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2011 Articles

September 19, 2011

Date Released: 19 September 2011
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Stan Gerson, MD
Director, Case CCC

Case Comprehensive Cancer Center Receives $11.3 Million Grant to Establish GI SPORE- GI Cancers Research Center

Last Friday, the Case CCC announced the receipt of an $11.3 million grant to establish a GI SPORE- GI Cancers Research Center at Case Western Reserve University. This was the only GI SPORE awarded this year! With this designation, CWRU joins only six other nationally recognized GI SPORE Centers of Excellence in the country. This award is the result of collaboration from researchers at CWRU, University Hospitals Seidman Cancer Center and Cleveland Clinic, all members of the cancer center. Congratulations to everyone, especially PI Sandy Markowitz, MD, PhD and Co-PI Nathan Berger, MD.

International Conference of the Society for Integrative Oncology (SIO)

The Society for Integrative Oncology meeting will be held November 10-12 in Cleveland. The SIO's approach of providing complimentary and fully integrated supportive oncology to practitioners and patients adds much value to patients, physicians, and hospitals.

This conference is an important event that pulls together international experts in the field, including keynote speaker Francis F. Collins, MD, PhD, Director of the National Institutes of Health. It is important the conference is well attended, and that the Case Comprehensive Cancer Center have a strong presence.

The following Cancer Center members are on the presentation agenda:

  • Pamela Davis, MD, PhD: Presenter, Welcome and Introduction of Dr. Gerson
  • Stan Gerson, MD: Presenter, The Future of Integrative Oncology
  • Nathan Berger, MD: Moderator, From Mice to Men: Evidence Basis for Integrative Medicine Practices in Cancer Prevention and Care
  • Sanjay Gupta, PhD: Panelist, From Mice to Men: Evidence Basis for Integrative Medicine Practices in Cancer Prevention and Care
  • Nora Nock, PhD: Panelist, From Mice to Men: Evidence Basis for Integrative Medicine Practices in Cancer Prevention and Care
  • Mladen Golubic, MD, PhD: Moderated Abstract Session,Participation in Lifestyle 180® Program Reduces Multiple Risk Factors for Chronic Diseases in Cancer Survivors

Please make every effort to register and attend.


Breast Cancer Breakthroughs
WPTV - Sep 16, 2011
Immunologist Vincent Tuohy hopes to kill breast cancer even before it can be found on a mammogram or in a breath test. At the Cleveland Clinic, ...

ODAC Recommends Accelerated Approval for Deferiprone
HemOnc Today - Sep 14, 2011
... and Mikkael Sekeres, MD, MS, a staff member in the department of hematologic oncology and blood disorders at Cleveland Clinic Taussig Cancer Institute, ...

Study Suggests Axitinib Is Superior to Sorafenib in Second-line Therapy for Metastatic RCC
Clinical Oncology News (registration) - Sep 9, 2011
... "axitinib should be the reference standard" for second-line therapy in mRCC, said Brian I. Rini, MD, presenting the data with his colleagues during the ...


Cancer Center Seminar Series: Cancer Cell Metabolism Alters Histone Acetylation by Influencing the Utilization of HDAC and HAT Mechanisms

Friday, September 23
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, September 23 at the next Cancer Center Seminar Series featuring Scott Bultman, PhD. Dr. Bultman, Assistant Professor of Genetics at University of North Carolina at Chapel Hill, will present Cancer Cell Metabolism Alters Histone Acetylation by Influencing the Utilization of HDAC and HAT Mechanisms.

Dr. Bultman's overall research focuses on the use of mouse models to investigate the role of molecular alterations in chromatin structure and epigenetic processes in DNA replication/repair and transcription that contribute to the development of cancer. Studying the SWI/SNF complex multiprotein nucleosome remodeling complex, containing a DNA dependent ATPase that destabilizes histone-DNA interactions, his lab has shown this complex serves as a tumor suppressor that protects against breast cancer, whereas mutation of these genes predispose to mammary, ovarian and uterine cancers similar to human mutations of ARID1A/BAF250α mutations. In another mouse model system, Dr. Bultman is studying the interaction of intestinal microbiota with butyrate, a short chain fatty acid derived from dietary fiber, for their role in ColoRectal Cancer mediated by its effect on histone acetylation via its metabolism to acetyl CoA.

Mandatory Research Staff Continuing Education Sessions

Research Staff Continuing Education Sessions
The Case CCC will be hosting continuing education sessions for research staff on Thursday, September 22 from 8 am - 12 pm or Friday, September 23 from 1 pm - 5 pm in Taussig Cancer Institute R3-002/003. Parking validation will be provided. Staff need to attend only one continuing education session.

These continuing education sessions are mandatory for all SCC and TCI research staff and is open to staff from other departments and institutes conducting clinical trials in oncology. Topics will cover an overview of the Case CCC, updates, and Standard Operating Procedures. Break-out sessions will cover the joint site initiation visit from several perspectives such as regulatory, nursing, data management and quality assurance.

Please direct any questions to Melissa Kadar, Director of UH/SCC Clinical Trials at or 216-286-6639.


Case CCC ACS IRG Awardees

Congratulations to the recent recipients of the Case CCC American Cancer Society (ACS) Institutional Research Grant (IRG) pilot awards:

  • Efstathios Karathanasis, PhD: Nanoparticle Platform for Delivery of Cancer Drugs with Tunable Release
  • Nora Nock, PhD: Exercising our ABCs' (African-American Breast Cancer Survivors)
  • Scott Welford, PhD: Polyamine Metabolism and Radiation Response in Glioblastoma
  • Guang Zhou, PhD: Transcriptional Coregulator JAB1 and Osteosarcoma

These funds are designed to provide seed money to support junior faculty members with an interest in cancer research who do not have national grant support of their own.

Case CCC Strategic Plan

All members should have recently received a draft of the Case CCC Strategic Plan for 2012-2018. This plan represents the efforts and discussion of the entire membership, Program Leaders, Executive Committee, and institutional leaders. It will be the basis for our renewal application and for institutional commitments for the coming six years.

Thoughts on gaps, and critical perspectives and needs are greatly appreciated. You may send any comments directly to Dr. Stan Gerson at All feedback will be discussed by the Executive Committee.

If you would like a copy of the Strategic Plan, please email Gillian Todd at


Induced Pluripotent Stem Cell Pilot Research Award: Deadline Extended

The Pluripotent Stem Cell Facility (PSCF) seeks to support the creation of up to eight disease–specific iPS cell lines in 2011. Investigators will provide a patient fibroblast sample which the PSCF will reprogram into an iPS cell line for study in the investigator's laboratory. It is expected that the creation of these disease–specific iPS cell lines will provide investigators with the preliminary data needed to apply for NIH or equivalent funding.

Deadline Extended: September 30

Lung Cancer Research Program Concept Award

The Lung Cancer Research Program (LCRP) Concept Awardsupports the exploration of highly innovative, untested, potentially high-gain concepts, theories, paradigms, and/or methods that address an important problem in lung cancer. The Concept Award is not intended to support a logical progression of an already established research project but, instead, allows PIs the opportunity to pursue serendipitous observations and new ideas. This award mechanism supports high-risk studies that have the potential to reveal entirely new avenues for investigation. Applications must describe how the new idea will enhance the existing knowledge of lung cancer or create an entirely new avenue for investigation.

Pre-Application Deadline: October 19
Deadline: November 9

American Medical Association Seed Grant Research Program

The American Medical Association (AMA) Foundation is currently accepting applications from medical students and residents/fellows for grants for basic science or clinical research projects in four categories: cardiovascular/pulmonary diseases, HIV/AIDS, pancreatic cancer, and neoplastic diseases.

Deadline: December 5



**All events are open to anyone interested in attending

September 19

September 20

Immunology Invited Speaker Seminar Series
Junying Miao, PhD
Professor, Cell Biology
Sandong University
Topic: The Role of Annexin A7 and a Novel Long Non-Coding RNA in Autophagy of Vascular Endothelial Cells
9 am NE1-205 Cleveland Clinic

Cancer Biology Invited Speaker Seminar
Eric Hsi, MD
Professor and Chair, Clinical Pathology
CWRU/ Cleveland Clinic
Topic: Phosphoprotein Detection in Primary Tissues- Functional Phenotyping
11 am NC1-202 Cleveland Clinic

Immunology Seminar Series
Michael Demetriou, MD, PhD
Associate Professor, Neurology and Microbiology and Molecular Genetics
University of California, Irvine
Topic: Genetics and the Environment Converge to Dysregulate N-glycosylation in Multiple Sclerosis
12 pm WRB 1-413

September 21

Hematology and Oncology Research Conference Special Presentation
Channing J. Paller, MD
Senior Oncology Fellow
Johns Hopkins University
Topic: Bench to Bedside: Novel Approaches in the Treatment of Prostate Cancer
8 am Lerner B-151

Immunology Invited Speaker Seminar Series
William Paul, MD
Chief, Laboratory of Immunology
National Institute of Allergy and Infectious Disease, NIH
Topic: Cytokines and CD4 T Cells: Dance Partners at the Immunology Ball
12 pm NC1-202 Cleveland Clinic

Tumor Microenvironment and Metastasis Focus Group Meeting
Khalid Sossey-Alaoui, PhD
Project Staff, Molecular Cardiology
Cleveland Clinic
Topic: Mechanisms of Regulation of WAVE3 in Cancer
1:30 pm WRB 3-136

LRI Showcase Seminar
Paul DiCorleto, PhD
Professor, Cell Biology, Physiology & Biophysics
CWRU/Cleveland Clinic
Topic: Activation of the Endothelium by Cytokines
4 pm NE1-205 Cleveland Clinic

Developmental Therapeutics Program Meeting
Miklos Gratzl, PhD
Associate Professor, Biomedical Engineering
Topic: Microengineered Platform for Drug Development in 3D Multicellular Models of Tumor Microenvironment
5 pm WRB 2-136

September 22

Research Staff Continuing Education Session
8 am R3-002/003 Cleveland Clinic

Cell Biology Visiting Professor Seminar
Douglas Green, PhD
Chair, Immunology
St. Jude Children's Research Hospital
Topic: Cutting Both Ways: How Caspase-8 Both Kills and Protects Cells
11 am NC1-202 Cleveland Clinic

Molecular and Microbiology Seminar
Alice Valentin-Torres
Bernstein Lab, Molecular and Microbiology
Topic: Bidirectional NK/DC Interactions Result in Reciprocal Activation and Promote HIV Infection
1 pm SOM W203

September 23

Hematology/Oncology Fellows Conference
Smitha Krishnamurthi, MD
Assistant Professor, Medicine-Hem/Onc
Topic: Introduction to Advanced Stage/Metastatic Colorectal Cancer
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Guillermo Garcia-Manero, MD
Professor, Leukemia- Cancer Medicine
University of Texas MD Anderson Cancer Center
Topic: MDS
8 am R3/002-003 Cleveland Clinic

Cell Biology Seminar Series
Mark Jackson, PhD
Assistant Professor, Pathology
Topic: Tumor Suppressor-Oncogene Interactions During Mammary Cell Transformation
10 am NC1-202 Cleveland Clinic

Cancer Center Seminar Series
Scott Bultman, PhD
Assistant Professor, Genetics
University of North Carolina at Chapel Hill
Topic: Cancer Cell Metabolism Alters Histone Acetylation by Influencing the Utilization of HDAC and HAT Mechanisms
12 pm BRB 105

Hematology/Oncology Fellows Conference
Lan Zhou, MD, PhD
Assistant Professor, Pathology
Topic: Introduction to Transfusion Medicine
1 pm Seidman 3

Research Staff Continuing Education Session
1 pm R3-002/003 Cleveland Clinic

Cancer Center Research in Progress
Shigemi Matsuyama, PhD
Assistant Professor, Medicine- Hem/Onc
Topic: Regulation of Bax-mediated Cell Death By Non-Bcl-2 Family Proteins
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Graft Versus Host Disease Conference
November 4
Renaissance Cleveland Hotel, 24 Public Square, Cleveland


8th International Conference of the Society for Integrative Oncology: Innovating Integrative Oncology: New Science, New Solutions
November 10-12
InterContinental Hotel Cleveland


DOD Defense University Research Instrumentation Program (DURIP)
Deadline: September 20

DOD BCRP Clinical Translational Research (CTR) Award
Pre-Application Deadline: September 20
Application Deadline: December 22

DOD BCRP Impact Award
Pre-Application Deadline: September 20
Application Deadline: December 22

AACR-American Cancer Society Award for Research Excellence in Cancer Epidemiology and Prevention
Deadline: September 26

AACR Award for Lifetime Achievement in Cancer Research
Deadline: September 26

AACR Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research
Deadline: September 26

AACR Princess Takamatsu Memorial Lectureship
Deadline: September 26

Robert Wood Johnson Foundation Health & Society Scholars program
Deadline: September 30

Szent-Györgyi Prize for Progress in Cancer Research
Deadline: September 30

CTSC Nutrition Obesity Research Pilot Funding
Deadline: September 30

Burroughs Wellcome Fund Medical Scientist Career Awards
Deadline: October 1

Cancer Research Institute Irvington Institute Fellowship Program
Deadline: October 1

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Deadline: October 11

AACR G.H.A. Clowes Memorial Award
Deadline: October 11

AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship
Deadline: October 11

AACR Award for Outstanding Achievement in Cancer Research
Deadline: October 11

AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
Deadline: October 11

AACR Richard and Hinda Rosenthal Memorial Award
Deadline: October 11

Robert Wood Johnson Foundation Scholars in Health Policy Research program
Deadline: October 12

DOD PRCRP Discovery Award
Pre-Application Deadline: October 13
Application Deadline: October 27

Oncology Nursing Society Oncology Nursing Health Policy and Advocacy Award
Deadline: October 31

DeGregorio Family Foundation for Gastric and Esophageal Cancer Research and Education
Deadline: November 1

Leukemia & Lymphoma Society Specialized Center of Research Program
Deadline: November 1

Friends of Jose Carreras International Leukemia Foundation (FJCILF) E.D. Thomas Postdoctoral Fellowship
Deadline: November 2

Robert Wood Johnson Foundation Health Policy Fellows program
Deadline: November 9

NCI Provocative Questions Project
Deadline: November 14

HHMI Medical Research Fellows Program
Deadline: January 11, 2012

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Review of Grants Information for Fiscal Year 2011 (NOT-OD-11-117)

Clarification of Requirements for Research Resource for Systematic Reviews of Complementary and Alternative Medicine Clinical Trials (R24), RFA-AT-12-001 (NOT-AT-11-006)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


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