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2012 Articles

September 24, 2012

Date Released: 24 September 2012
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Stan Gerson, MD
Director, Case CCC

Case CCC Strategic Plan 2012-2018

We have revised the Case CCC Strategic Plan 2012-2018 through consultation with the Executive Committee and Program Leaders. The revised Strategic Plan contains updates for each scientific program and the initiatives in genomics, breast cancer and brain tumors. We have also provided more focus on our disease-based efforts and the integration of nano medicine, imaging and bioinformatics.

We plan on posting the Strategic Plan on the Cancer Center website in two weeks, and will also have it available at the site visit on October 23. With this in mind, please review theStrategic Plan and send me your feedback within the next weeks.

Also, as a reminder as we prepare for the site visit, please keep your Program Leader up to date on recent grants and publications.


Broadview Heights Man Overcomes Disease, Continues to Live Life to the Fullest
Plain Dealer - Sep 18, 2012
Not only is his illness under control, but it has become nearly undetectable since he began seeing myeloma specialist Dr. Frederick Reu at the ...

Study shows vitamin E may decrease cancer risk in Cowden ...
Medical Xpress-Sep 17, 2012
... in the succinate dehydrogenase (SDH) genes may be responsible for cancer development, according to research by Charis Eng, M.D., Ph.D., ...

The Widow's Doctor Visit
New York Times (blog)-Sep 12, 2012
By MIKKAEL A. SEKERES, M.D.. Brian Stauffer. I walked into the examination room and saw her sitting there, her arm around her 10-year-old ...


Case CCC American Cancer Society Institutional Research Grant Pilot Awards

Congratulations to the recent recipients of the Case CCC American Cancer Society Institutional Research Grant pilot awards:

  • Medhat Askar, MD, PhD: The Impact of MHC Class I Chain-Related Gene A (MICA) Donor-Recipient Mismatches and MICA-129 Polymorphism On Unrelated Donor Hematopoietic Stem Cell Transplants (HSCT) for Hematological Malignancies
  • Paolo Caimi, MD: Finding new predictive and prognostic factors in Chronic Lymphocytic Leukemia: High - resolution flow cytometry analysis of CLL samples from the Eastern Cooperative Oncology Group Randomized Clinical Trial E2997
  • Hannah Gilmore, MD: Ex vivo expansion of cancer stem cells (CSCs) in breast malignancies using mammospheres
  • Justin D. Lathia, PhD: Interrogating cell communication in the Glioblastoma cellular hierarchy
  • Mary M. Step, PhD: Feasibility of a Team Approach for Discussing Prognosis and Treatment Goals (T-PAT) During Advanced Breast Cancer
  • Ramon V. Tiu, MD: In-vitro and In-vivo effects of spliceosome inhibitors/ modulators, hypomethylating agents, growth factors and immunomodulatory agents in SF3B1 mutant primary bone marrow cells and in mouse models of Sf3b1
  • Jennifer Yu, MD, PhD: Hyperthermia Sensitizes Glioblastoma Initiating Cells to Radiation Via Downregulation of AKT

These funds are designed to provide seed money to support junior faculty members with an interest in cancer research who do not have national grant support of their own.


Association for Research of Childhood Cancer

The Association for Research of Childhood Cancer is accepting applications for its grant award program. The purpose of these awards are to provide funding for basic science and clinical projects related to the goal of advancing knowledge in pediatric and adolescent cancers.

Deadline: January 1, 2013


September 18, 2012

Featured Article: Lung Cancer Genome Surveys Find Many Potential Drug Targets

Diagnostic Radiation Exposure May Raise Breast Cancer Risk in Some BRCA1/2 Mutation Carriers

New Drug Improves Survival in Patients with Advanced Lung Cancer

Drug Targeting Tumor Suppressor Shows Promise in First Human Study

Study Reveals How Breast Cancer Spreads to Lymph Nodes

Also in the Journals: Smoky Coal Associated with Increased Risk of Lung Cancer in Rural China

Also in the Journals: Best Practices Can Reduce Central-Line Infections in Children with Cancer


Guest Commentary by Assistant Secretary for Health Dr. Howard Koh: Changing Social Norms about Tobacco Use, One Campus at a Time

A Conversation with Dr. John Stamatoyannopoulos about ENCODE and Cancer Research

In Depth

Building a Biobank to Explore Mysteries of the Genome

Singled Out: Researchers Look to Single Cells for Cancer Insights

Featured Clinical Trial: Treating KSHV-Associated Multicentric Castleman Disease


AHRQ Update

FDA Update




September 24

Hematology/Oncology Special Conference
Ronald Maggiore, MD
Clinical Fellow, Div. of Hem/Onc
University of Chicago
Topic: Geriatric Oncology Approaches in Head/Neck Cancer
12 pm Wearn 137

Pathology Research Seminar Series
Chao Feng
Schmaier Lab, Div. of Hem/Onc
Topic: TBD
12 pm WRB 1-413

Physiology and Biophysics Seminar
Eric Delpire, PhD
Professor, Anesthesiology and Molecular Physiology & Biophysics 
Vanderbilt University
Topic: Ste20 and WNK kinases in the regulation of Na+-(K+)-Cl- transport
4 pm SOM / Robbins Building, E-501

September 25

Immunology Seminar Series
Cheng-Kui Qu, MD, PhD
Associate Professor, Div. of Hem/Onc
Topic: Bioenergetic Regulation of Hematopoietic Stem Cell Differentiation
12 pm WRB 1-413

Pharmacology Invited Seminar
Steven Ludtke, PhD
Associate Professor, Biochemistry and Molecular Biology
Baylor College
Topic: Macromolecular Motion and Variability Via CryoEM and CryoET
12 pm Webster Conference Rm, W331

Pharmacology Invited Seminar
David Goldstein, PhD
Director, Center for Human Genome Variation
The Richard and Pat Johnson Distinguished University Professor
Duke University
Topic: Complete Sequencing and Human Disease: A Genetic Approach to Genomics
1 pm Webster Conference Rm, W331

September 26

Hematology and Oncology Division Research Conference canceled

Immunology Invited Speaker Seminar Series
Pushpa Pandiyan, PhD
Assistant Professor, Biological Sciences
Topic: Suppressive and Non-Suppresive Functions of Foxp3+ Regulatory T Cells
12 pm NC1-202 Cleveland Clinic

Innovative Science Discussion Group
Topic: Discovery of New Mechanism of Oncogenic Mutation
12:15 pm WRB 3-136

September 27

September 28

Hematology/Oncology Fellows Conference/Curriculum Series
Hillard Lazarus, MD
Professor, Div. of Hem/Onc
Andy Parchman, MD
Fellow, Div. of Hem/Onc
Topic: Core Binding Factor Acute Myeloid Leukemia
8 am Wearn 137

Cell Biology Seminar Series
Dean Tang, MD, PhD
Professor, Carcinogenesis
University of Texas MD Anderson Cancer Center
Topic: Understanding the Cellular Heterogeneity of Prostate Cancer
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Yogen Saunthararajah, MD
Associate Professor, Hematologic Oncology and Blood Disorders
CWRU/Cleveland Clinic
Topic: Genetic-Epigenetic Interactions in Oncogenesis and Clinical Translation into Non-Cytotoxic Epigenetic Therapy
12 pm Frohring Auditorium – BRB 105

Cancer Center Research in Progress
Hong Zheng, PhD
Postdoctoral Scholar, Qu Lab, Div. of Hem/Onc
Topic: An Activating Mutation of Protein Tyrosine Phosphatase Ptpn11 (Shp2) in the Hematopoietic Microenvironment Induces Myeloproliferative Disorder
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


National GvHD Health Symposium
November 2
Embassy Suites Cleveland-Rockside


Ninth International Conference of the Society for Integrative Oncology
October 8-10
Albuquerque, NM

Biennial Science of Global Prostate Cancer Disparities conference
November 1-4
Nassau, The Bahamas

The Cancer Genome Atlas 2nd Annual Scientific Symposium: Enabling Cancer Research Through TCGA
November 27-28
Crystal City, Virginia
Deadline to submit abstracts: October 5

American Society of Hematology (ASH) Annual Meeting
December 8-11
Atlanta, Georgia

Pacific Symposium on Biocomputing 2013
January 3-7, 2013
Fairmont Orchid, Hawaii


Szent-Györgyi Prize for Progress in Cancer Research
Deadline: September 30

American Cancer Society Area of Special Interest: The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment
Deadline: October 15

American Cancer Society Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families
Deadline: October 15

American Cancer Society Priority Focus in Cancer Control and Prevention Research Program: Health Disparities Research
Deadline: October 15

Bonnie J. Addario Lung Cancer Foundation Research Grants
Deadline: October 15

Robert Wood Johnson Foundation Scholars in Health Policy Research program
Deadline: October 16

CTSC KL2 Training Program
Deadline: October 22

AACR–American Cancer Society Award for Research Excellence in Cancer Epidemiology and Prevention
Nomination Deadline: September 26

AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Nomination Deadline: September 26

AACR Award for Lifetime Achievement in Cancer Research
Nomination Deadline: September 26

AACR Princess Takamatsu Memorial Lectureship
Nomination Deadline: September 26

AACR Award for Outstanding Achievement in Chemistry in Cancer Research
Nomination Deadline: October 3

AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship
Nomination Deadline: October 3

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Nomination Deadline: October 3

Melanoma Research Alliance-Prostate Cancer Foundation Team Science Partnership Award
Deadline: October 15 

NCI Clinical Assay Development Program (CADP)
Deadline: October 15

Conquer Cancer Foundation Advanced Clinical Research Award (ACRA)
LOI Deadline: October 22
Full Application Deadline: December 5

Alex's Lemonade Stand Foundation Springboard Grant
Deadline: October 29

Leukemia & Lymphoma Society Specialized Center of Research Program
Deadline: November 1

DeGregorio Foundation Award for Cancers of the Upper GI Tract
Deadline: November 5

Limited Submission: NIH Director's Early Independence Award
Internal Deadline: November 26
LOI Deadline: December 30
Full Application: January 30, 2013

Alex's Lemonade Stand Foundation Epidemiology Awards
Deadline: December 17

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Selection of Appropriate Funding Opportunity under the National Cancer Institute (NCI) Initiative Research Answers to NCIs Provocative Questions(NOT-CA-12-014)

Notice of Intent to Publish a Funding Opportunity Announcement for U.S.-Russia Bilateral Collaborative Research Partnerships (CRP) on the Prevention and Treatment of HIV/AIDS and Co-morbidities (R21)(NOT-DA-12-020)

Research Answers to NCIs Provocative Questions- Group A (R01)(RFA-CA-12-015)

Research Answers to NCIs Provocative Questions- Group A (R21)(RFA-CA-12-016)

Research Answers to NCIs Provocative Questions- Group B (R01)(RFA-CA-12-017)

Research Answers to NCIs Provocative Questions- Group B (R21)(RFA-CA-12-018)

Research Answers to NCIs Provocative Questions- Group C (R01)(RFA-CA-12-019)

Research Answers to NCIs Provocative Questions- Group C (R21)(RFA-CA-12-020)

Research Answers to NCIs Provocative Questions- Group D (R01)(RFA-CA-12-021)

Research Answers to NCIs Provocative Questions- Group D (R21)(RFA-CA-12-022)

Revisions for Early-Stage Development of Informatics Technology (R01)(PAR-12-286)

Advanced Development of Informatics Technology (U24)(PAR-12-287)

Early-Stage Development of Informatics Technology (U01)(PAR-12-288)

Revisions for Early-Stage Development of Informatics Technology (U01)(PAR-12-289)

Revisions for Early-Stage Development of Informatics Technology (P01)(PAR-12-290)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

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