MESSAGE FROM THE DIRECTOR
Stan Gerson, MD
Director, Case CCC
In Memoriam: Janet Rowley
It is with sorrow that I report the passing of Janet Rowley, MD at the age of 88. Janet was a trailblazer in the field of cancer genomics, bringing the field from one of cutting out chromosomal preps to make the initial observation of the t(9:22) chromosomal translocation of CML, to participating on the most advanced studies of genetic changes in both primary and secondary leukemias. She taught us to inquire without preconceived notions, and to take our thoughts where the data directed. She was a giant in the field.
Please see the following from the American Medical Colleges:
Janet D. Rowley, MD, the Blum-Riese Distinguished Service Professor of Medicine, Molecular Genetics & Cell Biology and Human Genetics at the University of Chicago, died from complications of ovarian cancer on December, 17, 2013, at her home. She was 88. Dr. Rowley, a pioneer in connecting the development of cancer with genetic abnormalities, was the recipient of the Lasker Award, the National Medal of Science and the Presidential Medal of Freedom.
CASE CCC IN THE NEWS
The Ponatinib Problem: Debating the FDA's Recent Market Suspension
Oncology Times - Dec 23, 2013
The latest findings give sufficient reason to pause and review the drug's safety, said OT's Clinical Advisory Editor for Hematology/Oncology, Mikkael Sekeres, MD, MS, Director of the Cleveland Clinic Taussig Cancer Institute's Leukemia Program and Chair of the Hematology/Oncology Pharmacy and Therapeutics Committee, and member of the Case Comprehensive Cancer Center, one of several leukemia experts interviewed for this article.
Soy May Help Protect Lungs from Radiation Damage in NSCLC
Helio/HemOnc Today - Dec 23, 2013
Perspective by Mohamed Abazeed, MD, PhD, Associate staff physician, Department of radiation oncology, Cleveland Clinic Taussig Cancer Institute and Case Comprehensive Cancer Center. The prevention and mitigation of radiation-induced injuries impacts several aspects of public health and medicine. The explosion of a low-grade radiological weapon by terrorists, the outbreak of nuclear conflict, and nuclear power plants accidents (a la Chernobyl and Fukushima) can cause initial deaths and contaminate land, water, air, and food sources leading to increased risk of radiation-induced damage for decades.
Common Disorders: It's Not the Genes Themselves, but How They Are Controlled
Science Daily - Dec 20, 2013
New research from Case Western Reserve University School of Medicine to appear in the journal Genome Research finds that six common diseases arise from DNA changes located outside genes. The study from the laboratory of Case Comprehensive Cancer Center member Peter Scacheri, PhD, shows that multiple DNA changes, or variants, work in concert to affect genes, leading to autoimmune diseases including rheumatoid arthritis, Crohn's disease, celiac disease, multiple sclerosis, lupus and colitis. Further, for each disease, multiple different genes are manipulated by several small differences in DNA..."The Scacheri lab's study provides a new model for understanding how genetic variants explain variation in common, complex diseases such as rheumatoid arthritis and colitis. That is, the effect of an individual variant may be very small, but when coupled with other nearby variants, the manifestations are much greater," said Anthony Wynshaw-Boris, MD, PhD, chair of the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, the James H. Jewell MD '34 Professor of Genetics at the School of Medicine, and member of the Case Comprehensive Cancer Center.
Cleveland Clinic, 3 Others Get Grant to Study Treatment-resistant Prostate Cancer
The Plain Dealer - Dec 18, 2013
The non-profit Prostate Cancer Foundation has chosen the Cleveland Clinic, the National Cancer Institute, the University of Chicago and Thomas Jefferson University as recipients of a two-year, $600,000 Special Challenge Award to collaborate on research investigating what role abnormally high protein levels play in prostate cancer tumors..."African-American men have a two-fold higher mortality rate from prostate cancer than European-Americans," Case Comprehensive Cancer Center member Dr. Eric Klein, chairman of the Clinic's Glickman Urological & Kidney Institute and co-principal investigator on the grant, said in a statement.
In Search of Best Treatment for mRCC
Medscape - Dec 18, 2013
Two newly published phase 3 trials seek to answer different questions in the multiple-choice test that is the treatment of metastatic renal cell carcinoma (mRCC)...Thus the trial further confirmed the lack of evidence that combination therapy with a VEGFR inhibitor and an mTOR agent has an advantage over other strategies in the first line, including using an approved single agent, write the authors, led by Brian I. Rini, MD, from the Cleveland Clinic Taussig Cancer Institute and Case Comprehensive Cancer Center in Ohio.
Greatest Cancer Threats in Your 30s, 40s, 50s, and 60s
Yahoo Health - Dec 12, 2013
Increasingly unhealthy lifestyles are a major culprit, with an estimated 14.1 million people around the world developing cancer, the report stated. To find out more about the most common forms of cancer in women and men at different ages – and what action steps are most effective to reduce risk, I talked to Dr. Dale Shepard, a cancer specialist in the Solid Tumor Oncology department of the Cleveland ClinicCase Comprehensive Cancer Center.
Researchers and Advocates Work Together to Advance Glioblastoma Understanding and Treatment
CureToday.com - Dec 1, 2013
Then there is the fact that GBM is, well, brain cancer. "Because it's the brain, you can't remove the cancer totally," notes Manmeet Ahluwalia, staff physician at the Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center at the Cleveland Clinic and Case Comprehensive Cancer Center in Ohio.
SAVE THE DATE
Case CCC Annual Scientific Retreat
Please mark your calendars for the Case CCC Annual Scientific Retreat, July 10-11, 2014. More details to come!
Harrington Discovery Institute Faculty Candidate Seminars
The Harrington Discovery Institute will be hosting two faculty candidate seminars next week. These seminars are open to all who are interested in attending.
Dr. Arnold Han, Postdoctoral Research Fellow in the laboratory of Dr. Mark Davis in the Department of Microbiology and Immunology at Stanford University and Howard Hughes Medical Institute, will present Mucosal T Cells in Human Disease: Implications Celiac Disease and Beyond on Thursday January 9, 2014 at 4 pm in BRB 105.
Dr. Kelley Yan, a Post-doctoral Research Scholar studying intestinal stem cell biology in the laboratory of Dr. Calvin Kuo, and Instructor of Medicine-Hematology at Stanford University, will present Intestinal Stem Cell Dynamics on Friday, January 10, 2014 at 12 pm WRB 4-136.
Cancer-focused Harrington Scholars 2014: Dr. Darren Carpizo
In case you missed our newsletter announcement, earlier this month the Harrington Discovery Institute at University Hospitals Case Medical Center named 11 individuals as research scholars, three of which will study cancer. To highlight the translational nature of the Institute, we will identify the research each of these cancer-focused scholars in the coming weeks, starting with Darren Carpizo, MD, PhD from the Rutgers Cancer Institute of New Jersey. Dr. Carpizo was selected as a research scholar based on his novel observation that a known drug can reverse the mutant function of p53 in cancer. Please see his 2012 Cancer Cell paper that formed the basis of his application. Dr. Carpizo will be here in June 2014 to review his progress.
Vote for Dr. Stan Gerson for the AACR Nominating Committee
Our director, Dr. Stan Gerson, is on the ballot for the American Association for Cancer Research (AACR) Nominating Committee. The election will close on Friday, February 14, 2014. Voting instructions will be distributed to all voting members of AACR. Election results will be announced in March 2014 and elected candidates will assume office at the AACR Annual Meeting 2014 in April.
Please show your support for Dr. Gerson and vote for him! It would be great to have local votes that place our director on the Nominating Committee, which selects candidates for major awards, the annual meeting program committee, and the slate of candidates for national positions.
CWRU Nutrition Obesity Research Center Request for Pilot Proposals
New Investigators at CWRU are invited to submit applications for pilot projects for potential inclusion in the Nutrition Obesity Research Center Application (November 2014). Successful proposals will be included in the NIDDK NORC Application and will be considered for funding beginning February 2014. For the purpose of this RFP, new investigators are those without current or prior NIH research project support (RO1, PO1, R24) as a PD/PI Award Budget Limited to $50,000 Direct Costs. Preference will be given to proposals that focus on molecular and translational mechanisms, mediators, and modifiers of obesity and related comorbid disorders.
Deadline: January 17, 2014