Bing-Cheng Wang Honored with Professorship
Dr. Bing-Cheng Wang has been named the inaugural John and Josephine Wootton Professor in Research. Dr. Wang, Co-Leader of the Case CCC GU Malignancies Program, will be honored by the School of Medicine at a reception this week.
Cheng-Kui Qu Lab Establishes a Crucial Role of PTPMT1 in the Metabolic Regulation of HSC Function
Recent work from the laboratory of Dr. Cheng-Kui Qu, Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation, was published in the current issue of top biomedical research journal Cell Stem Cell. By dissecting the role of the mitochondrial phosphatase PTPMT1 in hematopoiesis, this work has uncovered a heretofore unknown mitochondrial metabolic regulation in hematopoietic stem cell (HSC) differentiation and self-renewal, which represents a conceptual advance in this field. While the Qu lab data establishes this novel concept within the context of HSCs, the investigators believe their findings may also extend to other somatic stem cells, embryonic stem cells, and even cancer stem cells. As such, the link between mitochondrial metabolism and stem cell function demonstrated in their report has widespread interest to the scientific community including stem cell biologists, hematologists, as well as those scientists involved in ageing, cancer and metabolism research.
Strong Cancer-related Funding Week for Anant Madabhushi and Team
The Center for Computational Imaging and Personalized Diagnostics (CCIPD) and a team led by Dr. Anant Madabhushi, Associate Professor and Director of the Center for Computational Imaging & Personalized Diagnostics, received updates on several important grants in the past week. Dr. Madabhushi will serve as Co-PI of a joint grant with Johns Hopkins, Active surveillance biomarkers for reclassification of Small Low Grade, Low Stage T1c Indolent Prostate Cancer Tumors, which was recommended for funding from the Department of Defense.
In addition, two people under the mentorship of Dr. Madabhushi also received funding news. Dr. Mirabela Rusu has been awarded a two-year DOD post-doctoral fellowship grant, Identifying MRI markers for viable, post-radiation prostate tumors in men undergoing radiation therapy followed by prostatectomy, and Dr. Satish Viswanath has been recommended for funding (contingent on fund availability) for a two-year DOD post-doctoral fellowship grant, Computerized Fusion of Elastography and Multiparametric Magnetic Resonance Imagery for Improved Prostate Cancer Diagnosis and Prognosis .
Intersections: SOURCE Poster Award Winners
Congratulations to the following students mentored by Cancer Center members, who received awards at the December 2012 SOURCE Intersections Poster Competition:
- Elena Svenson, 1st place, Natural Sciences Poster Competition: Network Effects of TP53 and PTEN Mutations in Glioblastoma Multiforme Patients
Faculty Mentor: Mark Chance, Center for Proteomics and Bioinformatics
- Kevin Chen, Tie for 2nd place, Engineering Poster Competition: Engineering Viral Nanoparticles for Application in Medicine: Developing CPMV as a Platform for Efficient Intracellular Delivery of Therapeutics
Faculty Mentor: Nicole Steinmetz, Biomedical Engineering
- Catherine Gormley, Tie for 2nd place, Engineering Poster Competition: Impact of Sterilization on Antibiotic Release and Bioactivity from Affinity-Based Drug Delivery Systems
Faculty Mentor: Horst von Recum, Biomedical Engineering
Now in its ninth year, Intersections: SOURCE Symposium and Poster Session is where CWRU undergraduates present their research and creative projects.
Limited Submission: NIH Shared Instrumentation Grant Program
The Shared Instrumentation Grant (SIG) program provides a cost-effective mechanism for groups of NIH-supported investigators to obtain commercially-available equipment that costs more than $100,000. Instruments in this price range are typically too expensive to be obtained through a research project grant. The maximum SIG award is $600,000. Types of instruments supported include, but are not limited to, confocal and electron microscopes, biomedical imagers, mass spectrometers, DNA sequencers, biosensors, cell-sorters, X-ray diffraction systems, and Nuclear Magnetic Resonance (NMR) spectrometers among others. Each institution may submit ONE application per type of equipment.
LOI Deadline: February 1
Application Due to Sponsor: March 21
American Cancer Society IRG Awards
The Case CCC, with funds from its American Cancer Society Institutional Research Grant, will provide seed money to foster cancer research by junior faculty who have no current national grant support of their own. Investigators in the CWRU School of Medicine and Cleveland Clinic Lerner College of Medicine as well as in other schools and colleges in the University are eligible. Grants, not to exceed $30,000, will be awarded to investigators who intend to gather preliminary data to be used in seeking future and independently funded programs.
LOI Deadline: February 18
Application Deadline: April 5
MARK YOUR CALENDARS
TRCCC Annual Meeting: The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity
Registration is open for the 16th Annual Meeting of the Translational Research Cancer Centers Consortium (TRCCC),The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity. Held February 20-22 at the Seven Springs Mountain Resort in Seven Springs, PA, this meeting will feature two symposiums focused on Tumor-mediated Immune Suppression and Vaccine and Cellular Therapy, with spotlight sessions on Imaging and Viral Vectors. The agenda will also include a poster session. Researchers, institutional officials, and students are invited to submit abstracts for poster presentations by February 4.
NCI CANCER BULLETIN
January 8, 2013
Featured Article: Newly Discovered Gene Linked to Hepatitis C Virus Clearance, Treatment Response
Following Up on Genetic Study, Researchers Identify Potential Therapy for Bladder Cancer
Drug Combination Could Help Treat Deadly Form of Thyroid Cancer
Test May Inform Care of Women Infected with HPV
Genetic Mutations Alone Do Not Dictate Cancer Cell Behavior
Also in the Journals: Substitute for Drug in Short Supply Found to Be Inferior
Also in the Journals: Video Explains Realities of CPR for Patients with Advanced Cancer
In Depth Read
U.S. Cancer Deaths Continue Long-Term Decline
Busting a Myth about How Chemotherapy Works
Personal Stories, Evidence Drive Successful Antismoking Ad Campaign
Featured Clinical Trial: Experimental Drug for Relapsed or Resistant Ovarian Cancer