CASE CCC IN THE NEWS
Sleep, Stress Management and Cancer Prevention
Huffington Post - Mar 31, 2014
Many of us have learned that a diet rich in fresh vegetables, fruits and whole grains, daily physical exercise, and protecting our skin from the sun can significantly reduce our cancer risk. Ending smoking and limiting alcohol are also high on the list of ways to prevent cancer. But how often do we realize that adequate sleep is necessary to maintain a strong immune system, to prevent the growth of cancer? Do we actively seek to manage stress in our daily lives so that we will not be harmed by its effects on our bodies and mind?...In 2012, Cheryl Thompson, PhD, of Case Western Reserve University School of Medicine and Case Comprehensive Cancer Center reported that lack of sleep in postmenopausal women is linked to more aggressive breast cancers. Case Comprehensive Cancer Center member Li Li, MD, PhD, a co-author of this study, noted that, "Short sleep duration is a public health hazard leading not only to obesity, diabetes and heart disease, but also cancer."
Alternate Sunitinib Schedule Decreased Toxicity in mRCC
HemOnc Today - Mar 28, 2014
Patients with metastatic renal cell carcinoma who received sunitinib in a 2-weeks-on, 1-week-off schedule experienced significantly less toxicity than those treated with the standard 4-weeks-on, 2-weeks off schedule, according to results of a retrospective study. Although dose reductions often are required for patients treated with sunitinib (Sutent, Pfizer), maintaining adequate dosing and drug levels are essential for optimizing clinical efficacy. In the current study, Case Comprehensive Cancer Center member Brian I. Rini, MD, a staff member in the department of solid tumor oncology at Cleveland Clinic and a HemOnc Today Editorial Board member, and colleagues reviewed the medical records of 30 patients with metastatic renal cell carcinoma.
New Prostate Cancer Tests Mark Era of Personalized Medicine
Urology Times - Mar 19, 2014
The first-generation biomarkers represent "incremental but important steps forward in making more precise judgments about how to manage patients," said Eric Klein, MD, Chairman of the Glickman Urological and Kidney Institute at Cleveland Clinic and member of the Case Comprehensive Cancer Center. Although not 100% accurate, the newer biomarkers improve upon the approximately 80% predictive accuracy achieved with the standard nomogram-based approach using prostate-specific antigen (PSA), Gleason grade, and clinical stage to assess prostate cancer aggressiveness, he said.
RESEARCH HIGHLIGHTS AND AWARDS
Tatiana V. Byzova Honored with the 2014 NAVBO Judah Folkman Award in Vascular Biology
Cancer Center member Tatiana V. Byzova, PhD has been selected by the North American Vascular Biology Organization (NAVBO) to receive the 2014 Judah Folkman Award in Vascular Biology. This award recognizes outstanding contributions from mid-career vascular biologists. Dr. Byzova, Vice-Chair of Molecular Cardiology and the Robert Canova Endowed Chair in Angiogenesis Research in the Cleveland Clinic Lerner Research Institute, was honored for her groundbreaking research with VEGF/VEGFR. She will present the Judah Folkman Award Lecture during Vascular Biology 2014 in Pacific Grove, California, on October 22, 2014.
Breast Cancer Publication Highlighted
A "Breast Cancer Research" paper co-authored by Drs. Bill Schiemann and Khalid Sossey-Alaoui has been designated as "Highly Accessed" by the journal website. The same paper, titled Fibroblast Growth Factor Receptor Splice Variants are Stable Markers of Oncogenic Transforming Growth Factor β1 Signaling in Metastatic Breast Cancers was also highlighted in the March 27 edition of "Mammary Cell News".
2014 Affymetrix® Tumor Profiling Grant Program
The 2014 Affymetrix® Tumor Profiling Grant Program is designed to support translational cancer researchers who are discovering and validating biomarkers to address an unmet clinical need by combining multiple omics data. Affymetrix will support up to three grants globally with reagents to profile up to 30 samples.
Deadline: April 15
Dr. Marty Veigl, Director of the Gene Expression & Genotyping Core Facility is available to assist anyone who may need information to put together their proposal.
Request for Proposals for Case CCC Funding for Pilot/Phase I Clinical Trials
The Case CCC is encouraging investigators to submit Letters of Intent (LOI) for Early Phase Clinical Research Support (EPCRS) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Priority will be given to trials which are developed jointly between UH and CCF with planned accrual at both institutions. (See revised NCI Cancer Center Support Grant EPCRS guidelines, page 43, Section 2.12). Please submit LOIs to Katarzyna Karelus, Case CCC Clinical Research Office, email@example.com, 216.844.4176.
LOI deadline: April 15
Doctors Cancer Foundation
The Doctors Cancer Foundation will offer one grant in 2014 to support the best program for the management of cancer. The Foundation is particularly interested in promoting the best young scientists who are currently under the radar screen. The project should be innovative, sound, and able to lead to clinical trials. PhDs are welcome to submit grant applications, and several have won grants in the past.
Deadline: May 31
Relay for Life of Case Western Reserve University
The Relay for Life of Case Western Reserve University will be Saturday, April 12. Relay For Life is an incredible and inspiring opportunity to unite as a campus to honor cancer survivors, raise awareness about what we can do to reduce our cancer risk, and raise money to help the American Cancer Society fight the disease. There is still time to join a team or make a donation to support this cause.
If you are looking for a way to help, Amy Wilson-Delfosse, PhD of the CWRU School of Medicine welcomes you to join her team. Come and walk on April 12, or help to raise funds. If you cannot make it, consider making a donation or dedicate a luminaria. Remember - no effort or donation is too small, and every little bit helps.
Join Our Team - Race for the Place
Walk or run with the Case Comprehensive Cancer Center team at the Race for the Place, June 1, 2014. This great event helps The Gathering Place to offer services to anyone touched by cancer, no matter their economic situation. Anyone is welcome to join our team. If you can't make the Race in person, please consider making a donation to support our efforts. Click here to view our team page.
MARK YOUR CALENDARS
On Friday, April 18, hundreds of researchers, scientists and scholars will come together at the Veale Convocation Center for Research ShowCASE. In line with the day's theme of collaboration, creativity, and innovation, Case CCC Director Dr. Stan Gerson will deliver the keynote address.
New in 2014, the Spring Undergraduate Symposium, Intersections, will be joining Research ShowCASE. Exhibits of real-world applications, critical insights, and creative and intellectual activities will be on view for students, faculty, staff, alumni, business and industry leaders and the community, highlighting the full range of faculty, postdoctoral, undergraduate and graduate research at CWRU. This event is free and open to the public.
GI SPORE Retreat
Registration is open for the Case Gastrointestinal Cancers SPORE Retreat, April 24 in Dively Rm. 202. Planned presentation topics include: Colon Cancer, Barrett's Esophagus, Cancer Metastasis, Cancer Prevention, and Cancer in Minorities.
The day will also feature poster presentations by trainees and fellows. To participate, submit abstracts to John Wang (firstname.lastname@example.org) by April 17.
CME Event - Screening for Cancer in Women: 2014
Registration is open for Screening for Cancer in Women: 2014, Wednesday, May 21 from 8 am - 3:35 pm at the Embassy Suites Hotel in Independence.
This conference will feature speakers from health centers across Northeast Ohio working together to fight cancer, who will offer expert insight, updates, and advice on screening for cancer in women.
Optimal strategies in cancer screening and detection are constantly evolving, and best practices are changing. This comprehensive symposium is aimed at primary care providers and cancer specialists with updates that can be incorporated into their practices including:
- New screening technologies, particularly to detect breast and lung cancer
- Current guidelines for colorectal, skin, lung, breast, and cervical cancer screening
- Dr. Brian Bolwell will discuss the impact of the Affordable Care Act
- Racial and economic disparities within cancer screening and detection
- When to refer a patient for a genetics referral or to a high-risk clinic
CME credit will be offered. Visit the conference website for more details and registration information.
American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine
The American Society for Matrix Biology (ASMB) is pleased to announce their 2014 biennial meeting. The event will be held in Cleveland, OH, from October 12-15, 2014. The theme,Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine, addresses the scientific interests of a broad audience. We anticipate that this meeting will stimulate exciting interactions among participants, with extensive opportunities to network and learn about the latest concepts, techniques and translational applications of fundamental matrix biology.
The ASMB meeting represents a unique opportunity for scientists, engineers, and medical professionals with an interest in matrix biology and cell matrix interactions to meet, discuss, learn, and network. Attendance is expected to exceed 300 participants, including ASMB members and nonmembers. Participation by the International Society for Matrix Biology (ISMB) and other guest societies, as well as special interest group sessions organized by ASMB members, will enhance the meeting experience for attendees. Register today - early bird rates end June 26.