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April 15, 2013


Case Western Reserve Team Finds Way to Convert Skin Cells to Brain Cells Destroyed by Cerebral Palsy, Multiple Sclerosis
The Plain Dealer - Apr 14, 2013
Scientists at Case Western Reserve University School of Medicine have developed a technique in mice models to convert skin cells to the types of brain cells that are found damaged in patients with cerebral palsy and multiple sclerosis.

The next step, said Dr. Paul Tesar, the lead investigator in the study, is to see if the technique can be applied to human cells.

New Technique 'Lights Up' Brain Tumor
Fox News - Apr 12, 2013
At the Cleveland Clinic, her brain surgeon, Dr. Michael Vogelbaum, associate director of the Brain Tumor and Neuro-Oncology Center, used an experimental technique, which helps the surgeon see the tumor better and remove more of it.

Stem Cell Proliferation and Differentiation Observed within Hydrogel
Science Codex - Apr 11, 2013
"We think that control over local biomaterial properties may allow us to guide the formation of complex tissues," said Eben Alsberg, an associate professor of Biomedical Engineering at Case Western Reserve. "With this system, we can regulate cell proliferation and cell-specific differentiation into, for example, bone-like or cartilage-like cells"

Cyberknife Therapy Offers Benefits for Recurring Gyn Cancers
Oncology Report Digital Network - Apr 10, 2013
"This is the first phase II clinical trial of robotic radiosurgery in the gynecologic oncology space. Robotic Cyberknife radiation therapy does definitely provide clinical benefit to your patients," commented lead author Dr. Charles Kunos, a radiation oncologist with the Case Comprehensive Cancer Center in Cleveland and the Summa Cancer Institute in Akron, Ohio.

More Months of Life with Colorectal Cancer
dailyRx - Apr 8, 2013
Neal Meropol, MD, American Society of Clinical Oncology (ASCO) Cancer Communications Committee member and gastrointestinal cancers expert, told dailyRx news, "Many people don't realize that even after colon cancer has spread to the liver, it may still be curable. But cure requires that a surgeon can remove the liver tumors. This study involved patients whose liver tumors were initially too extensive to be removed by a surgeon."...


Dr. Nathan Berger Made New Member of NCI Study Section

Dr. Nathan Berger was selected as a new standing member of the NCI Basic Mechanisms of Cancer Therapeutics study section.

CWRU Team Takes First at National Cancer Institute Competition

On April 7, the Center for Computational Imaging and Personalized Diagnostics (CCIPD) team won first place in the National Cancer Institute-sponsored Grand Challenge on Segmentation of Prostatic Structures from MRI.

The first-place Case Western Reserve University team was represented by graduate student Robert Toth, research associate Mirabela Rusu and biomedical engineering faculty member Anant Madabhushi.

Comment Period Extended: Development of ODP Strategic Plan for Fiscal Years 2013-2018

The opportunity to provide input on the NIH Office of Disease Prevention (ODP) Strategic Plan for Fiscal Years 2013-2018 has been extended from April 14 to April 30, 2013. Responses must be submitted via an online Request for Information.

Respondents are encouraged to review and provide comments on a set of draft strategic priorities, which will ultimately outline the priorities for the Office over the next five years and highlight the ODP's role in advancing prevention research at the NIH. Respondents can also provide recommendations on steps the ODP could take to improve processes the NIH uses to solicit, review, and administer prevention research grants and cooperative agreements.

Interested parties may include, but are not limited to, prevention researchers in academia and industry, health care professionals, patient advocates and advocacy organizations, scientific or professional organizations, federal agencies, and other members of the public. Organizations are strongly encouraged to submit a single response that reflects the views of their organization and membership as a whole. Please email with any questions.


Case CCC Clinical Research Retreat

The 2013 Case CCC Clinical Research Retreat will take place Monday, April 22 from 5-7 pm in the Wolstein Research Building Auditorium. The agenda will focus on scientific issues and initiatives. Register today.

Case Gastrointestinal Cancers SPORE Retreat

Registration is open for the Case Gastrointestinal Cancer SPORE Retreat, scheduled for Friday, April 26 in Dively Rm. 202. The agenda includes discussion on Colon Cancer; Barrett's Esophagus; Cancer Metastasis; Cancer Prevention; and Cancer in Minorities. There will be a poster session at noon. All trainees and fellows are invited to submit poster abstracts to Dr. John Wang at by Monday, April 15. A cash prize will be awarded to the best poster.

Comparative Effectiveness Research: From All Angles

Comparative Effectiveness Research: From All Angles, the third annual two-day conference (also available for course credit EPBI/MPHP 467 Section 100), will be held May 22-23, at CWRU. Many expert speakers are featured covering: methods, policy, physician practice, public acceptance, economics of payment, health care organizations, and ethical/legal/social issues. This is followed the next week,May 29-31, by a 3-day crash course in Cost-Effectiveness Analysis (EPBI/MPHP 467 Sections 101-102).Discounted registration for interns, residents, fellows, full-time students not taking for academic credit and employees of public health departments. For more information about the program and registration fees, or how to register for academic credit, visit:

Race for the Place- Join Our Team!

The Race for the Place, an event that benefits the Gathering Place, will be held Sunday, June 2 at Beachwood Place Mall. The Case CCC has created a team. Click here to join the team or to show your support by making a donation. Contact Gillian Todd for more information.


Ovarian Cancer Research Fund

The Ovarian Cancer Research Fund is accepting applications for the following opportunities:

LOI Deadline: May 23
Application Deadline: August 23

James S. McDonnell Foundation Postdoctoral Fellowship Award in Studying Complex Systems

The James S. McDonnell Foundation Postdoctoral Fellowship Award in Studying Complex Systems provides fellowships to students completing doctoral training in the multidisciplinary field of complex systems science. The JSMF Fellowship is intended to provide students in the final stages of completing a PhD degree more leeway in identifying and securing postdoctoral training opportunities in complex systems research.

Deadline: June 14

Computational Genomic Epidemiology of Cancer Postdoctoral Training Program

The Case CCC invites applications to its 2-3 year NCI-funded Computational Genomic Epidemiology of Cancer Postdoctoral Training Program. The program combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum.

This program is designed to prepare trainees for careers as independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics and computer science. Cancer researchers obtaining training will have the skills vital to decipher the complex pathways comprising genetic and environmental risk factors for disease, and will ultimately be able to provide clinicians and their patients with valuable information for the prevention and treatment of cancer.

Candidates with an MD, PhD, or MD/PhD degree, strong quantitative skills, and an interest in a career in genetics research are encouraged to apply.


Call for Pilot Projects: Barrett's Esophagus Translational Research Network (BETRNet)
Deadline: May 10

Harrington Discovery Institute Scholar-Innovator Grant Program
LOI Deadline: May 15
Application Deadline: August 2

NCI Provocative Questions
LOI Deadline: May 20
Applications Deadline: June 20

Lasker Clinical Research Scholars Program
LOI Deadline: May 24
Application Deadline: June 24

Lustgarten Foundation
Concept Deadline: May 24
Full Application Deadline: August 9

Chris4Life Colon Cancer Pilot Study Grant Program
Deadline: June 1

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

FAQs for Costing of NIH-Funded Core Facilities (NOT-OD-13-053)

Revisions to P50 Awards for Research on Detection of Pathogen-Induced Cancer (DPIC)(P50)(PAR-13-170)

Revisions to P01 Awards for Research on Detection of Pathogen-Induced Cancer (DPIC) (P01)(PAR-13-171)

Revision Applications to R01 Awards for Research on Detection of Pathogen-Induced Cancer (DPIC)(R01)(PAR-13-172)

Revision Applications to U01 Awards on Detection of Pathogen-Induced Cancer (DPIC) (U01)(PAR-13-173)

Revision Applications to P50 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P50)(PAR-13-174)

Revision Applications to P01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P01(PAR-13-175)

Revision Applications to U01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (U01)(PAR-13-176)

Revision Applications to R01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (R01)(PAR-13-177)

Collaborative Research in Integrative Cancer Biology (U01)(PAR-13-184)

Image-guided Drug Delivery in Cancer (R01)(PAR-13-185)

Imaging and Biomarkers for Early Cancer Detection (R01)(PAR-13-189)

Detection of Pathogen-Induced Cancer (DPIC)(R01)(PAR-13-190)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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April 15

Pathology Research Seminar Series
Adam Goldfarb, MD
Professor, Pathology
University of Virginia
Topic: A New Treatment Approach for Anemia of Chronic Disease: Targeting the Erythroid Iron Deprivation Response
12 pm WRB 5-136

Physiology and Biophysics Seminar
Manojkumar Puthenveedu, PhD
Assistant Professor, Biological Sciences
Carnegie Mellon University
Topic: Mechanism and Regulation of Endocytic GPCR Trafficking
4 pm SOM / Robbins Building, E-501

April 16

Radiation Oncology Grand Rounds
Qingrong Jackie Wu, PhD
Associate Professor, Radiation Oncology
Duke University
Topic: Knowledge Modeling and Clinical Application in Radiation Therapy
8:10 am Lerner B-181

Molecular Genetics Departmental Seminar
Kavitha Sarvepalli, PhD
Postdoctoral Research Fellow, Longworth Lab, Molecular Genetics
Cleveland Clinic
Topic: Exploring the Role of Condensin II/CAP-D3 in Gene Regulation
9:30 am NE1-205 Cleveland Clinic

Department of Pathology Dissertation Defense
Robert A. Koeth
PhD Candidate, Hazen Lab, Pathology
Topic: Dietary Trimethylamines, Intestinal Microbiota and Atherosclerosis
11 am WRB 5136

Immunology Seminar Series
Michael Diamond, MD
Professor, Div. of Infectious Diseases
Washington University
Topic: New Insights into Innate and Adaptive Immunity Against Alphaviruses
12 pm BRB 105

Medicine Grand Rounds
David Bobak, MD 
Associate Professor, Div. of Infectious Diseases and HIV Medicine
Topic: Farming the Human Microbiome for Health, Fame and Profit
12 pm Kulas Auditorium, Lakeside 5th Fl.

April 17

Hematology and Oncology Division Research Conference
Sergio Giralt, MD
Professor, Medicine
Weill Cornell Medical College
Topic: In Search of the Perfect Transplant
8 am Lerner B-151

Immunology Invited Speaker Seminar Series
Dean Sheppard, MD
Chief, Div. of Pulmonary, Critical Care, Allergy and Sleep
University of California, San Francisco
Topic: Critical Role of Integrin-Mediated TGFBeta Activation for Induction of Antigen-Specific TH17 Cells
12 pm NC1-202 Cleveland Clinic

April 18

Cancer Trainee Seminar
Lamis Yahya
PhD Student, Eng Lab, Genomic Medicine Institute
Cleveland Clinic
Topic: Whole-exome sequencing in the identification of novel predisposition genes in PTEN mutation negative Cowden Syndrome patients
12 pm WRB 3-136

Immunology Journal Club
James Sande
Graduate Student, Boom Lab
Topic: IL-1 Enhances Expansion, Effector Function, Tissue Localization, and Memory Response of Antigenspecific CD8 T Cells
12 pm WRB 5-136

Stem Cell Biology & Regenerative Medicine Guest Presentation
Chuan-Yuan Li, PhD
Professor and Vice Chair of Research, Dermatology
Duke University
Topic: Phoenix Rising and Wheel of Life: Redefining the Roles of Caspases in Cancer Therapy and Tissue Regeneration
1 pm NE1-205 Cleveland Clinic

April 19

Hematology and Oncology Fellows Conference
Topic: TBD
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Lilyana Angelov, MD
Brain Tumor and Neuro-Oncology Center
Cleveland Clinic
Topic: Spine Radiosurgery: Changing the Treatment Paradigm in Spinal Metastases
8 am R3/002-003 Cleveland Clinic

Biomedical Engineering Seminar
Edward Maytin, MD, PhD
Assistant Professor, Dermatology and Biomedical Engineering
CWRU/Cleveland Clinic
Topic: Photodynamic Therapy for Scar-free Treatment of Cancer
11 am NA1-142

Cancer Center Seminar Series
Brian Rubin, MD, PhD
Professor, Pathology
Director, Soft Tissue Pathology
CWRU/Cleveland Clinic
Topic: Activation of WWTR1 by Fusion to CAMTA1 in Epithelioid Hemangioendothelioma (EHE)
12 pm BRB 105

Cancer Center Research in Progress
Ben Bryson
Graduate Student, Jackson Lab, Pathology
Topic: The Paradoxical Role of Oncostatin M in Senescence and Transformation of Human Mammary Epithelial Cells
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Case CCC Clinical Research Retreat
April 22
5-7 pm Wolstein Research Building Auditorium

Case Gastrointestinal Cancers SPORE Retreat
April 26
Dively Rm. 202
Details and Abstract Submission

Breast Cancer Conference
May 24
Hilton Cleveland East

Annual Cancer Center Scientific Retreat
July 11-12


National GvHD Health Symposium
November 1