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2012 Articles

March 19, 2012

Date Released: 19 March 2012
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Cleveland Clinic Geneticist: We Need More People Who Can Explain Genetic Data to Patients
MedCity News - Mar 19, 2012
... according to Dr. Charis Eng, chair of Cleveland Clinic's Genomic Medicine Institute. For example, data analyzed incorrectly could be dangerous, ...

Multiple Myeloma: Relapsed and Refractory Patients, a Clinical Context Report
MedPage Today - March 18, 2012
I'm Michael Smith of MedPage Today, and I'm here with Dr. Stan Gerson, Director of the Seidman Cancer Center at University Hospitals Case Medical ...

Ohio Legislator Wants Insurance Coverage to be Same for Oral, Injectable Chemotherapy Treatments
Plain Dealer - Mar 17, 2012
"I was disappointed, blindsided," said Ballis, 77, who is under the care of Dr. Mikkael Sekeres, a hematologist/oncologist at the Cleveland Clinic...Fearigo's physician, Dr. Neal Meropol, had prescribed the drug for her on the strength of a clinical trial that showed favorable results in treating neuro-endocrine cancer...

Detecting Colon Cancer Early Can Save Your Life: NetWellness
Plain Dealer - Mar 14, 2012
This NetWellness column was reviewed by Dr. Gregory S. Cooper, professor of medicine, School of Medicine, Case Western Reserve University.

New Pathway Found for Regulation of Blood Vessel Growth in Cancer
Science Daily - Mar 2, 2012
Zerrouqi, postdoc Beata Pyrzynska and Van Meir collaborated with Maria Febbraio, PhD, a researcher at the Cleveland Clinic to probe angiogenesis and Daniel ...

New Tool to Help with Prognosis of Patients with Brain Metastases
Neurology Today - Feb 2, 2012
Lisa Rogers, DO, head of the medical neuro-oncology program at University Hospital Case Medical Center in Cleveland, said that such a tool becomes more important as the number of treatment options for brain metastases increase.


Case CCC Clinical Research Retreat

Registration is open for the Case CCC Clinical Research Retreat, April 4 in the Dively Building on CWRU campus. An opening reception will start at 5:30 pm, followed by dinner and presentations from 6-8:30 pm.

The agenda will focus on new initiatives of critical importance to clinical investigators. Topics will include:

  • Description of our new N01 Consortium that provides opportunities to access investigational agents from NCI and conduct multicenter trials;
  • Discussion of the Cancer IRB transition;
  • Enhancements of clinical research operations, policies, and procedures;
  • NIH regulations regarding clinical trial registration- PI responsibilities.

Please contact Katarzyna Karelus or Dana Rose with any questions.

Informatics Symposium

Register today for Informatics: Driving Discovery, Improving Health (IDD 2012)April 6 in the Wolstein Research Building. This symposium, sponsored by CWRU and Clinical and Translational Science Collaborative (CTSC), brings together all the disciplines involved in clinical and translational research for the shared benefits of networking and education.

Symposium themes will focus on the application and impact of information technology, such as:

  • Informatics for Integrating Biology and the Bedside
  • Electronic Health Record Facilitated Enterprise Performance Management
  • Multi-Modality, Multi-Resource Information Integration Environment for Multi-center Physiological and Clinical Research Studies
  • Grid and Cloud Platforms for Translational Informatics and Data Management

A discounted registration rate of $30 is available for students and CTSC/Cancer Center members.

Case CCC Scientific Series

Please mark your calendars for the next installments of the Case CCC Scientific Series:

Stem Cells
April 12
Reception and presentations, 4-6 pm BRB 105
Alex Huang, MDLongitudinal tracking of in vivo tumor microenvironment in high definition
Jeongwu Lee, PhDC-MET signaling in GBM stem cells and treatment resistance
Ofer Reizes, PhDObesity tips the scales on breast cancer: a role for the fat hormone leptin in cancer stem cells

Imaging Research
May 31
Reception and presentations, 4-6 pm WRB 1-413
Jim Basilion, PhDIntroduction
Chris Flask, PhDDevelopment of PARACEST-MRI Imaging Agents for In Vivo Assessment of Autophagy OR Magnetic Resonance Imaging as an Early-Stage Biomarker
Cheryl Thompson, PhDVariation in Breast Tissue Gene Expression by Mammographic Density

These extended conferences feature recent scientific investigation from our members, featuring presentations by investigators who received pilot funding after competitive peer review by the Cancer Center. Please make every effort to attend.


BETRNet Pilot Funding

Faculty members with an appointment at the Assistant Professor level or higher at participating institutions are invited to submit applications for individual and/or crossBarrett's Esophagus Translational Research Network (BETRNet) pilot projects. Participating institutions include CWRU, University of Pennsylvania, Fred Hutchinson Cancer Research Center, Johns Hopkins, University North Carolina, Washington University, and Mayo Clinic. BETRNet projects must be directed toward translational research related to Barrett's Esophagus or Esophageal Adeno Carcinoma. At least one specific aim should involve either direct patient contact or the study of patient derived tissue samples.

Deadline: May 18

The Doctors Cancer Foundation

The Doctors Cancer Foundation, Inc., is a non-profit corporation that has been formed to provide seed money for promising new concepts in cancer research. By supporting research projects seeking to find new principles of cancer management, the Foundation will encourage scientists to identify and explore untested forms of treatment and ultimately enhance the quality of care for the people who have cancer. The Foundation is accepting applications for the 2012 funding cycle. There is a strong interest in cancer stem cells, microRNAi agents, epigenetic agents, as well as many others. They are particularly interested in promoting the best of the young scientists, currently under the radar screen.

Deadline: May 31

HHMI Investigator Program Announces National Competition

The Howard Hughes Medical Institute (HHMI) invites applications for investigator positions from outstanding scientists who have demonstrated originality and substantial accomplishments in biomedical research and who show exceptional promise for future achievement and leadership in research. The Institute expects to appoint between 20-30 new investigators.

This HHMI investigator competition is open to scientists who study significant biological problems in all of the biomedical disciplines as well as in adjacent fields such as biophysics, chemical biology, biomedical engineering, and computational biology. Plant scientists, experimental evolutionary biologists, and patient-oriented researchers are welcome to apply to this competition.

Deadline to establish eligibility: May 1
Application Deadline: June 13


NCI Annual Report on Complementary and Alternative Medicine: FY2010 Released

The NCI Annual Report on Complementary and Alternative Medicine: FY2010 was recently released. This report is produced by the Office of Cancer Complementary and Alternative Medicine (OCCAM), which is an office of the NCI in the Division of Cancer Treatment and Diagnosis. OCCAM is responsible for NCI's research agenda in complementary and alternative medicine (CAM) as it relates to cancer prevention, diagnosis, treatment, and symptom management.

CWRU investigators Drs. Subrata Haldar and Aruna Basu are highlighted in the section on "Accelerating Progress in Cancer Prevention" for their research of whether the compound benzyl isothiocyanate (BITC), which is produced when digesting certain cruciferous vegetables, may be used to prevent or treat pancreatic cancer. Preliminary results have been promising, and have shown BITC alters the levels of microRNA in pancreatic cancer cells, and may be effective in slowing the growth of these cells.




**All events are open to anyone interested in attending

March 19

Physiology and Biophysics Seminar
Lukas Tamm, PhD
Harrison Professor of Molecular Physiology and Biological Physics
Director, Center for Membrane Biology 
University of Virginia
Topic: Assembly of the Synaptic Exocytotic Fusion Machine
4 pm SOM E501

F. Joseph Callahan Distinguished Lecture
Jerome Groopman, MD
Dina and Raphael Recanati Chair of Medicine
Harvard University/Beth Israel Deaconess Medical Center
Pamela Hartzband, MD
Assistant Professor, Medicine
Harvard University/Beth Israel Deaconess Medical Center
Topic: What's Missing in Medicine
5:30 pm Severance Hall
Reserve your free ticket

March 20

Department of Cancer Biology Invited Speaker Seminar
Quan Chen, PhD
Professor, The State Key Laboratory Biomembrane and Membrane Biotechnology
Chinese Academy of Sciences/Institute of Zoology
College of Life Sciences, Nankai University
Topic: Molecular Regulation of Mitochondrial Autophagy
11 am NC1-202 Cleveland Clinic

Immunology Seminar Series
Bing Su, PhD, MPH
Associate Professor, Immunobiology
Yale University
Topic: Mammalian TOR Function in Lymphocytes
12 pm WRB 1-403

Pharmacology Seminar
Mary Helen Barcellos-Hoff, PhD
Professor, Radiation Oncology and Cell Biology
New York University
Topic: Microenvironment Matters in Breast Cancer
12 pm SOM W331

Molecular Biology and Microbiology Thesis Presentation
Julian Wong
Karn Lab, Molecular Biology and Microbiology
Topic: The Role of Negative Elongation Factor NELF in the Regulation of HIV Transcription, Viral Latency and the Control of Cellular Gene Expression
1 pm SOM W203

March 21

Hematology and Oncology Division Research Conference
Brenda Cooper, MD
Professor, Div. of Hem/Onc
Santosh Rao, MD
Fellow, Div. of Hem/Onc
Topic: Burkitt's Lymphoma and the Use of Code White Team in Seidman Cancer Center 
8 am Lerner Tower B-151

Immunology Faculty Research in Progress Seminar
Anna Valujskikh, PhD
Associate Staff, Immunology
Cleveland Clinic
Topic: From Helper Memory T Cells to Pathogenic Alloantibodies: Lab Update
12 pm NC1-202 Cleveland Clinic

March 22

Cancer Center Faculty Candidate Seminar
Chunhong Yan, PhD
Assistant Professor, Center for Cell Biology and Cancer Research
Albany Medical College
Topic: A Transcription Network and Targeted Cancer Therapy
9 am WRB 3-136

Molecular Biology and Microbiology Seminar
Marissa Sherman
Nguyen Lab, Molecular Biology and Microbiology
Topic: Novel Targets for Potentiation of Antituberculous Activity of Classical Antifolates
Kerstin Wolff, PhD
Nguyen Lab, Molecular Biology and Microbiology
Topic: A Role for Eukaryotic-like Serine/Threonine Kinase G of Mycobacteria in Redox Regulation
1 pm SOM W203

Sternlicht Memorial Lectureship in Cancer Biology and Pharmacology
Gordon Shore, PhD
Professor, Biochemistry
McGill University
Topic: Targeting Mcl-1 for Synthetic Lethality in Cancer Therapy
4 pm WRB 1-413

March 23

Hematology/Oncology Fellows
Nicole Williams, MD
Fellow, Div. of Hem/Onc
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Laura Shepardson, MD
Staff, Diagnostic Radiology
Cleveland Clinic
Topic: Breast Imaging: Current Methodologies and Future Directions
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Candece Gladson, PhD
Topic: TBD
12 pm BRB 105

Cancer Center Research in Progress Seminar
Jonathan Kenyon
Graduate Student, Gerson Lab, Div. of Hem/Onc
Topic: The Age Related Loss of Mismatch Repair in Human Hematopoietic Stem/Progenitor Cells
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Case CCC Clinical Research Retreat
April 4
5:30-8:30 pm Dively Building

Breast Cancer 2012: Risk Assessment through Survivorship
May 18

Ca-PRI Annual Meeting: Learning from Our Differences
June 5-7 InterContinental Hotel


Grant Writing and Reviewing Workshop
March 29
Alan L. Willard, PhD
Deputy Director, Division of Extramural Research
Topic Writing and Reviewing Grants: Negotiating the NIH Grant System
10 am - 12 pm WRB 1-413
AND Job Opportunities in Health Research Administration at the NINDS
1-2 pm WRB 1-413

Department of Biomedical Engineering Special Seminar
May 3
Steve Zullo, PhD
Program Director, Division of Discovery Science and Technology
National Institute of Biomedical Imaging and Bioengineering, NIH
Topic: NIH Grant Machine Revealed, Not a Black Box Anymore
12 pm Wickenden 509


American Legacy Foundation Sybil G. Jacobs Award for Outstanding Use of Tobacco Industry Documents
Deadline: March 23

American Legacy Foundation Christine O. Gregoire Youth/Young Adult Award for Outstanding Use of Tobacco Industry Documents
Deadline: March 23

Multiple Myeloma Research Foundation 2012 Senior Research Award Program
Deadline: March 27

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt (ENGAGE) Summer Program
Deadline: March 30

Irvington Institute Fellowship Program
Deadline: April 1

American Cancer Society Postdoctoral Fellowships
Deadline: April 1

Clinical and Translational Informatics Funding Opportunity
Deadline: April 2

DAISY Foundation 2012 Patient Care Research Grant Program for Nurses
LOI Deadline: April 2
Application Deadline: June 8

Specialized Program of Research Excellence in Gastrointestinal Malignancies (GI SPORE)
Deadline: April 2

DOD Breast Cancer Research Program Postdoctoral Fellowship Award
Pre-Application Deadline: April 5
Application Deadline: April 19

DOD Breast Cancer Research Program Era of Hope Award
Pre-Application Deadline: April 5
Application Deadline: April 19

DOD Ovarian Cancer Research Program Pilot Award
Pre-Application Deadline: April 9
Application Deadline: July 18

SU2C-CRI Cancer Immunology Translational Research Dream Team
LOI Deadline: April 9

DOD Peer Reviewed Medical Research Program Investigator-Initiated Research Award
Pre-Application Deadline: April 10
Application Deadline: July 31

DOD Ovarian Cancer Research Program Ovarian Cancer Academy Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Synergistic Translational Leverage Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Teal Innovator Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Breast Cancer Research Program Idea Award Award
Pre-Application Deadline: April 26
Application Deadline: August 15

American Nurses Foundation Nursing Research Grants
Deadline: May 1

DOD Breast Cancer Research Program Impact Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Innovator Award Award Award
Pre-Application Deadline: May 3
Application Deadline: August 2

DOD Breast Cancer Research Program Clinical Translational Research Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Transformative Vision Award
Pre-Application Deadline: May 3
Application: August 15

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

NCI Will Participate in RFA-AI-12-004 Leadership Group for a Clinical Research Network on Therapeutics for HIV/AIDS and HIV-associated Infections in Adults (UM1)(NOT-CA-12-012)

The NCI Transition Career Development Award (K22)(PAR-12-121)

Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01)(PA-11-160)

Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R21)(PA-11-161)

Biomarkers of Infection-Associated Cancers (R01)(PA-11-158)

Biomarkers of Infection-Associated Cancers (R21)(PA-11-159)

The Tobacco Regulation Awareness, Communication, and Education Program (U1A)(RFA-FD-12-002)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


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