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April 8, 2013


Stan Gerson, MD
Director, Case CCC

Computational Needs to Support Large Scale Genomics Efforts

Dr. Harold Varmus is requesting information on our high throughput genomics computing aid. Our input will provide guidance as they put together packages to meet those needs. Please review the following message and respond. You may respond directly, or you may respond to me so we can put together a coordinated response. In any case, please copy me.

Message from the NCI

The advent of a variety of new research technologies has dramatically increased the rate at which biological data is generated, a rate of change that has strained conventional mechanisms for distributing and analyzing this information. The NCI (and the biomedical community broadly) is investigating next generation computational capabilities to support the biomedical research community. One possibility is the creation of public "cancer knowledge clouds", namely data repositories with co-located computational resources, allowing investigators to bring their analytic tools to the data rather than move the data to their analytic tools. Such clouds have the potential to increase the speed of discovery and democratize access to cancer genomics data, which is too often the province of organizations that can support the high cost of maintaining these enormous data sets. While there is an emerging consensus that such computational resources are going to be essential components of the resource environment in the near future, there is not yet a consensus on the implementation of such an environment. NCI believes that the correct approach is to conduct a series of pilots that will lead to the development of a cancer knowledge cloud or clouds.

In order to ensure that our initial efforts in this area are directed at the practical problems faced by biomedical researchers, we are writing to request your advice about the scientific questions that should guide the process of developing infrastructure to analyze these high volume data sets. Specifically, we are requesting that you provide us with information on:

  1. Situations where limitations in information technology capabilities are either preventing you from carrying out certain types of high value research, or where these limitations, while not preventing your research, are slowing the pace of discovery significantly.
  2. Your experiences using high performance computing environments for biological research, including custom environments and commercial clouds (private or public).
  3. Metrics that could be utilized to determine the level of success of pilot "cancer knowledge clouds".
  4. Your responses (along with those from other scientists and relevant oversight committees) will help to guide the NCI in its efforts to ensure that the research community has the tools it needs. If possible, we would like to receive your comments by May 3; they can be sent electronically to

Thank you for your prompt attention to this matter.

Harold E. Varmus, MD, Director, NCI

George A. Komatsoulis, PhD, Director (interim), Center for Biomedical Informatics and Information Technology

Louis M. Staudt, MD, PhD, Acting Co-Director, Center for Cancer Genomics

Stephen J. Chanock, MD, Acting Co-Director, Center for Cancer Genomics


New minimally invasive, MRI-guided laser treatment for brain tumor found to be promising in study
EurekAlert - Apr 5, 2013
The first-in-human study of the NeuroBlate™ Thermal Therapy System finds that it appears to provide a new, safe and minimally invasive procedure for treating recurrent glioblastoma (GBM), a malignant type of brain tumor. The study, which appears April 5 in the Journal of Neurosurgery online, was written by lead author Andrew Sloan, MD, Director of Brain Tumor and Neuro-Oncology Center at University Hospitals (UH) Case Medical Center and Case Comprehensive Cancer Center, who also served as co-Principal Investigator, as well as Principal Investigator Gene Barnett, MD, Director of the Brain Tumor and Neuro-Oncology Center at Cleveland Clinic and Case Comprehensive Cancer Center, and colleagues from UH, Cleveland Clinic, Cleveland Clinic Florida, University of Manitoba and Case Western Reserve University.

Kulas foundation has high impact on medical studies of music therapy
Plain Dealer - Apr 1, 2013
"This really looks at the effect on drug requirements during sedation in a quantifiable way," says Dr. Rosemary Leeming, a breast surgeon for the study and a medical director at the hospital system's Chagrin Highlands Medical Center.

Medical Mart Tenants: Global Center Floor 3
Crain's Business Cleveland - Apr 1, 2013
Dr. Pablo Ros, chairman of the department of radiology at University Hospitals Case Medical Center, said the organizations would like to regularly change their space to reflect the groups visiting the center, whether their specialty is pediatrics or cardiovascular care.


American Academy of Neurology

The American Academy of Neurology held it's annual meeting March 16-23 in San Diego.

Dr. Lisa Rogers co-moderated the scientific session, Clinical Research Advances in Neuro-oncology, and the Integrated Neuroscience Session, sponsored by the American Academy of Neurology and Society for Neuro-oncology: Advances in the Biology and Therapy of Gliomas.

Dr. Jeremy Rich presented, "Update on Tumor Stem Cells and Potential Therapeutic Strategies", during the session,Advances in the Biology and Therapy of Gliomas.

Click here to view a list of Cancer Center member presentations and poster abstracts.

OnCore Training Class Canceled

The OnCore Training Class scheduled for Wednesday, April 17 from 12-1 pm has been canceled. Future sessions will go on as planned.


Case CCC Clinical Research Retreat

The 2013 Case CCC Clinical Research Retreat will take place Monday, April 22 from 5:30-7 pm in the Wolstein Research Building Auditorium. The agenda is still being finalized and will focus on scientific issues and initiatives. Please contact Drs. Smitha Krishnamurthi or Robert Dreicer, MD with any questions.

Case Gastrointestinal Cancers SPORE Retreat

Registration is open for the Case Gastrointestinal Cancer SPORE Retreat, scheduled for Friday, April 26 in Dively Rm. 202. The agenda is still being finalized, but discussion topics include Colon Cancer; Barrett's Esophagus; Cancer Metastasis; Cancer Prevention; and Cancer in Minorities. There will be a poster session at noon. All trainees and fellows are invited to submit poster abstracts to Dr. John Wang at by Monday, April 15. A cash prize will be awarded to the best poster.

Race for the Place- Join Our Team!

The Race for the Place, an event that benefits the Gathering Place, will be held Sunday, June 2 at Beachwood Place Mall. The Case CCC has created a team. Click here to join the team or to show your support by making a donation. Contact Gillian Todd for more information.


Harrington Discovery Institute Scholar-Innovator Grant Program

The Harrington Discovery Institute has announced it's second annual Harrington Scholar-Innovator grant competition to support physician-scientists seeking to accelerate promising drug discoveries into novel treatments for patients. Applicants must have a doctorate in medicine and must demonstrate exceptional promise as physician-scientists.

LOI Deadline: May 15
Application Deadline: August 2

NCI Provocative Questions

The NCI is accepting applications for the next round of Provocative Questions, a list of 24 important questions from the research community to stimulate the NCI's research communities to use laboratory, clinical and populations sciences in especially effective and imaginative ways to answer the questions. The questions are categorized into four themes: Cancer Prevention and RiskMechanisms of Tumor Development or RecurrenceTumor Detection, Diagnosis, and Prognosis; and Cancer Therapy and Outcomes.

Dr. Emily Greenspan, Provocative Questions Program Director, will be holding an informational conference call on Friday, April 12 from 1-3 pm ET. Participants will have the chance to ask questions and obtain information on how to apply for funding. To participate, dial 1.866.734.3397, participant code 5040755.

LOI Deadline: May 20
Applications Deadline: June 20

Lasker Clinical Research Scholars Program

The National Institutes of Health in partnership with the Lasker Foundation is pleased to announce the Lasker Clinical Research Scholars Program, a historic "intramural-extramural" partnership to nurture the next generation of clinical researchers. The program supports a small number of exceptional clinical researchers in the early stages of their careers to promote their development to fully independent positions. Successful candidates are designated as Lasker Clinical Research Scholars.

LOI Deadline: May 24
Application Deadline: June 24

Computational Genomic Epidemiology of Cancer Postdoctoral Training Program

The Case CCC invites applications to its 2-3 year NCI-funded Computational Genomic Epidemiology of Cancer Postdoctoral Training Program. The program combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum.

This program is designed to prepare trainees for careers as independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics and computer science. Cancer researchers obtaining training will have the skills vital to decipher the complex pathways comprising genetic and environmental risk factors for disease, and will ultimately be able to provide clinicians and their patients with valuable information for the prevention and treatment of cancer.

Candidates with an MD, PhD, or MD/PhD degree, strong quantitative skills, and an interest in a career in genetics research are encouraged to apply.


Call for Pilot Projects: Barrett's Esophagus Translational Research Network (BETRNet)‌
Deadline: May 10

Lustgarten Foundation
Concept Deadline: May 24
Full Application Deadline: August 9

Chris4Life Colon Cancer Pilot Study Grant Program
Deadline: June 1

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01)(PAR-13-159)

Academic-Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01)(PAR-13-169)

AHRQ Patient-Centered Outcomes Research (PCOR) Mentored Clinical Investigator Award (K08)(PA-13-180)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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April 8

Pathology Research Seminar Series
Jenny Johnson
PhD Candidate, Pathology, Cobb Lab
Topic: Immune Modulation Through Bacterial Exposure
12 pm WRB 1-413

Student Seminar Series
Colin Stomberski
Student, Biochemistry, Stamler Lab
Topic: Mechanisms of Protein Denitrosylation
12 pm Wood W428

Sequencing Data Interest Group (SDIG)
Jonathan Kenyon, PhD
Postdoctoral Fellow, Institute of Urology
Topic: Aging Human Hematopoietic Stem Cells: A study in mutagenesis
2:30 pm WRB 2-505

Physiology and Biophysics Seminar
Christopher Miller, PhD
Professor, Biochemistry
Investigator, Howard Hughes Medical Institute
Brandeis University
Topic: Your precious bodily fluids: Channels and transporters counteracting fluoride toxicity
4 pm SOM / Robbins Building, E-501

April 9

Radiation Oncology Grand Rounds
Topic: TBD
8:10 am Lerner B-181

Molecular Genetics Departmental Seminar
Jinyu Wang
Graduate Student, Runge Lab, Molecular Genetics
Cleveland Clinic
Topic: Rif1 Phosphorylation in Telomere Length Regulation and Response to DNA Damage
9:30 am NE1-205 Cleveland Clinic

Immunology Seminar Series
Michael Tomasson, MD
Associate Professor, Div. of Oncology- Stem Cell Biology
Washington University
Topic: Let It Sno: The Genetics of Multiple Myeloma
12 pm WRB 1-413

Medicine Grand Rounds
Usha Stiefel, MD 
Assistant Professor and Chief, Div. of Infectious Diseases and HIV Medicine
Topic: Beyond Methicillin Resistance: Emerging Controversies in the Treatment of Staphylococcus Aureus
12 pm Kulas Auditorium, Lakeside 5th Fl.

April 10

Hematology and Oncology Division Research Conference
Smitha Krishnamurthi, MD
Assistant Professor, Div. of Hem/Onc
Topic: Metformin as an Anticancer Agent
8 am Lerner B-151

Immunology Students/Fellows Research in Progress Seminar Series
Mi-Hyun Hwang
Post Doctoral Fellow, Min Lab, Immunology
Cleveland Clinic
Topic: Systemic Immune Suppression During Virus Infection In The Central Nervous System
Natlibeth Barera-Hurtado
Research Scholar, Hamilton Lab, Immunology
Cleveland Clinic
Topic: The Integrated Stress Response Contributes to Inflammation During DSS Colitis
12 pm NC1-202 Cleveland Clinic

April 11

Molecular Genetics Guest Speaker
Peter Sarnow, PhD
Professor, Microbiology and Immunology
Stanford University
Topic: Regulation of hepatitis C virus RNA abundance and Insig1 poly(A) site usage by microRNA 122 isoforms
9:30 am NE1-205 Cleveland Clinic

Immunology Journal Club
Christina Antonopoulos
PhD Student, Dubyak Lab
Topic: Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-upsilon
12 pm WRB 5-136

April 12

Hematology and Oncology Fellows Conference
Topic: TBD
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Howard I. Scher, MD
Chief, Genitourinary Oncology Service
Memorial Sloan-Kettering Cancer Center
Topic: TBD
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Howard I. Scher, MD
Chief, Genitourinary Oncology Service
Memorial Sloan-Kettering Cancer Center
Topic: Biomarkers for the Development of New Generation Therapeutics in Prostate Cancer: One Cell at a Time
12 pm BRB 105

Pediatric Research Seminar
Sara E. Tomechko, PhD
Research Associate, Center for Proteomics and Bioinformatics
Topic: Proteomic Mass Spectrometry and Bioinformatics: What it can do for you and why you NEED to use it
9 am BRB 832

Cancer Center Research in Progress
Goutham Narla, MD, PhD
Assistant Professor, Medicine
Harrington Scholar, Institute for Transformative Molecular Medicine
Topic: Reactivating Tumor Suppressor Genes for the Treatment of Cancer
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Case CCC Clinical Research Retreat
April 22
5:30-7 pm Wolstein Research Building Auditorium

Case Gastrointestinal Cancers SPORE Retreat
April 26
Dively Rm. 202
Details and Abstract Submission

Breast Cancer Conference
May 24
Hilton Cleveland East

Annual Cancer Center Scientific Retreat
July 11-12


National GvHD Health Symposium
November 1