Cleveland Clinic Study Shows no Increased Risk of MDS After Radiation for Prostate Cancer
The Plain Dealer - Feb 27, 2014
A study published Wednesday in the Journal of the National Cancer Institute is providing encouraging news to prostate cancer patients who need radiation therapy. The findings of the study, conducted at the Cleveland Clinic, shows that those men have no greater risk for developing myelodysplastic syndromes, or MDS, than the general population.....For so long, it has been accepted at face value that if a patient had been previously treated for prostate cancer, and then years later developed MDS, it was a cause-and-effect relationship, said Dr. Mikkael Sekeres, director of the Leukemia Program at the Clinic's Taussig Cancer Institute, member of the Case Comprehensive Cancer Center, and the study's lead author.
Fever In, Fever Out –Improving Quality In Emergency Room Care of Patients with Fever and Neutropenia
Oncology Times - Feb 24, 2014
Dr. Mikkael Sekeres, director of the Leukemia Program at the Clinic's Taussig Cancer Institute and member of the Case Comprehensive Cancer Center, discusses improving quality in emergency room care of patients with fever and neutropenia.
Gland-Sparing RT Keeps Saliva Flowing
MedPage Today - Feb 24, 2014
Patients with oropharyngeal cancer retained salivary function, with no apparent increased risk of disease spread, with gland-sparing radiation therapy, data from two studies showed...The studies reflect the progress that has occurred in the treatment of head and neck cancer, which has placed more emphasis on patient-reported outcomes, said Mitchell Machtay, MD, of University Hospitals Case Medical Center and Case Comprehensive Cancer Center in Cleveland.
Patients Blame H&N Therapy for Lasting Speech Issues
MedPage Today - Feb 23, 2014
Patients with oropharyngeal cancer reported significant voice and speech impairment for up to 2 years after chemoradiation therapy, but most of their doctors saw no evidence of it, data from a prospective study showed...Press briefing moderator Mitchell Machtay, MD, said he found the study eye opening. "If you looked at radiation dose to larynx, not the area where the tumor was, I was struck by how doses of 20 to 30 Gy, which we don't normally consider as very toxic high doses that can damage the voicebox, still caused a fair amount of damage," said Machtay, of University Hospitals Case Medical Center and the Case Comprehensive Cancer Center in Cleveland.
Dr. Paul Tesar Recognized with Professorship of Innovative Cancer Therapeutics
Dr. Paul Tesar was appointed the Dr. Donald and Ruth Weber Goodman Professorship of Innovative Cancer Therapeutics at a ceremony held on Thursday, February 27, 2014.
Originally from Cleveland, Dr. Tesar is a CWRU alumnus, receiving his undergraduate degree in biology under the mentorship of Dr. Stephen Haynesworth. Dr. Tesar's potential was evident early on, attracting the notice of the National Institutes of Health, which bestowed on him a scholarship to complete his PhD at the University of Oxford.
Building on the work of the 2012 Nobel Prize winners in Medicine who discovered how to turn skin cells into stem cells, Dr. Tesar's lab took this landmark discovery even further and discovered how to transform skin cells directly into brain cells, or specifically, oligodendrocytes.
With Dr. Tesar's focus on the cellular and molecular processes that contribute to normal neural development, he is well positioned to make discoveries that impact an array of patients, from individuals facing brain cancer, to patients with Multiple Sclerosis, Cerebral Palsy, or children with leukodystrophies.
The late Donald Goodman, a CWRU alumnus from the School of Dental Medicine, was inspired to create this professorship in Cancer Research Innovation because of a seemingly miraculous treatment he received that cleared him of an aggressive form of leukemia, just 12 days after his first treatment.
Madabhushi/CCIPD Team Wins Accolades at SPIE Medical Imaging 2014
The lab of Cancer Center member Dr. Anant Madabhushi and the Center of Computational Imaging and Personalized Diagnostics (CCIPD) won four awards for papers presented at the SPIE Medical Imaging 2014 meeting in San Diego, CA, February 15-19, 2014.
Case-Coulter Translational Research Partnership
The Case-Coulter Translational Research Partnership (CCTRP) is accepting letters of intent for 2014. The purpose of CCTRP funding is to support collaborative translational research projects that address unmet or poorly met clinical needs. CCTRP seeks to reduce the market risk of promising new clinical products arising from the research programs of BME and other Case faculty.
LOI Deadline: March 28
Skin Disease Research Center
The Skin Disease Research Center (SDRC) sponsors innovative research through its Pilot and Feasibility (P&F) Program. The SDRC plans to support one new P&F project for funding for one or two years with an annual budget of $25,000. Projects are supported with the understanding that the PI will subsequently apply for NIH or equivalent funding using preliminary data acquired during the P&F project period. Funding for the second year is contingent upon satisfactory progress and submission of a progress report.
Deadline: March 31
Request for Proposals for Case CCC Funding for Pilot/Phase I Clinical Trials
The Case CCC is encouraging investigators to submit Letters of Intent (LOI) for Early Phase Clinical Research Support (EPCRS) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Priority will be given to trials which are developed jointly between UH and CCF with planned accrual at both institutions. (See revised NCI Cancer Center Support Grant EPCRS guidelines, page 43, Section 2.12). Please submit LOIs to Katarzyna Karelus, Case CCC Clinical Research Office, firstname.lastname@example.org, 216.844.4176.
LOI deadline: April 15
The Discovery Fast Track Challenge from the Discovery Partnerships with Academia (DPAc) group at GlaxoSmithKline (GSK) is now open for submissions. This is an outstanding opportunity to work with GSK to discover new pharmacologically active molecules via High Throughput Screening (HTS) and/or Encoded Library Technology (ELT). For successful applicants, this will help drive their research forward –and could lead to a partnership with GSK for the development of a new medicine. Applications require approval from the CWRU Technology Transfer Office. Please contact Stephanie Weidenbecher at email@example.com or 216.368.6191.
Deadline: May 16
Brian Werbel Memorial Fund
Applications are currently being accepted for summer cancer research fellowship fundingWerbel2014, provided by the Brian Werbel Memorial Fund. This fund was established in 2007 at University Hospitals Case Medical Center, and is dedicated to providing summer fellows an opportunity to focus on cancer research, with the ultimate goal to aid in curing cancer. Brian's hope was to find a cure for cancer – to make a difference in the world, just as he made a difference in the lives of everyone he touched. Applicants must be conducting cancer research with a Case Comprehensive Cancer Center member. Awardees are required to attend the Annual Golf Outing Event, typically held in July.
Deadline: April 25
Retreat: Engaging in Cultural Competence through Awareness, Knowledge and Action
Please mark your calendars for Thursday, March 13 from 2-5 pm to join the Case Comprehensive Cancer Center and the Case Center for Reducing Health Disparities as they explore issues related to cultural competence. Extend your knowledge and raise your awareness about the dynamic variety of people and communities the Case CCC serves. This retreat will feature a keynote address by Dr. Sonja Harris-Haywood, and will provide perspective on the growing need to be culturally competent and facilitate the impact of cultural beliefs within the health care setting, specifically in research.
The retreat is intended for investigators, research nurses, regulatory coordinators, outreach and training and education personnel. Pre-registration by Friday, March 7 is required. Please direct any questions to Katarzyna Karelus at 216.844.4176 or firstname.lastname@example.org.
PREVIOUSLY ANNOUNCED OPPORTUNITIES
Bladder Cancer Advocacy Network 2014 Young Investigator Awards
Alex's Lemonade Stand Foundation Springboard Grant
NIH BULLETIN – Notices and Funding Opportunities
Notice of Intent to Publish a Funding Opportunity Announcement for Physiologically Based Absorption and Pharmacokinetic Modeling and Simulation for Non-Gastrointestinally Absorbed Drug Products in Humans (U01)(NOT-FD-14-003)
Notice of Participation of the Office of Strategic Coordination in RFA-HG-14-020 "Development of Software and Analysis Methods for Biomedical Big Data in Targeted Areas of High Need (U01)"(NOT-RM-14-009)
HELP US HELP YOU!
If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at email@example.com.
Genetics Student Seminar
Student, Genetics and Genome Sciences
Topic: Dop/MAST2 Kinase is a Novel Regulator of Protrusion Formation to Promote Collective Migration
11 am BRB 105
Pathology Research Seminar Series
Alan Tarakoff, PhD
Topic: Cell Biology of Yeast Zygotes
12 pm WRB 1-413
Genomic Medicine Institute Seminar Series
Graduate Student, Eng lab, Genomic Medicine Institute
Topic: The Pten m3m4 Mouse: A Genetic Model for High Functioning ASD with Neuroinflammation
12:30 pm NE1-205 Cleveland Clinic
Physiology & Biophysics Seminar
Saptarsi M. Haldar, MD
Assistant Professor, Medicine and Cardiovascular Research Institute
Topic: Targeting Chromatin Dependent Signaling in Heart Failure
4 pm Robbins E-501
Radiation Oncology Grand Rounds/Physics Seminar
Chee-Wai Cheng, PhD
Director, Proton Medical Physics
Barry Wessels, PhD
Professor and Director, Div. of Medical Physics and Dosimetry
Topic: Proton Treatment Planning - Comparison to Competitive Modalities and TPS Selection
8:10 am Lerner Tower B-151
Imaging Center Seminar Series
Mark Griswold, PhD
Vikas Gulani, MD, PhD
Assistant Professor, Radiology
Topic: MR Fingerprinting: A Tale of True Collaboration
11:30 am BRB 105
AYA Cancer Institute Guest Lecturer
Sandhya Kharbanda, MD
Assistant Professor, Pediatric Hematology/Oncology and Stem Cell Transplantation
Topic: Allogeneic Hematopoietic Stem Cell Transplantation for Hemoglobinopathies
12 pm Wearn 137
Cancer Biology Seminar
Shuvojit Banerjee, PhD
Research Fellow, Silverman lab, Cancer Biology
Topic: Role of RNase L in the Migration of Prostate Cancer Cells
2 pm NC1-202 Cleveland Clinic
Jae-Sung Kim, PhD
Associate Professor, Surgery
University of Florida, Gainesville
Topic: Autophagy: A New Strategy to Suppress Reperfusion Injury in the Liver
4 pm NA5-03 Cleveland Clinic
Hematology and Oncology Division Research Conference
Jane Little, MD
Associate Professor, Div. of Hem/Onc
Topic: Sickle Cell Disease Update
8 am Lerner B-151
Genetics Journal Club
Students, Genetics and Genome Sciences
Topic: Acid Induced Reprogramming and the Creation of STAP Cells
12 pm BRB 732
Immunology Journal Club
Topic: Staphylococcus δ–Toxin Induces Allergic Skin Disease by Activating Mast Cells
12 pm WRB 5-136
Molecular Biology and Microbiology Seminar
Alan Tartakoff, PhD
Tartakoff lab, Pathology
Topic: Studies on Huntingtin Protein
1 pm Rottman Seminar Room, Wood W203
Hematology/Oncology Fellows Conference/Curriculum Series
8 am Breen Conference Rm.
Taussig Cancer Institute Grand Rounds
Mark Gilbert, MD
Professor, Neuro-Oncology - Cancer Medicine
University of Texas MD Anderson Cancer Center
Topic: Recent Studies of Brain Tumor Treatments: Paving the Way for Future Progress
8 am R3/002-003 Cleveland Clinic
Cellular and Molecular Medicine Seminar Series
Ulhas P. Naik, PhD
Director, Delaware Cardiovascular Research Center
Professor, Biology, Biochemistry, and Chemical Engineering
University of Delaware
10 am NC1-202 Cleveland Clinic
Cancer Center Seminar Series
Eric Holland, MD, PhD
Senior Vice President and Director, Human Biology Division
Director, Solid Tumor Translational Research, Human Biology Division
Professor, Neurological Surgery
Chap and Eve Alvord and Elias Alvord Chair in Neuro-Oncology
Director, Nancy and Buster Alvord Brain Tumor Center
University of Washington
Topic: Mouse Models of Radiation Response in Glioma
12 pm BRB 105
Cancer Center Research in Progress
PhD Student, Systems Biology and Bioinformatics
Topic: Mining TCGA Data: Protein Markers Predict Overall Survival In Glioblastoma Multiforme Patients
Selene M. Virk, PhD
Research Scientist and CoGEC Fellow, Barnholtz-Sloan lab, Div. of General Medical Sciences (Oncology) and Epidemiology & Biostatistics
Topic: Identification of Differentially Regulated miRNA's In Recurrent Glioblastoma Multiforme
4 pm WRB 3-136
Genomic Medicine Institute of CCF Integrative and Translational Seminar Series
Paul Wade, PhD
PI, Eukaryotic Transcriptional Regulation Group
National Institute of Environmental Health Sciences
National Institutes of Health
Topic: DNA Methylation and Chromatin Architecture: The Nuts and Bolts of Gene Regulation
12:30pm NE1-205 Cleveland Clinic
Screening for Cancer in Women: 2014
Embassy Suites - Rockside Rd. - Independence
Case CCC Annual Scientific Retreat
Wolstein Research Bldg/Corporate College East
1st Annual Multidisciplinary Colorectal Oncology Course
InterContinental Hotel & Bank of America Conference Center