Stan Gerson, MD
Director, Case CCC
Sequester Impact on Biomedical Research - Every Voice Counts
The effects of the sequester on the research community are becoming increasingly apparent, so we must take the opportunity to speak up and remind our political leaders that the reduced funding is having detrimental effects on biomedical research progress.
Last week, an open letter from 185 university leaders, including CWRU President Barbara R. Snyder, in the Washington, DC newspaper Politico, urged President Barack Obama and Congress to restore funding for research and education. Today, a Plain Dealer article highlighted the research of Dr. Yu-Chung Yang, a recent recipient of a Bridge Grant from the American Society of Hematology. Concerned that reduced NIH funding means reduced progress in cancer research, ASH is now offering funds to researchers whose work is considered promising, but was not scored well enough to secure funding from the NIH. As Dr. Yang pointed out in the article, it is not just her research that will suffer, but also that of the future generation of scientists and researchers.
The above examples are but a step in the right direction. Calling attention to the importance of reinstating funding levels for the NIH is the responsibility of every member of the cancer center and its community. Please take the time to voice your concerns and personal examples of just how the sequester will have a negative effect on your research progress. Write a short note to members of the Ohio caucus to reiterate how important this issue is to each of us, to our region, and to our national priorities.
Contact Information for Ohio Senators and Representatives:
Sen. Robert Portman
Sen. Sherrod Brown
Rep. Steve Chabot (District 1)
Rep. Brad Wenstrup (District 2)
Rep. Joyce Beatty (District 3)
Rep. Jim Jordan (District 4)
Rep. Bob Latta (District 5)
Rep. Bill Johnson (District 6)
Rep. Bob Gibbs (District 7)
Rep. John Boehner (District 8
Rep. Marcy Kaptur (District 9)
Rep. Michael Turner (District 10)
Rep. Marcia Fudge (District 11)
Rep. Pat Tiberi (District 12)
Rep. Tim Ryan (District 13)
Rep. David Joyce (District 14)
Rep. Steve Stivers (District 15)
Rep. Jim Renacci (District 16)
CWRU Researcher Benefits from National Grant Program Created to Protect Hematology Work from Budget Cuts (video)
The Plain Dealer - Aug 5, 2013
The American Society of Hematology is was to award a second round of ASH Bridge Grants this summer to scientists who have hit a roadblock in getting funding for their research. In April, Yu-Chung Yang, a professor in the department of biochemistry at Case Western Reserve University School of Medicine and Case Comprehensive Cancer Center, was one of 17 scientists (out of 45 applicants, all members of the society), awarded $100,000 as part of the first round of the awards, conceived last year.
University Hospitals Seidman Cancer Center expands to Parma hospital
The Plain Dealer - Aug 1, 2013
University Hospitals Seidman Cancer Center opened a new site today at Parma Community General Hospital, which will now provide Parma patients access to advanced cancer therapy and clinical trials...Dr. Stan Gerson, director of the UH Seidman Cancer Center, said in an interview that this kind of coordinated care is "dramatically different" from how cancer treatment normally works in a community setting. Instead of seeing one physician at a time, patients will benefit from multiple experts from a variety of disciplines early on.
NCI Panel: Stop Calling Low-Risk Lesions 'Cancer'
MedScape - Jul 30, 2013
"I agree with the premise of the article, and I agree in general with their suggestions," said Mikkael Sekeres, MD, director of the leukemia program at the Cleveland Clinic in Ohio, and chair of the US Food and Drug Administration Oncology Drug Advisory Committee, who was asked by Medscape Medical News for comment. Low-risk myelodysplastic syndrome, which is classified by the World Health Organization as a neoplasma, is another example of a condition in need of a nomenclature adjustment, he said. Patients are often diagnosed with myelodysplastic syndrome as a result of a routine blood test taken by the primary care doctor; as a result, they live with a diagnosis of cancer but typically receive no treatment because the condition is low risk and without symptoms, Dr. Sekeres explained. "This is a very similar situation but is less well known" than the scenarios involving prostate-specific antigen testing or ductal carcinoma in situ found with mammography, he noted.
Schiemann and Carlin Attempt to Further Understand Triple Negative Breast Cancers; Research Highlighted in Cancer Research Breaking Advances
Triple-negative breast cancers (TNBCs) are an unusually aggressive and metastatic form of breast cancer for which there are currently no FDA-approved treatments. Interestingly, TNBCs typically express robust levels of epidermal growth factor receptor (EGFR), whose clinical targeting has proven to be unremarkable for reasons that remain mysterious. A collaborative paper published in the Journal of Biological Chemistry by the Carlin and Schiemann laboratories identified an innovative mechanism that partially explains the ineffectiveness of EGFR inhibitors to alleviate TNBCs. Using a novel EGFR-driven model of TNBC development and metastatic progression, the authors found that primary tumor growth depends upon their ability to stimulate the proto-oncogene Stat3, an event that transpired through a Src-dependent EGFR signaling axis and could be inactivated by administration of EGFR antagonists. Importantly, inducing TNBCs to undergo an epithelial-mesenchymal transition (EMT) program not only enhanced their metastatic aggressiveness, but also switched the manner through which they activate Stat3 during metastasis. Indeed, post-EMT TNBCs relied upon fibronectin present in the tumor microenvironment to activate a β1 integrin:FAK/Pyk2:JAK2 signaling axis operant in stimulating Stat3 and their metastatic outgrowth. Unlike their pre-EMT counterparts, post-EMT TNBCs were insensitive to EGFR antagonists and instead acquired sensitivity to JAK2 and Stat3 inhibitors. Collectively, this study identified an important mechanism whereby TNBCs exploit EMT programs to bypass growth factor signaling pathways that are essential for tumor initiation in favor of tumor microenvironmental signals critical for their metastatic progression. Nikolas Balanis, Michael Wendt, Barbara Schiemann, John Wang,Bill Schiemann, and Cathleen Carlin contributed to this publication.
Team from the Center for Computational Imaging and Personalized Diagnostics Receives Coulter Translational Award
Drs. Pallavi Tiwari and Anant Madabhushi have been awarded a Coulter Translational Award for their project,NeuroRadVision: Image based risk assessment for presence of recurrent tumor or radiation effects on MRI. The project involves developing novel image analytic approaches to distinguish radiation effects from recurrent brain tumors, a significant clinical problem in the management of brain tumor patients. Clinical collaborators on this project include Drs.Lisa Rogers, Leo Wolansky, and Andrew Sloan.
Avon Safety Net Program
The Avon Safety Net Program supports institutions and organizations that have traditionally cared for uninsured, at-risk, low-income and minority patients to further our commitment of enabling medically underserved women and men to access post-screening diagnostics and care.
LOI Deadline: September 12
Application Deadline: October 24
Leukemia & Lymphoma Society (LLS) Career Development Program (CDP)
The Leukemia & Lymphoma Society Career Development Program offers the opportunity for researchers to take part in basic, clinical or translational research to help treat leukemia, lymphoma and myeloma.
PREVIOUSLY ANNOUNCED OPPORTUNITIES
American Cancer Society Institutional Research Grant (IRG) Awards
Uniting Against Lung Cancer Legacy Program
AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Case CCC Protocol Specific Research Support (PSRS)
International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
NIH BULLETIN – Notices and Funding Opportunities
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
HELP US HELP YOU!
If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!
Send items to email@example.com.
Special Chalk Talk: Division of Hematology and Oncology
Hisashi Tanaka MD, PhD
Assistant Professor, Molecular Genetics
Topic: Gene Amplification Mechanisms as Targets of Cancer Diagnosis and Therapy
9 am WRB 2-136
Immunology Invited Speaker Seminar Series
Peter Heeger, MD
Mt. Sinai Hospital
Topic: Bridging Innate and Adaptive T Cell Immunity Through Complement
12 pm NC1-202 Cleveland Clinic
Wanfeng Yu, PhD
Research Associate, Eng lab, Genomic Medicine Institute
Topic: Regulation of SDHD and PTEN Subcellular Trafficking and Tumor Suppression Function
12:30 pm NE1-205 Cleveland Clinic
DNA Damage/Repair Speaker Series
Youwei Zhang, PhD
Assistant Professor, Pharmacology
4 pm WRB 3-136
Hematology and Oncology Division Research Conference
Jakub Tolar, MD, PhD
Associate Professor, Pediatrics - Div. of Blood and Marrow Transplantation
University of Minnesota
Topic: More Than Skin Deep: Stem Cell Gene Therapy for Lethal Genodermatosis
8 am Lerner Tower B-151
Cancer Center Research in Progress will resume in September
Taussig Cancer Institute Grand Rounds will resume in September
Hematology and Oncology Fellows Conference
8 am Wearn 137
UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS
ADDITIONAL UPCOMING SEMINARS & EVENTS
MSC 2013: Adult Stem Cell Therapy & Regenerative Medicine
Cleveland Marriott Downtown at Key Center
Molecular Genetics Guest Speaker
Myron R. Szewczuk, PhD
Department of Biomedical and Molecular Sciences
Topic: Neu1 Sialidase and Matrix Metalloproteinase-9 Cross-talk Regulates Nucleic Acid-induced Endosomal TOLL-like Receptor-7 and -9 Activation, Cellular Signaling and Pro-inflammatory Responses
9:30 am NE1-205 Cleveland Clinic
National GvHD Health Symposium
Embassy Suites Cleveland-Rockside