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January 14, 2013


Bing-Cheng Wang Honored with Professorship

Dr. Bing-Cheng Wang has been named the inaugural John and Josephine Wootton Professor in Research. Dr. Wang, Co-Leader of the Case CCC GU Malignancies Program, will be honored by the School of Medicine at a reception this week.

Cheng-Kui Qu Lab Establishes a Crucial Role of PTPMT1 in the Metabolic Regulation of HSC Function




Recent work from the laboratory of Dr. Cheng-Kui QuMetabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation, was published in the current issue of top biomedical research journal Cell Stem Cell. By dissecting the role of the mitochondrial phosphatase PTPMT1 in hematopoiesis, this work has uncovered a heretofore unknown mitochondrial metabolic regulation in hematopoietic stem cell (HSC) differentiation and self-renewal, which represents a conceptual advance in this field. While the Qu lab data establishes this novel concept within the context of HSCs, the investigators believe their findings may also extend to other somatic stem cells, embryonic stem cells, and even cancer stem cells. As such, the link between mitochondrial metabolism and stem cell function demonstrated in their report has widespread interest to the scientific community including stem cell biologists, hematologists, as well as those scientists involved in ageing, cancer and metabolism research.

Strong Cancer-related Funding Week for Anant Madabhushi and Team

‌The Center for Computational Imaging and Personalized Diagnostics (CCIPD) and a team led by Dr. Anant Madabhushi, Associate Professor and Director of the Center for Computational Imaging & Personalized Diagnostics, received updates on several important grants in the past week. Dr. Madabhushi will serve as Co-PI of a joint grant with Johns Hopkins, Active surveillance biomarkers for reclassification of Small Low Grade, Low Stage T1c Indolent Prostate Cancer Tumors, which was recommended for funding from the Department of Defense.

In addition, two people under the mentorship of Dr. Madabhushi also received funding news. Dr. Mirabela Rusu has been awarded a two-year DOD post-doctoral fellowship grant, Identifying MRI markers for viable, post-radiation prostate tumors in men undergoing radiation therapy followed by prostatectomy, and Dr. Satish Viswanath has been recommended for funding (contingent on fund availability) for a two-year DOD post-doctoral fellowship grant, Computerized Fusion of Elastography and Multiparametric Magnetic Resonance Imagery for Improved Prostate Cancer Diagnosis and Prognosis .

Intersections: SOURCE Poster Award Winners

Congratulations to the following students mentored by Cancer Center members, who received awards at the December 2012 SOURCE Intersections Poster Competition:

  • Elena Svenson, 1st place, Natural Sciences Poster Competition: Network Effects of TP53 and PTEN Mutations in Glioblastoma Multiforme Patients
    Faculty Mentor: Mark Chance, Center for Proteomics and Bioinformatics
  • Kevin Chen, Tie for 2nd place, Engineering Poster Competition: Engineering Viral Nanoparticles for Application in Medicine: Developing CPMV as a Platform for Efficient Intracellular Delivery of Therapeutics
    Faculty Mentor: Nicole Steinmetz, Biomedical Engineering
  • Catherine Gormley, Tie for 2nd place, Engineering Poster Competition: Impact of Sterilization on Antibiotic Release and Bioactivity from Affinity-Based Drug Delivery Systems
    Faculty Mentor: Horst von Recum, Biomedical Engineering

Now in its ninth year, Intersections: SOURCE Symposium and Poster Session is where CWRU undergraduates present their research and creative projects.


Limited Submission: NIH Shared Instrumentation Grant Program

The Shared Instrumentation Grant (SIG) program provides a cost-effective mechanism for groups of NIH-supported investigators to obtain commercially-available equipment that costs more than $100,000. Instruments in this price range are typically too expensive to be obtained through a research project grant. The maximum SIG award is $600,000. Types of instruments supported include, but are not limited to, confocal and electron microscopes, biomedical imagers, mass spectrometers, DNA sequencers, biosensors, cell-sorters, X-ray diffraction systems, and Nuclear Magnetic Resonance (NMR) spectrometers among others. Each institution may submit ONE application per type of equipment.

LOI Deadline: February 1
Application Due to Sponsor: March 21

American Cancer Society IRG Awards

The Case CCC, with funds from its American Cancer Society Institutional Research Grant, will provide seed money to foster cancer research by junior faculty who have no current national grant support of their own. Investigators in the CWRU School of Medicine and Cleveland Clinic Lerner College of Medicine as well as in other schools and colleges in the University are eligible. Grants, not to exceed $30,000, will be awarded to investigators who intend to gather preliminary data to be used in seeking future and independently funded programs.

LOI Deadline: February 18
Application Deadline: April 5


TRCCC Annual Meeting: The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity

Registration is open for the 16th Annual Meeting of the Translational Research Cancer Centers Consortium (TRCCC),The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity. Held February 20-22 at the Seven Springs Mountain Resort in Seven Springs, PA, this meeting will feature two symposiums focused on Tumor-mediated Immune Suppression and Vaccine and Cellular Therapy, with spotlight sessions on Imaging and Viral Vectors. The agenda will also include a poster session. Researchers, institutional officials, and students are invited to submit abstracts for poster presentations by February 4.


January 8, 2013

Featured Article: Newly Discovered Gene Linked to Hepatitis C Virus Clearance, Treatment Response

Following Up on Genetic Study, Researchers Identify Potential Therapy for Bladder Cancer

Drug Combination Could Help Treat Deadly Form of Thyroid Cancer

Test May Inform Care of Women Infected with HPV

Genetic Mutations Alone Do Not Dictate Cancer Cell Behavior

Also in the Journals: Substitute for Drug in Short Supply Found to Be Inferior

Also in the Journals: Video Explains Realities of CPR for Patients with Advanced Cancer

NIH Research Radio: Dr. Barry Kramer on Cancer Screening

In Depth Read
U.S. Cancer Deaths Continue Long-Term Decline

Busting a Myth about How Chemotherapy Works

Personal Stories, Evidence Drive Successful Antismoking Ad Campaign

Featured Clinical Trial: Experimental Drug for Relapsed or Resistant Ovarian Cancer

Updates Update



2013 CTSC Annual Pilot Grant Funding
LOI Deadline: January 15

Caring for Carcinoid Foundation-AACR Grant for Carcinoid Tumor and Pancreatic Neuroendocrine Tumor Research
Deadline: January 15

Landon Foundation-AACR INNOVATOR Award for Research in Personalized Cancer Medicine
Deadline: January 15

Landon Foundation-AACR INNOVATOR Award for International Collaboration in Cancer Research
Deadline: January 23

Limited Submission: Samuel Waxman Cancer Research Foundation Individual Research Proposals
Internal Deadline: January 25
External Deadline: March 18

2013 Young Investigator Award (YIA)
Pre-Application Deadline: January 25
Application Deadline: March 15

Sarcoma Foundation of America
Deadline: January 31

National Research Council Associateship Programs
Deadline: February 1

Oncology Nursing Society Foundation Master's Degree Scholarships
Deadline: February 1

Oncology Nursing Society Foundation Doctoral Degree Scholarships
Deadline: February 1

Prostate Cancer Foundation 2013 Young Investigator Awards
Deadline: February 1

Avon Foundation 2013 Breast Cancer Research Program
LOI Deadline: February 4
Invited Full Proposal Deadline: April 1

LOI Deadline: February 18
Application Deadline: April 5

Leukemia and Lymphoma Society Translational Research Program
LOI Deadline: March 1
Full Application Deadline: March 15

Childhood Brain Tumor Foundation
Deadline: March 12

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

eRA Commons Users Can Now Generate a Publications Report for the PHS 2590 with My NCBI (NOT-OD-13-017)

Public Access Compliance Monitor: A New Resource for Institutions to Track Public Access Compliance (NOT-OD-13-020)

Dissemination and Implementation Research in Health (R21)(PAR-13-054)

Dissemination and Implementation Research in Health (R01)(PAR-13-055)

Dissemination and Implementation Research in Health (R03)(PAR-13-056)

Accelerating the Pace of Drug Abuse Research Using Existing Data (R01)(PAR-13-080)

Bridging the Gap Between Cancer Mechanism and Population Science (U01)(PAR-13-081)

Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21)(PAR-12-094)

Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21)(PAR-12-096)

Basic Cancer Research in Cancer Health Disparities (U01)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216.844.8317 phone
216.844.7832 fax


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January 14

Cancer Center Research Chalk Talk
Stan Gerson, MD
Director, Case CCC
Professor, Div. of Hem/Onc
Topic: TBD
12 pm WRB 3-136

January 15

Radiation Oncology Grand Rounds
Min Yao, MD, PhD
Associate Professor, Radiation Oncology
Topic: FDG PET in the Management of Head and Neck Squamous Cell Carcinoma
8:10 am Lerner Tower B-181

Cancer Biology Invited Speaker Seminar
David Odde, PhD
Professor, Biomedical Engineering
Director, Undergraduate Studies
University of Minnesota
Topic: Modeling the Mechanics of Cellular Traction Force
11 am NC1-202 Cleveland Clinic

Immunology Seminar Series
Russell Vance, PhD
Associate Professor, Immunology
University of California, Berkeley
Topic: Cytosolic Surveillance as a Strategy for Innate Detection of Pathogens
12 pm WRB 1-413

Medicine Grand Rounds
James Fang, MD
Director, Advanced Heart Failure & Transplant Center
UH Harrington Heart & Vascular Institute
Topic: Heart Failure - When to Worry
12 pm Kulas Auditorium, Lakeside 5th Fl.

January 16

Hematology and Oncology Division Research Conference
Alvin Schmaier, MD 
Professor, Div. of Hem/Onc
Topic: Prolylcarboxypeptidase: A Vasculoprotective Gene
8 am Lerner Tower B-151

Immunology Invited Speaker Seminar Series
Peggy Kendall, MD
Assistant Professor, Medicine and Pathology, Microbiology & Immunology
Vanderbilt University
Topic: The Secret Life of B Lymphocytes: Anergy and Autoreactivity in Type 1 Diabetes
12 pm NC1-202 Cleveland Clinic

OnCore Clinical Trials Management System Training Classes
April Firstencel
Registration Coordinator for and NCI/CTRP
Topic: What We Learned About Missing Info in OnCore Needed for the Grant Renewal and NCI Site Visit (including changes to the PRMC application)
12 pm Wearn 137

Frontiers in Biological Sciences Lecture Series
Jennifer Lippincott-Schwartz, PhD
Chief, Section on Organelle Biology
Cell Biology and Metabolism Branch
National Institute of Child and Human Development, National Institutes of Health
Topic: Navigating the Cellular Landscape with New Optical Probes, Imaging Strategies and Technical Innovations
1:30 pm WRB 1-413

January 17

Cancer Trainee Seminar
Katie Doud
Graduate Student, Pharmacology
Topic: Nuclear Receptor Ligand Targeting by the Fatty Acid Binding Proteins: Implications in Carcinogenesis
Andy Parchman, MD
Clinical Fellow, Div. of Hem/Onc
Topic: Pancreatic Cancer
12 pm WRB 3-136

National Center for Regenerative Medicine Seminar
Stan Gerson, MD
Director, National Center for Regenerative Medicine
Director, Case CCC
Topic: NCRM in 2013: Bringing Cleveland Stem Cells to the State of Ohio
1:30 pm WRB 1-413

January 18

Hematology/Oncology Fellows Conference/Curriculum Series
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Cynthia Austin, MD
Obstetrics and Gynecology
Cleveland Clinic 
Edmund Sabanegh, MD
Department Chair, Urology
Cleveland Clinic
Topic: Cancer and Fertility
R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Mohandas Narla, DSc
Vice President for Research
New York Blood Center
Topic: Insights into Erythropoiesis and Red Cells
12 pm BRB 105

Cancer Center Research in Progress
Jenny Parvani
Graduate Student, Schiemann Lab, Div. of General Medical Sciences-Oncology
Topic: Dissecting the Role of Beta1 Integrin in Oncogenic TGF-beta signaling and Metastatic Breast Cancer
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


The Role of Interferon in Metastasis and Resistance to DNA Damage in Prostate Cancer
February 7
Cleveland Clinic Room Q1-300

IMPACT: Improving Sickle Cell Patient Adherence Through Collaborative Teaching
March 23
Wolstein Research Building
Brochure and Registration

Breast Cancer Conference
May 17
Hilton Cleveland East


16th Annual Meeting of the Translational Research Cancer Centers Consortium (TRC3): The Power of Negative Thinking: Inhibiting the Inhibitors of Tumor Immunity
February 20-22
Seven Springs Mountain Resort, Seven Springs, PA

National GvHD Health Symposium
November 1