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March 31, 2014


ASPO Annual Meeting Showcases Innovative Approaches to Cancer Prevention
Oncology Times - Mar 27, 2014
Science, policy, and legislation are combining to foster progress in cancer prevention. That was the word from speakers here at the American Society of Preventive Oncology (ASPO) Annual Meeting...In addition to cutting-edge new science, the meeting also featured presentations on lifestyle behaviors such as smoking and physical activity. The following are some of the highlights of the research presented. Retinol-Binding Protein 4 & Risk of Colon Adenoma: A study believed to be the first of its kind showed that higher circulating levels of serum retinol-binding protein 4 (RBP4), a recently discovered biomarker of insulin resistance, are associated with a risk of colon adenoma --especially and surprisingly among those with a lower body mass index (BMI). Insulin resistance is believed to be a key linking obesity to colon cancer, said study co-author Li Li, MD, PhD, Associate Director for Prevention Research at the Case Comprehensive Cancer Center and Professor of Family Medicine at Case Western Reserve University

Reassurance from Large Study that Contrary to Earlier Thinking, Prostate Cancer Patients Receiving Radiation Do Not Have Increased Risk of MDS 
Oncology Times - Mar 25, 2014
Men who receive radiation treatment for prostate cancer are at no greater risk for developing myelodysplastic syndromes (MDS) than the general population, according to a study now available online ahead of print in the Journal of the National Cancer Institute. Common thinking, passed down to oncologists and largely from review articles, has been that patients exposed to radiation or any type of chemotherapy who then develop MDS have therapy-related MDS, said Mikkael A. Sekeres, MD, MS, senior author of the study and Director of the Leukemia Program at Cleveland Clinic's Taussig Cancer Institute.


AACR Annual Meeting

The American Association for Cancer Research (AACR) Annual Meeting will take place April 5-9 in San Diego. The Case CCC has many members participating in the meeting.

As was highlighted in last week's newsletter, we are especially pleased that two of our members, Drs. Charis Eng and Nima Sharifi have been recognized with awards and will be presenting lectures; what an honor! In addition,Dr. Neal Meropol will give a presentation on clinical trials funding; Dr. Yiping Han will speak about oral bacteria and colorectal cancer; and Dr. Lyndsay Harris will present on genomic markers and breast cancer.

The research of many of our members will also be highlighted at mini-symposiums and poster presentations. We wish all of you the best of luck! A full list of Cancer Center presentations is posted on the Cancer Center website.


2014 Affymetrix® Tumor Profiling Grant Program

The 2014 Affymetrix® Tumor Profiling Grant Program is designed to support translational cancer researchers who are discovering and validating biomarkers to address an unmet clinical need by combining multiple omics data. Affymetrix will support up to three grants globally with reagents to profile up to 30 samples. 
Deadline: April 15

Dr. Marty Veigl, Director of the Gene Expression & Genotyping Core Facility is available to assist anyone who may need information to put together their proposal.

Request for Proposals for Case CCC Funding for Pilot/Phase I Clinical Trials

The Case CCC is encouraging investigators to submit Letters of Intent (LOI) for Early Phase Clinical Research Support (EPCRS) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Priority will be given to trials which are developed jointly between UH and CCF with planned accrual at both institutions. (See revised NCI Cancer Center Support Grant EPCRS guidelines, page 43, Section 2.12). Please submit LOIs to Katarzyna Karelus, Case CCC Clinical Research Office,, 216.844.4176.
LOI deadline: April 15

DoD Breast Cancer Research Program

The Fiscal Year 2014 (FY14) Defense Appropriations Act provides $120 million (M) to the Department of Defense Breast Cancer Research Program (BCRP) to support innovative, high-impact breast cancer research.

The Breast Cancer Breakthrough Award Levels 1 and 2 supports promising research that has high potential to lead to or make breakthroughs in breast cancer. Research supported by the Breakthrough Award will have the potential for a major impact and accelerate progress toward ending breast cancer. The impact may be near-term or long-term, but must be significant and move beyond an incremental advancement. Two different funding levels, based on the scope of the research, are available under this Program Announcement.
Deadline: May 28

The Breast Cancer Breakthrough Award Levels 3 and 4 supports promising research that has high potential to lead to or make breakthroughs in breast cancer. Research supported by the Breakthrough Award will have the potential for a major impact and accelerate progress toward ending breast cancer. The impact may be near-term or long-term, but must be significant and move beyond an incremental advancement. Two different funding levels, based on the scope of the research, are available under this Program Announcement.
Deadline: May 28

The Breast Cancer Innovator Award supports visionary individuals who have demonstrated creativity, innovative work, and leadership in any field including, but not limited to, breast cancer. The Innovator Award will provide these individuals with the funding and freedom to pursue their most novel, visionary, high-risk ideas that could ultimately lead to ending breast cancer. 
Deadline: August 15

The Breast Cancer Era of Hope Scholar Award supports individuals who are early in their careers and have demonstrated significant potential for innovation in breast cancer research. These individuals should be exceptionally talented scientists who have shown that they are the "best and brightest" in their field(s) through extraordinary creativity, vision, and productivity. They should have demonstrated experience in forming effective partnerships and collaborations and should exhibit strong potential for leadership in the breast cancer research community. 
Deadline: August 15

DoD Bone Marrow Failure Research Program

The FY14 Defense Appropriations Act provides $3.2 million (M) to the Department of Defense Bone Marrow Failure Research Program (BMFRP) to support innovative research committed to advancing the understanding of inherited and acquired bone marrow failure diseases.

The BMFRP Idea Development Award is intended to support innovative ideas and high-impact approaches based on scientifically sound evidence to move toward the BMFRP vision of understanding and curing BMF diseases. This award mechanism is designed to support new ideas. Proposed research studies should have a high probability of revealing new avenues of investigation. Research projects should include a well-formulated, testable hypothesis based on strong scientific rationale and a developed and well-articulated research approach. Personnel on the proposed team should have a strong background in BMF research.
Deadline: August 28


GI SPORE Retreat

Registration is open for the Case Gastrointestinal Cancers SPORE Retreat, April 24 in Dively Rm. 202. Planned presentation topics include: Colon Cancer, Barrett's Esophagus, Cancer Metastasis, Cancer Prevention, and Cancer in Minorities.

The day will also feature poster presentations by trainees and fellows. To participate, submit abstracts to John Wang ( by April 17.

Screening for Cancer in Women: 2014

Register today for Screening for Cancer in Women: 2014Wednesday, May 21 from 8 am - 3:35 pm at the Embassy Suites Hotel in Independence.

Optimal strategies in cancer screening and detection are constantly evolving, and best practices are changing. This conference will feature speakers from health centers across Northeast Ohio working together to fight cancer, who will offer expert insight, updates, and advice on screening for cancer in women.

This comprehensive symposium is aimed at primary care providers and cancer specialists with updates that can be incorporated into their practices:

  • New screening technologies, particularly to detect breast and lung cancer
  • Current guidelines for colorectal, skin, lung, breast, and cervical cancer screening
  • Impact of the Affordable Care Act
  • Racial and economic disparities within cancer screening and detection
  • When to refer a patient for a genetics referral or to a high-risk clinic

CME credit will be offered. Visit the conference website for more details and registration information.


Skin Disease Research Center Pilot and Feasibility (P&F) Program
Deadline: March 31

Cancer Research Institute Irvington Postdoctoral Fellowship Program
Deadline: April 1

American Cancer Society RFA: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: April 1

Sta Op Tegen Kanker Dream Team Translational Cancer Research Grant
Deadline: April 1

Alex's Lemonade Stand Foundation Bridge Grant
Deadline: April 10

Alex's Lemonade Stand Foundation Springboard Grant
Deadline: April 10

Bladder Cancer Advocacy Network John Quale Travel Fellowship Program
Deadline: April 14

American Nuclear Society Radiation Science and Technology Award
Deadline: April 15

Brian Werbel Memorial Fund Summer Cancer Research Fellowships‌
Deadline: April 25

Prostate Cancer Foundation 2014 Movember-PCF Global Treatment Sciences (GTSN) Challenge Award For Metastatic Prostate Cancer
Deadline: April 30

Harrington Scholar-Innovator Award
LOI Deadline: May 2
Invited Application Deadline: August 1

GlaxoSmithKline Discovery Fast Track Challenge
Deadline: May 16

HHMI Investigator Program National Competition
Deadline: June 3

Lung Cancer Research Foundation
Deadline: June 16, 2014

Damon Runyon Fellowship Award
Deadline: August 15

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Intent to Publish a Funding Opportunity Announcement for Centers of Cancer Nanotechnology Excellence (U54) (NOT-CA-14-033)

Notice of National Cancer Institute's Interest in Supporting Cancer Nanotechnology Research Training Programs (NOT-CA-14-035)

Notice of Expiration of PAR-14-013 "Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R21)" (NOT-CA-14-036)

Notice of Intent to Publish a Funding Opportunity Announcement for Cancer Nanotechnology Research Platforms (U01)(NOT-CA-14-037)

Notice of Intent to Publish a Funding Opportunity Announcement for the Physical Sciences-Oncology Network (PS-ON): Physical Sciences-Oncology Projects (PS-OP) (U01)(NOT-CA-14-039)

Notice of National Cancer Institute (NCI) Participation in PA-14-155 "Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R01)" (NOT-CA-14-040)

Notice of National Cancer Institute (NCI) Participation in PA-14-156 "Extended Development, Hardening and Dissemination of Technologies in Biomedical Computing, Informatics, and Big Data Science (R01)" (NOT-CA-14-041)

Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R21)

Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R01)(PAR-14-166)

Biology of Manual Therapies (R21)

Biology of Manual Therapies (R01)


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at

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Mon, March 31

Radiation Oncology Guest Speaker
Neha Vapiwala, MD
Associate Professor, Radiation Oncology
Vice Chair of Education and Advisory Dean
Perelman School of Medicine
University of Pennsylvania
Topic: Immunotherapy and Radiation: In Vogue Again
9 am Lerner Tower B-151

Genomic Medicine Institute Seminar
Ying Ni, PhD
Eng lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Identify Susceptibility Genes for Cowden and Cowden-like Syndrome with Family-based Next-Gen Sequencing Strategy
12:30pm NE1-205 Cleveland Clinic

Breast Cancer Program Focus Group Meeting
Topic: Leveraging the Cancer Imaging Program and Its Expertise
2 pm WRB 3-136

Physiology & Biophysics Seminar
Merritt Maduke, PhD
Associate Professor, Molecular and Cellular Physiology
Stanford University
Topic: Structural Dynamics of CLC Transporters
4 pm Robbins E-501

Skeletal Research Center Seminar
Zhina Sadeghi, MD 
Jonathan Kenyon, PhD
Postdoctoral Research Fellows, Urology Institute
Topic: Clues About Mechanism of Multipotent Stem Cell Action in Improvement of Urinary Incontinence
4 pm Millis 123

Tues, April 1

Radiation Oncology Grand Rounds
Lam Tai-Chung, MBBS, FRCR, FHKAM
Resident Specialist, Clinical Oncology, Tuen Mun Hospital, Hong Kong
Fellow, Radiation Oncology, Dana-Farber/ Brigham and Women Cancer Center
Topic: Complications in "Undercomplicated" Spinal Metastases- the Role of Spinal Instability
8:10 am Lerner Tower B-151

Molecular Genetics Seminar
Josephine Dermawan
Graduate Student, Stark lab, Molecular Genetics
Cleveland Clinic
Topic: Signal-Specific, Genome-Wide Regulation of NF-κB Activation by EGF and IL-1
9:30 am NE1-205 Cleveland Clinic

Immunology Seminar Series
Dixon Dorand
Huang lab, Immunology
CWRU Topic: Interrogating the Role of Myeloid Derived Populations in the CNS Tumor Microenvironment
Chairut Vareechon
Pearlman lab, Immunology
Topic: The Role of P. aeruginosa Type III Secretion System in Impairing ROS Production by Neutrophils
12 pm WRB 1-413

DNA Damage and Repair Speaker Series
Matt Summers, PhD
Assistant Staff, Cancer Biology
Cleveland Clinic
Topic: TBD
4 pm WRB 3-136

Wed, April 2

Hematology and Oncology Division Research Conference
Lalitha Nayak, MD 
Assistant Professor, Div. of Hem/Onc
Topic: The Thromboprotective Effect of Bortezomib Is Dependent on Transcription Factor Kruppel-like Factor 2 (KLF2)
8 am Lerner B-151

Thurs, April 3

Immunology Journal Club
Gloria Tavera
Student, Immunology
Topic: Inducible Nitric Oxide Synthase is a Major Intermediate in Signaling Pathways for the Survival of Plasma Cells
12 pm WRB 5-136

Molecular Biology & Microbiology Seminar
Marisa Winkler
Bonomo lab, Molecular Biology & Microbiology
Topic: Understanding Protein Evolution in K. pneumoniae
Robert Bonomo, PhD
Molecular Biology & Microbiology
Topic: KPC: The Global Scourge 
1 pm Rottman Seminar Room, Wood W203

AYA Guest Lecture
Anur Praveen, MD, MPH
Div. of Pediatric Bone Marrow Transplantation
Memorial Sloan Kettering Cancer Center
Topic: Fanconi Anemia: Is BMT the only cure?
4 pm WRB 5-136

Fri, April 4

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Baidehi Maiti, MD
Cleveland Clinic
Topic: TBD
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Linda J.Z. Penn, PhD
Senior Scientist, Ontario Cancer Institute
University Health Network Director, Office of Research Trainees
Canadian Research Chair in Molecular Oncology
Topic: Targeting Tumor Cell Metabolism with Statins
12 pm BRB 105

Mon, April 7

Genomic Medicine Institute Seminar
Chunlei Zheng
Zhang lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Recent Progress in FVIII Secretory Pathway: ER Exit Mechanism and Beyond
12:30pm NE1-205 Cleveland Clinic

Case CCC Calendar

LRI Calendar


Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East


1st Annual Multidisciplinary Colorectal Oncology Course
April 23
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH

ASCO Review
June 26
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH