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April 7, 2014

CASE CCC IN THE NEWS

Sleep, Stress Management and Cancer Prevention
Huffington Post - Mar 31, 2014
Many of us have learned that a diet rich in fresh vegetables, fruits and whole grains, daily physical exercise, and protecting our skin from the sun can significantly reduce our cancer risk. Ending smoking and limiting alcohol are also high on the list of ways to prevent cancer. But how often do we realize that adequate sleep is necessary to maintain a strong immune system, to prevent the growth of cancer? Do we actively seek to manage stress in our daily lives so that we will not be harmed by its effects on our bodies and mind?...In 2012, Cheryl Thompson, PhD, of Case Western Reserve University School of Medicine and Case Comprehensive Cancer Center reported that lack of sleep in postmenopausal women is linked to more aggressive breast cancers. Case Comprehensive Cancer Center member Li Li, MD, PhD, a co-author of this study, noted that, "Short sleep duration is a public health hazard leading not only to obesity, diabetes and heart disease, but also cancer."

Alternate Sunitinib Schedule Decreased Toxicity in mRCC
HemOnc Today - Mar 28, 2014
Patients with metastatic renal cell carcinoma who received sunitinib in a 2-weeks-on, 1-week-off schedule experienced significantly less toxicity than those treated with the standard 4-weeks-on, 2-weeks off schedule, according to results of a retrospective study. Although dose reductions often are required for patients treated with sunitinib (Sutent, Pfizer), maintaining adequate dosing and drug levels are essential for optimizing clinical efficacy. In the current study, Case Comprehensive Cancer Center member Brian I. Rini, MD, a staff member in the department of solid tumor oncology at Cleveland Clinic and a HemOnc Today Editorial Board member, and colleagues reviewed the medical records of 30 patients with metastatic renal cell carcinoma.

New Prostate Cancer Tests Mark Era of Personalized Medicine
Urology Times - Mar 19, 2014
The first-generation biomarkers represent "incremental but important steps forward in making more precise judgments about how to manage patients," said Eric Klein, MD, Chairman of the Glickman Urological and Kidney Institute at Cleveland Clinic and member of the Case Comprehensive Cancer Center. Although not 100% accurate, the newer biomarkers improve upon the approximately 80% predictive accuracy achieved with the standard nomogram-based approach using prostate-specific antigen (PSA), Gleason grade, and clinical stage to assess prostate cancer aggressiveness, he said.


RESEARCH HIGHLIGHTS AND AWARDS

Tatiana V. Byzova Honored with the 2014 NAVBO Judah Folkman Award in Vascular Biology

Tatiana V. Byzova, PhDCancer Center member Tatiana V. Byzova, PhD has been selected by the North American Vascular Biology Organization (NAVBO) to receive the 2014 Judah Folkman Award in Vascular Biology. This award recognizes outstanding contributions from mid-career vascular biologists. Dr. Byzova, Vice-Chair of Molecular Cardiology and the Robert Canova Endowed Chair in Angiogenesis Research in the Cleveland Clinic Lerner Research Institute, was honored for her groundbreaking research with VEGF/VEGFR. She will present the Judah Folkman Award Lecture during Vascular Biology 2014 in Pacific Grove, California, on October 22, 2014.

Breast Cancer Publication Highlighted

A "Breast Cancer Research" paper co-authored by Drs. Bill Schiemann and Khalid Sossey-Alaoui has been designated as "Highly Accessed" by the journal website. The same paper, titled Fibroblast Growth Factor Receptor Splice Variants are Stable Markers of Oncogenic Transforming Growth Factor β1 Signaling in Metastatic Breast Cancers was also highlighted in the March 27 edition of "Mammary Cell News".


FUNDING OPPORTUNITIES

2014 Affymetrix® Tumor Profiling Grant Program

The 2014 Affymetrix® Tumor Profiling Grant Program is designed to support translational cancer researchers who are discovering and validating biomarkers to address an unmet clinical need by combining multiple omics data. Affymetrix will support up to three grants globally with reagents to profile up to 30 samples. 
Deadline: April 15

Dr. Marty Veigl, Director of the Gene Expression & Genotyping Core Facility is available to assist anyone who may need information to put together their proposal.

Request for Proposals for Case CCC Funding for Pilot/Phase I Clinical Trials

The Case CCC is encouraging investigators to submit Letters of Intent (LOI) for Early Phase Clinical Research Support (EPCRS) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Priority will be given to trials which are developed jointly between UH and CCF with planned accrual at both institutions. (See revised NCI Cancer Center Support Grant EPCRS guidelines, page 43, Section 2.12). Please submit LOIs to Katarzyna Karelus, Case CCC Clinical Research Office, kxk384@case.edu, 216.844.4176.
LOI deadline: April 15

Doctors Cancer Foundation

The Doctors Cancer Foundation will offer one grant in 2014 to support the best program for the management of cancer. The Foundation is particularly interested in promoting the best young scientists who are currently under the radar screen. The project should be innovative, sound, and able to lead to clinical trials. PhDs are welcome to submit grant applications, and several have won grants in the past. 
Deadline: May 31


ANNOUNCEMENTS

Relay for Life of Case Western Reserve University

The Relay for Life of Case Western Reserve University will be Saturday, April 12. Relay For Life is an incredible and inspiring opportunity to unite as a campus to honor cancer survivors, raise awareness about what we can do to reduce our cancer risk, and raise money to help the American Cancer Society fight the disease. There is still time to join a team or make a donation to support this cause.

If you are looking for a way to help, Amy Wilson-Delfosse, PhD of the CWRU School of Medicine welcomes you to join her team. Come and walk on April 12, or help to raise funds. If you cannot make it, consider making a donation or dedicate a luminaria. Remember - no effort or donation is too small, and every little bit helps.

Join Our Team - Race for the Place

Walk or run with the Case Comprehensive Cancer Center team at the Race for the Place, June 1, 2014. This great event helps The Gathering Place to offer services to anyone touched by cancer, no matter their economic situation. Anyone is welcome to join our team. If you can't make the Race in person, please consider making a donation to support our efforts. Click here to view our team page.


MARK YOUR CALENDARS

Research ShowCASE

On Friday, April 18, hundreds of researchers, scientists and scholars will come together at the Veale Convocation Center for Research ShowCASE. In line with the day's theme of collaboration, creativity, and innovation, Case CCC Director Dr. Stan Gerson will deliver the keynote address.

New in 2014, the Spring Undergraduate Symposium, Intersections, will be joining Research ShowCASE. Exhibits of real-world applications, critical insights, and creative and intellectual activities will be on view for students, faculty, staff, alumni, business and industry leaders and the community, highlighting the full range of faculty, postdoctoral, undergraduate and graduate research at CWRU. This event is free and open to the public.

GI SPORE Retreat

Registration is open for the Case Gastrointestinal Cancers SPORE Retreat, April 24 in Dively Rm. 202. Planned presentation topics include: Colon Cancer, Barrett's Esophagus, Cancer Metastasis, Cancer Prevention, and Cancer in Minorities.

The day will also feature poster presentations by trainees and fellows. To participate, submit abstracts to John Wang (zxw22@case.edu) by April 17.

CME Event - Screening for Cancer in Women: 2014

Registration is open for Screening for Cancer in Women: 2014Wednesday, May 21 from 8 am - 3:35 pm at the Embassy Suites Hotel in Independence.

This conference will feature speakers from health centers across Northeast Ohio working together to fight cancer, who will offer expert insight, updates, and advice on screening for cancer in women.

Optimal strategies in cancer screening and detection are constantly evolving, and best practices are changing. This comprehensive symposium is aimed at primary care providers and cancer specialists with updates that can be incorporated into their practices including:

  • New screening technologies, particularly to detect breast and lung cancer
  • Current guidelines for colorectal, skin, lung, breast, and cervical cancer screening
  • Dr. Brian Bolwell will discuss the impact of the Affordable Care Act
  • Racial and economic disparities within cancer screening and detection
  • When to refer a patient for a genetics referral or to a high-risk clinic

CME credit will be offered. Visit the conference website for more details and registration information.

American Society for Matrix Biology Biennial Meeting: Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine

The American Society for Matrix Biology (ASMB) is pleased to announce their 2014 biennial meeting. The event will be held in Cleveland, OH, from October 12-15, 2014. The theme,Integrating Extracellular Matrix and Cellular Networks in Biology and Medicine, addresses the scientific interests of a broad audience. We anticipate that this meeting will stimulate exciting interactions among participants, with extensive opportunities to network and learn about the latest concepts, techniques and translational applications of fundamental matrix biology.

The ASMB meeting represents a unique opportunity for scientists, engineers, and medical professionals with an interest in matrix biology and cell matrix interactions to meet, discuss, learn, and network. Attendance is expected to exceed 300 participants, including ASMB members and nonmembers. Participation by the International Society for Matrix Biology (ISMB) and other guest societies, as well as special interest group sessions organized by ASMB members, will enhance the meeting experience for attendees. Register today - early bird rates end June 26.

PREVIOUSLY ANNOUNCED OPPORTUNITIES

Alex's Lemonade Stand Foundation Bridge Grant
Deadline: April 10

Alex's Lemonade Stand Foundation Springboard Grant
Deadline: April 10

Bladder Cancer Advocacy Network John Quale Travel Fellowship Program
Deadline: April 14

American Nuclear Society Radiation Science and Technology Award
Deadline: April 15

Brian Werbel Memorial Fund Summer Cancer Research Fellowships‌
Deadline: April 25

Prostate Cancer Foundation 2014 Movember-PCF Global Treatment Sciences (GTSN) Challenge Award For Metastatic Prostate Cancer
Deadline: April 30

Harrington Scholar-Innovator Award
LOI Deadline: May 2
Invited Application Deadline: August 1

GlaxoSmithKline Discovery Fast Track Challenge
Deadline: May 16

DoD BCRP Breast Cancer Breakthrough Award Levels 1 and 2 
Deadline: May 28

DoD BCRP Breast Cancer Breakthrough Award Levels 3 and 4
Deadline: May 28

HHMI Investigator Program National Competition
Deadline: June 3

Lung Cancer Research Foundation
Deadline: June 16, 2014

Damon Runyon Fellowship Award
Deadline: August 15

DoD BCRP Breast Cancer Innovator Award
Deadline: August 15

DoD BCRP Breast Cancer Era of Hope Scholar Award
Deadline: August 15

DoD BMFRP Idea Development Award 
Deadline: August 28

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Evaluation of In Vitro Release Methods for Liposomal Drug Products (U01)(RFA-FD-14-016)

Development of Clinically Relevant In Vitro Performance Test for Generic OIDPs: Physiologically Relevant Models for Aerodynamic Particle Size Distribution Analysis (U01)(RFA-FD-14-022)

The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01)(PAR-13-159)

Collaborative Research in Integrative Cancer Biology (U01)(PAR-13-184)

Image-guided Drug Delivery in Cancer (R01)(PAR-13-185)

Physical Sciences-Oncology Network (PS-ON): Physical Sciences-Oncology Centers (PS-OC)(U54)(PAR-14-169)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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EVENTS

calendar

Mon, April 7

Pathology Seminar
Neena Singh, MD, PhD
Professor, Pathology
CWRU
Topic: Prion Protein Modulates Cellular Iron Uptake: Implications for Prion Disorders
12 pm WRB 1-413

Genomic Medicine Institute Seminar
Chunlei Zheng
Zhang lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Recent Progress in FVIII Secretory Pathway: ER Exit Mechanism and Beyond
12:30pm NE1-205 Cleveland Clinic

Physiology & Biophysics Seminar
Robert K. Nakamoto, PhD
Professor, Molecular Physiology and Biological Physics
University of Virginia
Topic: How Gram Negative Bacteria Eat: Permeation through the Outer Membrane
4 pm Robbins E-501


Tues, April 8

Molecular Genetics Seminar
George Aranjuez
Graduate Student, McDonald lab, Molecular Genetics
Cleveland Clinic
Topic: Dop/MAST2 Kinase is Required for Coordinated Protrusion Formation during Collective Cell Movement in Vivo
9:30 am NE1-205 Cleveland Clinic

Immunology Seminar Series
Nicole Ward, PhD
Associate Professor, Dermatology
CWRU/UH
Topic: Using Mouse Models to Better Understand the Pathogenesis of Psoriasis: From the Bench to the Bedside and Back Again
12 pm WRB 1-413


Wed, April 9

Hematology and Oncology Division Research Conference
Topic: TBD
8 am Lerner B-151

Immunology Seminar
John Atkinson, PhD
Chief, Div. of Rheumatology
Washington University
Topic: Excessive Activity of Innate Immunity Causing Human Disease
12 pm NC1-202 Cleveland Clinic

PRCHN Seminar Series
Claudia Coulton, PhD
Lillian F. Harris Professor of Urban Research & Social Change
CWRU
Topic: Individual and Contextual Effects on Perception of Neighborhood Scale
12 pm BioEnterprise PRCHN Ground Floor Conference Room

Case CCC Breast Cancer Program Seminar
Mark Jackson, PhD
Assistant Professor, Pathology
CWRU
Topic: Constructing Cancer: Identifying Novel Proteins Involved in Breast Cell Transformation and Metastasis
AND
Donna Plecha, MD
Assistant Professor, Radiology
CWRU/UH
Topic: Breast Imaging Research: A Review
5:30 pm Wearn 137


Thurs, April 10

Molecular Genetics Guest Speaker
Pamela Geyer, PhD
Department of Biochemistry
University of Iowa
Topic: Deciphering the Regulatory Code of the Drosophila Suppressor of Hairy-wing protein, A Multifunctional Transcription Factor
9:30 am NE1-205 Cleveland Clinic

Immunology Journal Club
Elizabeth Liu
Student, Immunology
CWRU
Topic: Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis
12 pm WRB 5-136

Molecular Biology & Microbiology Seminar
Curtis Dobrowolski
Karn lab, Molecular Biology & Microbiology
CWRU
Topic: A Customizable Primary Cell HIV Latency Model and Novel Molecular HIV NGS Techniques
AND
Mary Ann Checkley Luttge, PhD
Karn lab, Molecular Biology & Microbiology
CWRU
Topic: NK Cells Can Target and Eliminate Latently HIV-1-infected Primary T Cells Following Proviral Reactivatio
1 pm Rottman Seminar Room, Wood W203


Fri, April 11

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Paul Nguyen, MD
Associate Professor, Radiation Oncology
Harvard Medical School
Director, Prostate Brachytherapy and Clinical Trials for Genitourinary Radiation Oncology, Radiation Oncology
Dana-Farber Cancer Institute
Topic: Optimizing the Use of Androgen Deprivation Therapy for Prostate Cancer: Who is Helped and Who is Harmed?
8 am R3/002-003 Cleveland Clinic

Molecular Biology & Microbiology Seminar Series
Arne Rietsch, PhD
Assistant Professor, Molecular Biology & Microbiology
CWRU
Topic: P. aeruginosa Type III Secretion: Mechanism and Disease
1 pm Rottman Seminar Room, Wood W203

National Center for Regenerative Medicine Seminar
Kim Ly, PhD
Senior Product Manager, Cell Therapy
Irvine Scientific
Topic: Custom Media Development & Optimization for Serum-Free Stem Cell Expansion
3:30 pm WRB 1-203

Cancer Center Research in Progress
Anil Belur Nagaraj, PhD
Post Doctoral Scholar, DiFeo lab, Div. of General Medical Sciences- Oncology
CWRU/UH
Topic: An Old "Pain Killer" as a New Tool to Overcome Cisplatin Resistance in Ovarian Cancer
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Hematopoietic Disorders Scientific Program Meeting
April 25
3:15 pm Wolstein Research Bldg

Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence
Details

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East

ADDITIONAL UPCOMING SEMINARS & EVENTS

1st Annual Multidisciplinary Colorectal Oncology Course
April 23
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH
Details

ASCO Review
June 26
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH