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February 3, 2014


On Super Bowl Sunday, the Real Heroic Athlete isn't Even Playing Football: Michael K. McIntyre's Tipoff
Joe Boyle will lace up his running shoes and pound out a marathon – three times around a course through the city where he lives, Bowling Green – not for a payday or a shiny trophy or a trip to Disneyland. He's doing it for his three kids – Ellie, 11, Joey, 8 and Mark, 5 – who don't realize now that their "Captain America" – he's a bigger comic book nerd than any kid – displays more courage every day than all of the larger than life heroes of Marvel. Joe has metastatic kidney cancer. Experimental immunotherapy treatments start soon at the Cleveland Clinic. His diagnosis in 2011 interrupted a dream to run a marathon. So he's planning to fulfill it now, with his Clinic oncologist, Dr. Brian Rini, running alongside him.

New Research Data on Pre-cancers in Breast Tissue Could be Treatment Game-changer
the Plain Dealer - Jan 30, 2014
The findings of a study published today in the journal Cancer Prevention Research (a journal of the American Association for Cancer Research) suggest that patients with two types of breast tissue abnormalities have the same potential to develop breast cancer..."This is a really strong paper; I like the fact that it's changing the way that we think of these lesions," said Dr. Donna Plecha, director of breast imaging at University Hospitals Case Medical Center in Cleveland.

University Hospitals Study: Regular Mammograms for Women in Their 40s Remain Beneficial
The Plain Dealer - Jan 29, 2014
The findings of an expanded study conducted by researchers at University Hospitals Case Medical Center are lending even more credence to the value of screening mammograms for women in their 40s...Led by Dr. Donna Plecha, director of breast imaging at UH, the researchers first began looking at the topic shortly after a task force issued a recommendation in 2009 saying that women don't need regular annual mammograms before age 50.


Paul Fox Donates $1 Million to Establish Endowed Chair; Xiaoxia Li Will be the First Chair Holder

Dr. Paul FoxDr. Xiaoxia LiOne Case CCC member made an amazing donation to create an endowed chair at the Cleveland Clinic, and another Cancer Center researcher will benefit as the first holder of that chair.

Dr. Paul Fox, professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and the Robert Canova Endowed Chair in Inflammation Research at the Cleveland Clinic, donated $1 million to establish an endowed chair in Molecular Medicine at the Cleveland Clinic. The Fox Chair, which was established as part of the Lerner Research Institute's Endowed Chair Challenge where the Cleveland Clinic matches funds, is the first chair to be established by a staff member at the institute. This chair will provide funding for research to help advance the understanding of molecular mechanisms that underlie disease.

Dr. Xiaoxia Li, Cleveland Clinic Department of Immunology and a professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, will be the first Fox Chair holder. With support provided by the Chair, Dr. Li's goal is to develop new drugs to treat diseases of the immune system.

Vote for Dr. Stan Gerson for the AACR Nominating Committee

Our director, Dr. Stan Gerson, is on the ballot for the American Association for Cancer Research (AACR) Nominating Committee. The election will close on Friday, February 14. Voting instructions will be distributed to all voting members of AACR. Election results will be announced in March 2014 and elected candidates will assume office at the AACR Annual Meeting 2014 in April.

Please show your support for Dr. Gerson and vote for him! It would be great to have local votes that place our director on the Nominating Committee, which selects candidates for major awards, the annual meeting program committee, and the slate of candidates for national positions.

American Cancer Society, Stand Up To Cancer Announce $20 Million Partnership

From Philanthropy News Digest

The American Cancer Society and Stand Up To Cancer (SU2C), an initiative of the Entertainment Industry Foundation, have announced a partnership to advance research efforts in the fight against cancer.

To that end, each organization has committed $10 million over three years toward their first project, the creation of a "dream team" of researchers focused on developing new therapies for lung cancer, to which Bristol-Myers Squibb will provide $5 million through SU2C. Later this year, the American Association for Cancer Research, an SU2C partner, will issue a call for research proposals, with members of the team to be announced in 2015. Lung cancer is the leading cause of cancer death among both men and women in the United States, claiming the lives of approximately 160,000 people annually. [more]


Next-Generation Gene Expression and Data Analysis Workshop

The Gene Expression and Genotyping Core Facility (GEGF) is sponsoring a ‌workshop on February 5 in the Wolstein Research Building that will provide a comprehensive review of the new Affymetrix Human Transcriptome Array. The morning session will concentrate on describing what type of information the array can provide and how this product can enhance your research efforts. This session will also discuss sample preparation for the array, sample quantity needed and sample types that will work with this technology. The afternoon session will be smaller and more hands-on, and will provide a more in-depth discussion of software and data analysis. Please contact Marty Veigl, Director of the GEGF for more information.

Inaugural Case Comprehensive Cancer Center Academic Drug Development Seminar

The Inaugural Case Comprehensive Cancer Center Academic Drug Development Seminar, will be held on February 26 at 4pm in the Global Cardiovascular Innovation Center, 10000 Cedar Avenue. This first seminar will feature a presentation by Dr. Goutham Narla, Assistant Professor, Medicine and Transformative Molecular Medicine at CWRU/UH, on Drugging the Undruggable: Small Molecule Activators of Tumor Suppressor Genes.

As part of the Case CCC Developmental Therapeutics Program, this series will gather clinicians, scientists, medical chemists, computer-aided drug designers, screeners, and commercialization personnel in the same room as a stimulating presentation so that all attendees can learn and benefit from the sparked interaction. More details will be circulated in the near future, but please save the date and plan to attend this event. Free parking is available.

Screening for Cancer in Women: 2014

Please mark your calendars and plan to attend Screening for Cancer in Women: 2014, on Wednesday, May 21 from 8 am - 3 pm at the Embassy Suites Hotel in Independence.

Optimal strategies in cancer screening and detection are constantly evolving and best practices are changing.

This update is aimed at primary care providers and cancer specialists with guides that can be incorporated into their practices:

  • New screening technologies, particularly to detect breast and lung cancer
  • Current guidelines for colorectal, skin, lung, breast, and cervical cancer screening
  • Impact of the Affordable Care Act and racial and economic disparities on cancer detection
  • When to refer a patient for a genetics referral or to a high-risk clinic

CME credit will be offered. Pre-registration is required. Check the Cancer Center website for more information.


Scholar Awards in Studying Complex Systems 2014 Grant Competition

The James S. McDonnell Foundation (JSMF) Scholar Awards program derives from and is consistent with JSMF's commitment to supporting high quality research and scholarship leading to the generation of new knowledge and its responsible application. For Scholar Awards the program's emphasis is furthering the science of complex systems via the continued development of the theory and tools used in the study of complex research questions and not on particular fields of research per se. JSMF is particularly interested in projects attempting to apply complex systems approaches to coherently articulated questions.
Deadline: March 12

Brian Werbel Memorial Fund

Applications are currently being accepted for summer cancer research fellowship funding, provided by the Brian Werbel Memorial Fund. This fund was established in 2007 at University Hospitals Case Medical Center, and is dedicated to providing summer fellows an opportunity to focus on cancer research, with the ultimate goal to aid in curing cancer. Brian's hope was to find a cure for cancer – to make a difference in the world, just as he made a difference in the lives of everyone he touched. Applicants must be conducting cancer research with a Case Comprehensive Cancer Center member. Awardees are required to attend the Annual Golf Outing Event, typically held in July. 
Deadline: April 25


NIH Center for Accelerated Innovations at Cleveland Clinic Technology Development Program
LOI Deadline: February 3

Alex's Lemonade Stand Foundation Pediatric Oncology Student Training Program Pediatric Oncology Student Training (POST) Program
Deadline: February 10

2014 Bladder Cancer Research Innovation Award
LOI Deadline: February 12
Application Deadline: April 23

Leukemia & Lymphoma Society Translational Research Program
LOI Deadline: February 15
Application Deadline: March 1

ASH HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award
Deadline: February 21

Dan David Prize Scholarships
Deadline: February 28

CWRU Department of Medicine Team Science Challenge
Deadline: March 1

Bladder Cancer Advocacy Network 2014 Young Investigator Awards
Deadline: March 5

Childhood Brain Tumor Foundation Pediatric Brain Tumor Grant Awards
Deadline: March 14

Childhood Brain Tumor Foundation Astrocytoma Research Award
Deadline: March 14

Damon Runyon-Sohn Pediatric Cancer Fellowship Award
Deadline: March 17

Damon Runyon Fellowship Award
Deadline: March 17

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt Summer Program (ENGAGE)
Deadline: March 28

Cancer Research Institute Irvington Postdoctoral Fellowship Program
Deadline: April 1

American Cancer Society RFA: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: April 1

Brian Werbel Memorial Fund Summer Cancer Research Fellowships‌
Deadline: April 25

HHMI Investigator Program National Competition
Deadline: June 3

Damon Runyon Fellowship Award
Deadline: August 15

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Extension of the Response Date for NOT-CA-14-014 "Request for Information (RFI) on Sharing Precursors for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) Imaging Agents" (NOT-CA-14-030)

Updated Electronic Application Forms (FORMS-C) Now Available for Administrative Supplement (non-competing Type 3), Successor-in-Interest (Type 6), and Change of Grantee Organization (Type 7) Applications (NOT-OD-14-044)

NIH Reminds Applicants to Use Updated Electronic Application Forms (FORMS-C) for F, K, T and D Submissions with Due Dates on/after January 25, 2014 - Correction (NOT-OD-14-045)

NIH and AHRQ Extend Due Dates for Applications Due Jan 31-Feb 3 to Feb 4 (NOT-OD-14-047)

Notice of Informational Webinar for RFA-RM-13-019 "NIH Director's Biomedical Research Workforce Innovation Award: Broadening Experiences in Science Training Award (BEST) (DP7)" (NOT-RM-14-006)

Notice to Solicit Compounds for Inclusion in the NIH-Industry New Therapeutic Uses Program (NOT-TR-14-001)

PHS 2014-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])(PA-14-071)

PHS 2014-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])(PA-14-072)

Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp)

Change of Grantee Organization (Type 7 Parent)(/PA-14-078)

Successor-in-Interest (Type 6 Parent)(PA-14-079)


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at

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February 3

Genetics Student Seminar
Olivia Corradin
Student, Genetics and Genome Sciences
Topic: Decoding GWAS: Combinatorial Effects of Non-coding Variants
11 am BRB 105

Pathology Research Seminar Series
Jenny Parvani
PhD Candidate, Schiemann lab, Pathology
Topic: Mechanisms of Oncogenic TGF-beta Signaling in Breast Cancer Metastasis
12 pm WRB 1-413

Physiology and Biophysics Seminar
Daniel L. Minor, Jr., PhD
Professor, Cardiovascular Research Institute
University of California-San Francisco
Topic: Structural and Chemical Biology Studies of Ion Channels
4 pm SOM/Robbins Building E-501

February 4

Cellular and Molecular Medicine Seminar Series
Shiyou Chen, PhD
Associate Professor, Physiology & Pharmacology
University of Georgia College of Veterinary Medicine 
Topic: TGF-beta Signaling in Smooth Muscle Differentiation and Vascular Remodeling
10 am NC1-202 Cleveland Clinic

Immunology Seminar Series
Hana Russo
PhD Candidate, Dubyak lab, Pathology
Topic: Caspase-1 Dependent Pyroptosis: A Mode of Inflammatory Cell Death
Jessica Perez
PhD Candidate, Abbott lab, Pathology
Topic: Novel IKK Phosphorylation of E3 Ubiquitin Ligases in Inflammation
12 pm BRB 105

Ophthalmology and Visual Sciences Speaker Series
Przemyslaw Sapieha, PhD
Assistant Research Professor, Ophthalmology
University of Montreal
Topic: Neurovascular and Neuroimmune Crosstalk in Retinopathy
12 pm Wood 331

Cancer Biology Seminar
Candece Gladson, MD
Professor, Cancer Biology
Cleveland Clinic
Topic: Regulation of Angiogenesis in Glioblastoma
2 pm NC1-202 Cleveland Clinic

DNA Damage/Repair Focus Group Meeting
Scott Welford, PhD
Assistant Professor, Radiation Oncology
Title: Polyamine Catabolism and Therapeutic Resistance in Glioblastoma Multiforme
4 pm WRB 3-136

February 5

Hematology and Oncology Division Research Conference
Topic: TBD
8 am Lerner B-151

Next-generation Gene Expression and Data Analysis Workshop
10 am-3 pm WRB

Pathology Faculty Candidate
Tsan Sam Xiao, PhD
Chief of Structural Immunobiology Unit
Laboratory of Immunology
Topic: Molecular Mechanisms of Nucleic Acid Sensing in Infection and Inflammation
11 am WRB 5-136

Cancer Imaging Program Meeting
12 pm WRB 2-136

February 6

Genetics and Genome Sciences Journal Club
Emily Pontzer
George Aranjuez
Students, Genetics
Topic: Tumors Give up their Secrets: The Mutational Landscape of 12 Major Cancer Types
12 pm BRB 732

Immunology Journal Club
Jackie Golden
Student, Immunology
Topic: IL-32 Promotes Angiogenesis
12 pm WRB 5-136

February 7

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Jessica Mester, MS, CGC
Genomic Medicine Institute
Cleveland Clinic
Topic: PTEN: When Overgrowth Bumps into Cancer
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Nima Sharifi, MD
Associate Staff, Cancer Biology
Kendrick Family Endowed Chair for Prostate Cancer Research
Lerner Research Institute
Cleveland Clinic
Topic: Androgen Metabolism in Prostate Cancer: From Mechanism to Therapy
12 pm BRB 105

Cancer Center Research in Progress
Fred Allen
Graduate Student, Huang lab, Pathology
Iuliana Bobanga, MD
Surgical Resident, Huang lab, Pathology
Topic: Inflammatory Chemokines CCL3 and CCL4 Alter Immunogenicity of Mouse Colorectal Cancer In Vivo
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East


2014 Multidisciplinary Head and Neck Cancer Update
February 14-15
Sanibel Harbour Marriott Resort & Spa
Fort Myers, FL

International Symposium on Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery
February 21-23
The Naples Beach Hotel & Golf Club
Naples, FL