracts will be published online on the conference website and the conference program. Abstract submission deadline is June 1.

In addition, the conference will offer Cancer Stem Cell Conference Abstract Awards that are sponsored by the CWRU School of Medicine Dean's Office. Six outstanding graduate students will be chosen to receive free registration to attend this conference and present their abstracts. This opportunity is open to all graduate students interested in attending this conference. Contact Lyn Haselton (lyn.haselton@case.edu; 216.844.5375) for more information.

PREVIOUSLY ANNOUNCED OPPORTUNITIES

American Society of Hematology (ASH) Scholar Awards
LOI Deadline: May 7
Invited Application Deadline: August 1

2014 AACR Outstanding Investigator Award for Breast Cancer Research, funded by Susan G. Komen®
Nomination deadline: May 14

GlaxoSmithKline Discovery Fast Track Challenge
Deadline: May 16

L'Oréal USA For Women in Science Fellowship Program
Deadline: May 19

DoD OCRP Pilot Award
Pre-Application Deadline (Required): May 22
Application Deadline (Invite Only): August 20

DoD BCRP Breast Cancer Breakthrough Award Levels 1 and 2 
Deadline: May 28

DoD BCRP Breast Cancer Breakthrough Award Levels 3 and 4
Deadline: May 28

Doctors Cancer Foundation
Deadline: May 31

HHMI Investigator Program National Competition
Deadline: June 3

DoD OCRP Clinical Translational Leverage Award
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): August 27

DoD OCRP Investigator-Initiated Research Award 
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): August 27

DoD Ovarian Cancer Academy Dean and Assistant Dean (Leadership) Award
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): August 20

DoD Ovarian Cancer Academy Award – Early-Career Investigator
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): August 27

DoD LCRP Career Development Award
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): September 17

DoD LCRP Clinical Exploration Award (CEA)
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): September 17

DoD LCRP Idea Development Award
Pre-Application Deadline (Required): June 3
Application Deadline (Invite Only): September 17

Vilcek Prizes For Creative Promise in Biomedical Science
Deadline: June 10

Lung Cancer Research Foundation
Deadline: June 16

2014 AACR Distinguished Lecture on the Science of Cancer Health Disparities, funded by Susan G. Komen®
Nomination deadline: June 18

2014 AACR Award for Outstanding Achievement in Cancer Prevention Research
Nomination deadline: June 18

Stand Up To Cancer (SU2C)-Cancer Research UK Translational Research Fellowship
Deadline: July 28

Damon Runyon Fellowship Award
Deadline: August 15

DoD BCRP Breast Cancer Innovator Award
Deadline: August 15

DoD BCRP Breast Cancer Era of Hope Scholar Award
Deadline: August 15

DoD BMFRP Idea Development Award 
Deadline: August 28

DoD PRCRP Idea Award with Special Focus
Pre-Application Deadline: June 10
Application Deadline (Invite Only): September 17

DoD PRCRP Career Development Award
Pre-Application Deadline: June 10
Application Deadline (Invite Only): September 17

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Transition Plans for Reporting Sex/Gender, Race, and Ethnicity Information in Non-Competing Type 5 Progress Reports (NOT-OD-14-085)

NIH Launching New System and Procedures for Reporting Sex/Gender, Race, and Ethnicity Information to the NIH (NOT-OD-14-086)

Notice of Change in Eligibility for RFA-OD-14-005 "NIH Research Evaluation and Commercialization Hub (REACH) Awards (U01)"(/NOT-OD-14-087)

Notice of Clarification of Career (K) Award Eligibility (NOT-OD-14-088)

Centers of Excellence in Genomic Science (CEGS)(RM1)(PAR-14-195)

Administrative Supplements for Research on Dietary Supplements (Admin Supp)(PAR-14-201)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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EVENTS

Mon, May 5

Pathology Research Seminar Series
Gaurav Choudhary
PhD Candidate, Almasan Lab, Pathology
CWRU/Cleveland Clinic
Topic: Targeting Mcl-1 by BH3 Mimetics and Cyclin Inhibition
12 pm WRB 1-413

Genomic Medicine Institute Seminar
Scott Small, PhD
Serre Lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Genomics of Wuchereria Bancrofti: The primary causative agent of Lymphatic Filariasis
12:30pm in NE1-205 Cleveland Clinic

Department of Physiology & Biophysics
Benjamin M. Gaston, MD
Chief, Divisions of Pediatric Allergy & Immunology and Pediatric Pulmonary
Professor, Pediatric Medicine
CWRU/UHCMC
Topic: Respiratory Physiology of S-nitrosothiol-based Signaling Molecules
4pm SOM/Robbins Building E-501


Tues, May 6

Radiation Oncology Grand Rounds
Mazen Mislmani, MD 
Radiation Oncology
CWRU/UH
Topic: Prophylactic Cranial Irradiation for Lung Cancer
8:10 am Lerner B-151

Immunology Seminar Series
James Obondo Sande
PhD Candidate, Boom Lab, Pathology, Boom Lab
CWRU/UH
Topic: TBD
12 pm WRB 1-413

DNA Damage and Repair Focus Group Meeting
Nancy Oleinick, PhD
Professor, Radiation Oncology
CWRU
Topic: Inhibiting Base Excision Repair with Methoxyamine to Enhance Radiosensitization by Pemetrexed in Preclinical Lung Cancer Models
4 pm WRB 3-136


Wed, May 7

Hematology and Oncology Division Research Conference
Dr. Siraji Obayo 
Visiting Oncologist, Uganda Cancer Institute
Topic: Cancer in Sub-Saharan Africa
8 am Lerner B-151

Special Cancer Center Seminar
Wafik El-Deiry, MD, PhD
Rose Dunlap Professor of Medicine
Chief, Division of Hematology/Oncology
Penn State College of Medicine/Milton S. Hershey Medical Center
Associate Director for Translational Research
Penn State Hershey Cancer Institute
Topic: Personalizing Colon Cancer Therapy
11 am WRB 1-413


Thurs, May 8

Molecular Biology & Microbiology Seminar
David Alvarez-Carbonell
Karn Lab, Molecular Biology & Microbiology
CWRU
Topic: Infected Microglia-Induction of HIV-Related Neurodegeneration
AND
Stephanie Milne
Karn Lab, Molecular Biology & Microbiology
CWRU
Topic: Understand Underlying Molecular Mechanisms in Regulating HIV latency in Microglial Cells
1 pm Rottman Seminar Room, Wood W203


Fri, May 9

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Steven Lietman, MD
Co-Director, Musculoskeletal Tumor Center
Cleveland Clinic
Topic: Bone Metastasis
8 am R3/002-003 Cleveland Clinic

World Health Interest Group Seminar
Paul Wille, PhD
Postdoctoral Fellow, Div. of Infectious Diseases and HIV Medicine
CWRU
Topic: The cis-Acting Genomic RNA Packaging Enhancer (GRPE) Enhances HIV-1 and Lentiviral Vector Genome Packaging
9 am BRB 433

Cellular and Molecular Medicine Seminar Series
Long Zheng,MD, PhD
Associate Professor, Pathology and Laboratory Medicine
University of Pennsylvania
Topic: Thrombotic Thrombocytopenic Purpura (TTP) - Molecular Mechanism, Diagnosis and Novel Therapeutics
10 am NC1-202 Cleveland Clinic

BME Joint Appt Seminar
Darlene Lobel, MD
Associate Staff, Center for Neurological Restoration, Neurological Institute
Cleveland Clinic
Topic: Brain Machine Interface: Bypass Systems to Restore Neurologic Function
11 am NE1-205 Cleveland Clinic

Cancer Center Research in Progress
Srividya Venkitachalam, PhD
Research Associate, Guda Lab, General Medical Sciences (Oncology)
CWRU/UH
Topic: Novel Glycosylation-associated Gene Mutations In Colon Cancer
4 pm WRB 3-136


Mon, May 12

Breast Cancer Program Seminar
Patricia Marshall, PhD
Professor, Bioethics
CWRU
Topic: Community Vices on Health Disparities and Genetic Research
AND
Tithi Biswas, MD
Associate Professor, Radiation Oncology
CWRU/UH
Topic: Surgery for Stage IV Breast Cancer
4 pm Wearn 137

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence
Details

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East

Cancer Stem Cell Conference
August 17-20, 2014
Cleveland, OH
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

Cancer Pharmacology Training Program Symposium
May 19
9:30 am - 1:15 pm Wood W331 (CWRU campus)

16th Annual Midwest DNA Repair Symposium
May 17-18
Detroit, MI
Details

ASCO Review
June 26
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH

American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine
October 12-15
Cleveland, OH
Details

Society for Integrative Oncology
October 26-28, 2014
Houston, Texas
Details