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February 18, 2013


Cleveland Clinic Develops Clinical Screening Program for Top Genetic Cause of Colon Cancer
EurekAlert - Feb 14, 2013
Led by Charis Eng, MD, PhD, Hardis Chair and Founding Director of the Cleveland Clinic Lerner Research Institute's Genomic Medicine ...

Discovery in HIV May Solve Efficiency Problems for Gene Therapy
EurekAlert (press release)-Feb 14, 2013
Led by professor Eric Arts, PhD, the scientists discovered that the process of gene therapy..."Using lentivirus for gene transfer appears to be a safe option," said Stanton L. Gerson, MD, director of the Case Comprehensive Cancer Center ...

Lentigen Receives U.S. Orphan Drug Designation for Novel Gene Therapy for Glioblastoma Multiforme
Yahoo Finance - Feb 13, 2013
LG631-CD34 is currently being evaluated in a NIH grant-funded Phase I clinical trial at University Hospitals (UH) Case Medical Center under the leadership of Stanton Gerson, MD...and Andrew Sloan, MD...

Vaccine With Drug Payload Shows Promise Against Tumors
U.S. News & World Report - Feb 11, 2013
While the study is "by no means definitive" overall, that's good news, said Dr. Neal Meropol, chair of the division of hematology and oncology at ...


Summer Volunteers: Placements Needed

It's that time of year again where we receive requests from students inquiring about summer research positions. If you have room in your lab for a summer student, please send an email to Lyn Haselton, Cancer Center Training Program Manager. We will add your name to a list and will send you resumes if we receive them.

Case CCC Funding for Pilot/Phase I Clinical Trials

The Case CCC is encouraging investigators to submit Letters of Intent for Early Phase Clinical Research Support (EPCRS; former Protocol Specific Research Support) funding. These in-house funds are available for the conduct of early phase clinical trials of relatively short duration. Revised NCI Cancer Center Support Grant EPCRS guidelines are effective as of April 1, 2013. Studies developed jointly between UH and Cleveland Clinic with planned accrual at both institutions will be given higher priority. There are no specific deadlines for submission, and applications will be accepted until all funds are committed. Please direct questions and requests for information about the revised guidelines and funding process to Katarzyna Karelus, Clinical Research Office Administrative Director,, 216.844.4176.

Tissue Microarray Survey

The Cancer Center is considering an initiative to build a series of Tissue Microarrays (TMAs) for member usage. We would like to assess the needs of our members so that we can start with the most feasible and useful TMAs. Please take this short survey regarding your research goals and needs.

Database Systems Development Survey

The Cancer Center is considering a more standardized and integrated database system to assist members in collection of clinical and research datasets. This new system would allow for the integration of many types of data that are commonly used in research studies, such as (but not limited to) biological samples, data from the clinical record, outcomes, pathology, survey, demographics and "omics" data results.

We recognize that we do not have optimal systems currently in place. To help us assist you in your research needs regarding your data collection and data management needs over the next 2 to 5 years, we have developed a short questionnaire.

We cannot entertain this investment without considerable use by Cancer Center members. Your responses will help us make a strategic decision on database systems development.

Reminder: Registration of Studies in and Reporting of Clinical Trial Results

Section 801 of the Food and Drug Administration Amendments Act (FDAAA 801) requires Responsible Parties to register and submit summary results of clinical trials with Clinical trial results registration became effective as of September 2008. The FDA is currently empowered to enforce the reporting requirements, as well as financial penalties on non-compliant investigators and institutions.

Clinical trial and result registration is centralized within the Case CCC, and April Firstencel, Case CCC Registration Coordinator, has been working with investigators, study staff and statisticians to ensure the Case CCC complies with federal requirements. This announcement serves as a reminder about our on-going efforts and the need for everybody's assistance and collaboration to meet these obligations. Please direct questions to April Firstencel, Case CCC Registration Coordinator for, 216.286.2294,



The American Society of Hematology (ASH) has partnered with the Harold Amos Medical Faculty Development Program (AMFDP) of the Robert Wood Johnson Foundation to increase the number of scholars from historically disadvantaged backgrounds receiving academic and research appointments in the field of hematology. The AMFDP offers four-year postdoctoral research awards to historically disadvantaged physicians who are committed to developing careers in academic medicine and to serving as role models for students and faculty of similar backgrounds. The program defines "historically disadvantaged" individuals as those who face challenges because of their race, ethnicity, socioeconomic status, or other similar factors.

Deadline: March 14

Computational Genomic Epidemiology of Cancer Postdoctoral Training Program

The Case CCC invites applications to its 2-3 year NCI-funded Computational Genomic Epidemiology of Cancer Postdoctoral Training Program. The program combines a mentored cancer research project designed by the fellow in collaboration with their mentors with a specialized curriculum of formal didactic training and individualized longitudinal curriculum.

This program is designed to prepare trainees for careers as independent investigators engaged in research at the intersection of cancer research, genetics, epidemiology, biostatistics and computer science. Cancer researchers obtaining training will have the skills vital to decipher the complex pathways comprising genetic and environmental risk factors for disease, and will ultimately be able to provide clinicians and their patients with valuable information for the prevention and treatment of cancer.

Candidates with an MD, PhD, or MD/PhD degree, strong quantitative skills, and an interest in a career in genetics research are encouraged to apply.


Research Best Practices Day 2013

Registration is now open for Research Best Practices Day 2013Friday, March 1. This annual event is open to the entire research community. Each year, several topics are presented by our local experts as part of CWRU's ongoing training in the Responsible Conduct of Research. Faculty, staff and students are encouraged to attend one or more of the sessions that are applicable to their research.

Planned topics include:

  • Integrity in Research and Authorship
  • Understanding Health Literacy and its Impact on Informed Consent
  • Maximizing the Features in UHCare to Manage your Research Participants
  • Understanding Stem Cells and the new Human Stem Cell Research Oversight Committee
  • Laboratory Safety: Where we were- Where we are- Where we are going

Breast Cancer Program in Development Annual Retreat

Drs. William Schiemann and Lyndsay Harris, Co-Leaders of the Breast Cancer Program in Development, invite you to attend the program Annual Retreat on Monday, March 11from 9 am-3 pm in the Dively Building on CWRU campus. The agenda and program information will be available soon.

Melanoma Mini-Symposium

A melanoma mini-symposium is scheduled from 3-7 pm on Monday, March 11 in the Wolstein Research Building Auditorium. The purpose of this symposium is to provide a forum for physician scientists and biomedical researchers to foster communication and develop new collaborations on melanoma research. Please watch the newsletter for updates.

Annual Cancer Center Retreat

The Annual Cancer Center Scientific Retreat will commence the evening of Thursday, July 11 and continue through Friday, July 12. Location and agenda are still be finalized. Details will be posted in the newsletter in the coming months.



LOI Deadline: February 18
Application Deadline: April 5

Lymphoma Research Foundation Follicular Lymphoma and Small Lymphocytic Lymphoma Collaborative Grant
Deadline: February 19

Lymphoma Research Foundation Follicular Lymphoma Pathways Grant
Deadline: February 19

Lymphoma Research Foundation Mantle Cell Lymphoma Exploratory/Development Grant
Deadline: February 19

QuadW Foundation-AACR Fellowship for Clinical/Translational Sarcoma Research
Deadline Extended: February 26

AACR Clinical and Translational Cancer Research Fellowships
Deadline: February 27

Leukemia and Lymphoma Society Translational Research Program
LOI Deadline: March 1
Full Application Deadline: March 15

Alex's Lemonade Stand Foundation Pediatric Oncology Student Training Program
Deadline: March 4

Childhood Brain Tumor Foundation
Deadline: March 12

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

National Cancer Institute (NCI) will Participate in PAR-13-109 "Mechanistic Insights from Birth Cohorts (R01)"


Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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February 18

Immunology Seminar Series
Richard Ransohoff, MD
Staff and Director, Neuroinflammation Center
Cleveland Clinic
Topic: Myeloid Cells of the Inflamed CNS: Where They Come From and What They Do
12 pm WRB 1-413

February 19

Medicine Grand Rounds
Michael Lederman, MD
Professor, Div. of Infectious Diseases and HIV Medicine
Director, AIDS Clinical Trials Unit
Topic: Role of Immune Activation and Inflammation in HIV Pathogenesis and Clinical Outcomes
12 pm Kulas Auditorium, Lakeside 5th Fl.

February 20

Hematology and Oncology Division Research Conference
Neal Meropol, MD
Dr. Lester E. Coleman, Jr. Professor of Cancer Research and Therapeutics
Chief, Div. of Hem/Onc
Topic: Interventions to Overcome Barriers to Clinical Trials Accrual
8 am Lerner B-151

Immunology Invited Speaker Seminar Series
Angus Thomson, PhD
Professor, Immunology, Microbiology & Molecular Genetics, and Clinical and Translational Science
University of Pittsburgh
Topic: Understanding and Manipulating the Role of Dendritic Cells in Transplantation
12 pm NC1-202 Cleveland Clinic

February 21

Molecular Genetics Seminar
Blaine Bartholomew, PhD
Professor, Biochemistry & Molecular Biology
Southern Illinois University
Topic: Nucleosome Organization and ATP-dependent Chromatin Remodeling
9:30 am NE1-205 Cleveland Clinic

Cancer Trainee Seminar
Allison Condie
Topic: Toward the Development of Fluorescent Probes for Imaging DNA Abasic Sites in Situ
Oana Paun, MD
Fellow, Div. of Hem/Onc
Topic: Pediatric Hematologic Malignancies
12 pm WRB 3-136

Stem Cell Biology and Regenerative Medicine
Xinyu Zhao, PhD
Associate Professor, Neuroscience
University of Wisconsin-Madison
Topic: Post-Transcriptional Regulation of Neural Stem Cells
1 pm NE1-205 Cleveland Clinic

February 22

Cancer Center Research in Progress canceled

Hematology/Oncology Fellows Conference/Curriculum Series
Mikkael Sekeres, MD, MS
Hematologic Oncology and Blood Disorders, CCF Associate Professor, Hematologic Oncology and Blood Disorders
CWRU/Cleveland Clinic
Topic: Myelodysplastic Syndromes 
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Halle Moore, MD
Staff, Solid Tumor Oncology
Cleveland Clinic
Machelle Moeller, CNP
Solid Tumor Oncology
Cleveland Clinic
Topic: Breast Cancer Survivorship
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Lorna H. McNeill, PhD, MPH
Associate Professor, Health Disparities Research
University of Texas MD Anderson Cancer Center
Topic: Project CHURCH: African American Participation in a Research Partnership
12 pm BRB 105

Case CCC Calendar

LRI Calendar


Breast Cancer Program in Development Annual Retreat
March 11
9 am-3 pm Dively Building

Melanoma Mini-Symposium
March 11
3-7 pm Wolstein Research Building

IMPACT: Improving Sickle Cell Patient Adherence Through Collaborative Teaching
March 23
Wolstein Research Building
Brochure and Registration

Breast Cancer Conference
May 17
Hilton Cleveland East

Annual Cancer Center Scientific Retreat
July 11-12
Location TBD


16th Annual Meeting of the Translational Research Cancer Centers Consortium (TRC3): The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity
February 20-22
Seven Springs Mountain Resort, Seven Springs, PA

National GvHD Health Symposium
November 1