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December 11, 2013


Stan Gerson, MD
Director, Case CCC

Investing in the NIH for the Future Health of the Nation

Sen. Sherrod Brown, along with 34 colleagues, recently sent a letter to this year's Budget Conferees urging them to support a strong commitment to NIH funding. Please review the letter and contact your legislative parties to stress the necessity of funding for the NIH. We must continue to voice our concerns and remind decision makers the personal and detrimental impact these budgets have had, and will have, on cancer research and our nation.


Cleveland Clinic Researchers Find Link Between Smoking History and Blood Disorder Prognosis
The Plain Dealer - Dec 10, 2013
Cleveland Clinic researchers have discovered a link between smoking's impact on how myelodysplastic syndrome, or MDS, progresses in patients...In a study led by Dr. Mikkael Sekeres, a hematologist/oncologist at the Clinic's Taussig Cancer Institute, researchers conducted gene sequencing (analyzing a person's genetic makeup), and analyzed health records and smoking habits of 151 patients treated at the Clinic for MDS between 2000-2012.

Controversial Diabetes Drug Linked to Decreased Cancer Risk in Women, Cleveland Clinic Research Shows
The Plain Dealer - Dec 6, 2013
A controversial class of diabetes drugs appears to reduce the risk of cancer in women by almost a third, according to a large study by Cleveland Clinic researchers. The drugs, in a class called oral insulin sensitizers, include the controversial drug Avandia (rosiglitazone), which until recently had been restricted by the Food and Drug Administration due to fears of increased heart attack risk.

NE Ohio Woman Mentioned in Obamacare Speech Gets Treatment
Fox 8 - Dec 6, 2013
While some have been critical of Obamacare, a Northeast Ohio family said their situation proves it works. Justine Ula, 23, of the Youngstown suburb of Poland, began five days of chemotherapy treatment at University Hospitals Seidman Cancer Center Friday...President Obama used Ula's story as an example that the Affordable Care Act is working for her and three million other young adults who gain coverage by staying on their parents' plan until age 26. He learned of her situation from an email Ula's mother sent to The White House praising the Affordable Care Act. Dr. Robin Norris, Ula's oncologist at University Hospitals Seidman Cancer Center agreed. "The ACA really lets us focus on taking care of her and getting rid of her cancer," she said.

Should Bone Marrow Donors Be Paid?
Med Page Today - Dec 5, 2013
The federal government's proposal to ban compensation for a specific method of bone marrow donation has drawn heated responses from both supporters and opponents...Brenda Cooper, MD, a hematologist at University Hospitals Case Medical Center in Cleveland, said there are an increasing number of ways to collect bone marrow donations and create better matches, making paying unnecessary. "I think that the number of potentially usable donors that you're going to recruit by paying somebody is probably not going to enhance the system that's currently in place," she told MedPage Today in a video interview.


Dr. David Wald Named as UH Harrington Discovery Institute Research Scholar

Congratulations to Dr. David Wald, who one of 11 researchers named as research scholars by the Harrington Discovery Institute at University Hospitals Case Medical Center. Each scholar will receive grants up to $200,000 over two years for their work. In addition to the funding, the scholars gain access to the Institute's Innovation Support Center, where biotech experts help guide their discoveries into marketable products.

San Antonio Breast Cancer Symposium

The San Antonio Breast Cancer Symposium will be held December 10-14 in San Antonio, Texas. Every year, this symposium provide state-of-the-art information on the experimental biology, etiology, prevention, diagnosis, and therapy of breast cancer and premalignant breast disease, to an international audience of academic and private physicians and researchers.

The Case CCC is pleased to have many breast cancer experts participating in this important event. We wish everyone luck with their presentations!

2013 Scientific Meeting and Education Day of the Society for Neuro-Oncology

The Fourth Quadrennial Meeting of the World Federation of Neuro-Oncology was held in conjunction with the 2013 Scientific Meeting and Education Day of the Society for Neuro-Oncology on November 21-24, 2013. This meeting brought together top researchers in the neuro-oncology sector, and was attended by many members of the Case CCC. Congratulations to all presenters!

Affymetrix Promotion

The Gene Expression and Genotyping (GEGF) Core Facility would like to let you know about an attractive promotion that Affymetrix is offering on their new and very exciting Human Transcriptome Array (HTA). This array, which assesses total gene expression and alternative splicing transcripts, is an extremely competitive, budget-friendly alternative platform to RNA sequencing. The technology is capable of handling RNA from Fresh, Frozen and FFPE materials and works with starting amounts as little as 50ng of totRNA. Click here for more details and a comparison of RNAseq and the HTA microarray platform. You can also visit the Affymetrix web site for more information on the HTA Expression Product.

Details of Affymetrix Promotion:

Sample Isolated from Fresh or Frozen Tissue: Out the door price (includes sample processing, reagents & array)= $390/sample
Promotion expires Friday, Dec 27: Price will then increase to $500/sample

Sample Isolated from FFPE Material: Out the door price (includes sample processing, reagents & array)=$490/sample
Promotion expires Friday, Dec 27: Price will then increase to $600/sample

Note: Additional processing discounts are available for larger studies. Please inquire.

If you wish to avail yourself of this promotion, contact Debora Poruban at 368-8748 or by close of day Friday, December 27. Questions about the technology: Contact Marty Veigl at (216.368.5689 or or Patrick Leahy (216.368.0761 or


AACI Translational Cancer Research Fellowship

The Case Comprehensive Cancer Center may nominate ONE candidate for the AACI Translational Cancer Research Fellowship. The intent of the fellowship is to provide additional support to individuals who are engaged in any area of clinical and/or translational cancer research in order to further the development of their careers and enhance their future success in an academic discipline. The AACI fellowship will provide a one-year non-renewable grant to support post-doctoral training to individuals who have completed at least one year of training in any field of oncology and have at least one year of training remaining at an AACI member institution. Interested candidates should forward a letter of support from their mentor and their 4-page NIH biosketch to Terri Daso at by Friday, December 13.
Internal Deadline: December 13
External Deadline: February 3, 2014

Basser Research Center for BRCA External Grant Program

The Basser Research Center for BRCA at Penn Medicine's Abramson Cancer Center announces the Basser External Research Grant Program, which focuses on projects that have the potential to advance the care of individuals living with BRCA1 and BRCA2 mutations. Research grant applications in basic science, early detection, translational or clinical research and relevant to the study of BRCA1/2 will be considered. Grants that demonstrate a potential for translation into clinical practice will be prioritized for funding.

  • The Basser Team Science Award is open to teams with a minimum of two principal investigators. Preference will be given to multi-institutional applications.
  • The Basser Innovation Award will fund high-risk idea projects.

LOI Deadline: Monday, January 6, 2014
Full Application Deadline: Friday, February 14, 2014

American Brain Tumor Association Research Funding Opportunities

The American Brain Tumor Association is accepting applications for the following funding opportunities:

  • American Brain Tumor Association Basic Research Fellowships are open to applicants that are on-track to pursue a career in brain tumor research with a sponsor who has a demonstrated history of brain tumor research and mentorship.
    Deadline: January 8, 2014
  • American Brain Tumor Association Medical Student Summer Fellowships are open to medical students wishing to spend a summer conducting brain tumor research. The fellowship is to be conducted in a neuro-oncology laboratory with a mentorship setting that will provide an introductory learning experience. Studies are to be conducted at laboratories in the United States or Canada. 
    Deadline: January 8, 2014


AACR-Aflac Inc. Career Development Award for Pediatric Cancer Research
Deadline: December 11

AACI Translational Cancer Research Fellowship
Internal Deadline: December 13
External Deadline: February 3, 2014

AACR-Thomas J. Bardos Science Education Awards for Undergraduate Students
Deadline: December 13

Alex's Lemonade Stand Foundation Epidemiology Grants
Deadline: December 16

Ohio Brain Tumor SPORE Working Group Pilot Grants‌
Deadline: December 16

Conquer Cancer Foundation of ASCO Medical Student Rotation for Underrepresented Populations
Deadline: December 17

Conquer Cancer Foundation of ASCO Resident Travel Award for Underrepresented Populations (RTA)
Deadline: December 17

DOD Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: December 19
Application Deadline: January 9, 2014

Ohio Brain Tumor SPORE Working Group Career Development Scholars Training Program
Deadline: December 23

Pilot Grants: Use of Tumor Genomic Evaluation for Clinical Decision-Making
Revised Deadline: December 2

Society of Surgical Oncology Clinical Investigator Award
Deadline: January 13, 2014

2014 CTSC Annual Pilot Grant Funding
Deadline: January 15, 2014

Radiological Society of North America Research Seed Grants
Deadline: January 15, 2014

International Association for the Study of Lung Cancer Fellowship and Young Investigators Programs
Deadline: January 16, 2014

Audrey Meyer Mars International Fellowship in Clinical Oncology
Deadline: February 1, 2014

Radiological Society of North America Research Medical Student Grants 
Deadline: February 1, 2014

ASH HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award
Deadline: February 21, 2014

Dan David Prize Scholarships
Deadline: February 28, 2014

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Reissuance of Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) and Short-Term Institutional Research Training Grant (Parent T35)(NOT-OD-14-029)

Notice of National Institute of Nursing Research (NINR) Participation in RFA-HG-14-001 "BD2K-LINCS-Perturbation Data Coordination and Integration Center (DCIC) (U54)"(NOT-NR-14-003)

Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)(PA-14-015)

Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)(PA-14-016)

Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21)(PAR-12-094)

Basic Cancer Research in Cancer Health Disparities (U01)(PAR-12-095)

Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21)(PAR-12-096)

BD2K-LINCS-Perturbation Data Coordination and Integration Center (DCIC) (U54)(RFA-HG-14-001)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

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December 11

Hematology and Oncology Research Conference
Clark Distelhorst, MD 
Professor, Div. of Hem/Onc
Topic: How Steroids Kill Leukemia and Lymphoma Cells
8 am Lerner B-151

Pathology Grand Rounds
Jeffrey M. Hardacre, MD
Associate Professor, Div. of Surgical Oncology
Topic: Surgical Management of Pancreatic Cancer
8 am Pathology Amphitheatre

Pathology Faculty Candidate
Tara Strutt, PhD
Instructor, Pathology
University of Massachusetts
Topic: Regulation of innate inflammation by memory CD4 T cells
11 am WRB 1-413

Immunology Seminar
Brian Kelsall, MD
Chief, Mucosal Immunobiology Section, Laboratory of Molecular Immunology
National Institute of Allergy and Infectious Disease
Topic: Phenotype and Function of Intestinal Mononuclear Phagocytes
12 pm NC1-202 Cleveland Clinic

Case Cardiovascular Research Institute Seminar Series
Jack Rubinstein, MD
Director, Clinical Scientist Training Program
University of Cincinnati
Topic: Loss and Gain of Function Analysis of Transient Receptor Potential Vanilloid 2 Reveals Novel Roles in Baseline Cardiac Function, Contractility, Lusitropy and Hypertrophy
4 pm WRB 4-136

December 12

Prostate Cancer Working Group Seminar Series and Journal Club
Gerard Karsenty, MD, PhD
Professor and Chair, Genetics and Development
Columbia University Medical Center
Topic: Regulation of Male Fertility by Osteocalcin
3 pm NE1-205 Cleveland Clinic

December 13

Taussig Cancer Institute Grand Rounds canceled

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Wearn 137/Breen Conference Rm.

Cancer Center Seminar Series
Shai Izraeli, MD
Head, Functional Genomics and Childhood Leukemia Research
Sheba Medical Center, Tel-Hashomer, Israel
Professor, Pediatrics, Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel-Aviv University
Topic: Drivers of high risk leukemias – lessons from Down Syndrome
12 pm BRB 105

Cancer Center Research in Progress
Courtney Bartel
Graduate Student, Jackson lab, Pathology
Topic: Regulation of FAM83A and FAM83B: Key Intermediaries in EGFR/RAS Signaling During Transformation
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar



2014 Multidisciplinary Head and Neck Cancer Update 
February 14-15, 2014
Sanibel Harbour Marriott Resort & Spa
Fort Myers, FL

International Symposium on Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery
February 21-23, 2014
The Naples Beach Hotel & Golf Club
Naples, FL