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February 4, 2013


Stan Gerson, MD
Director, Case CCC

CWRU Strategic Planning Process

I want to bring the entire Cancer Center community up to date on the university's strategic planning process. However, I am at the retreat today at Dively and will report on its findings next week.

The overall strategic planning effort can be viewed online, and its progress and notes are worth your while. Take a moment to review the elements. Please take this process seriously, just as you have the  and the SOM strategic plan.

Key words that stand out in this process are tactical, transformative, strategic, and overarching, with ideas that are designed to promote internationalism, team and cross-school efforts, moving the institution forward nationally.

As a slight digression, last week I was encouraged to see the following:

Off on a Book Leave... By Nicholas Kristof
New York Times - January 31, 2013
"Today's column is my last one for a number of months. I'm taking a book leave from my column to work with my wife, Sheryl WuDunn, on a new book. The theme is the benefits to ourselves when we engage in a cause larger than ourselves, and, given that, how we can engage in a way that actually works. In other words: the emerging science of how to make a difference."

Indeed, each of us can embrace this concept and make it our own.

I have noticed that only a few Cancer Center members have volunteered to participate in the strategic planning process, yet the Cancer Center has a dominant position in the university. To maintain that position, we need your help. Please offer comments and participate in both the CWRU and SOM strategic planning process! Now is your chance to answer the question: How we can be be innovative, experimental, and discriminating?


Effect of Prostate-specific Antigen Screening on Metastatic Disease Burden 10 Years After Diagnosis
UroToday - Feb 1, 2013
Written by: Jay P. Ciezki, MD as part of Beyond the Abstract on This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.

49ers' Ted Ginn Jr. and Donte Whitner Grateful to Share Super Bowl with Glenville Coach Ted Ginn Sr. Who's Been Battling Pancreatic Cancer
Plain Dealer - Feb 1, 2013
...During post-operative exams, his surgeon, Dr. Jeffrey Hardacre, discovered a tumor on Ginn's pancreas that was producing excess insulin...

A Doctor's Struggle With Numbers
New York Times (blog)- Jan 31, 2013
Blog entry written by Mikkael A. Sekeres, M.D... My youngest child has been struggling with numbers...

Vaccines Might Become Another Way to Fight Cancer
U.S. News & World Report - Jan 18, 2013
Dr. Jeffrey Hardacre, who's researching a pancreatic cancer vaccine, agreed. ... Hardacre is an associate professor of surgery and head of the ...

Alcohol and Your Cancer Risk 
Everyday Health - Jan 11, 2013
"In head and neck cancer, it is the combination of smoking and drinking that is the biggest risk," says Dale Shepard, MD, PhD, an oncologist at the Cleveland Clinic...

Surgery After Imatinib Improved Survival for Patients with Metastatic, Recurrent GIST
Helio/HemOnc Today - Jan 23, 2013
Perspective by Dale Shepard, MD, PhD, Staff physician, department of solid tumor oncology, Taussig Cancer Institute, Cleveland Clinic....


NCI Annual Report

The National Cancer Institute recently released their 2013 Annual Plan and Budget for the National Cancer Program. The purpose of this report is to summarize key research findings that were made possible through NCI support, and provide an update to the nation on NCI-led collaborative efforts to control and ultimately defeat cancer.

Research stemming from the Case CCC Aging and Energy Balance Program was featured in this report as examples of key issues faced by the nation:

  • Dr. Siran Koroukian and her study of comorbidities in elderly patients (page 40);
  • Dr. Julia Rose and her research on coping and communications in advanced cancer patients, especially older adults (page 77);
  • Dr. Nathan Berger and his mouse model studies on the impact of exercise on outcomes in older cancer patients; research findings have been translated into a feasibility study of African American women who just finished treatment for breast cancer (page 78-79).

PRMC Update

David Goldblatt, PRMC Manager, will be leaving his position. The PRMC process will remain the same with the following changes, effective Monday, February 11. Questions should be directed to Katarzyna Karelus, Clinical Research Office Administrative Director,, 216-844-4176.

  • All new protocol submissions, submission of actions on already reviewed and/or approved studies, and any other documents should be submitted to April Firstencel,, 216-286-2294.
  • All inquiries on studies currently undergoing PRMC review, as well as all general questions about the PRMC process, forms, requirements, etc. should be directed to Katarzyna Karelus,, 216-844-4176.


American Cancer Society IRG Awards

The Case CCC, with funds from its American Cancer Society Institutional Research Grant, will provide seed money to foster cancer research by junior faculty who have no current national grant support of their own. Investigators in the CWRU School of Medicine and Cleveland Clinic Lerner College of Medicine as well as in other schools and colleges in the University are eligible. Grants, not to exceed $30,000, will be awarded to investigators who intend to gather preliminary data to be used in seeking future and independently funded programs.

LOI Deadline: February 18
Application Deadline: April 5


Case GI SPORE Seminar Series

Mark your calendars for the first installment of the Case GI SPORE Seminar Series, on Wednesday, February 13 at 5:30 pm in Lerner B-151. Dr. Sandy Markowitz, Professor in the Division of Hematology and Oncology and principal investigator of the Case GI SPORE, will present Case GI SPORE: Genetic Studies of Colon Cancer.

After this initial presentation, the Series will meet monthly on the first Wednesday of the month, from 5:30-6:30 pm in Lerner Tower B-151. Presentations will alternate monthly between the faculty seminar series and journal club, where a SPORE pilot/career development awardee will present. All members of the Cancer Center community, including fellows and residents, are encouraged to attend.

TRCCC Annual Meeting: The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity

Registration is open for the 16th Annual Meeting of the Translational Research Cancer Centers Consortium (TRCCC),The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity. Held February 20-22 at the Seven Springs Mountain Resort in Seven Springs, PA, this meeting will feature two symposiums focused on Tumor-mediated Immune Suppression and Vaccine and Cellular Therapy, with spotlight sessions on Imaging and Viral Vectors. The agenda will also include a poster session. Researchers, institutional officials, and students are invited to submit abstracts for poster presentations by February 4.

Miltenyi Biotec is offering special discounts in relation to the upcoming TRCCC conference. Special offers include:

  • 10% off gentleMACS™ or gentleMACS™ Octo Dissociators
  • Plus FREE MACS® Tumor Dissociation Kit of choice
  • Plus 25 FREE gentleMACS™ C Tubes for tumor dissociation
  • Plus 5% TRCCC contribution – 5% of the gentleMACS purchase price will be contributed by Miltenyi Biotec to sponsor the TRCCC meeting.

Click here for more information.


Avon Foundation 2013 Breast Cancer Research Program
LOI Deadline: February 4
Invited Full Proposal Deadline: April 1

LOI Deadline: February 18
Application Deadline: April 5

Leukemia and Lymphoma Society Translational Research Program
LOI Deadline: March 1
Full Application Deadline: March 15

Alex's Lemonade Stand Foundation Pediatric Oncology Student Training Program
Deadline: March 4

Childhood Brain Tumor Foundation
Deadline: March 12

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Reminders and Updates: NIH Policy on Post-Submission Application Materials (NOT-OD-13-030)

Notice of an Extension of Expiration Date for PA-12-100 "Administrative Supplements for Existing NIH Grants and Cooperative Agreements (Parent Admin Supp)" (NOT-OD-13-031)

Notice Announcing Frequently Asked Questions (FAQs) for RFA-RM-12-023 "Diffusion of Medical Technology and Effects on Outcomes and Expenditures (U01)" and RFA-RM-12-024 "Determinants and Consequences of Personalized Health Care and Prevention (U01)" (NOT-RM-13-010)

School Nutrition and Physical Activity Policies, Obesogenic Behaviors, and Weight Outcomes (R21)(PA-13-098)

School Nutrition and Physical Activity Policies, Obesogenic Behaviors and Weight Outcomes (R03)(PA-13-099)

School Nutrition and Physical Activity Policies, Obesogenic Behaviors and Weight Outcomes (R01)(PA-13-100)

Planning for a National Center for Particle Beam Radiation Therapy Research (P20)(PAR-13-096)

PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])

Planning for a National Center for Particle Beam Radiation Therapy Research (P20)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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February 4

Pathology Research Seminar Series
Adriano Rossi, PhD
Chair of Respiratory and Inflammation, Pharmacology
University of Edinburgh
Topic: Dying for Inflammation Resolution
12 pm WRB 1-413

February 5

Radiation Oncology Grand Rounds
Mitch Machtay, MD
Professor and Chair, Radiation Oncology
Topic: RTOG & NRG Update
8:10 am Lerner Tower B-181

Immunology Seminar Series
Luis Muniz-Feliciano
PhD Candidate, Subauste Lab, Pathology
Topic: Toxoplasma Gondii Modulates Host Signaling to Prevent Autophagosomes from Targeting the Parasite
12 pm WRB 1-413

Medicine Grand Rounds
Gregory Cooper, MD
Professor, Div. of Gastroenterology
Topic: Colon Cancer Screening
12 pm Kulas Auditorium, Lakeside 5th Fl.

February 6

Hematology and Oncology Division Research Conference canceled

Global Approaches Driving Biological Discovery
Pieter Dorrestein, PhD
Associate Professor, Pharmacology, Chemistry and Biochemistry
University of California
Topic: Capturing Bacterial Conversations with Imaging Mass Spectrometry on Petri Dishes and Hosts
10 am WRB 1-413

Global Approaches Driving Biological Discovery
Pieter Dorrestein, PhD
Associate Professor, Pharmacology, Chemistry and Biochemistry
University of California
Topic: Toward the Creation of a Molecular 'Genbank' and 'GoogleMAP' for Molecular Space and Organisms
4 pm WRB 1-413

February 7

The Role of Interferon in Metastasis and Resistance to DNA Damage in Prostate Cancer
8:30 am - 3 pm Q1-300 Cleveland Clinic
Pre-registration required

February 8

Hematology/Oncology Fellows Conference/Curriculum Series
Hillard Lazarus, MD 
Professor, Blood and Marrow Transplant Program, Div. of Hem/Onc
Topic: When, How and What Cell Source for Transplantation in Acute Lymphoblastic Leukemia First Complete Remission 
8 am Wearn 137/Breen Conference Rm.

Taussig Cancer Institute Grand Rounds
Lee Krug, MD
Director, Mesothelioma Program
Memorial Sloan-Kettering Cancer Center
Topic: Improving Therapies for Mesothelioma
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Lyndsay Harris, MD
Diana Hyland Chair in Breast Cancer
Professor, Div. of Hem/Onc
Medical Director, Seidman Cancer Center Breast Health Program
Topic: Personalized Medicine for Breast Cancer in Post Genomic Era
12 pm BRB 105

Cancer Center Research in Progress
Shunji Egusa, PhD
Research Associate, Saunthararajah Lab, Translational Hematology Oncology Research
CWRU/Cleveland Clinic
Topic: Gold Nanoparticle-mediated Drug Delivery for Cancer-selective Chemotherapy
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


IMPACT: Improving Sickle Cell Patient Adherence Through Collaborative Teaching
March 23
Wolstein Research Building
Brochure and Registration

Breast Cancer Conference
May 17
Hilton Cleveland East


16th Annual Meeting of the Translational Research Cancer Centers Consortium (TRC3): The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity
February 20-22
Seven Springs Mountain Resort, Seven Springs, PA

National GvHD Health Symposium
November 1