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January 6, 2014

MESSAGE FROM THE DIRECTOR

Stan Gerson, MDStan Gerson, MD
Director, Case CCC

Congressional Budget Approval

The House and Senate have approved a budget deal that will replace the sequester, at least for next two years. The agreement provides an additional $22 billion for the appropriations committees to allocate to important programs such as the NIH; allocations should be decided by January 15, 2014. While this is good news and causes some relief, we must remember that it is still very important to remind Congress of the importance of supporting the NIH and cancer research as a whole. We must not forget that sequester cuts are still planned for 2016-2020.

As Francis S. Collins wrote in a Washington Post opinion piece, we must invest in the nation's health. "Biomedical research is at a critical juncture – a moment of exceptional opportunities that demand exceptional attention if their promise is to be fully realized," said Collins. "The National Institutes of Health (NIH) is responsible for turning scientific discoveries into better health, but a combination of sequestration-mandated spending cuts and budgets that have not kept pace with biomedical research inflation over the past 10 years has weakened NIH's ability to carry out its mission." Collins goes on to give examples of these discoveries, including The Cancer Genome Atlas, pointing out that without proper funding, these important data collection projects will be of no use if researchers lack the tools to manipulate the data in a necessary manner.

For the time being we can take a breath and be thankful that Congress has delayed budget cuts, though we must keep our eye on the future and strategize on how to make clear the detrimental effect that a lack of funding will have on the field of biomedical research, and the health of our nation. Write a short note to members of the Ohio caucus to reiterate how important this issue is to each of us, to our region, and to our national priorities.

Contact Information for Ohio Senators and Representatives:
Sen. Robert Portman
Sen. Sherrod Brown
Rep. Steve Chabot (District 1)
Rep. Brad Wenstrup (District 2)
Rep. Joyce Beatty (District 3)
Rep. Jim Jordan (District 4)
Rep. Bob Latta (District 5)
Rep. Bill Johnson (District 6)
Rep. Bob Gibbs (District 7)
Rep. John Boehner (District 8
Rep. Marcy Kaptur (District 9)
Rep. Michael Turner (District 10)
Rep. Marcia Fudge (District 11)
Rep. Pat Tiberi (District 12)
Rep. Tim Ryan (District 13)
Rep. David Joyce (District 14)
Rep. Steve Stivers (District 15)
Rep. Jim Renacci (District 16)
Rep. Bob Peterson (District 17)


CASE CCC IN THE NEWS

Tolerability Better With Weekly Paclitaxel
Clinical Oncology News - Dec 2013

As adjuvant therapy for high-risk breast cancer, once-weekly paclitaxel without a growth factor is just as effective–but generally better tolerated–than every-two-week paclitaxel with a growth factor, according to data presented at the 2013 annual meeting of the American Society of Clinical Oncology (ASCO)..."What this tells me is that in terms of efficacy, you have a choice," said lead author G. Thomas Budd, MD, an oncologist at Cleveland Clinic and Case Comprehensive Cancer Center in Ohio. Dr. Budd reported that the main tolerability advantage with the weekly paclitaxel regimen was a significantly reduced risk for grade 3 or 4 neuropathy and musculoskeletal pain.


SAVE THE DATE

Case CCC Annual Scientific Retreat

Please mark your calendars for the Case CCC Annual Scientific Retreat, July 10-11, 2014. More details to come!


ANNOUNCEMENTS

Cleveland Clinic Researchers Create Online Colorectal Cancer Risk Calculator

Brian Wells, MD, PhDResearchers at Cleveland Clinic have developed a new tool called CRC-PRO that allows physicians to quickly and accurately predict an individual's risk of colorectal cancer, as published in the current edition of the Journal of the American Board of Family Medicine.

CRC-PRO, or Colorectal Cancer Predicted Risk Online, is designed to help both patients and physicians determine when screening for colorectal cancer is appropriate. Current guidelines recommend patients are screened at the age of 50. However, with this new tool, physicians will be better able to identify who is truly at risk and when screenings for patients are necessary.

To develop the calculator, the researchers – led by Brian Wells, MD, PhD, of the Department of Quantitative Health Sciences in Cleveland Clinic's Lerner Research Institute – analyzed data on over 180,000 patients from a longitudinal study conducted at the University of Hawaii. Patients were followed for up to 11.5 years to determine which factors were highly associated with the development of colorectal cancer. [more]


FUNDING OPPORTUNITIES

Alex's Lemonade Stand Foundation Pediatric Oncology Student Training Program

ALSF is dedicated to funding pediatric oncology researchers at critical points in their careers. The Pediatric Oncology Student Training (POST) Program is designed for graduate and medical students who have an interest in pediatric oncology research and would like to experience the field first hand. Students train with a pediatric oncology research mentor. Students may join a research project underway in a mentor's lab or begin an original investigation with the mentor.
Deadline: February 10

ENGAGE 2014

Now in its seventh year, the National CENter for ReGenerAtive Medicine UnderGraduate StudEnt Summer Program (ENGAGE), accepting applications. The purpose of the program is to promote and support undergraduate students participation in research and creative projects within the field of stem cells and regenerative medicine. Proposed projects will be expected to match the complexity for what is accepted by SOURCE funding. This program is now open to all undergraduate students, not just CWRU students. Mentors have to be full NCRM members in order to qualify for funding. Projects that provide matching funds and reduce the overall cost of the student will be given higher consideration for inclusion into the program.
Deadline: March 28

Cancer Research Institute Irvington Postdoctoral Fellowship Program

The Cancer Research Institute Irvington Postdoctoral Fellowship Program supports qualified young scientists at leading universities and research centers around the world who wish to receive training in cancer immunology. A panel of scientists drawn from our Scientific Advisory Council rigorously evaluates each candidate, the intended sponsor and training environment, and the nature and feasibility of the proposed project. The Institute seeks hypothesis driven, mechanistic studies in both immunology and tumor immunology. The applicant and sponsor must clearly state the potential of the proposed studies to directly impact our understanding of the immune system's role in cancer risk, tumor initiation, progression, metastasis, host response to tumors and/or the treatment of cancer.
Deadline: April 1

PREVIOUSLY ANNOUNCED OPPORTUNITIES

Basser External Research Grant Program
LOI Deadline: Monday, January 6
Full Application Deadline: Friday, February 14

Pilot Grants: Use of Tumor Genomic Evaluation for Clinical Decision-Making
Deadline: January 7

American Brain Tumor Association Basic Research Fellowships
Deadline: January 8

American Brain Tumor Association Medical Student Summer Fellowships
Deadline: January 8

Society of Surgical Oncology Clinical Investigator Award
Deadline: January 13

2014 CTSC Annual Pilot Grant Funding
Deadline: January 15

Radiological Society of North America Research Seed Grants
Deadline: January 15

International Association for the Study of Lung Cancer Fellowship and Young Investigators Programs
Deadline: January 16

CWRU Nutrition Obesity Research Center Request for Pilot Proposals
Deadline: January 17

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: February 1

Radiological Society of North America Research Medical Student Grants 
Deadline: February 1

ASH HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award
Deadline: February 21

Dan David Prize Scholarships
Deadline: February 28

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Participation of NHLBI in PAR-14-041 "Centers for AIDS Research and Developmental Centers for AIDS Research (P30)"(NOT-AI-14-024)

Notice of National Cancer Institute (NCI) Participation in PA-13-354 "Advancing the Science of Geriatric Palliative Care (R01)"(NOT-CA-14-016)

Notice of National Cancer Institute (NCI) Participation in PA-13-355 "Advancing the Science of Geriatric Palliative Care (R21)"(NOT-CA-14-017)

Notice of National Cancer Institute (NCI) Participation in PA-13-356 "Advancing the Science of Geriatric Palliative Care (R03)"(NOT-CA-14-018)

Notice of National Cancer Institute (NCI) Participation in RFA-HL-14-031 "Development of an NIH BD2K Data Discovery Index Coordination Consortium (U24)"(NOT-CA-14-019)

Small Grants Program for Cancer Epidemiology (R03)

Using Social Media to Understand and Address Substance Use and Addiction (R01)(RFA-CA-14-008)

Using Social Media to Understand and Address Substance Use and Addiction (R21)(RFA-CA-14-009)

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades! Send items to Gillian Irwin at gillian.irwin@case.edu.

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EVENTS

calendar

January 6

Genetics Student Seminar
Anthony Scott
Student, Genetics
CWRU
Topic: PTPRT Regulates High-fat Diet-induced Obesity and Insulin Resistance
11 am BRB 732

Visiting Professor Seminar
Neena Kapoor, MD
Clinical Director, Div. of Research Immunology/Bone Marrow Transplantation
Medical Director, Center for Cancer and Blood Diseases
Children's Hospital of Los Angeles
Topic: New Strategies for Old Problems in BMT
12 pm WRB 3-136


January 7

Radiation Oncology Grand Rounds
Tarun Podder, PhD
Associate Professor, Radiation Oncology
CWRU
Topic: Microspheres for the Treatment of Hepatocellular Carcinoma
8:10 am Lerner Tower B-151

DNA Damage and Repair Focus Group Meeting
Shigemi Matsuyama, PhD
Associate Professor, Div. of Hem/Onc
CWRU/UH
Topic: Bax Deficiency Extends the Life Span of Ku70 Null Mouse that have Premature Aging Phenotype
4 pm WRB 3-136


January 8

Hematology and Oncology Division Research Conference
Jennifer Eads, MD 
Assistant Professor, Div. of Hem/Onc
CWRU/UH
Topic: DNA Repair Pathways in Pancreatic Neuroendocrine Tumors
8 am Lerner Tower B-151

Genetics and Genome Sciences
Maria Hatzoglou, PhD
Professor, Pharmacology
CWRU
Topic: Cellular Stress Responses and Development of Disease
11 am BRB 105

Immunology Students/Fellows Research in Progress Series
Toyofumi Abe, MD, PhD
Student, Immunology
Cleveland Clinic
Topic: Anti-CD20 Antibody Therapy for Antibody-Mediated Rejection of Renal Allografts in a Mouse Model
AND
Jarod Zepp
Student, Immunology
Cleveland Clinic
Topic: Non-Redundant Role of TRAF4 in IL-17R Signaling
12 pm NC1-202 Cleveland Clinic

Prevention Research Seminar Series
Mary Holmes
President, Innovative Farmers of Ohio
Topic: Do We Have the Courage to Prevent Disease?
12 pm 1st Fl. BioEnterprise Bldg.

Breast Cancer Program Seminar
Deborah Collyar
President, Patient Advocates in Research (PAIR)
Topic: Accelerating Research Results with Patient Advocates
5:30 pm WRB 1-413


January 9

Neurosciences and Pathology Seminar
Richard Ransohoff, MD
Director, Neuroinflammation Research Center
CWRU/Cleveland Clinic
Topic: Neurodegeneration: Echoes of Neurodevelopment
12:10 pm BRB 105

Stem Cell Biology and Regenerative Medicine
Leslie Miller, MD, FACC
Creator/Chair, USF Stem Cell Research Group
University of South Florida
Topic: Regenerative Medicine: The Future of CV Therapy
1 pm NE1-205 Cleveland Clinic

Harrington Discovery Institute Seminar Faculty Candidate
Arnold Han, MD
Postdoctoral Research Fellow, Davis lab, Microbiology & Immunology
Stanford University and Howard Hughes Medical Institute
Topic: Mucosal T Cells in Human Disease: Implications Celiac Disease and Beyond
4 pm BRB 105


January 10

Hematology/Oncology Fellows Conference/Curriculum Series
Jane Little, MD
Associate Professor, Div. of Hem/Onc
CWRU/UH
Topic: Sickle Cell Disease
8 am Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Rebecca Cook, MS, CGC
Genomics
Cleveland Clinic
Topic: Inherited Cancer Predisposition: The Current Landscape of Evaluation and Testing
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar Series
Weibo Luo, PhD
Department of Biological Chemistry
Johns Hopkins University
Topic: Regulation of Hypoxia Inducible Factor 1 in Human Cancer
10 am NC1-202 Cleveland Clinic

Harrington Discovery Institute Seminar Faculty Candidate
Kelley Yan, MD, PhD
Post-doctoral Research Scholar, Kuo lab, Div. of Hematology
Stanford University
Topic: Intestinal Stem Cell Dynamics
12 pm WRB 4-136

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Screening for Cancer in Women: 2014
May 21
Embassy Suites - Rockside Rd. - Independence

Case CCC Annual Scientific Retreat
July 10-11
Wolstein Research Bldg/Corporate College East

ADDITIONAL UPCOMING SEMINARS & EVENTS

2014 Multidisciplinary Head and Neck Cancer Update
February 14-15
Sanibel Harbour Marriott Resort & Spa
Fort Myers, FL
Details

International Symposium on Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery
February 21-23
The Naples Beach Hotel & Golf Club
Naples, FL
Details