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October 14, 2013


BioMotiv Forms Second Spinoff Company with N.Y. Medical School
Crain's Business Cleveland - Oct 14, 2013
A local company that aims to help commercialize all sorts of pharmaceuticals has formed its second spinoff company, with the help of a medical school in New York City...One of the inventors behind the technology is Dr. Goutham Narla, who was recruited from Mount Sinai to University Hospitals Case Medical Center. The hospital system's Harrington Discovery Institute last year named him as its first Harrington Distinguished Scholar.

Cancer Patients, Survivors Turn Treatment Masks into Works of Art; Exhibit Runs Through Oct. 19
The Plain Dealer - Oct 11, 2013
A special exhibit of art work from local cancer patients, survivors, caregivers and cancer center employees is on display at the Beachwood Community Center Art Gallery. "Transformations: Honoring the Cancer Journey" opened last Sunday and runs through Oct. 19. It is a collaboration of theCleveland Clinic Taussig Cancer Institute, North Coast Cancer Foundation, The Gathering Place and University Hospitals Seidman Cancer Center, all of which provide art therapy for patients. The Gathering Place also offers art therapy for family members.

Trusting the Doctor
New York Times - Oct 10, 2013
Dr. Mikkael Sekeres writes about trusting the doctor.

Non-specific and Specific RNA Binding Proteins Found to be Fundamentally Similar
Lab Manager Magazine- Oct 10, 2013
But the Case Western Reserve team has published a new study in Nature showing that non-specific proteins actually do have the ability to be specific about where they bind to RNA – seeking out and binding with particular sequences of nucleotides. "There seems to be no such thing as specific or non-specific proteins; in essence, they are all specific. But they use their specificity differently," said Eckhard Jankowsky, PhD, co-senior author and professor in the Center for RNA Molecular Biology at the School of Medicine. "Our findings advance understanding of how proteins and nucleic acids control gene expression, which leads to insights into how this control is lost or altered in cancer, viral infections and other diseases."

Government shutdown, in its ninth day, continues to affect medical, scientific communities
The Plain Dealer - Oct 9, 2013
Less visible, however, is the effect that the shutdown is having on other medical and scientific research..."People I deal with every day at NCI in the development of cancer studies are not allowed to work," said Dr. Neal Meropol, chief of the division of hematology/oncology at University Hospitals Case Medical Center and Case Western Reserve University School of Medicine.


Jackson Lab Article Highlighted as Top Science in Mammary Cell News

An article by Dr. Mark Jackson, "Tumor Microenvironmental Signaling Elicits Epithelial-Mesenchymal Plasticity through Cooperation with Transforming Genetic Events", was highlighted as the week's top science in the October 10 edition of Mammary Cell News.


New Treatment Paradigms for Melanoma: A Case-based Discussion

Registration is open for New Treatment Paradigms for Melanoma: A Case-based Discussion, presented by the Case Comprehensive Cancer Center on Friday, October 18 at the Holiday Inn-Cleveland South. This conference is intended to provide melanoma caregivers a case-driven overview of current melanoma treatment paradigms. Case CCC faculty will discuss multidisciplinary approaches to the management of early and late stage melanoma.

The conference will cover the integration of new diagnostic and treatment technologies in care of the melanoma patient. In addition, the role of new targeted and immune therapies in the melanoma treatment as well as management of associated novel toxicities will be reviewed. A case-based discussion format will provide the opportunity audience interaction with the course faculty. CME credit is available.

Graft-versus-Host Disease (GvHD) National Symposium

Registration today the Graft-versus-Host Disease (GvHD) National SymposiumFriday, November 1 at the Embassy Suites Cleveland. This conference is intended to raise awareness about the signs and symptoms of GvHD, review cutting edge approaches to prevention and treatment, and highlight and promote research to further our understanding of its cause. The symposium will have two tracks: a scientifically rigorous one for physicians and practitioners, and a survivor track that will focus on challenges faced by BMT recipients and their families. CME credit is available.

Regulatory Affairs 101: Navigating the FDA Process

The CWRU SOM is hosting a workshop, Regulatory Affairs 101: Navigating the FDA Process, on Tuesday, November 12 from 1-5 pm in the Wolstein Research Building Auditorium. This workshop is designed to provide investigators with awareness of regulatory requirements and acceptable standards for the conduct of clinical trials and the protection of human subjects. The desired outcome from this workshop is that researchers be able to understand the function of the FDA and Investigator responsibilities for those holding Investigational New Drug (IND) applications or Investigational Device Exemptions (IDE) or those investigators conducting research under and IND or IDE. CME/CREC credits are available. Pre-registration is required.


American Association for Cancer Research

The American Association for Cancer Research (AACR) is accepting applications for the following funding opportunities:

  • The Breast Cancer Research Foundation-AACR Grants for Translational Breast Cancer Research represent a joint effort to promote and support innovative breast cancer research. The research proposed for funding must be translational in nature and must have direct applicability and relevance to breast cancer. These grants are available to full time, independent junior and senior investigators for breast cancer research projects designed to accelerate the discovery, development, and application of new agents to treat breast cancer and/or for pre-clinical research with direct therapeutic intent. 
    LOI Deadline: October 23
    Application Deadline: February 5, 2014
  • The Caring for Carcinoid Foundation-AACR Grant for Carcinoid Tumor and Pancreatic Neuroendocrine Tumor Research represents a joint effort to promote and support innovative cancer research. This grant is available to full time, independent junior and senior investigators to develop and study new ideas and innovative approaches that have direct application and relevance to carcinoid tumors or pancreatic neuroendocrine tumors. Proposed research may be in any discipline of basic, translational, clinical, or epidemiological cancer research.
    Application Deadline: November 19
  • The Kure It-AACR Grant for Kidney Cancer Researchrepresents a joint effort to promote and support innovative cancer research. This grant is available to full time, independent junior and senior investigators to develop and study new ideas and innovative approaches that have direct application and relevance to kidney cancer patients. Applicants with experience in other areas of cancer or biomedical/health science research who have promising ideas and approaches that can be applied to kidney cancer research are encouraged to apply.
    Application Deadline: November 19

Limited Submission Reminder: NIH Director's Early Independence Awards

The NIH Director's Early Independence Awards provide an opportunity for exceptional junior scientists, who have already established a record of innovation and research productivity, to have an accelerated entry into an independent research career. It is also an opportunity for research intensive institutions to invigorate their research departments by recruiting outstanding, early career scientists. Exceptional graduate students or clinicians nearing the completion of their PhD (or equivalent) or for clinicians (MD or equivalent) the end of their medical residency may contact appropriate Institutional scientific leaders to seek an appointment as an independent research scientist. Each institution may nominate TWO candidates.
LOI Internal Deadline: October 31
LOI External Deadline: December 31
Application Deadline: January 31, 2014

DOD Breast Cancer Research Program Postdoctoral Fellowship Award

Applications to the Fiscal Year 2013 Breast Cancer Research Program (BCRP) are being solicited for the Assistant Secretary of Defense for Health Affairs, Defense Health Program, by the U.S. Army Medical Research Acquisitions Activity. The Postdoctoral Fellowship Award supports exceptionally talented recent doctoral or medical graduates in pursuit of innovative, high-impact breast cancer research during their postdoctoral training and allows them to obtain the necessary experience for an independent career at the forefront of breast cancer research. Those individuals should be exceptionally talented scientists who have demonstrated that they are the “best and brightest” of their peers. Applicants for this award must exhibit a strong desire to pursue a career in breast cancer research. 
Pre-Application Deadline: December 19
Application Deadline: January 9, 2014

2014 CTSC Annual Pilot Grant Funding

The Clinical and Translational Science Collaborative (CTSC) of CWRU and the Case Coulter Translational Research Partnership (CCTRP) is accepting letters of intent for the 2014 CTSC Annual Pilot Grant Funding. The grant will support innovative translational research projects focused upon the invention, preclinical development and/or first in man studies of novel therapeutic agents, biomedical devices and diagnostics designed to address unmet clinical needs. The CTSC and CCTRP will provide seed money to faculty in multidisciplinary programs for Pilot Projects that will lead to efficient use of resources and support of inter-institutional, Clinical and Translational research in the City of Cleveland. Investigators in the basic science and clinical departments at CWRU, Cleveland Clinic, MetroHealth Medical Center, UHCMC and Louis Stokes Cleveland VA Medical Center are eligible. The PI is required to be a faculty member from one of the five CTSC partner institutions and eligible to be a PI for an NIH grant. 
Deadline: January 15, 2014

AACI Translational Cancer Research Fellowship

Association of American Cancer Institutes (AACI) is accepting applications for Translational Cancer Research Fellowships. The intent of the fellowship is to provide additional support to individuals who are engaged in any area of clinical and/or translational cancer research in order to further the development of their careers and enhance their future success in an academic discipline.

Applicants must be committed to advancing patient-oriented research. The successful applicant must:

  • Be sponsored by a mentor from an AACI member cancer center (one applicant permitted per institution)
  • Have completed at least one year of training in any oncology specialty and have at least one year of training remaining at an AACI member institution
  • Show innovation with potential for major scientific or clinical advancement
  • Have an appropriate mentor for the project
  • Hold a professional degree of MD, PhD, PharmD, DO, or MD/PhD or foreign equivalency
  • Not yet have been appointed to a faculty position, including that of instructor

Deadline: February 3, 2014


Limited Submission: NSF Major Research Instrumentation Program
Internal Deadline: October 14
External Deadline: January 23, 2014

Alex's Lemonade Stand Foundation Reach Award
Deadline: October 15

NCI Clinical Assay Development Program (CADP)
Deadline: October 15

RFA: Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Deadline: October 15

AACR G.H.A. Clowes Memorial Award
Nomination Deadline: October 17

Conquer Cancer Foundation Advanced Clinical Research Award in Breast Cancer
LOI Deadline: October 21
Application Deadline: December 2

Foundation for Women's Cancer Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 
Deadline: October 23

Foundation for Women's Cancer Dr. John L. Lewis, Jr./William F. O'Connor Foundation Research Prize
Deadline: October 23

Foundation for Women's Cancer Perlman Family CARE Lynch Syndrome Research Prize 
Deadline: October 23

Pancreatic Cancer Action Network-AACR Career Development Awards
Application Deadline: October 29

Doris Duke Clinical Scientist Development Award
Pre-proposal Deadline: October 31
Application Deadline: February 25, 2014

Fourth Annual DeGregorio Foundation Award for Cancers of the Upper GI Tract
Deadline: October 31

GI SPORE Scholars Training Program
Deadline: October 31

American Society of Hematology
Deadline: November 1

Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease Awards
Deadline: November 1

2013 Movember-Prostate Cancer Foundation Challenge Award
Deadline: November 6

Stand Up To Cancer (SU2C)-Farrah Fawcett Foundation Human Papillomavirus (HPV) Translational Research Team Grant
Deadline: November 6

Stand Up To Cancer (SU2C)-Lustgarten Foundation Pancreatic Cancer Convergence Dream Team Translational Research Grant
Deadline: November 7

Alex's Lemonade Stand Foundation Innovation Awards
LOI Deadline: November 11
Application Deadline: March 3, 2014

Prostate Cancer Foundation 2014 Young Investigator Award
Deadline: November 13

Robert Wood Johnson Foundation Health Policy Fellows
Deadline: November 13

Melanoma Research Alliance Young Investigator Awards
Proposal Deadline: November 13

Melanoma Research Alliance Established Investigator Academic-Industry Partnership Awards
Proposal Deadline: November 13

Burroughs Wellcome Fund Innovation in Regulatory Science Award
Deadline: November 18

Sidney Kimmel Foundation Scholar Award
Deadline: December 4

Sidney Kimmel Foundation Translational Science Award
Deadline: December 4

Alex's Lemonade Stand Foundation Epidemiology Grants
Deadline: December 16

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Cancer Education Grants Program (R25)(PAR-12-049)

Feasibility Studies to Build Collaborative Partnerships in Cancer Research (P20)(PAR-13-068)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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October 14

Pathology Pathology Research Seminar Series
Zhenghe John Wang, PhD
Associate Professor, Genetics and Genome Sciences
Topic: Targeting Mutant PI3K Specific Protein Interaction for Cancer Therapy
12 pm WRB 1-413

Physiology and Biophysics Seminar
Michael J. Decker PhD, RN
Associate Professor, Nursing
Topic: Hypoxia-induced Dopaminergic Dysfunction Contributes to Behavioral and Executive Impairment
4 pm SOM E-501

Skeletal Research Center 
Diego Correa MD, PhD
Senior Research Associate, Skeletal Research Center, Biology
Topic: Bone Marrow MSCs Regulate Cancer Cell Extravasation at their Perivascular Niche
4 pm Millis 123

October 15

Radiation Oncology Grand Rounds
Mitchell Machtay, MD
Professor and Chair, Radiation Oncology
Topic: ASCO 2013 Review- Radiation Oncology Related Studies
8:10 am Lerner Tower B-151

Immunology Seminar Series
Qing Yi, MD, PhD
Betsy B. de Windt Endowed Chair in Cancer Biology
Cleveland Clinic
Topic: Targeting the Microenvironment for Cancer Therapy: Insights from Myeloma
12 pm BRB 105

Department of Medicine Grand Rounds
Marcos de Lima, MD
Professor, Medicine-Hematology/Oncology
Topic: Cord Blood Transplantation
12 pm Kulas Auditorium

LRI Seminar
Ahmed Chadli, PhD
Associate Professor, Radiology
Georgia Regents University Cancer Center
Topic: Molecular Chaperones and Human Cancer: the Hsp90 Machine as a Molecular Target
4 pm NA5-03 Cleveland Clinic

October 16

Hematology and Oncology Research Conference
Afshin Dowlati, MD
Professor, Div. of Hem/Onc
Topic: Lung Cancer
8 am Lerner B-151

Immunology Seminar
Neetu Gupta, PhD
Assistant Professor, Immunology
CWRU/Cleveland Clinic
Topic: Faculty Update
12 pm NC1-202 Cleveland Clinic

October 17

Cancer Trainee Seminar
Mary Doherty
Jackson Lab, Pathology
Topic: The Role of IFNb as a Potential Inhibitory Modulator in Breast Cancer
Nathan Langer
Topic: Liver Cancer
12 pm WRB 3-136

Immunology Journal Club
Chairut Vareechon
Topic: The Rac Activator DOCK2 Regulates Natural Killer Cell-mediated Cytotoxicity in Mice Through the Lytic Synapse Formation
12 pm WRB 5-136

Prostate Cancer Working Group Seminar Series and Journal Club
Ao Zhang, PhD
Medical Student
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
Topic: A Novel Role for Rnase L in Restricting Retrotransposon Mobilization
3 pm NE1-205 Cleveland Clinic

Frontiers in Chemistry
Thomas Cech, PhD
Distinguished Professor, Chemistry and Biochemistry
University of Colorado at Boulder
Topic: From the RNA World to the RNP World: Ribozymes, Telomerase, and IncRNAs
5 pm Schmitt Lecture Hall, Pytte Science Center

October 18

Hematology/Oncology Fellows Conference/Curriculum Series canceled

Cancer Center Seminar Series canceled

New Treatment Paradigms for Melanoma: A Case-based Discussion
7:30 am Holiday Inn–Cleveland South
Pre-registration required

Taussig Cancer Institute Grand Rounds
Julie Brahmer, MD
Associate Professor, Oncology
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Topic: Harnessing the Immune System via Checkpoint Inhibitors for the Treatment for Non-Small Cell Lung Cancer
8 am R3/002-003 Cleveland Clinic

Cellular and Molecular Medicine Seminar Series
Rosalind A. Coleman, MD
Professor, Nutrition
University of North Carolina
Topic: Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis
10 am NC1-202 Cleveland Clinic

BME Spotlight Seminar
Kiyotaka Fukamachi, MD, PhD
Staff, Biomedical Engineering
Cleveland Clinic
Topic: Mechanical Circulatory Support: Left, Right, and Total
11 am NA1-142 Cleveland Clinic

University Hospitals Case Medical Center Candidate Seminar
Jesus Gonzalez Bosquet, MD, PhD
University of South Florida/Moffitt Cancer Center
Topic: Analysis of Ovarian Cancer Chemo-Response Using Publicly Available High Throughput Data
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


National GvHD Health Symposium
November 1
Embassy Suites Cleveland-Rockside


15th Annual ASTRO Review 2013
October 26
Embassy Suites Cleveland-Rockside

13th Annual Multidisciplinary Genitourinary Oncology Course
November 19
InterContinental Hotel & Bank of America Conference Center