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March 17, 2014

CASE CCC IN THE NEWS

Cleveland Clinic's Dr. Charis Eng: A Q & A with the Cancer Geneticist
The Plain Dealer - Mar 14, 2014
Dr. Charis Eng, Chair of the Genomic Medicine Institute and member of the Case Comprehensive Cancer Center, is a rock star in the scientific world. Even before she arrived at the Cleveland Clinic in the fall of 2005, hand-picked to assemble the hospital's Genomic Medicine Institute (housed in the Center for Genomics Research, which had opened earlier that year), of which she is founder and chair, Eng had already made her mark...During a recent interview with The Plain Dealer, Eng talked about the importance of mentors, the challenge she has faced being a woman scientist, and the benefits of wine – in medicine and in life.

Statewide Colorectal Cancer Prevention Study is Screening Patients, Relatives for Lynch Syndrome
The Plain Dealer - Mar 12, 2014
Four hospitals in Northeast Ohio have joined a colorectal cancer prevention and research study that aims to screen everyone in the state diagnosed with colon cancer since Jan. 1, 2013 in an effort to help them avoid additional cancers. Researchers not only want to identify every patient who has a genetic disorder called Lynch syndrome, they also want to test the patients' first-degree relatives to see if they, too, are at higher risk of developing colorectal cancer and other cancers. Starting this month, Cleveland Clinic, Fairview Hospital, MetroHealth System and Summa Western Reserve Hospital joined the Ohio Colorectal Cancer Prevention Initiative...At the Cleveland Clinic, the routine screening for Lynch syndrome in new colorectal cancer and endometrial cancer patients whose tumors are surgically removed has been in place for several years. "There are definitely red flags," said Dr. Matthew Kalady, a colorectal surgeon at the Clinic. Among the signs: a diagnosis at a younger age, cancer on the right side of the colon, and an extensive family history of the disease are among the signals.

University Hospitals: Screenings Save Pledge
Fox 8 - Mar 11, 2014
In honor of Colon Cancer Awareness Month, Drs. Greg Cooper and John Dumot of University Hospitals Case Medical Center and the Case Comprehensive Cancer Center discuss the six biggest myths about colon cancer.

No Apparent Increased Risk of Myelodysplastic Syndrome With Definitive Radiotherapy in Prostate Cancer 
Mar 11, 2014
Exposure to ionizing radiation has been associated with increased risk of myelodysplastic syndrome, and it remains unclear whether radiation doses used in prostate cancer treatment result in increased risk. In a retrospective cohort study reported in the Journal of the National Cancer Institute,Dr. Sudipto Mukherjee et al found no significantly increased risk of myelodysplastic syndrome over relatively short-term follow-up.

Stereotactic Radiosurgery for More than Four Brain Metastases
Lancet Oncology - Mar 10, 2014
In this piece, Drs. Simon Lo, Mitchell Machtay and Andrew Sloan of University Hospitals Case Medical Center and the Case Comprehensive Cancer Center comment on the use of stereotactic radiosurgery for patients with more than four brain mestastases.

Personalized Medicine Revolution Gains Momentum
Cure Magazine - Mar 3, 2014
In no cancer is that process clearer than in chronic myeloid leukemia (CML), a "disease defined by its biomarker," the Philadelphia chromosome, according to Mikkael A. Sekeres, director of the leukemia program at the Cleveland Clinic in Cleveland, chairman of the Food and Drug Administration's (FDA) oncologic drugs advisory committee, and member of the Case Comprehensive Cancer Center. Individuals with chronic phase CML carry this genetic abnormality in their leukemia cells, and this "fusion gene" encodes a protein called BCR-ABL, which tells leukemia cells to "grow, grow, grow," he says, crowding out healthy blood cells and damaging bone marrow.

Colorectal Cancer Prevention and Detection: Brief Reports From the 2014 ASCO GI Cancers Symposium
Gastroenterology and Endoscopy News - Mar 2014
Are patients who undergo colonoscopy more likely to undergo screening for other cancers? Researchers from Case Western Reserve University, Cleveland, addressed this question in a study of 717,334 Medicare patients who underwent colonoscopy at two time points—between 2004 and 2008 and between 2009 and 2010. Examining the rates of mammography and prostate-specific antigen (PSA) testing in the later period, the investigators found that individuals with more than one previous colonoscopy were five times more likely to undergo mammography and nearly three times more likely to undergo PSA testing, reported Gregory S. Cooper, MD, Co-Leader for the Cancer Prevention and Control Program at the Case Comprehensive Cancer Center.


ANNOUNCEMENTS

January 2014 CTSC Core Utilization Pilot Awards Recipients

Congratulations to the January 2014 CTSC Core Utilization Pilot Awards Recipients

  • Tracey Bonfield, PhD: Anti-Inflammatory Properties of Mesenchymal Stem Cells in CF
  • Afshin Dowlati, MDConstruction of a small-cell lung cancer tissue microarray
  • Justin Lathia, PhDHigh throughput flow cytometry screen to identify TNBC adhesion molecules in a CSC-reporter Triple-negative breast cancer (TNBC) model system linked to patient survival
  • Parameswaran Ramakrishnan, PhD: Antibody based therapeutics to treat autoimmune diabetes

FUNDING OPPORTUNITIES

V Foundation for Cancer Research: Translational Projects in Bladder Cancer

The V Foundation for Cancer Research is interested in funding a translational research project in the focus area of bladder cancer. The Case CCC has been invited to submit ONE LOI. All letters of intent will be considered by a subgroup of the Scientific Advisory Committee of The V Foundation and past grant recipients. After this review, three to five institutions will be invited to submit a grant proposal.

Anyone interested in applying for this grant should contact Kristin Waite (kristin.waite@case.edu) as soon as possible for more information.
Internal LOI Deadline: March 26
External LOI Deadline: April 30

Bladder Cancer Advocacy Network

The Bladder Cancer Advocacy Network (BCAN) is accepting applications for the John Quale Travel Fellowship Program. This is a special opportunity for early career physicians and scientists interested in bladder cancer research to attend the Ninth Annual BCAN Bladder Cancer Think Tank, which will be held held August 7-9, 2014 in San Diego, California. 
Deadline: April 14

Request for Proposals for Case CCC Funding for Pilot/Phase I Clinical Trials

The Case CCC is encouraging investigators to submit Letters of Intent (LOI) for Early Phase Clinical Research Support (EPCRS) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Priority will be given to trials which are developed jointly between UH and CCF with planned accrual at both institutions. (See revised NCI Cancer Center Support Grant EPCRS guidelines, page 43, Section 2.12). Please submit LOIs to Katarzyna Karelus, Case CCC Clinical Research Office, kxk384@case.edu, 216.844.4176.
LOI deadline: April 15

Brian Werbel Memorial Fund

Applications are currently being accepted for summer cancer research fellowship fundingWerbel2014, provided by the Brian Werbel Memorial Fund. This fund was established in 2007 at University Hospitals Case Medical Center, and is dedicated to providing summer fellows an opportunity to focus on cancer research, with the ultimate goal to aid in curing cancer. Brian's hope was to find a cure for cancer – to make a difference in the world, just as he made a difference in the lives of everyone he touched. Applicants must be conducting cancer research with a Case Comprehensive Cancer Center member. Awardees are required to attend the Annual Golf Outing Event, typically held in July. 

Deadline: April 25


MARK YOUR CALENDARS

Screening for Cancer in Women: 2014

Registration is now open for Screening for Cancer in Women: 2014Wednesday, May 21 from 8 am - 3:35 pm at the Embassy Suites Hotel in Independence.

Optimal strategies in cancer screening and detection are constantly evolving, and best practices are changing. This conference will feature speakers from health centers across Northeast Ohio working together to fight cancer, who will offer expert insight, updates, and advice on screening for cancer in women.

This comprehensive symposium is aimed at primary care providers and cancer specialists with updates that can be incorporated into their practices:

  • New screening technologies, particularly to detect breast and lung cancer
  • Current guidelines for colorectal, skin, lung, breast, and cervical cancer screening
  • Impact of the Affordable Care Act
  • Racial and economic disparities within cancer screening and detection
  • When to refer a patient for a genetics referral or to a high-risk clinic

CME credit will be offered. Visit the conference website for more details and registration information.

PREVIOUSLY ANNOUNCED OPPORTUNITIES

Damon Runyon-Sohn Pediatric Cancer Fellowship Award
Deadline: March 17

Damon Runyon Fellowship Award
Deadline: March 17 

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt Summer Program (ENGAGE)
Deadline: March 28

Case-Coulter Translational Research Partnership
LOI Deadline: March 28

Skin Disease Research Center Pilot and Feasibility (P&F) Program
Deadline: March 31

Cancer Research Institute Irvington Postdoctoral Fellowship Program
Deadline: April 1

American Cancer Society RFA: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: April 1

Sta Op Tegen Kanker Dream Team Translational Cancer Research Grant
Deadline: April 1

Alex's Lemonade Stand Foundation Bridge Grant
Deadline: April 10

Alex's Lemonade Stand Foundation Springboard Grant
Deadline: April 10

American Nuclear Society Radiation Science and Technology Award
Deadline: April 15

Brian Werbel Memorial Fund Summer Cancer Research Fellowships‌
Deadline: April 25

GlaxoSmithKline Discovery Fast Track Challenge
Deadline: May 16

HHMI Investigator Program National Competition
Deadline: June 3

Lung Cancer Research Foundation
Deadline: June 16, 2014

Damon Runyon Fellowship Award
Deadline: August 15

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Adjustments to May 25-28, 2014 Grant Application Due Dates (NOT-OD-14-070)

Notice of National Cancer Institute (NCI) Participation in RFA-HG-14-020 "Development of Software and Analysis Methods for Biomedical Big Data in Targeted Areas of High Need (U01)"(NOT-CA-14-038)

Request for Information (RFI): Availability of Data and Samples from Randomized Smoking Cessation Trials (NOT-DA-14-005)

Feasibility Studies to Build Collaborative Partnerships in Cancer Research (P20)(PAR-14-152)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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EVENTS

calendar

Mon, March 17

Genetics Student Seminar
Robert Karl
Student, Genetics and Genome Sciences
CWRU
Topic: Enabling Technologies to Study Human Myelin Diseases
11 am BRB 105

Genomic Medicine Institute of CCF Integrative and Translational Seminar Series
Matt Cannon, PhD
Fellow, Serre lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Post-natal Epigenetic Reprogramming of the Liver in Mice
12:30 pm NE1-205 Cleveland Clinic

Physiology & Biophysics Seminar
Jonathan H. Lin, MD, PhD
Assistant Professor, Pathology
University of California - San Diego
Topic: Mechanisms of Endoplasmic Reticulum Stress-Induced Cell Death and Pathology
4 pm Robbins E-501


Tues, March 18

Radiation Oncology Grand Rounds
Ande Bao, PhD
Assistant Professor, Radiation Oncology
CWRU/UH
Topic: Multimodality Image Coregistration in Radiation Therapy
8:10 am Lerner Tower B-151

Molecular Genetics Seminar
Faegheh Jafarifar, PhD
Postdoctoral Fellow, Padgett lab, Molecular Genetics
Cleveland Clinic
Topic: In vitro and in vivo studies of human developmental disorder MOPD I
9:30 am NE1-205 Cleveland Clinic


Wed, March 19

Hematology and Oncology Division Research Conference
Topic: TBD
8 am Lerner B-151

Cancer Imaging Program Meeting
12 pm WRB 3-136

Breast Cancer Program Seminar
Ofer Reizes, PhD
Assistant Professor, Cell Biology
CWRU/Cleveland Clinic
Topic: The Role of Cancer Stem Cell Gap Junctions in Triple Negative Breast Cancer
AND
G. Thomas Budd, MD
Professor, Solid Tumor Oncology
CWRU/Cleveland Clinic
Topic: Opportunities for Translational Studies in a Completed Phase III Clinical Trial
5 pm WRB 1-413


Thurs, March 20

Cancer Trainee Seminar
Kelsey Herrmann
Student, CWRU
Topic: PTPmu Targeted Agents for Glioma Detection and Treatment 
AND
Nicole William, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: Brain Tumors
12 pm WRB 3-136

Molecular Biology and Microbiology Seminar
Myron Cohen, MD
Associate Vice Chancellor for Global Health
Yeargan-Bate Distinguished Professor of Medicine, Microbiology and Immunology, and Epidemiology
Chief, Division of Infectious Diseases
Director, Institute for Global Health & Infectious Diseases
University of North Carolina
Topic: Strategies for Prevention of HIV: Biology Transformed to Policy
1 pm Rottman Seminar Room, Wood W203


Fri, March 21

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Paul Sperduto, MD
Minneapolis Radiation Oncology
Topic: Current Concepts in the Management of Brain Metastases
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Topic: TBD
12 pm BRB 105

Cancer Center Research in Progress
Topic: TBD
4 pm WRB 3-136


Mon, March 24

Genomic Medicine Institute Integrative and Translational Seminar Series
Michael Aldred, PhD
Associate Staff, Genomic Medicine Institute
Cleveland Clinic
Topic: ROS and Readthrough - New Insights into Pulmonary Hypertension
12:30pm NE1-205 Cleveland Clinic

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence
Details

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East

ADDITIONAL UPCOMING SEMINARS & EVENTS

1st Annual Multidisciplinary Colorectal Oncology Course
April 23
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH
Details

ASCO Review
June 26
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH