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April 29, 2013


‌Stan Gerson, MDStan Gerson, MD
Director, Case CCC

Impact of Genomics on Cancer Diagnosis and Treatment

The Open Drug Policy Forum that we are planning for June 10 could not be more timely, with the topic of precision medicine receiving prominent attention. It will be the focus of a discussion at the Association of American Cancer Institutes (AACI) annual meeting in September, and was also featured in Sunday's New York Times. This article discussed the efforts being made by cancer centers to perfect their ability to sequence patient's genes, leading to more precise and effective medical treatments. The article raised questions that will be discussed at our upcoming forum, such as how to implement the proper use of genomic tests to select therapeutics, and how to pay for the genomic sequencing tests.

As part of this forum, we hope to go beyond these issues to address additional consequences of this genomic revolution, such as regulatory and reimbursement policies. Experts from the government, pharmaceutical and insurance industries, public health sector, and the cancer research community will participate in dynamic lectures and discussions to consider the complexities of integrating genetic testing into cancer care. Please plan on attending this free forum and help Ohio to get a head start on addressing the complex issues associated with these developments that may transform how we diagnose and treat cancer.


Supplements Don't Help With Prostate Cancer - Apr 29, 2013
Dr. Eric Klein, chair of the Glickman Urological and Kidney Institute at the Cleveland Clinic in Ohio, said the new review's findings are consistent with past research.

Nurses Study Patients' Critical Connections During Phase 1 Clinical Trials: Clues to Cancer
Plain Dealer - Apr 29, 2013
Whether patients are on a clinical trial for a few weeks or a few months, the relationships they forge with the people who care for them are often intense. It's part of what Dr. Stanton Gerson, director of University Hospitals Seidman Cancer Center, calls a "high hover index."

Margene Manning Must Decide if Signing on for Phase 1 Clinical Trials is Worth Sacrifice: Clues to Cancer
Plain Dealer - Apr 29, 2013
Cancer patients who agree to take part in Phase 1 trials — early studies of experimental drugs and therapies to gauge their safety in humans — are a special breed, says Dr. Afshin Dowlati, director of the Developmental Therapeutics Program at Case Comprehensive Cancer Center since 2007...Manning's oncologist referred her to Dr. Neal Meropol, chief of the division of hematology/oncology at UH and associate director for clinical programs at UH Seidman. Meropol told Manning that it might be time to start thinking about a clinical trial...

Scared but Resolute, Vince Petro Enters the Unknown of Phase 1 Clinical Trial: Clues to Cancer
Plain Dealer - Apr 28, 2013
"The most innovative and cutting-edge concepts are being tested in Phase 1," says Dr. Neal Meropol, chief of the division of hematology/oncology at UH and CWRU Medical School, and associate director for clinical research...One week after Petro learned how serious his brain cancer was, and one day before his 59th birthday, he returned to UH to have the sutures removed and meet with Dr. Mitchell Machtay, chairman of radiation oncology at UH Case Medical Center and CWRU School of Medicine, and UH neuro-oncologist Dr. Lisa Rogers.

Vince Petro Gets Some Encouraging News, Keeps his Focus Forward: Clues to Cancer
Plain Dealer - Apr 28, 2013
"How are we doing here?" Dr. Hillard Lazarus asked Petro right before injecting him with the biopsy needle...In September, Petro once again traveled from his home in Ashtabula to see radiologist Dr. Mitchell Machtay...

God and Doctor
New York Times (blog) - Apr 25, 2013
Blog entry by Dr. Mikkael Sekeres...When he came to the hospital, he did not look well.

You might think that everyone with a recent leukemia diagnosis appears ill, but that isn't true. Some go to their primary care doctor with vague complaints of feeling tired or of having a cold, and a few hours after having their blood drawn are stunned to receive a phone call that they must get to the hospital immediately. Some get "stuck" in the Kübler-Ross stage of denial, refusing to believe they have leukemia even after they've received chemotherapy for it, or in the bargaining stage, negotiating for just one more bone marrow biopsy to confirm the diagnosis...

Prostate Cancer Risk Doubles in Patients with Lynch Syndrome
Helio/HemOnc Today - Apr 24, 2013
Perspective by Dr. Jorge Garcia...Prostate cancer remains the most common malignancy in men in North America. Despite major technical and therapeutic advances observed during the past decade – such as chemoprevention and early diagnosis...

Vitamin E Can Protect Against Liver Disease Associated With Obesity
Nature World News - Apr 24, 2013
Researchers found the role of vitamin E on liver in a group of obese mice by accident. Danny Manor, an associate professor at the Case Western Reserve University School of Medicine, said that the team was actually practicing surgical techniques on liver tissue while they were investigating the effect of vitamin E deficiency in the central nervous system of mice.


Race for the Place- Join Our Team!

The Race for the Place, an event that benefits the Gathering Place, will be held Sunday, June 2 at Beachwood Place Mall. The Case CCC has created a team. Click here to join the team or to show your support by making a donation. Contact Gillian Todd for more information.

Annual Scientific Retreat

The Annual Cancer Center Scientific Retreat will commence the evening of Thursday, July 11 with a speaker and reception in the Wolstein Research Building Auditorium. The Retreat will continue the next day, Friday, July 12, at Corporate College East. The agenda is still be finalized. Details will be circulated soon!


SPORE Supplement: Call for Projects

The NCI has announced an opportunity for SPOREs to apply for funding for a two-year supplemental project, at $150K per year direct costs, that is directed at the study of microbial pathogens and cancers. Dr. Sanford Markowitz, PI of the Case GI Cancer SPORE, has asked that any investigators with project ideas that fit the above description and are focused on GI cancer send a short email to

Computational Genomic Epidemiology of Cancer Postdoctoral Training Program

The Case CCC invites applications to its 2-3 year NCI-funded Computational Genomic Epidemiology of Cancer Postdoctoral Training Program. The program combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum.

This program is designed to prepare trainees for careers as independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics and computer science. Cancer researchers obtaining training will have the skills vital to decipher the complex pathways comprising genetic and environmental risk factors for disease, and will ultimately be able to provide clinicians and their patients with valuable information for the prevention and treatment of cancer.

Candidates with an MD, PhD, or MD/PhD degree, strong quantitative skills, and an interest in a career in genetics research are encouraged to apply.


2013 Health Care Hero Awards

Congratulations to the following Cancer Center members were recognized by Crain's Cleveland Business as 2013 Health Care Heroes:

  • Physician Category, research: Dr. Michael Lederman
  • Advancements in Healthcare Category, individual: Dr. Goutham Narla

Recipients will be honored at a luncheon later this May.

NSG Gamma Mice Available for Purchase

The Athymic Animal & Xenograft Core Facility has a large number of NSG gamma mice available for purchase. The mice are a variety of weights and ages, up to 12 weeks of age. If interested, please contact Pamela Steel at and provide PI name, phone number, protocol number, and speedtype.


Call for Pilot Projects: Barrett's Esophagus Translational Research Network (BETRNet)‌
Deadline: May 10

Limited Submission: The Brain Research Foundation Scientific Innovations Award in Neuroscience
Internal Deadline: May 10
External Deadline: July 1

Harrington Discovery Institute Scholar-Innovator Grant Program
LOI Deadline: May 15
Application Deadline: August 2

NCI Provocative Questions
LOI Deadline: May 20
Applications Deadline: June 20

Ovarian Cancer Research Fund Program Project Development Grants
LOI Deadline: May 23
Application Deadline: August 23

Ovarian Cancer Research Fund Liz Tilberis Scholars Early Career Awards
LOI Deadline: May 23
Application Deadline: August 23

Ovarian Cancer Research Fund Ann Schreiber Mentored Investigator Award
LOI Deadline: May 23
Application Deadline: August 23

Lasker Clinical Research Scholars Program
LOI Deadline: May 24
Application Deadline: June 24

Lustgarten Foundation
Concept Deadline: May 24
Full Application Deadline: August 9

Chris4Life Colon Cancer Pilot Study Grant Program
Deadline: June 1

James S. McDonnell Foundation Postdoctoral Fellowship Award in Studying Complex Systems
Deadline: June 14

Request for Proposals for Pilot Collaborations with LMICs in Global Cancer Research or Global Health Research at NCI-Designated Cancer Centers
Deadline: June 14

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)

Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)

Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice to Extend the Expiration Date for PAR-10-165 "National Cancer Institute (NCI) Cancer Education and Career Development Program (R25)" (NOT-CA-13-008)

Limited Competition: Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (D43)(PAR-13-126)

Paul Calabresi Career Development Award for Clinical Oncology (K12)(/PAR-13-201)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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April 29

Pathology Research Seminar Series
Channing Der, PhD
Kenan Distinguished Professor, Pharmacology
University of North Carolina
Topic: Abherrant Ras and Rho Signaling in Cancer: drugging the undruggable
12 pm WRB 1-413

Pathology Dissertation Defense
Ashley Rettew
PhD Candidate, Greenfield Lab, Pathology
Topic: Specific Receptor Tyrosine Kinases Promote the Metastatic Phenotype of Osteosarcoma
1 pm WRB 5-136

Cancer Center Faculty Candidate
Pierre Alexandre Vidi, PhD
Postdoctoral Trainee, Basic Medical Sciences
Purdue University
Topic: Tissue Architecture and Nuclear Organization in the DNA Damage Response
3 pm WRB 1-413

Physiology and Biophysics Seminar
John J. Lemasters, MD, PhD
Professor, Biochemistry & Molecular Biology and Pharmaceutical Sciences
Director, Center for Cell Death, Injury and Regeneration
Medical University of South Carolina
Topic: Iron Translocation from Lysosomes to Mitochondria in Oxidative Stress-Induced Injury
4 pm SOM/Robbins Building, E-501

April 30

Radiation Oncology Grand Rounds
Tithi Biswas, MD
Radiation Oncology
Topic: Triple Negative Breast Cancer
8:10am Lerner Tower B-181

Molecular Genetics Departmental Seminar
Takaaki Watanabe, PhD
Postdoctoral Research Fellow, Tanaka Lab, Molecular Genetics
Cleveland Clinic
Topic: Structural Evolution of Myc Amplicons Through Replication Fork Stalling and Template Switching in Human Cancer Cells
9:30 am NE1-205 Cleveland Clinic

Cancer Biology Visiting Professor Seminar
Gabriel Nuñez, MD
Paul de Kruif Endowed Professor, Pathology
University of Michigan
Topic: Control of Enteric Pathogens by Host Immunity and the Microbiota
11 am NC1-202 Cleveland Clinic

Medicine Grand Rounds
Yngve Falck-Ytter, MD
Div. of Gastroenterology and Liver Disease
Topic: Is Hepatitis C Birth Cohort Screening a Cancer Prevention Strategy?
12 pm Kulas Auditorium, Lakeside 5th Fl.

Immunology Seminar Series
Charles Su
PhD Candidate, Fairchild Lab, Pathology
Topic: Prolonged Ischemia Increases the Early Infiltration and Activation of CD8+ Memory T Lymphocytes in Cardiac Allografts
Tom Richardson
PhD Candidate, Harding Lab, Pathology
Topic: Mycobacterium Tuberculosis Promotes Macrophage Alternative Activation Through TLR2 and ERK Signaling
12 pm BRB 105

May 1

Hematology and Oncology Division Research Conference
Cheng Chee, MD
Assistant Professor, Div. of Hem/Onc
Topic: Methylated Vimentin DNA in Blood as a Novel Biomarker in Colorectal Cancer
8 am Lerner B-151

May 2

Department of Stem Cell Biology and Regenerative Medicine Seminar
Carlo Croce, MD
John W. Wolfe Chair in Human Cancer Genetics
Chairman, Molecular Virology
Ohio State University
Topic: Causes and Consequences of microRNA Dysregulation in Cancer
1 pm NE1-205 Cleveland Clinic

Sternlicht Lectureship in Cancer Biology and Pharmacology
Lewis Cantley, PhD
Director, Cancer Center at Weill Cornell Medical College and NewYork-Presbyterian Hospital
Topic: PIK3 and Cancer Cell Metabolism
3 pm BRB 105

May 3

Taussig Cancer Institute Grand Rounds canceled

Hematology and Oncology Fellows Conference
Basem William, MD 
Assistant Professor, Div. of Hem/Onc
Topic: Autologous Hematopoietic Stem Cell Transplantation for Lymphomas
8 am Wearn 137/Breen Conference Rm.

Cancer Center Seminar Series
Nancy E. Davidson, MD
Director, University of Pittsburgh Cancer Institute and UPMC Cancer Center
Associate Vice Chancellor for Cancer Research
University of Pittsburgh
Topic: Epigenetics and Breast Cancer
12 pm BRB 105

Cancer Center Research in Progress
David Wald, MD, PhD
Assistant Professor, Pathology
Topic: Discovery of a Novel HdmX Inhibitor for Cancer
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Breast Cancer Conference
May 24
Hilton Cleveland East

Impact of Genomics on Cancer Diagnosis and Treatment: Open Drug Policy Forum
June 10
9 am - 3 pm Wolstein Research Building Auditorium
Draft Agenda‌

Annual Cancer Center Scientific Retreat
July 11-12


Advantages of Multiple Modalities, Image Fusion, and Data Analysis in Preclinical Small Animal Imaging
May 8
8:30 am - 2 pm DoubleTree by Hilton- The Tudor Arms Hotel

National GvHD Health Symposium
November 1