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September 23, 2013


Making the Most of Media Coverage: The Case Comprehensive Cancer Center Experience 
AACI Commentary - Fall 2013
Stanton L. Gerson, MD, Director of the Case Comprehensive Cancer Center in Cleveland, discusses the Plain Dealer "Clues to Cancer" series and offers insight on how cancer centers can actively engage the media and encourage their continued interest in our work.

Functional Disability High Among Newly Diagnosed Older Breast Cancer Patients
Science Daily - Sept 23, 2013
Many older women with newly diagnosed breast cancer have difficulty accomplishing daily tasks, and African-Americans seem to be disproportionately affected. Those are the findings of a new study published early online in Cancer, a peer-reviewed journal of the American Cancer Society...Case Comprehensive Cancer Center member Cynthia Owusu, MD, MS, of the Case Western Reserve University School of Medicine and University Hospitals Case Medical Center in Cleveland, and her colleagues looked to see if there are racial differences in functional disability among older women with newly diagnosed breast cancer.

UH Seidman Cancer Center Breaks Ground on $30 Million Proton Therapy Center
The Herald - Sept 20, 2013
University Hospitals Seidman Cancer Center is breaking ground today on a $30 million proton therapy center, becoming one of an elite group of cancer centers in the country to offer this revolutionary technology..."There are several benefits to the delivery of radiation treatment with protons rather than photons for certain types of cancer, and we believe that this represents the next important advancement in radiation therapy. We are very excited to bring this leading-edge technology to Ohio," says Nathan Levitan, MD, President, UH Seidman Cancer Center..."Proton beams have unique physical properties that allow reduced doses of radiation to uninvolved normal tissue," says David Mansur, MD, Director of the Proton Therapy Center..."With the addition of a proton beam facility, we will be able to offer a full array of the latest in cutting edge radiotherapy," says Mitch Machtay, MD, Chairman of Radiation Oncology at UH Case Medical Center and Case Western Reserve University School of Medicine..."Building a proton therapy center is a huge boon for our patients as well as this entire region," says Stan Gerson, MD, Director of the UH Seidman Cancer Center and the Case Comprehensive Cancer Center.

Internationally Recognized Gene Therapy Investigators Release Book Chronicling Latest Advances in Cancer Treatment 
Newswise - Sept 19, 2013
The field of gene therapy promises to dramatically transform the treatment of disease, as well as fundamentally change the delivery of healthcare in the twenty-first century. With an acceleration of advances taking place in the field, a new book provides a comprehensive review of the field of gene-based therapeutics in an expanded third edition textbook that concentrates on advances in areas that were in their infancy when the last edition was published in 2002. The new book,Gene Therapy of Cancer Translational Approaches from Preclinical Studies to Clinical Implementation 3 (Elsevier Limited, Oxford, United Kingdom) is co-edited by internationally recognized investigators Stanton L. Gerson, MD, Director of the Case Comprehensive Cancer Center, and Edmund C. Lattime, PhD, Rutgers Cancer Institute of New Jersey.

Cleveland Clinic Forms Spinoff-company to Move its Breast Cancer Vaccine to Clinical Trials
Yahoo Health - Sept 18, 2013
A Cleveland Clinic researcher who has spent the past 11 years working on a breast cancer vaccine that would both prevent the disease and keep it from recurring has secured enough funding to move the drug to clinical trials. Vincent Tuohy, an immunologist at the Clinic's Lerner Research Institute and member of the Case Comprehensive Cancer Center, will head up the company, called Shield Biotech, as its chief science officer. Shield Biotech, so named because the vaccine it is developing will act as a defense against breast cancer, is a spinoff-company created by Cleveland Clinic Innovations, the commercialization arm of the hospital system.

Study Sheds New Light On The Appropriate Role Of Reduced-Intensity Donor Transplantation In Older MDS Patients
MDS Beacon - Sept 18, 2013
A recent international study provides new insights into the appropriate role of reduced-intensity donor stem cell transplantation in the care of older people with myelodysplastic syndromes...In an editorial that accompanied the study, Case Comprehensive Cancer Center member Dr. Mikkael Sekeres from the Cleveland Clinic explained that, with a median age of 64 years, the patients included in Dr. Koreth's study more closely resemble the MDS patients typically seen by physicians, compared to the patients previously included in studies investigating when to use stem cell transplantation for MDS.

Immune Checkpoint Inhibition in Renal Cell Carcinoma
OncLive - Sept 18, 2013
Dr. Brian Rini, professor and staff in the department of Solid Tumor Oncology at the Cleveland Clinic Taussig Cancer Institute and Co-Leader of the GU Malignancies Program at the Case Comprehensive Cancer Center, joins a panel of experts to discuss immune checkpoint inhibition in renal cell carcinoma.

Despite Headlines, Role of Statins in Cancer Prevention Far from Proven
Helio/Cardiology Today - Sept 2013
The potential role of statins in cancer prevention has received tremendous attention from the medical research community and the media..."It shows up on the news that statins are protective of cancer," Dale R. Shepard, MD, PhD, staff physician in the department of solid tumor oncology at Cleveland Clinic's Taussig Cancer Institute and Case Comprehensive Cancer Center, said in an interview..."There is strong experimental evidence that some of the actions of statins may occur independent of their lipid-lowering effects,"Mukesh K. Jain, MD, Case Comprehensive Cancer Center member, professor of medicine, and director of the Case Cardiovascular Research Institute at Case Western Reserve University, Cleveland, told Cardiology Today.


AACR Cancer Cancer Progress Report 2013

The American Association for Cancer Research (AACR) Cancer Progress Report 2013 is now available. As in past years, this year's Cancer Progress Report continues to highlight the many advances and breakthroughs in cancer treatment and emphasizes the need for continued investment in cancer research.

Dr. Nathan Berger served on the report's writing committee, and wrote the section on Energy Balance and Cancer, including the sections on Sleep, Obesity, Diabetes and Physical Activity.


Breast Cancer Program Meeting

The Breast Cancer Program will hold its first monthly working group meeting today, September 23 from 4-5 pm in Wolstein 3-136. This first meeting will be an introductory/business meeting to present the program structure, its leaders, focus groups, resources, etc, as well as a means to hear membership ideas to improve, strengthen, and build the program. Parking will be validated. Please RSVP to

Basic Sciences Program Mini-Retreat

The Basic Sciences Program, led by Drs. Clark Distelhorst and Alex Almasan, will be hosting a mini-retreat on Thursday, September 26 from 1-5 pm in WRB 3-136. The retreat will explain the restructuring of the program, feature short, informal presentations, and offer open time to discuss collaborations with other members. All members of the Basic Sciences Program are invited. Please RSVP by Monday, September 23 to


American Brain Tumor Association

The American Brain Tumor Association is accepting Letters of Intent for the Discovery Grants research program. These awards support high risk/high impact projects that have the potential to change current diagnostic or treatment paradigms for either adult or pediatric brain tumors. Discovery-driven science and proof-of-concept studies are encouraged to apply, particularly those with no or little history of previous funding. Priority will be given to concepts focused on experimental therapeutics and experimental therapeutics with reduced toxicities. 
LOI Deadline: October 9

Prostate Cancer Foundation

The Prostate Cancer Foundation is accepting applications for the following opportunities:

  • The new 2013 Movember-PCF Challenge Award will support one large-scale research project concerning metastatic prostate cancer over a duration of two years, providing up to a total of $1 million for one team. The award will focus on funding translational and clinical science to advance immunotherapy. Proposals must be from teams of at least three highly experienced investigators capable of providing unique scientific expertise to the solution of a significant problem in prostate cancer research. The team may be assembled from one institution or several institutions from across the globe, and must embed a young investigator as an integral contributor to the team.
    Deadline: November 6
  • The 2014 Young Investigator Award funds may be used flexibly to advance the career and research efforts of the awardee. Documentation of an equal in-kind level of support will be requested in the form of dedicated space, equipment, institutional overhead, core institutional resources, etc. The documentation required is a letter from the Cancer Center Director or Departmental Chairperson which confirms institutional commitment to the career development of the PCF Young Investigator while under the direct supervision of a Mentor. Mentorship is required for every PCF Young Investigator applicant and grantee.
    Deadline: November 13

Robert Wood Johnson Foundation

The Robert Wood Johnson Foundation Health Policy Fellowsprogram provides the nation's most comprehensive fellowship experience at the nexus of health science, policy and politics in Washington, D.C. It is an outstanding opportunity for exceptional midcareer health professionals and behavioral and social scientists with an interest in health and health care policy promoting the health of the nation. Fellows participate in the policy process at the federal level and use that leadership experience to improve health, health care and health policy.
Deadline: November 13

Sidney Kimmel Foundation for Cancer Research

The Sidney Kimmel Foundation for Cancer Research is accepting applications for the following funding opportunities:

  • The Kimmel Scholar Award funds accomplished young investigators dedicated to a career in cancer research. Applications are limited to those who achieved the equivalent rank of Assistant Professor on or after July, 2010. However, physicians who have both clinical and research responsibility are eligible if appointed on or after July, 2009. These awards are designed for researchers who do not yet have their own R01 funding. 
    Deadline: December 4
  • The Kimmel Translational Science Award is specifically for physicians engaged in translational science. Eligibility includes those with MD or equivalent degrees, who have achieved the rank of Assistant Professor on or after July, 2009. Candidates must not hold R01 funding for the laboratory component of their cancer research. Applicants must demonstrate a significant personal involvement in the laboratory component of the translational project described. The translational research may involve primarily animal studies but must include reasonable application to subsequent human investigation.
    Deadline: December 4


AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Nomination Deadline: September 26

Szent-Györgyi Prize for Progress in Cancer Research
Deadline: September 30

American Skin Association Research Scholar Award in Melanoma/Non-Melanoma Skin Cancer
Deadline: October 1

American Skin Association Research Grants
Deadline: October 1

American Skin Association Medical Student Grants Targeting Melanoma and Skin Cancer
Deadline: October 1

Brain Tumor Funders' Collaborative 
LOI Deadline: October 1
Application Deadline: December 15

Burroughs Wellcome Fund Career Awards for Medical Scientists
Deadline: October 1

CTSC Child Health Themed Pilot Awards
Deadline: October 1

Leukemia & Lymphoma Society Scholar
LOI Deadline: October 1
Application Deadline: October 15

Leukemia & Lymphoma Society Scholar in Clinical Research
LOI Deadline: October 1
Application Deadline: October 15

Leukemia & Lymphoma Society Special Fellow
LOI Deadline: October 1
Application Deadline: October 15

Leukemia & Lymphoma Society Special Fellow in Clinical Research
LOI Deadline: October 1
Application Deadline: October 15

Leukemia & Lymphoma Society Fellow
LOI Deadline: October 1
Application Deadline: October 15

AACR Award for Outstanding Achievement in Chemistry in Cancer Research
Nomination Deadline: October 3

AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship
Nomination Deadline: October 3

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Nomination Deadline: October 3

Melanoma Research Alliance Team Science Awards
LOI Deadline: October 7

Pancreatic Cancer Action Network-AACR Innovative Grants
LOI Deadline: October 7
Application Deadline: January 15, 2014

Pancreatic Cancer Action Network-AACR Research Acceleration Network (RAN) Grants
LOI Deadline: October 7
Application Deadline: January 15, 2014

BCRP Breakthrough Award
Pre-Application Deadline: October 8
Application Deadline: January 15, 2014

Robert Wood Johnson Foundation Scholars in Health Policy Research
Deadline: October 9

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Nomination Deadline: October 10

AACR Richard and Hinda Rosenthal Memorial Award
Nomination Deadline: October 10

Limited Submission: NSF Major Research Instrumentation Program
Internal Deadline: October 14
External Deadline: January 23, 2014

Alex's Lemonade Stand Foundation Reach Award
Deadline: October 15

NCI Clinical Assay Development Program (CADP)
Deadline: October 15

RFA: Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Deadline: October 15

AACR G.H.A. Clowes Memorial Award
Nomination Deadline: October 17

Foundation for Women's Cancer Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 
Deadline: October 23

Foundation for Women's Cancer Dr. John L. Lewis, Jr./William F. O'Connor Foundation Research Prize
Deadline: October 23

Foundation for Women's Cancer Perlman Family CARE Lynch Syndrome Research Prize 
Deadline: October 23

Pancreatic Cancer Action Network-AACR Career Development Awards
Application Deadline: October 29

Fourth Annual DeGregorio Foundation Award for Cancers of the Upper GI Tract
Deadline: October 31

American Society of Hematology
Deadline: November 1

Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease Awards
Deadline: November 1

Melanoma Research Alliance Young Investigator Awards
Proposal Deadline: November 13

Melanoma Research Alliance Established Investigator Academic-Industry Partnership Awards
Proposal Deadline: November 13

Burroughs Wellcome Fund Innovation in Regulatory Science Award
Deadline: November 18

Alex's Lemonade Stand Foundation Epidemiology Grants
Deadline: December 16

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Intent to Reissue the Funding Opportunity Announcement "Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (Parent T32)"(NOT-OD-13-115)

Revisions for Early-Stage Development of Informatics Technology (R01)(PAR-12-286)

Pre-application: Opportunities for Collaborative Research at the NIH Clinical Center (X02)(PAR-13-357)

Opportunities for Collaborative Research at the NIH Clinical Center (U01)(PAR-13-358)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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September 23

Breast Cancer Program Meeting
4 pm WRB 3-136

Physiology and Biophysics Seminar
John T. Williams, PhD
Senior Scientist, Vollum Institute
Oregon Health & Science University
Topic: Can a Kinetic Approach be Used to Understand Acute Opioid Receptor Desensitization?
4 pm SOM E-501

September 24

Special Seminar
Orian Shirihai, MD, PhD
Associate Professor, Medicine
Boston University 
Topic: Mitochondrial Dynamics Links Metabolic Diseases and Aging
4 pm NA5-03 Cleveland Clinic

September 25

Hematology and Oncology Research Conference
James R. Eckman, MD
Professor, Hematology and Medical Oncology
Emory University/Winship Cancer Institute
Topic: Improving Care in Sickle Cell Disease: Opportunities for the next 100 Years
8 am Lerner B-151

Pathology Grand Rounds
Robert Maitta, MD, PhD
Assistant Professor, Pathology
Topic: Parkinson's Synucleins and Their New Found Roles in Malignancy, Hematopoiesis and Immunodeficiency 
8 am Pathology Amphitheatre

Genetics and Genome Sciences Seminar
Goutham Narla, MD, PhD
Assistant Professor, Medicine and Transformative Molecular Medicine
Topic: Small Molecule Based Approaches to Reactivate Tumor Suppressor Genes for Cancer Treatment
11 am BRB 105

Immunology Seminar
Jack Keene, PhD
James B. Duke Professor, Molecular Genetics & Microbiology
Duke University
Topic: Global Dynamics of RNA Operons and Regulons in T Cells
12 pm NC1-202 Cleveland Clinic

September 26

Stem Cell Biology & Regenerative Medicine Seminar
Martin Ronis, PhD
Professor, Pediatrics
University of Arkansas for Medical Sciences
Topic: Role of Reactive Oxygen Species in Adipogenesis and the Development of Fatty Liver Disease
9 am NE1-205 Cleveland Clinic

Immunology Journal Club
Heather Clark
Graduate Student, Immunology/Pathology, Pearlman lab
Topic: Cochlin Produced by Follicular Dendritic Cells Promotes Antibacterial Innate Immunity
12 pm WRB 5-136

Basic Sciences Program Mini-Retreat
1-5 pm WRB 3-136

September 27

Hematology/Oncology Fellows Conference/Curriculum Series
Timothy O'Brien, MD
Director, MetroHealth Cancer Care Center
Chief, Div. of Hem/Onc
CWRU/MetroHealth Medical Center
Topic: Approach to Anemia
8 am Wearn 137/Breen Conference Rm

Taussig Cancer Institute Grand Rounds
Topic: M & M Conference
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series: 2013 Sidney H. Sachs, MD Lecture
Brian J. Czerniecki, MD, PhD
Rhoades-Harrington Associate Professor in Surgery
Co-Director, Rena Rowan Breast Center
University of Pennsylvania
Topic: Breast Cancer Vaccines: Fact or Fiction?
12 pm BRB 105

Case CCC Calendar

LRI Calendar


New Directions in Melanoma and Non-Melanoma Skin Cancers
October 18
Holiday Inn–Cleveland South

National GvHD Health Symposium
November 1
Embassy Suites Cleveland-Rockside


Society for Immunotherapy Regional Conference: Advances in Immunotherapy
October 4
Intercontinental Hotel and Conference Center at Cleveland Clinic

Point of Care Technologies for Cancer
October 7-9
Bethesda, MD