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January 27, 2014


Immunotherapy Duo Ups Survival in Pancreatic Ca
MedPage Today - Jan 20, 2014
Looking beyond the preliminary nature of the study, the results "are exciting for a poor-prognosis cancer," said Smitha Krishnamurthi, MD, who moderated a press briefing where Le discussed the study. "This is a phase II study, but it is the first randomized study of immunotherapy in metastatic pancreatic cancer demonstrating improved survival," said Krishnamurthi, of University Hospitals Case Medical Center in Cleveland. "This was accomplished without the toxicity of chemotherapy."


Cryoablation Therapy offers Relief to Metastatic Cancer Patients

A study led by Dr. J. David Prologo, Assistant Professor of Interventional Radiology at CWRU and University Hospitals Case Medical Center, found that metastatic cancer patients who received cryoablation therapy – a treatment that freezes and destroys abnormal or cancerous cells with the use of liquid nitrogen – reported significant decreases in pain. The study found that most patients felt relief from pain immediately after the one-time treatment, and that the results lasted for at least three months. Patients also reported a decrease in the amount pain medication needed.


Angela Ting, PhD Receives Ovarian Cancer Research Funding from Colleen's Dream Foundation

Cancer Center member Dr. Angela Ting, Assistant Staff in the Cleveland Clinic Genetic Medicine Institute, received funding from Colleen's Dream Foundation to support ovarian cancer research. According to a news release, one of Dr. Ting's research goals is to establish an epigenetic signature for chemo-resistance in ovarian cancer.



Screening for Cancer in Women: 2014

Please mark your calendars and plan to attend Screening for Cancer in Women: 2014, on Wednesday, May 21 from 8 am - 3 pm at the Embassy Suites Hotel in Independence.

Optimal strategies in cancer screening and detection are constantly evolving and best practices are changing.

This update is aimed at primary care providers and cancer specialists with guides that can be incorporated into their practices:

  • New screening technologies, particularly to detect breast and lung cancer
  • Current guidelines for colorectal, skin, lung, breast, and cervical cancer screening
  • Impact of the Affordable Care Act and racial and economic disparities on cancer detection
  • When to refer a patient for a genetics referral or to a high-risk clinic

CME credit will be offered. Pre-registration is required. Check the Cancer Center website for more information.


NIH Center for Accelerated Innovations at Cleveland Clinic Technology Development Program

The NIH Center for Accelerated Innovations (NCAI) at Cleveland Clinic is offering funding for promising emerging technologies in order to facilitate their translation to commercialized products that improve patient care and enhance health. Proposals are accepted from investigators at NCAI partner institutions Cleveland Clinic, CWRU, Ohio State University, University of Cincinnati, and Cincinnati Children's Hospital Medical Center.
LOI Deadline: February 3

Bladder Cancer Research Innovation Award

The Bladder Cancer Advocacy Network is accepting applications for the 2014 Bladder Cancer Research Innovation Award. The aim of this award is to support exceptionally novel and creative projects with great potential to produce breakthroughs in the management of bladder cancer. Proposals will be accepted for creative ideas and innovative approaches that have direct application and relevance to bladder cancer.
LOI Deadline: February 12
Application Deadline: April 23

CWRU Department of Medicine Team Science Challenge

The CWRU Department of Medicine is delighted to announce Team Science Challenge grants. These grants are meant to encourage applicants for scientific projects that include PIs from more than one division within the Department of Medicine and/or other departments in the university. 
Deadline: March 1

Childhood Brain Tumor Foundation

The Childhood Brain Tumor Foundation is soliciting grant applications for the calendar year 2014. There will be two categories of awards:

  • Pediatric Brain Tumor Grant Awards: Our standard grant request for pediatric brain tumor awards will continue as usual. We anticipate funding up to three (3) research proposals that are a maximum of two years in duration. 
    Deadline: March 14
  • Astrocytoma Research Award: We have specific funds for one, 1-year research proposal related to all grades of astrocytoma. 
    Deadline: March 14

Damon Runyon Fellowship Awards

The Damon Runyon Cancer Research Foundation is accepting applications for the following fellowship opportunities:

  • Damon Runyon-Sohn Pediatric Cancer Fellowship Award: The Damon Runyon Cancer Research Foundation has joined together with the Sohn Conference Foundation, dedicated to curing pediatric cancers, to establish the Damon Runyon-Sohn Pediatric Cancer Fellowship Award. This award provides funding to basic scientists and clinicians who conduct research with the potential to significantly impact the prevention, diagnosis or treatment of one or more pediatric cancers. 
    Deadline: March 17
  • Damon Runyon Fellowship Award: The Foundation encourages all theoretical and experimental research relevant to the study of cancer and the search for cancer causes, mechanisms, therapies and prevention.
    Deadline: March 17 and August 15

Applicants may apply for either the Damon Runyon Postdoctoral Fellowship Award or the Damon Runyon-Sohn Pediatric Fellowship Award, not for both. Candidates must apply for these fellowships under the guidance of a Sponsor – a scientist (tenured, tenure-track or equivalent position) capable of providing mentorship to the Fellow. In addition to aiding in the planning, execution and supervision of the proposed research, the Sponsor's role is to foster the development of the Fellow's overall knowledge, technical and analytical skills, and capacity for scientific inquiry. The Sponsor is also expected to assist the Fellow in attaining his/her career goals.

Brian Werbel Memorial Fund

Applications are currently being accepted for summer cancer research fellowship funding, provided by the Brian Werbel Memorial Fund. This fund was established in 2007 at University Hospitals Case Medical Center, and is dedicated to providing summer fellows an opportunity to focus on cancer research, with the ultimate goal to aid in curing cancer. Brian's hope was to find a cure for cancer – to make a difference in the world, just as he made a difference in the lives of everyone he touched. Applicants must be conducting cancer research with a Case Comprehensive Cancer Center member. Awardees are required to attend the Annual Golf Outing Event, typically held in July. 
Deadline: April 25


American Institute for Cancer Research Investigator-Initiated Grants
LOI Deadline: January 27

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: February 1

Radiological Society of North America Research Medical Student Grants 
Deadline: February 1

Alex's Lemonade Stand Foundation Pediatric Oncology Student Training Program Pediatric Oncology Student Training (POST) Program
Deadline: February 10

Leukemia & Lymphoma Society Translational Research Program
LOI Deadline: February 15
Application Deadline: March 1

ASH HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award
Deadline: February 21

Dan David Prize Scholarships
Deadline: February 28

Bladder Cancer Advocacy Network 2014 Young Investigator Awards
Deadline: March 5

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt Summer Program (ENGAGE)
Deadline: March 28

Cancer Research Institute Irvington Postdoctoral Fellowship Program
Deadline: April 1

American Cancer Society RFA: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: April 1

Brian Werbel Memorial Fund Summer Cancer Research Fellowships‌
Deadline: April 25

HHMI Investigator Program National Competition
Deadline: June 3

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Intent to Publish a Funding Opportunity Announcement for Physical Sciences-Oncology Centers Program (U54)(NOT-CA-14-028)

Notice of Clarification of Salary Support for RFA-HG-14-007 "Mentored Career Development Award in Biomedical Big Data Science for Clinicians and Doctorally Prepared Scientists (K01)"(NOT-HG-14-021) 


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at


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January 27

Pathology Research Seminar Series
Tyler Miller
PhD Candidate, Rich/Tesar labs, Pathology
CWRU/Cleveland Clinic
Topic: Targeting Epigenetic Regulation to Disrupt Glioma Stem Cell Maintenance
12 pm WRB 1-413

Case CCC Breast Cancer Group Focus Group Meeting
4 pm WRB 3-136

Physiology and Biophysics Seminar
P. Hemachandra Reddy, PhD
Associate Scientist, Div. of Neuroscience
Oregon Health and Science University
Topic: Mitochondrial Damage and Neurodegenerative Diseases
4 pm SOM/Robbins Building E-501

January 28

Radiation Oncology Grand Rounds
Francoise Adan, MD
Assistant Professor, Psychiatry
Medical Director, Connor Integrative Medicine Network
Topic: Integrative Medicine: What We Can Do for Your Patients
8:10 am Lerner B-151

Molecular Genetics Departmental Seminar
Muraleedharan Veleeparambil, PhD
Postdoctoral Fellow, Sen lab, Molecular Genetics
Cleveland Clinic
Topic: Role of EGFR in TLR9 Signaling
9:30 am NE1-205 Cleveland Clinic

Immunology Seminar Series
Charles Su
PhD Candidate, Fairchild lab, Pathology
Topic: Endogenous Memory CD8 T Cells in Cardiac Allograft Rejection
12 pm BRB 105

January 29

Hematology and Oncology Division Research Conference
Elizabeth Weinstein, MD, MS
Medical Director, Supportive Oncology
Topic: Discussing Resuscitation Preference
8 am Lerner B-151

Pathology Faculty Candidate
Tangsheng Yi, PhD
Postdoctoral Research Fellow, Immunology/Microbiology
Howard Hughes Medical Institute
University of California, San Francisco
Topic: The Roles of EBI2 and its Oxysterol Ligand in Regulating Immune Cell Trafficking and Function
10 am WRB 1-413

Genetics and Genomes Sciences Seminar
Wei-Xing Zong, PhD
Professor, Molecular Genetics & Microbiology
Stony Brook University
Topic: Proteotoxic Stress in Tumorigenesis and Cancer Therapy
11 am BRB 105

Immunology Students/Fellows Research in Progress Seminar Series
Miwa Morita, PhD
Lu/Qian lab, Immunology
Cleveland Clinic
Topic: Graft Non-hematopoietic Cells Contribute Liver Allograft Acceptance through IFNy Signaling
Hsiao-Hsuan Kuo
Baldwin lab, Immunology
Cleveland Clinic
Topic: Platelets in Early Antibody-Mediated Rejection of Renal Transplants
12 pm NC1-202 Cleveland Clinic

January 30

Immunology Journal Club
Tom Richardson
Student, Immunology
Topic: Granulocyte Macrophag-Colony Stimulating Factor Induced Zn Sequestration Enhances Macrophage Superoxide and Limits Intracellular Pathogen Survival
12 pm WRB 5-136

Stem Cell Biology and Regenerative Medicine Seminar
Johan Skog, PhD 
Chief Scientific Officer
Exosome Diagnostics, Inc
Topic: Exosomes as Tumor Biomarkers
1 pm NE1-205 Cleveland Clinic

2013 Science Nobel Prizes - What Were They Given For?
Glenn Starkman, PhD: Physics Prize
Martin Snider, PhD: Physiology or Medicine Prize
Michael Weiss, MD, PhD: Chemistry Prize
4:15 pm Rockefeller 301

January 31

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
David Weissman, MD
Medical College of Wisconsin
Topic: Palliative Care and Oncology: Finding the Common Ground
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar Series
Helen Salz, PhD
Professor, Genetics and Genome Sciences
Topic: Stem Cell Differentiation, Sexual Identity and Tumors in the Drosophila Ovary
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Nickolas Papadopoulos, PhD
Professor, Oncology
Director of Translational Genetics
Ludwig Center for Cancer Genetics & Therapeutics
Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center
Topic: Landscapes of Cancer Genomes and Translation of the Genetic Information to Clinical Applications
12 pm BRB 105

Pathology Thesis Defense
Mausita Karmakar
PhD Candidate, Pearlman lab, Pathology
Topic: Inflammasome Dependent and Independent IL-1B Processing by Neutrophils during Bacterial Keratitis
12 pm WRB 1-413

Cancer Center Research in Progress
Kristy Miskimen, PhD
Research Associate, Harris lab, Div. of Hem/Onc
Topic: Targeted DNA Sequencing of Breast Cancers: Insights into 3D Culture Systems and Clonal Heterogeneity
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East


2014 Multidisciplinary Head and Neck Cancer Update
February 14-15
Sanibel Harbour Marriott Resort & Spa
Fort Myers, FL

International Symposium on Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery
February 21-23
The Naples Beach Hotel & Golf Club
Naples, FL