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December 16, 2013


Cleveland Clinic Immunologist Presents Preventive Vaccine Research to Breast Cancer Field for 1st Time
The Plain Dealer - Dec 13, 2013
More than three years after his research on a potential breast cancer vaccine appeared in the scientific journal Nature Medicine, Cleveland Clinic immunologist and Case Comprehensive Cancer Center member Vincent Tuohy is finally presenting his work to the scientific breast cancer community...

Research roundup: News from the 2013 San Antonio Breast Cancer Symposium
The Plain Dealer - Dec 13, 2013
Initial research findings from University Hospitals Seidman Cancer Center and the Case Comprehensive Cancer Center are shedding new light on how changes in breast cancer tumors, after just one dose of biologic therapy or chemotherapy, can predict a patient's prognosis. Led by Dr. Lyndsay Harris, director of UH Seidman's Breast Cancer Program, the researchers found that through deep genome sequencing (a process that identifies mutations within tumors in a specific region), they could observe a reduction in the most commonly mutated genes in breast cancer after just one dose of preoperative therapy.

Energy Efficient Light Bulbs Could Pose UV-risk to Skin, Trigger Migraines
Fox News - Dec 13, 2013
Broader use of compact fluorescents (CFLs) may actually come with some unwanted health risks – most notably in regards to people's skin..."Ultraviolet light is similar to the ultraviolet wavelengths found in natural sunlight, and we do not want huge amounts or extra amounts of ultraviolet light on our skin because it can cause biological effects that can lead to cancer," Dr. Elma Baron, director in the lasers and photomedicine department at UH Case Medical Center in Cleveland and member of the Case Comprehensive Cancer Center, told

Early Warning Signs of Cancer: Are You at Risk?
Yahoo Health - Dec 10, 2013
It's tragically common for patients to ignore warnings of other types of cancer, adds Dale Shepard, MD, PhD, a cancer specialist in the department of solid tumor oncology at the Cleveland Clinic and member of the Case Comprehensive Cancer Center. "Cancer can almost always be cured if it's caught early, but all too often, people wait so long to see a doctor that the disease has spread to the point that it's no longer curable."


Case CCC Annual Scientific Retreat

Please mark your calendars for the Case CCC Annual Scientific Retreat, July 10-11, 2014. More details to come!


Case CCC Leadership Awards

Case CCC Leadership Awards

Every year at the Cancer Center Holiday Party we recognize an outstanding Cancer Center leader for their efforts. This year, Chris Flask, PhD was recognized for dedicating his time and effort to improving the quality and support of the cores in the Cancer Center and in the medical school. Amitabh Chak, MD was also recognized for his efforts to facilitate tissue-based research in the Cancer Center and for accepting the responsibility to chair the tissue research review committee. Both Drs. Flask and Chak received a clock to commemorate their award.

Vote for Dr. Stan Gerson for the AACR Nominating Committee

Our director, Dr. Stan Gerson, is on the ballot for the American Association for Cancer Research (AACR) Nominating Committee. The election opens today, December 16 and will close on Friday, February 14, 2014. Voting instructions will be distributed to all voting members of AACR. Election results will be announced in March 2014 and elected candidates will assume office at the AACR Annual Meeting 2014 in April.

Please show your support for Dr. Gerson and vote for him! It would be great to have local votes that place our director on the Nominating Committee, which selects candidates for major awards, the annual meeting program committee, and the slate of candidates for national positions.

Affymetrix Promotion

The Gene Expression and Genotyping (GEGF) Core Facility would like to let you know about an attractive promotion that Affymetrix is offering on their new and very exciting Human Transcriptome Array (HTA). This array, which assesses total gene expression and alternative splicing transcripts, is an extremely competitive, budget-friendly alternative platform to RNA sequencing. The technology is capable of handling RNA from Fresh, Frozen and FFPE materials and works with starting amounts as little as 50ng of totRNA. Click here for more details and a comparison of RNAseq and the HTA microarray platform. You can also visit the Affymetrix web site for more information on the HTA Expression Product.

Details of Affymetrix Promotion:

Sample Isolated from Fresh or Frozen Tissue: Out the door price (includes sample processing, reagents & array)= $390/sample
Promotion expires Friday, Dec 27: Price will then increase to $500/sample

Sample Isolated from FFPE Material: Out the door price (includes sample processing, reagents & array)=$490/sample
Promotion expires Friday, Dec 27: Price will then increase to $600/sample

Note: Additional processing discounts are available for larger studies. Please inquire.

If you wish to avail yourself of this promotion, contact Debora Poruban at 368-8748 or by close of day Friday, December 27. Questions about the technology: Contact Marty Veigl at (216.368.5689 or or Patrick Leahy (216.368.0761 or


P50 Research Center Grants for Specialized Programs of Research Excellence (SPOREs)

The NIH is accepting applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPOREs). Case CCC administration is available to assist with planning and submission of SPORE applications.

This Funding Opportunity Announcement invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPOREs). The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer (or a related group of cancers). SPOREs are expected not only to conduct a wide spectrum of research activities, but also to contribute significantly to the development of specialized shared resources core facilities, improved research model systems, and collaborative research projects with other institutions. The research supported through this program must be translational in nature and must always be focused upon knowledge of human biology stemming from research using cellular, molecular, structural, biochemical, and/or genetic experimental approaches with the goal of a translational human endpoint within the project period of the grant. In addition, SPOREs must include both a Developmental Research Program for pilot studies and a Career Development Program to foster careers in organ-based translational science.
Application Deadlines: February 13, 2014; May 20, 2014; September 23, 2014

New Connections: Increasing Diversity of RWJF Programming

The Robert Wood Johnson Foundation New Connections program provides support and training to Junior Investigators and Mid-Career Consultants to address priorities related to RWJF's program areas: Childhood Obesity, Coverage, Human Capital, Pioneer, Public Health, Quality/Equality and Vulnerable Populations. This round of New Connections funding will focus on research projects addressing health disparities.
Proposal Deadline: January 15, 2014

Avon Foundation Breast Cancer Research Program

To develop new strategies to prevent breast cancer, we need to understand the causes of breast cancer in people, changes in breast cells that give rise to cancer, markers for disease, and how breast cancer progresses. The 2014 Avon Foundation Research Program seeks proposals in these areas to advance understanding of causes of breast cancer and prevention.
LOI Deadline: January 31, 2014
Application Deadline: March 28, 2014


Alex's Lemonade Stand Foundation Epidemiology Grants
Deadline: December 16

Ohio Brain Tumor SPORE Working Group Pilot Grants
Deadline: December 16

Conquer Cancer Foundation of ASCO Medical Student Rotation for Underrepresented Populations
Deadline: December 17

Conquer Cancer Foundation of ASCO Resident Travel Award for Underrepresented Populations (RTA)
Deadline: December 17

DOD Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: December 19
Application Deadline: January 9, 2014

Ohio Brain Tumor SPORE Working Group Career Development Scholars Training Program‌
Deadline: December 23

Pilot Grants: Use of Tumor Genomic Evaluation for Clinical Decision-Making
Revised Deadline: December 2

Basser External Research Grant Program
LOI Deadline: Monday, January 6, 2014
Full Application Deadline: Friday, February 14, 2014

American Brain Tumor Association Basic Research Fellowships
Deadline: January 8, 2014

American Brain Tumor Association Medical Student Summer Fellowships
Deadline: January 8, 2014

Society of Surgical Oncology Clinical Investigator Award
Deadline: January 13, 2014

2014 CTSC Annual Pilot Grant Funding
Deadline: January 15, 2014

Radiological Society of North America Research Seed Grants
Deadline: January 15, 2014

International Association for the Study of Lung Cancer Fellowship and Young Investigators Programs
Deadline: January 16, 2014

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: February 1, 2014

Radiological Society of North America Research Medical Student Grants 
Deadline: February 1, 2014

ASH HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award
Deadline: February 21, 2014

Dan David Prize Scholarships
Deadline: February 28, 2014

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Extension of Expiration date for PA-11-180 "Research on Ethical Issues in Biomedical, Social and Behavioral Research (R01)"(NOT-OD-14-031)

Notice of Extension of Expiration date for PA-11-182 "Research on Ethical Issues in Biomedical, Social and Behavioral Research (R21)"(NOT-OD-14-033)

U.S.-South Africa Program for Collaborative Biomedical Research (R01)(RFA-AI-14-009)

U.S.-South Africa Program for Collaborative Biomedical Research (R21)(RFA-AI-14-010)

Computational Analyses Exploiting Reference Epigenomic Maps (R01)(RFA-RM-14-001)

NIH/PEPFAR Collaboration for Implementation Science (Admin Supp)(PA-14-024)

Administrative Supplements for Research on Sex/Gender Differences (Admin Supp)(PA-14-027)

Administrative Supplement to Existing NIH Director's Biomedical Research Workforce Innovation Award: Broadening Experiences in Scientific Training (BEST)(Admin Supp)(PA-14-040)

Pre-application for a Biomedical Technology Research Resource (X02)(PAR-14-023)

Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21)(PAR-14-028)

Specialized Programs of Research Excellence (SPOREs) in Human Cancer for Year 2014 (P50)(PAR-14-031)

Centers of Biomedical Research Excellence (COBRE) (P20)(PAR-14-035)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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December 16

Genetics and Genome Sciences
Jinyu Wang
Graduate Student, Runge lab, Genetics and Genome Sciences
Topic: Rif1 Phosphorylation in Telomere Length Regulation and Response to DNA Damage
11 am BRB 105

December 17

Radiation Oncology Grand Rounds
Simon Lo, MD
Director, Radiosurgery Services & Neurologic Radiation Oncology
Topic: Emerging Applications of Stereotactic Ablative Radiotherapy
8:10 am Lerner Tower B-151

Immunology Seminar Series
Daniel Popkin, MD, PhD
Assistant Professor, Dermatology
Topic: Dendritic Cells Serve as a Gateway to Chronic Viral Infection
12 pm WRB 1-413

Medicine Grand Rounds
Guilherme Oliveira, MD, FACC
Associate Professor, Div. of Cardiovascular Medicine 
Director, Harrington Heart & Vascular Institute Advanced Heart Failure and Transplantation Center
Director, Harrington Heart & Vascular Institute Onco-Cardiology Center
Topic: Cardiovascular Effects of Cancer Therapies: From Prevention to Advanced Treatment
12 pm Kulas Auditorium, Lakeside 5th Floor

Cancer Biology Seminar Series
Zhenfei Li, PhD
Research Fellow, Sharifi lab, Cancer Biology
Cleveland Clinic
Topic: Biology and Targeting Androgen Metabolism in Castration Resistant Prostate Cancer
2 pm NC1-202 Cleveland Clinic

December 18

Hematology and Oncology Division Research Conference
Stephen Fink, PhD
Instructor, Div. of Hem/Onc
Topic: CCSP-1: A Secreted Protein Highly Induced in Colon Cancer and Associated with Poor Survival
8 am Lerner Tower B-151

Immunology Seminar
Eric Pearlman, PhD
Professor, Ophthalmology and Visual Sciences
Topic: A Novel Population of Neutrophils that Produce and Respond to IL-17 - Implications for Infection, Inflammation and Autoimmunity
12 pm NC1-202 Cleveland Clinic

December 19

Cancer Trainee Seminar
Tyler Miller
Graduate Student, Rich and Tesar labs
CWRU/Cleveland Clinic
Topic: Targeting Epigenetic Regulation to Disrupt Glioma Stem Cell Maintenance
Raj Choudhary, MD
Fellow, Div. of Hem/Onc
Topic: Pancreatic Cancer
12 pm WRB 3-136

December 20

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Arno Mundt, MD
Professor and Chair, Gynecologic Cancers
University of California
Topic: Gynecologic IMRT: Past, Present and Future
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar Series
Hong Chen, PhD
Assistant Professor, Biochemistry and Molecular Biology
University of Oklahoma Health Sciences Center
Topic: The Role of Ubiquitin-Binding and Endocytic Adaptor Proteins Epsins in Angiogenesis and Atherosclerosis
10 am NC1-202 Cleveland Clinic

Case CCC Calendar

LRI Calendar


Screening for Cancer in Women: 2014
May 21, 2014
Embassy Suites - Rockside Rd. - Independence


2014 Multidisciplinary Head and Neck Cancer Update
February 14-15, 2014
Sanibel Harbour Marriott Resort & Spa
Fort Myers, FL

International Symposium on Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery
February 21-23, 2014
The Naples Beach Hotel & Golf Club
Naples, FL