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March 3, 2014

CASE CCC IN THE NEWS

Cleveland Clinic Study Shows no Increased Risk of MDS After Radiation for Prostate Cancer
The Plain Dealer - Feb 27, 2014
A study published Wednesday in the Journal of the National Cancer Institute is providing encouraging news to prostate cancer patients who need radiation therapy. The findings of the study, conducted at the Cleveland Clinic, shows that those men have no greater risk for developing myelodysplastic syndromes, or MDS, than the general population.....For so long, it has been accepted at face value that if a patient had been previously treated for prostate cancer, and then years later developed MDS, it was a cause-and-effect relationship, said Dr. Mikkael Sekeres, director of the Leukemia Program at the Clinic's Taussig Cancer Institute, member of the Case Comprehensive Cancer Center, and the study's lead author.

Fever In, Fever Out –Improving Quality In Emergency Room Care of Patients with Fever and Neutropenia
Oncology Times - Feb 24, 2014
Dr. Mikkael Sekeres, director of the Leukemia Program at the Clinic's Taussig Cancer Institute and member of the Case Comprehensive Cancer Center, discusses improving quality in emergency room care of patients with fever and neutropenia.

Gland-Sparing RT Keeps Saliva Flowing
MedPage Today - Feb 24, 2014
Patients with oropharyngeal cancer retained salivary function, with no apparent increased risk of disease spread, with gland-sparing radiation therapy, data from two studies showed...The studies reflect the progress that has occurred in the treatment of head and neck cancer, which has placed more emphasis on patient-reported outcomes, said Mitchell Machtay, MD, of University Hospitals Case Medical Center and Case Comprehensive Cancer Center in Cleveland.

Patients Blame H&N Therapy for Lasting Speech Issues
MedPage Today - Feb 23, 2014
Patients with oropharyngeal cancer reported significant voice and speech impairment for up to 2 years after chemoradiation therapy, but most of their doctors saw no evidence of it, data from a prospective study showed...Press briefing moderator Mitchell Machtay, MD, said he found the study eye opening. "If you looked at radiation dose to larynx, not the area where the tumor was, I was struck by how doses of 20 to 30 Gy, which we don't normally consider as very toxic high doses that can damage the voicebox, still caused a fair amount of damage," said Machtay, of University Hospitals Case Medical Center and the Case Comprehensive Cancer Center in Cleveland.


ANNOUNCEMENTS

Dr. Paul Tesar Recognized with Professorship of Innovative Cancer Therapeutics

‌Dr. Paul TesarDr. Paul Tesar was appointed the Dr. Donald and Ruth Weber Goodman Professorship of Innovative Cancer Therapeutics at a ceremony held on Thursday, February 27, 2014.

Originally from Cleveland, Dr. Tesar is a CWRU alumnus, receiving his undergraduate degree in biology under the mentorship of Dr. Stephen Haynesworth. Dr. Tesar's potential was evident early on, attracting the notice of the National Institutes of Health, which bestowed on him a scholarship to complete his PhD at the University of Oxford.

Building on the work of the 2012 Nobel Prize winners in Medicine who discovered how to turn skin cells into stem cells, Dr. Tesar's lab took this landmark discovery even further and discovered how to transform skin cells directly into brain cells, or specifically, oligodendrocytes.

With Dr. Tesar's focus on the cellular and molecular processes that contribute to normal neural development, he is well positioned to make discoveries that impact an array of patients, from individuals facing brain cancer, to patients with Multiple Sclerosis, Cerebral Palsy, or children with leukodystrophies.

The late Donald Goodman, a CWRU alumnus from the School of Dental Medicine, was inspired to create this professorship in Cancer Research Innovation because of a seemingly miraculous treatment he received that cleared him of an aggressive form of leukemia, just 12 days after his first treatment.

Madabhushi/CCIPD Team Wins Accolades at SPIE Medical Imaging 2014

Dr. Anant MadabhushiThe lab of Cancer Center member Dr. Anant Madabhushi and the Center of Computational Imaging and Personalized Diagnostics (CCIPD) won four awards for papers presented at the SPIE Medical Imaging 2014 meeting in San Diego, CA, February 15-19, 2014.

  • Geert Litjens, former visiting graduate student at CCIPD, was awarded runner-up for the Robert F. Wagner Best Student paper for his manuscript Distinguishing benign confounding treatment changes from residual prostate cancer on MRI following laser ablation. Dr. Madabhushi, Associate Professor of Biomedical Engineering, was the senior author on this study, which also included Drs. Robin Elliot from the Case Institute of Pathology and Dr. Satish Viswanath, research assistant professor, Case BME.
  • Eileen Hwang, former visiting undergraduate student at CCIPD, won the Cum Laude Award for her posterSpectral embedding based registration (SERg) aligning multimodal prostate histology and MRI. Dr. Madabhushi was the senior author on this study that also included post-doctoral fellow Dr. Mirabela Rusu in Case BME.
  • Dr. Pallavi Tiwari, research assistant professor at Case BME, won an Honorable mention Award for her posterComputerized image analysis for texture descriptors in multi-parametric MRI to distinguish recurrent brain tumors from radiation necrosis. Dr. Madabhushi was the senior author on this study that also included Prateek Prasanna, graduate student at Case BME, along with Drs. Mark Cohen, Leo Wolansky, and CCC members Drs. Lisa Rogers and Andrew Sloan.
  • Dr. Pallavi Tiwari, research assistant professor at Case BME, and Dr. Madabhushi also won the Cum Laude Award for her poster Identifying MRI markers to evaluate early treatment-related changes post-laser ablation for cancer pain management. This work was done jointly with Dr. Shabbar Danish, MD at Rutgers University.

FUNDING OPPORTUNITIES

Case-Coulter Translational Research Partnership

The Case-Coulter Translational Research Partnership (CCTRP) is accepting letters of intent for 2014. The purpose of CCTRP funding is to support collaborative translational research projects that address unmet or poorly met clinical needs. CCTRP seeks to reduce the market risk of promising new clinical products arising from the research programs of BME and other Case faculty.
LOI Deadline: March 28

Skin Disease Research Center

The Skin Disease Research Center (SDRC) sponsors innovative research through its Pilot and Feasibility (P&F) Program. The SDRC plans to support one new P&F project for funding for one or two years with an annual budget of $25,000. Projects are supported with the understanding that the PI will subsequently apply for NIH or equivalent funding using preliminary data acquired during the P&F project period. Funding for the second year is contingent upon satisfactory progress and submission of a progress report.
Deadline: March 31

Request for Proposals for Case CCC Funding for Pilot/Phase I Clinical Trials

The Case CCC is encouraging investigators to submit Letters of Intent (LOI) for Early Phase Clinical Research Support (EPCRS) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Priority will be given to trials which are developed jointly between UH and CCF with planned accrual at both institutions. (See revised NCI Cancer Center Support Grant EPCRS guidelines, page 43, Section 2.12). Please submit LOIs to Katarzyna Karelus, Case CCC Clinical Research Office, kxk384@case.edu, 216.844.4176.
LOI deadline: April 15

GlaxoSmithKline

The Discovery Fast Track Challenge from the Discovery Partnerships with Academia (DPAc) group at GlaxoSmithKline (GSK) is now open for submissions. This is an outstanding opportunity to work with GSK to discover new pharmacologically active molecules via High Throughput Screening (HTS) and/or Encoded Library Technology (ELT). For successful applicants, this will help drive their research forward –and could lead to a partnership with GSK for the development of a new medicine. Applications require approval from the CWRU Technology Transfer Office. Please contact Stephanie Weidenbecher at saw43@case.edu or 216.368.6191.
Deadline: May 16

Brian Werbel Memorial Fund

Applications are currently being accepted for summer cancer research fellowship fundingWerbel2014, provided by the Brian Werbel Memorial Fund. This fund was established in 2007 at University Hospitals Case Medical Center, and is dedicated to providing summer fellows an opportunity to focus on cancer research, with the ultimate goal to aid in curing cancer. Brian's hope was to find a cure for cancer – to make a difference in the world, just as he made a difference in the lives of everyone he touched. Applicants must be conducting cancer research with a Case Comprehensive Cancer Center member. Awardees are required to attend the Annual Golf Outing Event, typically held in July. 

Deadline: April 25


SAVE THE DATE

Retreat: Engaging in Cultural Competence through Awareness, Knowledge and Action

Please mark your calendars for Thursday, March 13 from 2-5 pm to join the Case Comprehensive Cancer Center and the Case Center for Reducing Health Disparities as they explore issues related to cultural competence. Extend your knowledge and raise your awareness about the dynamic variety of people and communities the Case CCC serves. This retreat will feature a keynote address by Dr. Sonja Harris-Haywood, and will provide perspective on the growing need to be culturally competent and facilitate the impact of cultural beliefs within the health care setting, specifically in research.

The retreat is intended for investigators, research nurses, regulatory coordinators, outreach and training and education personnel. Pre-registration by Friday, March 7 is required. Please direct any questions to Katarzyna Karelus at 216.844.4176 or katarzyna.karelus@case.edu.

PREVIOUSLY ANNOUNCED OPPORTUNITIES

Bladder Cancer Advocacy Network 2014 Young Investigator Awards
Deadline: March 5

James S. McDonnell Foundation (JSMF) Scholar Awards program
Deadline: March 12

Childhood Brain Tumor Foundation Pediatric Brain Tumor Grant Awards
Deadline: March 14

Childhood Brain Tumor Foundation Astrocytoma Research Award
Deadline: March 14

Damon Runyon-Sohn Pediatric Cancer Fellowship Award
Deadline: March 17

Damon Runyon Fellowship Award
Deadline: March 17 

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt Summer Program (ENGAGE)
Deadline: March 28

Cancer Research Institute Irvington Postdoctoral Fellowship Program
Deadline: April 1

American Cancer Society RFA: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: April 1

Sta Op Tegen Kanker Dream Team Translational Cancer Research Grant
Deadline: April 1

Alex's Lemonade Stand Foundation Bridge Grant
Deadline: April 10

Alex's Lemonade Stand Foundation Springboard Grant 
Deadline: April 10

Brian Werbel Memorial Fund Summer Cancer Research Fellowships
Deadline: April 25

HHMI Investigator Program National Competition
Deadline: June 3

Lung Cancer Research Foundation
Deadline: June 16, 2014

Damon Runyon Fellowship Award
Deadline: August 15

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Change to the Duration of Career Development Awards Supported by the NIBIB (K01, K25, K08, K23)(NOT-EB-14-003)

Notice of Intent to Publish a Funding Opportunity Announcement for Pharmacometric Modeling and Simulation for Generic Drugs Evaluation (U01)(NOT-FD-14-002)

Notice of Intent to Publish a Funding Opportunity Announcement for Physiologically Based Absorption and Pharmacokinetic Modeling and Simulation for Non-Gastrointestinally Absorbed Drug Products in Humans (U01)(NOT-FD-14-003)

Notice of Change to Application Due Date and Expiration Date for RFA-FD-14-002 "The Use of Polyethylene Glycol in the Pediatric Population (R01)" (NOT-FD-14-004)

Notice of Participation of the Office of Strategic Coordination in RFA-HG-14-020 "Development of Software and Analysis Methods for Biomedical Big Data in Targeted Areas of High Need (U01)"(NOT-RM-14-009)

Request for Information (RFI): Challenges and Opportunities in Understanding Genome Structure/Function Relationships (PA-14-114)

PHS 2014-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])(PA-14-071)

PHS 2014-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])(PA-14-072)

Quantitative Imaging for Evaluation of Response to Cancer Therapies (U01)(PAR-14-116)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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EVENTS

calendar

Mon, March 3

Genetics Student Seminar
George Aranjuez
Student, Genetics and Genome Sciences
CWRU
Topic: Dop/MAST2 Kinase is a Novel Regulator of Protrusion Formation to Promote Collective Migration
11 am BRB 105

Pathology Research Seminar Series
Alan Tarakoff, PhD
Professor, Pathology
CWRU/UH
Topic: Cell Biology of Yeast Zygotes
12 pm WRB 1-413

Genomic Medicine Institute Seminar Series
Amanda Tilot
Graduate Student, Eng lab, Genomic Medicine Institute
Cleveland Clinic
Topic: The Pten m3m4 Mouse: A Genetic Model for High Functioning ASD with Neuroinflammation
12:30 pm NE1-205 Cleveland Clinic

Physiology & Biophysics Seminar
Saptarsi M. Haldar, MD
Assistant Professor, Medicine and Cardiovascular Research Institute
CWRU/UH
Topic: Targeting Chromatin Dependent Signaling in Heart Failure
4 pm Robbins E-501


Tues, March 4

Radiation Oncology Grand Rounds/Physics Seminar
Chee-Wai Cheng, PhD
Director, Proton Medical Physics
CWRU/UH
AND
Barry Wessels, PhD
Professor and Director, Div. of Medical Physics and Dosimetry
CWRU/UH
Topic: Proton Treatment Planning - Comparison to Competitive Modalities and TPS Selection
8:10 am Lerner Tower B-151

Imaging Center Seminar Series
Mark Griswold, PhD
Professor, Radiology
CWRU/UH
AND
Vikas Gulani, MD, PhD
Assistant Professor, Radiology
CWRU/UH
Topic: MR Fingerprinting: A Tale of True Collaboration
11:30 am BRB 105

AYA Cancer Institute Guest Lecturer
Sandhya Kharbanda, MD
Assistant Professor, Pediatric Hematology/Oncology and Stem Cell Transplantation
Stanford University
Topic: Allogeneic Hematopoietic Stem Cell Transplantation for Hemoglobinopathies
12 pm Wearn 137

Cancer Biology Seminar
Shuvojit Banerjee, PhD
Research Fellow, Silverman lab, Cancer Biology
Cleveland Clinic
Topic: Role of RNase L in the Migration of Prostate Cancer Cells
2 pm NC1-202 Cleveland Clinic

LRI Seminar
Jae-Sung Kim, PhD
Associate Professor, Surgery
University of Florida, Gainesville
Topic: Autophagy: A New Strategy to Suppress Reperfusion Injury in the Liver
4 pm NA5-03 Cleveland Clinic


Wed, March 5

Hematology and Oncology Division Research Conference
Jane Little, MD 
Associate Professor, Div. of Hem/Onc
CWRU/UH
Topic: Sickle Cell Disease Update
8 am Lerner B-151


Thurs, March 6

Genetics Journal Club
Jacob Wisotsky
AND
Olivia Corradin
Students, Genetics and Genome Sciences
CWRU
Topic: Acid Induced Reprogramming and the Creation of STAP Cells
12 pm BRB 732

Immunology Journal Club
Janice Jun
Student, Immunology
CWRU
Topic: Staphylococcus δ–Toxin Induces Allergic Skin Disease by Activating Mast Cells
12 pm WRB 5-136

Molecular Biology and Microbiology Seminar
Alan Tartakoff, PhD
Professor, Pathology
CWRU/UH
AND
Chun-Lun Ni
Tartakoff lab, Pathology
CWRU/UH
Topic: Studies on Huntingtin Protein
1 pm Rottman Seminar Room, Wood W203


Fri, March 7

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Mark Gilbert, MD
Professor, Neuro-Oncology - Cancer Medicine
University of Texas MD Anderson Cancer Center
Topic: Recent Studies of Brain Tumor Treatments: Paving the Way for Future Progress
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar Series
Ulhas P. Naik, PhD
Director, Delaware Cardiovascular Research Center
Professor, Biology, Biochemistry, and Chemical Engineering
University of Delaware
Topic: TBD
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Eric Holland, MD, PhD
Senior Vice President and Director, Human Biology Division
Director, Solid Tumor Translational Research, Human Biology Division
Professor, Neurological Surgery
Chap and Eve Alvord and Elias Alvord Chair in Neuro-Oncology
Director, Nancy and Buster Alvord Brain Tumor Center
University of Washington
Topic: Mouse Models of Radiation Response in Glioma
12 pm BRB 105

Cancer Center Research in Progress
Lindsay Stetson
PhD Student, Systems Biology and Bioinformatics
CWRU
Topic: Mining TCGA Data: Protein Markers Predict Overall Survival In Glioblastoma Multiforme Patients
AND
Selene M. Virk, PhD
Research Scientist and CoGEC Fellow, Barnholtz-Sloan lab, Div. of General Medical Sciences (Oncology) and Epidemiology & Biostatistics
Topic: Identification of Differentially Regulated miRNA's In Recurrent Glioblastoma Multiforme
4 pm WRB 3-136


Mon, March 10

Genomic Medicine Institute of CCF Integrative and Translational Seminar Series
Paul Wade, PhD
PI, Eukaryotic Transcriptional Regulation Group
National Institute of Environmental Health Sciences
National Institutes of Health
Topic: DNA Methylation and Chromatin Architecture: The Nuts and Bolts of Gene Regulation
12:30pm NE1-205 Cleveland Clinic

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East

ADDITIONAL UPCOMING SEMINARS & EVENTS

1st Annual Multidisciplinary Colorectal Oncology Course
April 23
InterContinental Hotel & Bank of America Conference Center
Cleveland, OH
Details