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November 11, 2013


Tamoxifen Resistance in Breast Cancer Patients May Have Mutated Gene to Blame, Research Shows
Plain Dealer - Nov 11, 2013
Researchers have discovered a mutated version of the estrogen receptor, the presence of which may explain why the drug tamoxifen (brand names: Novaldex and Soltamox) is no longer effective in some patients being treated for ER-positive breast cancer. The findings were published online today in Cancer Research, a journal of the American Association for Cancer Research...That five of the metastasized samples had a mutated receptor is more than just chance alone, said Dr. Lyndsay Harris, director of the Breast Cancer Program at University Hospitals Seidman Cancer Center and professor at Case Western Reserve University School of Medicine, who called the findings significant.

What Our Patients Can Teach Us
New York Times - Nov 7, 2013
Dr. Mikkael Sekeres offers another perspective on rising health care costs.

Molecular Imaging: Better Training is Key
Medical Physics Web - Oct 18, 2013
Molecular imaging has vast potential to improve healthcare in the coming years by allowing more directed, personalized therapy. But molecular imaging's contribution may be limited until more imaging specialists are trained to interpret scans acquired with the new types of tracers being developed...Neurobiology and neuroscience are among the disciplines expected to benefit from molecular imaging, said James Basilion, professor of radiology, biomedical engineering, and pathology at Case Western Reserve University in Cleveland. He also sees molecular imaging making inroads in cardiovascular disease for identifying vulnerable plaque.


Case Comprehensive Cancer Center Call for Applications

The Case Comprehensive Cancer Center has released the following pilot grant funding opportunities:

  • Pilot Grants: Opportunities for Developing Patient-Derived Xenografts will support the development of patient-derived tumor xenografts (PDX) that will benefit collaborative, multi-investigator projects within the Cancer Center. This RFA is open to all Cancer Center members, regardless of institution.
    Deadline: November 15
  • Pilot Grants: Use of Tumor Genomic Evaluation for Clinical Decision-Making will provide seed money to foster collaborations and promote and increase institution-wide capacity and competitiveness in the use of tumor genomic evaluation for clinical decision-making. Case CCC members with faculty appointment at all levels (eligible to apply for independent nationally competitive research grants) are encouraged to apply. Proposals from both junior and senior investigators are encouraged. Research proposals must involve patients and/or their tissues.
    Deadline: December 2
  • Pilot Grants: Planning for Multi-Investigator Proposals will provide funding to further the important goal of facilitating successful applications for large multi-investigator grants (e.g., P01, P50, U54) in the current funding cycle. Applicants must demonstrate they are in communication with appropriate NIH administration, other structures within NIH, or other funding agencies (e.g., formal invitation, preparatory meeting, LOI and/or positive response to RFA or PA). Applicants must be Cancer Center members with faculty appointments, demonstrate intent to apply for national funding within a defined timeline, and describe new research that could not be achieved without the collaboration.
    Deadline: Open

AACR-Aflac Inc. Career Development Award for Pediatric Cancer Research

The AACR-Aflac Inc. Career Development Award for Pediatric Cancer Research represents a joint effort to encourage and support junior faculty who are in the first five years of a faculty appointment (at the start of the grant term) to conduct pediatric cancer research and establish successful career paths in this field. The research proposed for funding may be basic, translational, clinical, or epidemiological in nature and must have direct applicability and relevance to pediatric cancer.
Deadline: December 11

AACI Translational Cancer Research Fellowship

The Case Comprehensive Cancer Center may nominate ONE candidate for the AACI Translational Cancer Research Fellowship. The intent of the fellowship is to provide additional support to individuals who are engaged in any area of clinical and/or translational cancer research in order to further the development of their careers and enhance their future success in an academic discipline. The AACI fellowship will provide a one-year non-renewable grant to support post-doctoral training to individuals who have completed at least one year of training in any field of oncology and have at least one year of training remaining at an AACI member institution. Interested candidates should forward a letter of support from their mentor and their 4-page NIH biosketch to Gillian Todd by Friday, December 13.
Internal Deadline: December 13
External Deadline: February 3, 2014

AACR-Thomas J. Bardos Science Education Awards for Undergraduate Students

The AACR is pleased to offer AACR-Thomas J. Bardos Science Education Awards for Undergraduate Students for participation in two consecutive AACR Annual Meetings. Available to full-time, third-year undergraduate students majoring in science, these two-year awards are intended to inspire young science students to enter the field of cancer research and provide a unique educational opportunity for these students in the development of their careers in science.
Deadline: December 13

Audrey Meyer Mars International Fellowships in Clinical Oncology

The purpose of the Audrey Meyer Mars International Fellowship in Clinical Oncology is to provide one year of advanced training in clinical oncology at participating cancer centers in the United States to qualified physicians and dentists from other countries, particularly countries where advanced training is not readily available. Applications for training in basic cancer research will not be accepted for the award. Training will be conducted at one of the United States National Cancer Institute designated cancer centers participating in the program, including the Case Comprehensive Cancer Center. 
Deadline: February 1, 2014


5th Annual NCRM Scientific Retreat

Registration is open for the 5th Annual NCRM Scientific Retreat that will be held Monday, December 2 at the Museum of Contemporary Art (MOCA). This year's retreat will showcase the many scientific highlights in stem cell and regenerative medicine happening within NCRM as well as engage in interactive panel discussions that will develop into new ideas for promising projects of tomorrow.

The retreat will conclude with poster presentations, and all attendees are invited to enjoy a cocktail reception while gathering around a network of leaders in stem cell and regenerative medicine. All are invited to submit abstracts to be included in the NCRM Retreat Poster Sessions. Please submit your abstract using the online registration form.


Pilot Grants: Opportunities for Developing Patient-Derived Xenografts
Deadline: November 15

Alex's Lemonade Stand Foundation Innovation Awards
LOI Deadline: November 11
Application Deadline: March 3, 2014

Prostate Cancer Foundation 2014 Young Investigator Award
Deadline: November 13

Robert Wood Johnson Foundation Health Policy Fellows
Deadline: November 13

A Survivorship Action Partnership – United States of America (ASAP USA)
Deadline: November 13

Melanoma Research Alliance Young Investigator Awards
Proposal Deadline: November 13

Melanoma Research Alliance Established Investigator Academic-Industry Partnership Awards
Proposal Deadline: November 13

Burroughs Wellcome Fund Innovation in Regulatory Science Award
Deadline: November 18

Caring for Carcinoid Foundation-AACR Grant for Carcinoid Tumor and Pancreatic Neuroendocrine Tumor Research
Application Deadline: November 19

Kure It-AACR Grant for Kidney Cancer Research
Application Deadline: November 19

Pilot Grants: Use of Tumor Genomic Evaluation for Clinical Decision-Making
Deadline: December 2

Sidney Kimmel Foundation Scholar Award
Deadline: December 4

Sidney Kimmel Foundation Translational Science Award
Deadline: December 4

Alex's Lemonade Stand Foundation Epidemiology Grants
Deadline: December 16

Ohio Brain Tumor SPORE Working Group Pilot Grants
Deadline: December 16

Conquer Cancer Foundation of ASCO Medical Student Rotation for Underrepresented Populations
Deadline: December 17

Conquer Cancer Foundation of ASCO Resident Travel Award for Underrepresented Populations (RTA)
Deadline: December 17

DOD Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: December 19
Application Deadline: January 9, 2014

Ohio Brain Tumor SPORE Working Group Career Development Scholars Training Program
Deadline: December 23

2014 CTSC Annual Pilot Grant Funding
Deadline: January 15, 2014

Radiological Society of North America Research Seed Grants
Deadline: January 15, 2014

International Association for the Study of Lung Cancer Fellowship and Young Investigators Programs
Deadline: January 16, 2014

Radiological Society of North America Research Medical Student Grants 
Deadline: February 1, 2014

Dan David Prize Scholarships
Deadline: February 28, 2014

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

Pilot Grants: Planning for Multi-Investigator Proposals
Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) – Revision to Enhance the Collection of Cervical Cancer Screening Data (U54)(RFA-CA-14-001)

Notice of Change in Application Due Date for PAR-13-371 "Planning for a National Center for Particle Beam Radiation Therapy Research (P20)(NOT-CA-14-001)"

Amendments to NOT-CA-13-019 "Request for Information on Proposed NCI Policy Ensuring Public Availability of Results from NCI-Supported Clinical Trials" (NOT-CA-14-005)

Notice of Change in Application Due Date for PAR-13-294, "Advanced Development of Informatics Technology (U24)" (NOT-CA-14-007)

NCI Community Oncology Research Program (NCORP) Community Sites (UM1)(RFA-CA-13-013)

Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) – Revision to Enhance the Collection of Cervical Cancer Screening Data (U54)(RFA-CA-14-001)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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November 11

Visiting Professor Seminar
Peter Kurre, MD
Associate Professor, Pediatrics Hem/Onc
Director, Bone Marrow Failure Clinic
Oregon Health & Science University
Topic: Cell Membrane-derived Vesicles in AML-biology and Biomarker Potential
12 pm 3-136

Pathology Research Seminar Series
Hung-Ying Kao, PhD
Professor, Biochemistry
Topic: The Tumor Suppressor Protein PML in Metabolism and Oxidative Stress Response
12 pm WRB 1-413

LRI Seminar
Jorge DiPaola, MD
Associate Professor, Pediatrics
University of Colorado, Denver
Topic: Genomic Approaches to Disorders of Hemostatis
12:30 pm NE1-205 Cleveland Clinic

Physiology and Biophysics Seminar
Derek Taylor, PhD
Assistant Professor, Pharmacology
Topic: Structural and Biophysical Analysis of Telomere Assembly and Chromosome End Protection
4 pm SOM E-501 Cleveland Clinic

Imaging Center Seminar Series
Hiram Bezerra, MD, PhD
Assistant Professor, Cardiovascular Medicine
Medical Director, Cardiovascular Imaging Core Laboratory, UH Harrington Heart & Vascular Institute
David L. Wilson, PhD
Robert Herbold Professor of Biomedical Engineering and Radiology
Topic: Computer-assisted Vascular Assessments from Optical Coherence Tomography
5:15 pm BRB 105

November 12

Live-Cell Kinetic Imaging Applications Seminar and Demo
Kathryn Artymovich, PhD
Essen BioScience
Topic: IncuCyte Zoom™
9 am WRB 1-413

Molecular Genetics Departmental Seminar
Munir Tanas, MD
Postdoctoral Research Fellow, Rubin Lab, Molecular Genetics
Cleveland Clinic
Topic: WWTR1 is Constitutively Activated by Fusion to CAMTA1 in Epithelioid Hemangioendothelioma
9:30 am NE1-205 Cleveland Clinic

Cancer Biology Staff Candidate
Aaron LeBeau, PhD
Department of Radiology and Biomedical Imaging
University of California San Francisco
Topic: Targeting the Plasminogen Activation System for Imaging and Therapy in Cancer
11 am NC1-202 Cleveland Clinic

Medicine Grand Rounds
William Annable, MD 
Chief Quality Officer and Director, UH Quality Institute
University Hospitals
Topic: Quality
12 pm Kulas Auditorium, Lakeside 5th Floor

Immunology Seminar Series
Christina Antonopoulos
PhD Candidate, Dubyak lab, Pathology
Topic: Nigericin-Induced Activation of Non-Canonical ASC/Caspase-8 Signaling Platforms for IL-1β Processing in Murine BMDC
12 pm BRB 105

November 13

Hematology and Oncology Research Conference
Brenda Cooper, MD
Professor, Div. of Hem/Onc
Topic: Epigenetic Therapy for Acute Myelogenous Leukemia
8 am Lerner B-151

Genetics and Genome Sciences
Antonio Iavarone, MD
Professor, Neurology and Pathology
Institute for Cancer Genetics
Columbia University Herbert Irving Comprehensive Cancer Center
Topic: The Master Regulators and Drivers of Oncogenesis of Brain Tumors
11 am BRB 105

Immunology Seminar
Ritika Jaini, PhD
Research Associate, Immunology
Cleveland Clinic
Topic: Alpha Lactalbumin Targeted Breast Cancer Vaccine: Update
12 pm NC1-202 Cleveland Clinic

Breast Cancer Seminar
Khalid Sossey-Alaoui, PhD
Assistant Professor, Molecular Cardiology
Topic: Novel Wave3-directed Biomarkers and Therapeutic Options for Triple Negative Breast Cancer
Nicole Williams, MD
Fellow, Div. of Hem/Onc
Topic: Triple Negative Breast Cancer Clinical Trial
5:30 pm Robbins E301/Teleconference at Cleveland Clinic R3-002

November 14

Immunology Journal Club
Luis Muniz-Feliciano
Graduate Student, Subauste lab, Pathology/Immunology
Topic: Defective Sphingosine 1-Phosphate Receptor 1 (S1P1) Phosphorylation Exacerbates Th17-mediated Autoimmune Neuroinflammation
12 pm WRB 5-136

Visiting Professor Seminar
Alix Eden Seif, MD, MPH
Assistant Professor, Pediatrics 
University of Pennsylvania/Children's Hospital of Philadelphia
Topic: Paging Dr. Coley: Approaches to Breaking Immune Tolerance to Acute Lymphoblastic Leukemia
12 pm WRB 3-136

14th Annual Jerome I. Kleinerman, MD Lecture
Serpil C. Erzurum, MD
Chair, Pathology
Joint Staff with Respiratory Institute
Alfred Lerner Memorial Chair in Innovative Biomedical Research
CWRU/Cleveland Clinic
Topic: Pulmonary Hypertension: New Insights into Pathogeneses and Rationale for Therapies
4 pm WRB 1-413

Frontiers in Biological Sciences
Jorge Moscat, PhD
Director, Cell Death and Survival Networks Program
Scientific Director, Cancer Metabolism
Sanford-Burnham Medical Research Institute
Topic: Autophagy and Cancer Metabolism Reprogramming by the P62 Network
4 pm BRB 105

November 15

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Wearn 137/Breen Conference Rm.

BME Spotlight Seminar
Matthew Plow, PhD
Project Staff, Biomedical Engineering
Cleveland Clinic
Topic: Promoting Health and Wellness in People with Chronic Disabling Conditions Using Distance Learning Technology
11 am NA1-142 Cleveland Clinic

Cancer Center Seminar Series
Nissim Hay, PhD
Distinguished University Professor, Biochemistry and Molecular Genetics
University of Chicago at Illinois
Topic: Glucose Metabolism and Cancer Therapy
12 pm BRB 105

Cancer Center Research in Progress
Seunghwan Lim, PhD
Research Associate, Letterio lab, Pediatrics CWRU/UH
Topic: Development of a Novel 3D Microtissue Assay to Screen Inhibitors of Bone Metastatic Cancer
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Special Presentation: Hematology and Oncology Research Conference
November 20
Peter Senter, PhD
Vice President, Seattle Genetics, Inc.
Topic: The Past, Present, and Future of Antibody Drug Conjugates
4 pm WRB 2-136


13th Annual Multidisciplinary Genitourinary Oncology Course
November 19
InterContinental Hotel & Bank of America Conference Center

2014 Multidisciplinary Head and Neck Cancer Update 
February 14-15, 2014
Sanibel Harbour Marriott Resort & Spa
Fort Myers, FL