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May 6, 2013


CWRU School of Medicine Researchers Discover New Target for Personalized Cancer T2herapy
E Science News - May 5, 2013
A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results...By disrupting the mutated signaling pathway, the Case Western Reserve team, led by John Wang, PhD, inhibited the growth of cancer cells, opening the possibility to new cancer therapies..."This research will impact the field by focusing us on new targets for treating and preventing metastasis in patients in a many different types of human cancers," said Stanton Gerson, MD.

FDA Panel Votes Down Two Cancer Drugs
MedPage Today - May 2, 2013
"I cannot picture how I would be able to talk with a patient about treating him or her with a drug, tivozanib, that would allow that person to live without progression longer but to possibly die faster than if I treated that person with another available renal cell carcinoma drug," committee Chair Mikkael Sekeres, MD, MS, of the Cleveland Clinic's Taussig Cancer Institute, said.

Increased Exposure Likely Driving 'Epidemic' of HPV-associated Cancers
Helio/HemOnc Today - Apr 25, 2013
"The expectation is that the vaccines will prevent oropharyngeal cancers in future, but we are not there yet,"David Adelstein, MD, a staff physician in the department of solid tumor oncology at Cleveland Clinic's Taussig Cancer Institute, told HemOnc Today.

Clues to Cancer

For the past week, the Plain Dealer has been running Clues to Cancer, a series of stories about Phase I clinical trials at Seidman Cancer Center and the Case Comprehensive Cancer Center. The articles attempt to show various aspects of clinical trials, from patients and their families, to the doctors and nurses who treat the patients, and the researchers searching for a cure.

Clues to Cancer: Plain Dealer series follows patients as they join doctors on road to discovery

Vince Petro gets some encouraging news, keeps his focus forward

Scared but resolute, Vince Petro enters the unknown of Phase 1 clinical trial 

Nurses study patients' critical connections during Phase 1 clinical trials

Side effects of drugs push Margene Manning to the limit

Margene Manning must decide if signing on for Phase 1 clinical trials is worth sacrifice

The road to enrollment in Phase 1 clinical trials is a long one

Who pays for drugs used in Phase 1 clinical trials? 

Keeping clinical trials on track is a challenge to doctors, nurses

A weakening Carl Gehringer Jr. can't continue with new treatments

New trials give 2 lymphoma and leukemia patients will to keep fighting

Centers put high value on doing their own research

20 years of collaboration and lab work precede testing in humans

Larry Tremaglio and Georgine Riley consider trials, say, 'Why not?'

Minority patient participation crucial to Phase 1 clinical trials

Despite a losing battle, John Soley hopes his case helps others

Janet Whitney was open to all options for treatment

For Barbara Malone and other patients, success often comes in modest steps 

2-way street of inspiration in a grandmother and her family

What is learned during clinical trials and how patients benefit


2013 Theodore J. Castele, MD Lecure

The Department of Radiology will present the 21st Annual Theodore J. Castele, MD Lecure on Tuesday, May 21 in the Wolstein Research Building Auditorium. Guest speaker Sanjiv Sam Gambhir, MD, the Virginia & DK Ludwig Professor of Cancer Research and Chair of Radiology at Stanford University, will present, Novel Strategies for the Earlier Detection of Cancer. The evening will start with award presentations at 5 pm followed by the lecture at 5:30 pm. Please RSVP to by May 13.

Race for the Place- Join Our Team!

The Race for the Place, an event that benefits the Gathering Place, will be held Sunday, June 2 at Beachwood Place Mall. The Case CCC has created a team. Click here to join the team or to show your support by making a donation. Contact Gillian Todd for more information.

Impact of Genomics on Cancer Diagnosis and Treatment: Open Drug Policy Forum

The Case CCC, in partnership with five other Midwest comprehensive cancer centers, will convene a public forum on the emerging revolution in genetic testing known as precision or personalized medicine on Monday, June 10. Experts from the government, pharmaceutical and insurance industries, public health sector, and the cancer research community will participate in dynamic lectures and discussions to consider the complexities of integrating genetic testing into cancer care.

This forum is free and open to the public. Pre-registration is required:

Planned discussions include:

Keynote Address: How Genomics May Transform Cancer Care
Arul Chinnaiyan, MD, PhD

How to Validate Genomic Based Decision Making in Cancer
Moderator: Sanford Markowitz, MD, PhD
Panel Members: Carl Morrison, DVM, MD; Robert J. Penny, MD, PhD; Michael A. Tainsky, PhD

Implications for Public Policy-Discussion with Congressional Representatives and NCI/FDA
Moderator: Donald L. Trump, MD
Panel Members: James H. Doroshow, MD; Stanton L. Gerson, MD; Elizabeth A. Mansfield, PhD; Anthony Murgo, MD, MS; Richard Schilsky, MD

Challenges for the FDA and CMS: Drug Approval and Reimbursement for Off-label Drug Use for Cancer Genetic Alteration
Moderator: Richard Schilsky, MD
Panel Members: James H. Doroshow, MD; Martine George, MD, MSc; Elizabeth A. Mansfield, PhD; Neal Meropol, MD; Anthony Murgo, MD, MS

Genomics and Drug Reimbursement: White Paper from the Cleveland Forum 2013
Moderator: Stanton L. Gerson, MD
Panel Members: Brian Bolwell, MD; Richard Schilsky, MD; Donald L. Trump, MD; Max S. Wicha, MD

Implementing Proper Use of Genomic Tests to Select Therapeutics
Moderator: Lyndsay Harris, MD
Panel Members: James H. Doroshow, MD, Candace S. Johnson, PhD; Patricia M. LoRusso, DO

More information is on the Cancer Center site.

Annual Scientific Retreat

The Annual Cancer Center Scientific Retreat will commence the evening of Thursday, July 11 with a speaker and reception in the Wolstein Research Building Auditorium. The Retreat will continue the next day, Friday, July 12, at Corporate College East. The agenda is still be finalized. Details will be circulated soon!


Ovarian Cancer Research Program

Applications to the Fiscal Year 2013 (FY13) Ovarian Cancer Research Program (OCRP) are being solicited for the Assistant Secretary of Defense for Health Affairs, Defense Health Program, by the U.S. Army Medical Research Acquisitions Activity:

  • The overarching goal of the Ovarian Cancer Academy is to develop successful, highly productive ovarian cancer researchers in a collaborative research training environment. The Ovarian Cancer Academy Award - Early-Career Investigator is soliciting additional Early-Career Investigators to join the existing Academy.
  • The OCRP Pilot Award supports conceptually innovative, high-risk/high-reward research that could ultimately lead to critical discoveries or major advancements that will drive the field of ovarian cancer research forward. The proposed research should include a testable hypothesis based on strong scientific rationale and serve as a catalyst to expand or modify current thinking about and/or approaches in ovarian cancer research.
  • The OCRP Teal Innovator Award supports a visionary individual from any field principally outside of, but not exclusive of, ovarian cancer to focus his/her creativity, innovation, and leadership on ovarian cancer research.

Pre-Application Deadline: June 12
Application Deadline: August 28


Dr. Andrew Sloan Receives Award for

Last month, Dr. Andrew Sloan received the Mahaley Award for Clinical Research in Neuro-Oncology by the National Brain Tumor Foundation at the 81st Annual Meeting of the American Association of Neurological Surgeons for his work targeting glioma stem cells. Dr. Sloan gave a presentation, Targeting Glioma Stem Cells in GBM: A Phase O/II study of Hedgehog Pathway inhibitor GDC-0449, on which he collaborated with Drs. Charles Nock, Amber Kerstetter, John PinkJeremy Rich, MD, Naoko Takebe, Robert Miller, Michael Prados, and Stuart Grossman.

BME Student Wins Second Place at Imaging Conference

Asha Singanamalli, a second year student in Biomedical Engineering mentored by Dr. Anant Madabhushi, was runner-up for best student paper at SPIE Medical Imaging 2013. She beat out 40 other student papers and seven other finalists to receive second place for her paper, Identifying in Vivo Dce MRI parameters correlated with ex Vivo quantitative microvessel characteristics: a radiohistomorphometric approach. The paper introduces a framework called radiohistomorphometry that allows for identification of novel DCE MRI biomarkers for distinguishing prostate cancer patients who need aggressive treatment from those who may be more suited for active surveillance.


Call for Pilot Projects: Barrett's Esophagus Translational Research Network (BETRNet)‌
Deadline: May 10

Limited Submission: The Brain Research Foundation Scientific Innovations Award in Neuroscience
Internal Deadline: May 10
External Deadline: July 1

Harrington Discovery Institute Scholar-Innovator Grant Program
LOI Deadline: May 15
Application Deadline: August 2

NCI Provocative Questions
LOI Deadline: May 20
Applications Deadline: June 20

Ovarian Cancer Research Fund Program Project Development Grants
LOI Deadline: May 23
Application Deadline: August 23

Ovarian Cancer Research Fund Liz Tilberis Scholars Early Career Awards
LOI Deadline: May 23
Application Deadline: August 23

Ovarian Cancer Research Fund Ann Schreiber Mentored Investigator Award
LOI Deadline: May 23
Application Deadline: August 23

Lasker Clinical Research Scholars Program
LOI Deadline: May 24
Application Deadline: June 24

Lustgarten Foundation
Concept Deadline: May 24
Full Application Deadline: August 9

Chris4Life Colon Cancer Pilot Study Grant Program
Deadline: June 1

James S. McDonnell Foundation Postdoctoral Fellowship Award in Studying Complex Systems
Deadline: June 14

Request for Proposals for Pilot Collaborations with LMICs in Global Cancer Research or Global Health Research at NCI-Designated Cancer Centers‌
Deadline: June 14

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Request for Information (RFI) Regarding Opportunities for Cancer-relevant Innovative Technologies with Transformative Potential (NOT-CA-13-009)

Short Courses on Innovative Methodologies in the Behavioral and Social Sciences (R25)(RFA-OD-13-009)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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May 6

Pathology Dissertation Defense
Gaurav Choudhary
PhD Candidate, Almasan Lab, Pathology
CWRU/Cleveland Clinic
Topic: Targeting BCL–2 family proteins by BH3 Mimetics
1 pm WRB 1-413

Physiology and Biophysics Seminar
John E. Hall, PhD
Arthur C. Guyton Professor & Chair, Physiology and Biophysics
Associate Vice Chancellor for Research
University of Mississippi Medical Center
Topic: Pathophysiology of Hypertension in Obesity/Metabolic Syndrome
4 pm SOM/Robbins Building, E-501

May 7

Radiation Oncology Grand Rounds
Jerald Katcher, MD
Radiation Oncology
Topic: Peer Review, Improving Quality and Safety in Radiation Oncology
8:10am Lerner Tower B-181

Cancer Biology Invited Speaker Seminar
Youwei Zhang, PhD
Assistant Professor, Pharmacology
Topic: Cell Cycle Checkpoint Regulation and Cancer Therapy
11 am NC1-202 Cleveland Clinic

Medicine Grand Rounds
Michael DeGeorgia, MD
Professor, Neurology
Director, Center for Neurological Care
Director, Center for Music and Medicine
Co-Director, Cerebrovascular Center Neurological Institute
Topic: Cleveland, Rock and Roll, and the Legacy of University Hospitals
12 pm Kulas Auditorium, Lakeside 5th Fl.

Immunology Seminar Series
Bradley Martin
PhD Candidate, Li Lab, Pathology
Topic: A Novel Molecular Mechanism of Inflammasome Regulation
12 pm WRB 1-413

Immunology Seminar
Ed Palmer, MD, PhD
Professor, Experimental Transplantation Immunology, Biomedicine
University of Basel
Topic: Affinity Thresholds in Tolerance and Autoimmunity
2 pm NC1-202 Cleveland Clinic

Physiology and Biophysics CAPT Seminar
Bing-Cheng Wang, PhD
Professor, Medicine-Nephrology
Topic: EphA2 Paradox: Oncogene or Tumor Suppressor Gene?
4 pm SOM / Robbins Building, E-501

May 8

Hematology and Oncology Division Research Conference
Neelesh Sharma, MD
Assistant Professor, Div. of Hem/Onc
Topic: EGFR TKI in the Treatment of Non Small Cell Lung Cancer 
8 am Lerner B-151

May 9

Immunology Journal Club
Elizabeth Liu
PhD Student, Pathology
Topic: Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice
12 pm WRB 5-136

May 10

Hematology and Oncology Fellows Conference
Topic: TBD
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Patrick Wen, MD
Director, Center for Neuro-Oncology
Professor, Neurology
Harvard University/Dana Farber Cancer Institute
Topic: Novel Therapies for Gliomas: How Can We Do Things Better?
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Glenn Merlino, PhD
Chief, Laboratory of Cancer Biology & Genetics
Deputy Director, Center for Cancer Research
Topic: Modeling Melanoma Initiation and Progression in the Mouse
12 pm BRB 105

Cancer Center Research in Progress
Tony Scott
Graduate Student, Wang, Lab, Genetics and Genome Sciences
Topic: Role of Paxillin Tyrosine-88 Phosphorylation in Colorectal Cancer Development
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Breast Cancer Conference
May 24
Hilton Cleveland East

Impact of Genomics on Cancer Diagnosis and Treatment: Open Drug Policy Forum
June 10
9 am - 3 pm Wolstein Research Building Auditorium
Draft Agenda‌

Annual Cancer Center Scientific Retreat
July 11-12


Advantages of Multiple Modalities, Image Fusion, and Data Analysis in Preclinical Small Animal Imaging
May 8
8:30 am - 2 pm DoubleTree by Hilton- The Tudor Arms Hotel

National GvHD Health Symposium
November 1