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2012 Articles

July 23, 2012

Date Released: 23 July 2012
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Stan Gerson, MD
Director, Case CCC

Case CCC Clinical Trials Leadership Appointments

Rob Dreicer, MD, Chair of Solid Tumor Oncology at Taussig Cancer Institute (TCI), has been appointed as Director for Clinical Trials for the Cancer Center, and in this capacity serves on the Executive Committee of the Case CCC and as chair of the Clinical Research Operations Committee (CROC). At TCI, Dr. Dreicer is also Deputy Director for Clinical Research. With this role, he is the TCI principal investigator for the N01 phase II clinical trials contract with NCI-CTEP and will be in charge of TCI interactions with cooperative groups. Dr. Dreicer will also be instrumental in clinical trial accrual, and, working together with Dr. Brian Rini, with TCI strategic planning for genomics. He will continue to lead Solid Tumor Oncology research.

Mikkael Sekeres, MD, MS has been appointed Vice Chair for Clinical Research at TCI. He will be in charge of clinical research in the region and affiliates; database development; conflict of interest; biostatistics; research compliance; clinical trial accrual and minority accrual; and operations. He will serve as the medical director for the TCI Clinical Trials Unit that interacts directly with the Case CCC Clinical Research Office. Dr. Sekeres will also be participating in genomic strategic planning.

Notes from the Site Visit Preparation Retreat

The Cancer Center Annual Retreat was held July 10. We reviewed the nature of the NCI site visit and its goals. Two Programs gave preliminary presentations, and four cores were discussed. Images from the retreat are posted on our website.

Case CCC members can provide the following assistance for the upcoming site visit:

Recent scientific advances: Program leaders would like to highlight recent scientific advances, preferably in the context of collaboration aligned with the scientific focus areas of the program. If you have a recent advance, publication or grant please email or discuss with your program leader. They will be preparing 10 minute presentations for the EAB on September 7.

Clinical trial accrual: We will provide an update of accrual through September 30, 2012. Thus, your clinical research efforts over the next three months really matter! Please take the opportunity to discuss clinical trials with your patients.

New collaborative efforts: Please let program leaders know about new grant submissions, papers published, new clinical trials developed, even at the LOI stage, and new collaborations.

Journal Covers: We are collecting images of journal covers featuring Cancer Center member research from the past five years. Please send an image of the cover to Gillian Todd.

The EAB meeting is set for September 7 in Thwing, and will be a full rehearsal for the site visit. A number of individuals not presenting will be asked to attend individual program presentations to support the science presented. The roster for the site visit will be circulated the first week of October.

Case CCC Community Advisory Board

The Case CCC recently named a community advisory board to guide the Cancer Center in addressing cancer care disparities in our minority and underserved populations. The Board partners with the community and the Cancer Center. Among its goals are better understanding of the underlying factors contributing to disparities, and developing meaningful education programs to underscore the importance of preventive care and screening to detect cancer at an early stage. Also emphasized will be cancer care options and the importance of clinical research in developing new and more effective treatments.

The Community Advisory Board recently represented the Cancer Center at Brother to Brother Health and Wellness Rap Session for Cuyahoga Metropolitan Housing Authority (CMHA) men, and publicized the lung cancer screening program at Cleveland Clinic and University Hospitals. Upcoming events include other community programs where we can educate the public on the importance of early detection and prevention care for cancer.

Notes from the NCI Board of Scientific Advisors Meeting

The NCI Board of Scientific Advisors met on June 25. During this public meeting, the board reviewed key decision point initiatives at the NCI. Those of note to Cancer Center members include:

Establishment of an AIDS malignancies task force for NCI: I have been asked to join this subcommittee to review opportunities to expand world-wide and NCI cancer center based efforts in the area of HIV-associated malignancies. We will evaluate current research and database activities, demographics of cancer risk and the role of ongoing HIV infection, and interactions between CFARs and Cancer Centers. Given our initiatives in these areas and ongoing efforts in Uganda, this is an ideal opportunity to increase our visibility in this research area.

Bullet points from the NCI

  • The NCI is preparing an improved algorithm for assessing low dose CT for lung cancer screening.
  • The Provocative Questions initiative received 750 applications. Each had three reviews; 15% were reviewed by Program Leaders with NCI leadership, and they expect to fund 50-60 proposals. The date of announcement is unclear. There may be a re-issue with a revised list of Questions.
  • The Clinical Trials Network RFA will be issued in "several months".
  • The NCI will establish a NCAB Center for Cancer Genomics Working Group to advise the NCI and NIH on using genomic science to better diagnose and treat cancer patients. Details of this initiative were not stated. However, our Cancer Genomic Initiative will keep tabs on this process and participate where we can.
  • The NCI has reinvented CaBIG into the National Cancer Informatics Program. This effort will establish standards for genomics, bio-informatics, biosample annotation, and links of databases under HIPAA. The emphasis will be facilitation of existing systems rather than creation of new efforts with high barriers of adoption. This is a welcome change from the perspective of the CaBIG initiative.


Genetic Aberrations Seen as Path to Stop Colon Cancer
New York Times - Jul 18, 2012
... but their work lacked the scope of the new project, and it provided more limited information on genetic changes, said Dr. Sanford Markowitz, ...

Hope for brain cancer treatment lies within vaccine being tested at Ridgewood hospital
The Record - July 16, 2012
..." Cancer vaccines are in their infancy," said Dr. Andrew Sloan, director of brain tumor and neuro-oncology at University Hospitals Case Medical Center in Cleveland...


Mukesh Jain, MD to Lead the American Society for Clinical Investigation

‌Dr. Mukesh JainDr. Mukesh Jain has been elected Vice President of the American Society for Clinical Investigation (ASCI). Following his tenure as Vice President of ASCI, Dr. Jain will advance to President Elect, then President in successive years. Established in 1908, the ASCI is one of the nation's oldest and most respected medical honor societies, and has more than 3,000 members.


DOD Broad Agency Announcement for Extramural Biomedical Research and Development

The United States Special Operations Command (USSOCOM)seeks novel biomedical solutions to preserve the high level of performance and save the lives of Special Operations Forces (SOF) in field environments. Any projects proposed must be unique to the requirements of SOF who typically conduct combat operations in austere, remote locations without timely access to medical evacuation or elevated levels of medical care. It is these far-forward and/or isolated operations that make SOF medicine unique and result in material solutions characterized by ruggedness, light weight, small volume, and low power requirements. USSOCOM is also interested in research that will lead to improved techniques and procedures that do not necessarily require new material.

Pre-proposal Deadline: August 3
Application Deadline: October 12

Foundation for Women's Cancer

The Foundation for Women's Cancer is accepting applications for its research grants and awards program. Awards will be given to support ovarian cancer research. The Foundation will fund the best project applications, with priority given to young investigators. The Foundation will accept one application per person per year.

Abstracts Deadline: August 13
Application Deadline: November 9

AACR-Kure It Grant for Kidney Cancer Research

The AACR-Kure It Grant for Kidney Cancer Researchrepresents a joint effort to promote and support innovative cancer research. This grant is available to independent investigators to develop and study new ideas and approaches that have direct application and relevance to kidney cancer patients.

Applications are invited from researchers currently in the field as well as from investigators with experience in other areas of cancer research who have promising ideas or research approaches that can be applied to kidney cancer research.

Deadline: August 21

Burroughs Wellcome Fund

The Burroughs Wellcome Fund is accepting applications for two programs that are designed for advanced postdoctoral scientists to help make the transition to a faculty appointment:

  • Career Awards for Medical Scientists: These awards are targeted toward medically trained individuals whose research proposal is in basic biomedical, disease-oriented, translational, or molecular, genetic, or pharmacological epidemiology research, and who intend to pursue careers in academia. 
    Pre-Proposal Deadline: September 4
    Application Deadline: October 1
  • Career Awards at the Scientific Interface: These awards are targeted toward researchers whose doctoral training is in one of the physical, chemical or computational sciences and who intend to pursue academic research doing work that addresses biological questions.
    Pre-Proposal Deadline: September 4
    Application Deadline: January 10, 2013
Pezcoller Foundation-AACR International Award for Cancer Research

The American Association for Cancer Research is currently accepting nominations for the Pezcoller Foundation-AACR International Award for Cancer Research. This award recognizes an individual scientist or co-nominated scientists of international renown who have made a major scientific discovery in basic or translational cancer research, and whose ongoing work holds promise for continued substantive contributions to progress in the field of cancer. The recipient of the Pezcoller Foundation-AACR International Award for Cancer Research will receive an unrestricted grant of €75,000 and a commemorative plaque. In addition, he or she will receive full support to attend the AACR Annual Meeting 2013, to be held April 6-10 in Washington, D.C., and will give a 50-minute award lecture at the Annual Meeting.

Deadline: September 12

Robert Wood Johnson Foundation Human Capital Programs

The Robert Wood Johnson Foundation (RWJF) has released a call for proposals to support new projects in Human Capital:

  • New Connections: Increasing Diversity of RWJF Programming aims to expand the diversity of perspectives that inform RWJF programming and introduce new researchers and scholars to RWJF, while simultaneously helping to meet staff needs for data analysis. The program invites Junior Investigators – scholars from historically disadvantaged and underrepresented communities – to submit proposals that address programming priorities for one of RWJF's program areas. 
    Deadline: August 29
  • New Connections: Increasing Diversity of RWJF Programming aims to expand the diversity of perspectives that inform RWJF programming and introduce new researchers and scholars to the Foundation who would help teams with their research and evaluation needs. The program invites Midcareer Consultants – scholars from historically disadvantaged and underrepresented communities who have between 10-15 years of research and/or evaluation experience – to address program priorities for RWJF's teams and portfolios.
    Deadline: August 29
  • The RWJF Health & Society Scholars program provides two years of support to postdoctoral scholars at all stages of their careers to build the nation's capacity for research and leadership to address the multiple determinants of population health and contribute to policy change.
    Deadline: September 21
  • The RWJF Scholars in Health Policy Research programdevelops and supports a new generation of creative health policy thinkers and researchers within the disciplines of economics, political science and sociology. 
    Deadline: October 16
CTSC KL2 Training Program

The Clinical and Translational Science Collaborative KL2 Training Program seeks candidates to fill Clinical Research Scholar positions. These positions will be available in July 2013. The training program is a component of the Cleveland CTSC and is funded by the NIH.

Deadline: October 22




**All events are open to anyone interested in attending

July 23

July 24

July 25

Hematology and Oncology Division Research Conference
Cheng Chee, MD
Assistant Professor, Div. of Hem/Onc
Topic: Early Stage Colorectal Cancer
8 am Lerner Tower B-151

July 26

July 27

Cancer Center Research in Progress will resume in September

Cancer Center Seminar Series will resume in September.

Taussig Cancer Institute Grand Rounds will resume in September

Hematology/Oncology Fellows Conference/Curriculum Series
Richard Creger, PharmD
Associate Professor, Div. of Hem/Onc
Topic: Antiemetrics
8 am Wearn 137

Case CCC Calendar

LRI Calendar


Developmental Therapeutics Program Retreat: Cancer Drug Development at the Case Comprehensive Cancer Center
August 16
3-7 pm, Dively Building 202

Second Annual Imaging Solutions in Cancer Management: A Case-Based Conference
September 21
Wolstein Research Building
Brochure and Registration Form

National GvHD Health Symposium
November 2
Embassy Suites Cleveland-Rockside


Ninth International Conference of the Society for Integrative Oncology
October 8-10
Albuquerque, NM

Biennial Science of Global Prostate Cancer Disparities conference
November 1-4
Nassau, The Bahamas

Pacific Symposium on Biocomputing 2013
January 3-7, 2013
Fairmont Orchid, Hawaii
Call for Abstracts Deadline: July 31


Alex's Lemonade Stand Foundation Bridge Grant
Deadline: July 16

Kinship Foundation Searle Scholars Program
Internal Deadline: July 23
External Deadline: September 28

DOD Prostate Cancer Research Program Health Disparity Research Award
Pre-Application Deadline: July 26
Application Deadline: August 9

Alex's Lemonade Stand Foundation Nursing Grants Program Explorer Awards
Deadline: August 1

Alex's Lemonade Stand Foundation Nursing Grants Program Pathfinder Award: Intermediate Nurse Researcher Grants
Deadline: August 1

Alex's Lemonade Stand Foundation Nursing Grants Program Discovery Award: Independent Nurse Researcher Grants
Deadline: August 1

American Cancer Society Clinical Research Professor
LOI Deadline: August 1
Application Deadline: October 15

International Myeloma Foundation Brian D. Novis Senior Research Award
Deadline: August 1

International Myeloma Foundation Brian D. Novis Junior Research Award
Deadline: August 1

University Hospitals Harrington Discovery Institute Scholar-Innovator Grants program
Deadline: August 1

Case CCC ACS Institutional Research Grant Awards
Application Deadline: August 3

DOD Lung Cancer Research Program Concept Award
Pre-Application Deadline: August 9
Application Deadline: August 23

Uniting Against Lung Cancer (UALC)
Deadline: August 15

2013 NIH Director's Transformative Research Awards
LOI Deadline: August 21
Application Deadline: September 21

Oncology Nursing Society Foundation Advancing Care through Science Conference Scholarship
Deadline: September 1

Alex's Lemonade Stand Foundation 'A' Award
Deadline: September 17

Robert Wood Johnson Foundation Health & Society Scholars program
Deadline: September 21

Szent-Györgyi Prize for Progress in Cancer Research
Deadline: September 30

Alex's Lemonade Stand Foundation Epidemiology Awards
Deadline: December 17

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Tobacco Centers of Regulatory Science for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (P50) (RFA-DA-13-003)

Physical activity and weight control interventions among cancer survivors: Effects on biomarkers of prognosis and survival (R01) (PAR-12-228)

Physical activity and weight control interventions among cancer survivors: Effects on biomarkers of prognosis and survival (R21) (PAR-12-229)

Prioritizing Molecular Targets for Cancer Prevention with Nutritional Combinations (R01)(PA-10-035)

Development, Application, and Evaluation of Prediction Models for Cancer Risk and Prognosis (R01)(PA-10-025)

Epigenetic Approaches in Cancer Epidemiology (R01)(PA-10-031)

Epigenetic Approaches in Cancer Epidemiology (R21)(PA-10-032)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


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