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September 16, 2013


Taussig Cancer Institute is Giving Clinic's Reach a Big Lift
Crain's Business Cleveland - Sept 16, 2013
Enter Dr. Brian Bolwell, a roughly 25-year veteran of the Clinic, who quietly stepped into Taussig's leadership role on an interim basis. Despite the Clinic launching a national search for Dr. Raghavan's permanent successor, the health system chose to stick with Dr. Bolwell – and for good reason...Last year, Dr. Nathan Levitan, president of UH's Seidman Cancer Center, told Crain's the region's aging population was one of the main reasons UH was expanding its cancer program so heavily...One of Taussig's burgeoning research interests – and one of the Clinic's overall – is in the area of personalized medicine and genomics. Within the last month, one of Taussig's newest docs, Dr. Davendra Sohal, started enrolling patients in a new study that allows select cancer patients to have their tumors analyzed individually for genetic mutations that might avail them of new treatments.

Cleveland Clinic Starts Trial of Cancer Drug to Treat Alzheimer's Disease
The Plain Dealer - Sept 12, 2013
Researchers at the Cleveland Clinic are taking a small step forward in testing for the first time on people a promising treatment for Alzheimer's disease – a cancer drug that rapidly removed the damaging protein implicated in the progression of the illness from the brains of mice in early trials at Case Western Reserve University...The Clinic researchers are building off the work of Case neurosciences professor Gary Landreth and his former graduate student, Paige Cramer, who is currently employed at pharmaceutical giant Merck & Co.

OSU to Open New Triple Negative Breast Cancer Study; Cleveland Clinic, UH and 6 Others Also to Enroll Patients
The Plain Dealer - Sept 12, 2013
By the end of the month, the Ohio State University James Cancer Hospital will open a Phase 2 clinical trial to test two drugs for the treatment of triple negative breast cancer — a very aggressive type of cancer with high rates of recurrence...Up to 40 patients will be enrolled in the trial. Along with OSU, eight other sites across the country – including the Cleveland Clinic Taussig Cancer Institute and University Hospitals Seidman Cancer Center — will offer the trial.

FDA Panel Backs Pre-Surgery Drug for Breast Cancer
New York Times - Sept 12, 2013
A federal advisory committee cleared the way on Thursday for the first approval of a cancer drug that would be used to treat patients before surgery to remove their tumors..."This is a historic moment," Dr. Mikkael A. Sekeres, an associate professor at the Cleveland Clinic who served as the chairman of the advisory committee, said immediately after the vote. "We are supporting the rapid movement of a highly active drug for metastatic cancer to the first-line setting, with the hope that women with earlier stages of breast cancer will live longer and better."

Biomarker May Predict Prostate Cancers Requiring Treatment 
Cancer Network - Sept 11, 2013
Researchers at Columbia University in New York City have now identified a 3-gene signature that could indicate whether a particular early-stage prostate cancer is indolent. .."These types of markers will, for the first time, give us the opportunity to measure biological features of cancer in the same patient, with multiple biopsies spread out over many years," said Eric Klein, MD, chairman, Glickman Urological and Kidney Institute at the Cleveland Clinic in Ohio.

Affordable Care Act implementation looms amid hope, speculation
Helio/HemOnc Today - Sept 10, 2013
A fee-for-service model of health care delivery – rather than the fee-for-value model envisioned under the ACA – contributed significantly to skyrocketing costs, said Brian J. Bolwell, MD, FACP, chairman of Cleveland Clinic's Taussig Cancer Institute...


Research on Leptin Receptor Highlighted in Mammary Cell News

An article by Dr. Ofer Reizes, titled Leptin Receptor Maintains Cancer Stem-Like Properties in Triple Negative Breast Cancer Cells, was recently highlighted in "Mammary Cell News". The authors tested the hypothesis that the Leptin Receptor (LEPR), expressed in mammary cancer cells, is necessary for maintaining cancer stem cell-like and metastatic properties. They silenced LEPR via shRNA lentivirus transduction and determined that expression of stem cell self-renewal transcription factors NANOG, SOX2, and OCT4 are inhibited. Co-authors on the study include Qiao Zheng, Lauren Banaszak, Sarah Fracci, Diana Basali, Sarah M Dunlap, Stephen D Hursting, Jeremy N RichAnita B Hjelmeland, Amit Vasanji, Nathan A Berger, and Justin D Lathia.


Basic Sciences Program Mini-Retreat

The Basic Sciences Program, led by Drs. Clark Distelhorst and Alex Almasan, will be hosting a mini-retreat on Thursday, September 26 from 1-5 pm in WRB 3-136. The retreat will explain the restructuring of the program, feature short, informal presentations, and offer open time to discuss collaborations with other members. All members of the Basic Sciences Program are invited. Please RSVP by Monday, September 23 to

Society for Immunotherapy Regional Conference: Advances in Immunotherapy

The Society for Immunotherapy's regional Advances in Immunotherapy program will be held October 4 at the Intercontinental Hotel and Conference Center at Cleveland Clinic. This CME-accredited program, sponsored by Cleveland Clinic Center for Continuing Medical Education in collaboration with the Case Comprehensive Cancer Center, is specifically designed for the entire unit of care involved in treating cancer. Through several lectures by leading cancer immunologists, this program will summarize central themes in research advances and approvals to facilitate understanding of more sophisticated principles of tumor immunology and immunotherapy, and promote appropriate clinical application. Registration deadline is September 25.


Brain Tumor Funders' Collaborative

The Brain Tumor Funders' Collaborative (BTFC) funding initiative intends to support a fuller characterization of long term survivors based on the physiological, genetic, and molecular characteristics of not just the tumor, but of the entire organism in which a disease occurs (e.g. immunological changes, altered metabolism). The BTFC believes this broad, holistic approach is critical for understanding patient management and for informing clinical trial designs in the highly heterogeneous, noisy background against which interventions are tested. The complicated nature of the problem addressed by this BTFC initiative and the relatively small numbers of long-term survivors indicates to the BTFC that successful applications will require multi-institutional collaborations and extended community outreach accrual efforts. 
LOI Deadline: October 1
Application Deadline: December 15

CTSC Child Health Themed Pilot Awards

The Clinical and Translational Science Collaborative (CTSC) at CWRU seeks applications for pilot research funding from faculty at CWRU, Cleveland Clinic, Metro Health Medical Center, University Hospitals Case Medical Center, and the Louis Stokes Veterans' Administration Medical Center. The primary goal of the Child Health Themed Pilot Award is to support and encourage collaborative research in clinical and translational medicine focused on child health that will lead to both external funding opportunities and new discoveries that will promote and advance child health. 
Deadline: October 1

Clinical Assay Development Program

The NCI Clinical Assay Development Program (CADP) is accepting applications from investigators seeking clinical assay development and validation resources. These resources are designed to assist with the development of assays that may predict therapy response or prognostic behavior of a diagnosed cancer, primarily for use in clinical trials. In addition to access to the Institute's assay and validation resources, approved projects will receive project management support.
Deadline: October 15


Alex's Lemonade Stand Foundation 'A' Award
Deadline: September 16

PCRP Health Disparity Research Award
LOI Deadline: September 18
Application Deadline: October 9

PCRP Clinical Consortium Award
LOI Deadline: September 18
Application Deadline: October 9

PCRP Prostate Cancer Pathology Resource Network (PCPRN or Network) Award
LOI Deadline: September 18
Application Deadline: October 9

PCRP Population Science Impact Award
LOI Deadline: September 18
Application Deadline: October 9

AACR-American Cancer Society Award for Research Excellence in Cancer Epidemiology and Prevention
Nomination Deadline: September 19

AACR Princess Takamatsu Memorial Lectureship
Nomination Deadline: September 19

AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Nomination Deadline: September 26

Szent-Györgyi Prize for Progress in Cancer Research
Deadline: September 30

American Skin Association Research Scholar Award in Melanoma/Non-Melanoma Skin Cancer
Deadline: October 1

American Skin Association Research Grants
Deadline: October 1

American Skin Association Medical Student Grants Targeting Melanoma and Skin Cancer
Deadline: October 1

Burroughs Wellcome Fund Career Awards for Medical Scientists
Deadline: October 1

Leukemia & Lymphoma Society Scholar
LOI Deadline: October 1
Application Deadline: October 15

Leukemia & Lymphoma Society Scholar in Clinical Research
LOI Deadline: October 1
Application Deadline: October 15

Leukemia & Lymphoma Society Special Fellow
LOI Deadline: October 1
Application Deadline: October 15

Leukemia & Lymphoma Society Special Fellow in Clinical Research
LOI Deadline: October 1
Application Deadline: October 15

Leukemia & Lymphoma Society Fellow
LOI Deadline: October 1
Application Deadline: October 15

AACR Award for Outstanding Achievement in Chemistry in Cancer Research
Nomination Deadline: October 3

AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship
Nomination Deadline: October 3

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Nomination Deadline: October 3

Melanoma Research Alliance Team Science Awards
LOI Deadline: October 7

Pancreatic Cancer Action Network-AACR Innovative Grants
LOI Deadline: October 7
Application Deadline: January 15, 2014

Pancreatic Cancer Action Network-AACR Research Acceleration Network (RAN) Grants
LOI Deadline: October 7
Application Deadline: January 15, 2014

BCRP Breakthrough Award
Pre-Application Deadline: October 8
Application Deadline: January 15, 2014

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Nomination Deadline: October 10

AACR Richard and Hinda Rosenthal Memorial Award
Nomination Deadline: October 10

Limited Submission: NSF Major Research Instrumentation Program
Internal Deadline: October 14
External Deadline: January 23, 2014

Alex's Lemonade Stand Foundation Reach Award
Deadline: October 15

RFA: Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Deadline: October 15

AACR G.H.A. Clowes Memorial Award
Nomination Deadline: October 17

Foundation for Women's Cancer Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 
Deadline: October 23

Foundation for Women's Cancer Dr. John L. Lewis, Jr./William F. O'Connor Foundation Research Prize
Deadline: October 23

Foundation for Women's Cancer Perlman Family CARE Lynch Syndrome Research Prize 
Deadline: October 23

Pancreatic Cancer Action Network-AACR Career Development Awards
Application Deadline: October 29

Fourth Annual DeGregorio Foundation Award for Cancers of the Upper GI Tract
Deadline: October 31

American Society of Hematology
Deadline: November 1

Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease Awards
Deadline: November 1

Melanoma Research Alliance Young Investigator Awards
Proposal Deadline: November 13

Melanoma Research Alliance Established Investigator Academic-Industry Partnership Awards
Proposal Deadline: November 13

Burroughs Wellcome Fund Innovation in Regulatory Science Award
Deadline: November 18

Alex's Lemonade Stand Foundation Epidemiology Grants
Deadline: December 16

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Intent to Publish an Announcement for Availability of Funds for Administrative Supplements for HIV/AIDS Implementation Science in PEPFAR Settings (NOT-AI-13-061)

Request for Information (RFI) on Directions and Needs for Cancer Nanotechnology Research and Development (NOT-CA-13-017)

Academic Research Enhancement Award (Parent R15)

NIH Support for Conferences and Scientific Meetings (Parent R13/U13)

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September 16

Biochemistry Student Seminar Series
Shuang Guo
Biochemistry Student
Topic: The Tumor Suppressor PML in a Novel Regulator of Antioxidative Response
12 pm Wood W428

Pathology Research Seminar Series
Xiao-Fan Wang, PhD
Donald and Elizabeth Cooke Professor of Experimental Oncology
Professor, Pharmacology and Cancer Biology
Duke University
Topic: Tumor Microenvironment: MicroRNAs and Metastasis
12 pm WRB 1-413

Physiology and Biophysics Seminar
Robert Hsiu-Ping Chow, MD, PhD
Associate Professor, Physiology & Biophysics
Zilkha Neurogenetic Institute, Keck School of Medicine
Topic: Stimulus-secretion Coupling in Neuroendocrine Cells
4 pm SOM E-501

Imaging Center Seminar Series
Hannah Gilmore, MD
Director, Surgical Pathology
Assistant Professor, Pathology
Topic: Pathologic Markers of Prognosis in Invasive Breast Cancer
Anant Madabhushi, PhD
Director, Center for Computational Imaging and Personalized Diagnostics 
Associate Professor, Biomedical Engineering
Topic: Computerized Image Based Predictor of Aggressiveness in ER+ Breast Cancers
5:15 pm BRB 105

September 17

Radiation Oncology Grand Rounds
Janice Lyons, MD
Associate Professor, Radiation Oncology
Topic: Early Stage Breast Cancer: Management of Lymph Nodes Fractionation Schedules & Technique
8:10 am Lerner Tower B-181

September 18

Hematology and Oncology Research Conference
Topic: TBD
8 am Lerner B-151

MetroHealth Research Symposium
8 am - 6 pm Rammelkamp 170 MetroHealth Medical Center

Immunology Seminar
Gregory Plautz, MD
Professor, Immunology and Pediatric Hem/Onc
CWRU/Cleveland Clinic
Topic: Faculty Update
12 pm NC1-202 Cleveland Clinic

September 19

Cancer Trainee Seminar
James Ignatz-Hoover
PhD Student, Wald lab, Pathology
Topic: Understanding GSK3 Beta's role in AML
Peter Oppelt, MD
MD Resident
Topic: Adult Hematologic Malignancies
12 pm WRB 3-136

Immunology Journal Club
Jessica Perez
Student, Immunology
Topic: The Scavenger Receptor SCARF1 Mediates the Clearance of Apoptotic Cells and Prevents Autoimmunity
12 pm WRB 5-136

Prostate Cancer Working Group Seminar Series and Journal Club
Goutham Narla, MD, PhD
Assistant Professor, Medicine and Transformative Molecular Medicine
Topic: Small Molecule Based Activation of PP2A Targets AR Degradation in Prostate Cancer
3 pm NE1-205 Cleveland Clinic

September 20

Cancer Center Seminar Series canceled

George Stark 80th Birthday Celebration Symposium
8 am - 5 pm Bunts Auditorium Cleveland Clinic

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Wearn 137/Breen Conference Rm

Taussig Cancer Institute Grand Rounds
Charles Ryan, MD
Associate Clinical Professor, Medicine- Hem/Onc
University of California San Francisco
Topic: Optimizing the Development of Androgen Synthesis Inhibitors in Castration Resistant Prostate Cancer
8 am R3/002-003 Cleveland Clinic

Case CCC Calendar

LRI Calendar


New Directions in Melanoma and Non-Melanoma Skin Cancers
October 18
Holiday Inn–Cleveland South

National GvHD Health Symposium
November 1
Embassy Suites Cleveland-Rockside


Point of Care Technologies for Cancer
October 7-9
Bethesda, MD