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February 11, 2013


Exercise May Cut Prostate Cancer in Whites, But Not Blacks
Everyday Health - Feb 8, 2013
But Timothy Gilligan M.D., a medical oncologist with the Cleveland Clinic in Ohio, says he is skeptical of the findings.

Tamoxifen May Have Long-term Benefits in Fighting Breast Cancer
Plain Dealer - Feb 4, 2013
"While you do get more side effects long term, the benefits significantly outweighed the side effects," said Dr. Rosemary Leeming, a surgical oncologist at University Hospitals... Because the ATLAS trial focused on a large patient population that was followed for a long period of time, oncologists probably will be very receptive to the findings, said Dr. G. Thomas Budd, a medical oncologist at the Cleveland Clinic Taussig Cancer Institute

Cancer Research by the Numbers
The Cancer Genome Atlas - Feb 6, 2013
Biostatistician Dr. Jill Barnholtz-Sloan strives to make a difference in the field of cancer research while inspiring her students at the same time. Learn more about how she uses TCGA data in her career in this TCGA in Action Researcher Profile.


Finke Receives NCI R01

Dr. Jim Finke was awarded an R01 from the National Cancer Institute to study the individual contributions of inflammatory proteins and their impact in promoting the activation and migration of highly active MDSC subsets, particularly those expressing the chemokine receptor CXCR2, with the hope that research findings may lead to new targets for therapeutic intervention.

Pizarro Receives Grant to Study Gastric Cancers

Dr. Theresa Pizarro, Associate Professor of Pathology and Medicine at CWRU, recently received a grant from the DeGregorio Family Foundation for her proposal, Role of the novel IL-1 family member, IL-33, in the gastritis-metaplasiacarcinoma sequence. Dr. Pizarro will work with Dr. Li Li, co-investigator, and Dr. Wei Xin, collaborator, on this project.

Tissue Microarray Survey

The Cancer Center is considering an initiative to build a series of Tissue Microarrays (TMAs) for member usage. We would like to assess the needs of our members so that we can start with the most feasible and useful TMAs. Please take this short survey regarding your research goals and needs.

December CTSC Core Utilization Pilot Awards

Congratulations to the recipients of the December CTSC Core Utilization Pilot Awards:

  • Shu Chen, PhD: Identification of novel substrates of LRRK2, a Parkinson disease associated kinase
  • Evren Gurkan-Cavusoglu, PhD: Analysis of the cell cycle dynamics for fludarabine or ABT-737 resistant Nalm-6 cells
  • Youwei Zhang, PhDRoles of long non-coding RNAs (lncRNAs) in DNA damage response
  • Edward Medof, MD, PhDEvidence for a plasma membrane complex containing C5a receptor (C5aR), IL-6-receptor (IL-6R), and vascular endothelial cell growth factor receptor-2 (VEGFR-2) that governs vascular endothelial cell (EC) viability and growth signaling
  • Catherine Stein, PhD: Exploration of pathways underlying resistance to M. tuberculosis infection

Reminder: Registration of Studies in and Reporting of Clinical Trial Results

Section 801 of the Food and Drug Administration Amendments Act (FDAAA 801) requires Responsible Parties to register and submit summary results of clinical trials with Clinical trial results registration became effective as of September 2008. The FDA is currently empowered to enforce the reporting requirements, as well as financial penalties on non-compliant investigators and institutions.

Clinical trial and result registration is centralized within the Case CCC, and April Firstencel, Case CCC Registration Coordinator, has been working with investigators, study staff and statisticians to ensure the Case CCC complies with federal requirements. This announcement serves as a reminder about our on-going efforts and the need for everybody's assistance and collaboration to meet these obligations. Please direct questions to April Firstencel, Case CCC Registration Coordinator for, 216.286.2294,


American Association for Cancer Research

The AACR is accepting applications for the following funding opportunities:

  • The Fight Colorectal Cancer-AACR Fellowship, in memory of Lisa Dubow represents a joint effort to encourage and support a postdoctoral or clinical research fellow to conduct translational or clinical research that focuses on novel therapeutic approaches for late-stage metastatic colorectal cancer. This grant will support a project designed to lead to individualized therapeutic options for treatment or the development of promising new cancer therapeutics for patients with metastatic colorectal cancer. Emphasis will be placed on proposed projects which will translate into clinical applications within a few year period, including those with predictive biomarker studies. 
    Deadline Extended: February 13
  • The QuadW Foundation-AACR Fellowship for Clinical/Translational Sarcoma Research represents a joint effort to encourage and support a postdoctoral or clinical research fellow to conduct translational or clinical sarcoma research and to establish a successful career path in this field.
    Deadline: February 19
  • The AACR Clinical and Translational Cancer Research Fellowships are open to postdoctoral and clinical research fellows working at an academic, medical or research institution who will be in the first five years of their postdoctoral training at the start of the grant term. Proposed research projects may be in any area of clinical and/or translational cancer research.
    Deadline: February 27

American Cancer Society IRG Awards

The Case CCC, with funds from its American Cancer Society Institutional Research Grant, will provide seed money to foster cancer research by junior faculty who have no current national grant support of their own. Investigators in the CWRU School of Medicine and Cleveland Clinic Lerner College of Medicine as well as in other schools and colleges in the University are eligible. Grants, not to exceed $30,000, will be awarded to investigators who intend to gather preliminary data to be used in seeking future and independently funded programs.

LOI Deadline: February 18
Application Deadline: April 5

Lymphoma Research Foundation

The Lymphoma Research Foundation (LRF) Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL), Follicular Lymphoma (FL) and Mantle Cell Lymphoma (MCL) Consortiums are seeking proposals for high quality research studies in the following three disease areas:

Applications to this initiative must include the study of primary CLL/SLL, FL or MCL patient samples to assure relevance to the human disease. In addition, applicants are required to explicitly delineate how the proposed research will incorporate collaborative interactions between/among investigators in different disciplines (e.g. pathology & medical oncology, basic science research & clinical investigators) and/or different institutions.

Deadline: February 19


Breast Cancer Program in Development Annual Retreat

Drs. William Schiemann and Lyndsay Harris, Co-Leaders of the Breast Cancer Program in Development, invite you to attend the program Annual Retreat on Monday, March 11from 9 am-3 pm in the Dively Building on CWRU campus. The agenda and program information will be available soon.

Melanoma Mini-Symposium

A melanoma mini-symposium is scheduled from 3-7 pm on Monday, March 11 in the Wolstein Research Building Auditorium. The purpose of this symposium is to provide a forum for physician scientists and biomedical researchers to foster communication and develop new collaborations on melanoma research. Please watch the newsletter for updates.

Annual Cancer Center Retreat

The Annual Cancer Center Scientific Retreat will commence the evening of Thursday, July 11 and continue through Friday, July 12. Location and agenda are still be finalized. Details will be posted in the newsletter in the coming months.



Fight Colorectal Cancer-AACR Fellowship, in memory of Lisa Dubow
Deadline Extended: February 13

LOI Deadline: February 18
Application Deadline: April 5

Leukemia and Lymphoma Society Translational Research Program
LOI Deadline: March 1
Full Application Deadline: March 15

Alex's Lemonade Stand Foundation Pediatric Oncology Student Training Program
Deadline: March 4

Childhood Brain Tumor Foundation
Deadline: March 12

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Participation of Additional NIH Institutes and Centers in PA-11-110 "Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (Parent F30)" (NOT-OD-13-032)

Notice of Participation of Additional NIH Institutes and Centers in PA-11-111 "Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Parent F31)" (NOT-OD-13-033)

Notice of Intent to Publish the Reissuance of Funding Opportunity Announcement "NIH Pathway to Independence Award (Parent K99/R00)" (NOT-OD-13-034)

NIH Requires Use of RPPR for All SNAP and Fellowship Progress Reports, and Expands RPPR Functionality (NOT-OD-13-035)

New Review Criteria for NIH Construction (C06 and UC6) and Modernization (G20) Grant Applications (NOT-OD-13-038)

NCI Experimental Therapeutics-Clinical Trials Network with Phase 1 Emphasis (ET-CTN) (UM1)(RFA-CA-13-006)

Obesity Policy Evaluation Research (R01)(PA-13-110)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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February 11

Pathology Research Seminar Series
Charles Glabe, PhD
Professor, Molecular Biology & Biochemistry
University of California, Irvine
Topic: Conformational Polymorphisms of Amyloid in Alzheimer' Disease
12 pm WRB 1-413

Cancer Biology Midterm Review Seminar
Matthew Summers, PhD
Assistant Staff, Cancer Biology
Cleveland Clinic
Topic: Dynamics of Ubiquitin-mediated Cell Cycle Control
2 pm NC1-202 Cleveland Clinic

Sequencing Data Interest Group (SDIG)
Daniel Sprockett
Research Assistant, Dermatology
Marie Tuttle, MD
Assistant Professor, Dermatology
Topic: NGS Tools for Investigating the Human Microbiome
2:30 pm WRB 1-403

February 12

Molecular Genetics Departmental Seminar
Maupali Dasgupta, PhD
Postdoctoral Research Fellow, Stark Lab, Molecular Genetics
Cleveland Clinic
Topic: Post-translational Modifications of Stat3 and Their Roles in Directing Gene Activation
9:30 am NE1-205 Cleveland Clinic

Cancer Biology Invited Speaker Seminar
Aaron Severson, PhD
Assistant Professor, Biology, Geology, Environmental Science 
Cleveland State University
Topic: Establishing and Removing Sister Chromatid Cohesion to Promote Normal Gamete Formation in C. elegans
11 am NC1-202 Cleveland Clinic

Immunology Seminar Series
Richard Zigmond, PhD
Professor, Neurosciences
Topic: A New Phenotype for an Old Mouse: A Critical Role in the Conditional Lesion Response of Inflammation Near Axotomized Cell Bodies
12 pm WRB 1-413

Medicine Grand Rounds
Vikram Kashyap, MD, FACS
Chief, Div. of Vascular Surgery and Endovascular Therapy
Co-Director, UH Harrington Heart & Vascular Institute
Topic: AAA and EVAR as well as TVAR
12 pm Kulas Auditorium, Lakeside 5th Fl.

Research & Technology Management Seminar
Charles Wessner, PhD
Director Technology, Innovation, and Entrepreneurship
The National Academies
Topic: The Global Innovation Imperative: The Challenge of Sustaining US Leadership
4 pm WRB 1-413

February 13

Hematology and Oncology Division Research Conference
Hyunseok Kang, MD
Fellow, Hematology and Medical Oncology
Emory University/Winship Cancer Institute
Topic: Exploring Novel Therapeutic and Preventive Strategies in Head and Neck Cancer
8 am Lerner B-151

Genetics and Genome Sciences Seminar
Christopher Cullis, PhD
Professor and Chair, Biology
Topic Transgenerational Inheritance in Flax – Epigenetics or Programmed Genome Rearrangements?
11 am BRB 105

Immunology Faculty Research in Progress
Trine Jorgensen, PhD
Assistant Staff, Immunology
Cleveland Clinic
Topic: Faculty Update
12 pm NC1-202 Cleveland Clinic

Case GI SPORE Seminar Series: Moved to March 6
Sanford Markowitz, MD, PhD
Professor, Div. of Hem/Onc
Principal Investigator, Case GI SPORE
Topic: Case GI SPORE: Genetic Studies of Colon Cancer
5:30 pm Lerner B-151

February 14

Pathology Special Seminar
Parameswaran Ramakrishnan, PhD
Postdoctoral Fellow, Div. of Biology
California Institute of Technology
Topic: Regulation of the Regulator, NF-κB, in the Immune System
12 pm WRB 5-136

February 15

Cancer Center Research in Progress canceled

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
David Gaffney, MD, PhD
Professor and Medical Director
University of Utah/Huntsman Cancer Hospital
Topic: The Role of Radiation in Cervical and Endometrial Cancer
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Philip S. Low, PhD
Ralph C. Corley Distinguished Professor of Chemistry
Director of the Purdue Center for Drug Discovery
Purdue University
Topic: Ligand-Targeted Imaging and Therapeutic Agents for Cancer and Inflammatory Diseases
12 pm BRB 105

Case CCC Calendar

LRI Calendar


IMPACT: Improving Sickle Cell Patient Adherence Through Collaborative Teaching
March 23
Wolstein Research Building
Brochure and Registration

Breast Cancer Conference
May 17
Hilton Cleveland East


16th Annual Meeting of the Translational Research Cancer Centers Consortium (TRC3): The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity
February 20-22
Seven Springs Mountain Resort, Seven Springs, PA

National GvHD Health Symposium
November 1