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2011 Articles

October 24, 2011

Date Released: 24 October 2011
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Stan Gerson, MD
Director, Case CCC

National GVHD Symposium

The Case CCC and the Meredith A. Cowden Foundation are bringing a national educational conference on Graft vs. Host Disease (GvHD) to Cleveland on Friday, November 4, 7:30 am to 5 pm, at the Renaissance Cleveland Hotel. The conference will unite leading specialists in hematology, oncology, bone marrow transplantation and immunology from more than a dozen of the nation's top cancer research centers and educational institutions to present information on cutting-edge research and treatments.

Following bone marrow transplantation, an estimated 60 percent of all leukemia and other blood cancer patients experience GvHD, making this topic extremely relevant to our Center. Please make every effort to register and attend this conference.


Research Ties Dermatology Workforce Balance and Melanoma Outcomes
ModernMedicine - Oct 22, 2011
The East and West Coast regions are fairly well saturated with dermatologists, while there appears to be a relative shortage throughout the center of the country," says Savina Aneja, B.A. ... Cleveland, under the direction of Jeremy S. Bordeaux, MD, MPH, assistant professor of dermatology, Case Western Reserve University School of Medicine, ...

ABC - Radiotherapy Packs a Powerful Anti-Cancer Punch
ABC News - Oct 19, 2011
Dr. Janice Lyons of University Hospitals Case Medical Center discusses the benefits of radiation after a lumpectomy...


Cancer Center Seminar Series: Autophagy, Tumor Dormancy and Taxane Sensitivity in Human Ovarian Cancer


Friday, October 28
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, October 28 at the next Cancer Center Seminar Series featuring Robert C. Bast, Jr, MD, who will present Autophagy, Tumor Dormancy and Taxane Sensitivity in Human Ovarian Cancer.

Dr. Bast is Vice President for Translational Research at the UT MD Anderson Cancer Center. His office facilitates translation of new strategies, drugs and devices from the laboratory to the clinic, as well as the movement of human material and data from the clinic to laboratory. A former director of the Duke Comprehensive Cancer Center, Dr. Bast has a history of research at other distinguished institutions such as Johns Hopkins Hospital, the NCI, Harvard, and Dana-Farber Cancer Institute. He is also a member of the Parent Committee for Cancer Center Reviews for the NCI.

Dr. Bast is best known for developing the OC125 monoclonal antibody that led to the production of the CA125 radioimmunoassay. Serum CA125 levels have provided the first generally useful serum biomarker for ovarian cancer that is now used worldwide for monitoring the course of patients with this disease. CA125 is currently being evaluated as one component of a screening strategy for early detection of ovarian cancer. His early studies focused on the use of immunostimulants and monoclonal antibodies for cancer therapy. Over the last 20 years, his group has pioneered in defining molecular alterations in ovarian and breast cancers that might serve as targets for therapy as well as diagnosis. His most recent studies have focused on the identification of ARHI, a novel ras-related imprinted tumor suppressor gene that can induce autophagy and tumor dormancy, providing the first inducible model for tumor dormancy in ovarian cancer.

Federal Research Priorities and Budgets for FY12

Do you wish you knew where federal agencies are headed and how to align your funding requests to their priorities and direction? Join your colleagues October 31-November 2 forthis webinar and hear directly from personnel at the NIH, NSF, National Endowment for the Humanities, Office of Naval Research, Army Medical and Materiel Command, National Aeronautics and Space Administration, and the Departments of Agriculture, Education and Energy as they share agency direction and funding priorities for the coming year.

Registration is not necessary. Stop in the Sears Library Building, Room 670 and view the agency presentations relevant to your research initiatives.

The Cancer Genome Atlas Program: Comprehensive Cancer Genomics Data on 5,000+ Cases Across 24 Cancer Subtypes

The NCI Office of Cancer Centers presents the next webinar in its Learning Series, The Cancer Genome Atlas Program: Comprehensive Cancer Genomics Data on 5,000+ Cases Across 24 Cancer Subtypes, on Tuesday, November 1 from 2-3:30 pm. This presentation will address The Cancer Genome Atlas (TCGA) program, which aims to complete the comprehensive genomic characterization of more than 11,000 tumors by the end of 2014.

The featured speakers are: Kenna Shaw, PhD, Deputy Director of The Cancer Genome Atlas Program Office, who will discuss the current projects and discoveries of the TCGA program, and Jill Barnholtz-Sloan, PhD, Associate Professor at Case Western Reserve University/University Hospitals, who will provide information about her work for the TCGA program.

Pre-registration is required.

Coulter Legacy Lecture

The Coulter Legacy Lecture will be held Tuesday, November 1 at 10:45 am in the Wolstein Research Building Auditorium. Sue Van, President & Chief Executive Officer of the Coulter Foundation, will give a lecture on the legacy of Wallace H. Coulter and his influence on entrepreneurism, and his path as a serial innovator and entrepreneur.

Mr. Coulter founded Coulter Corp. and continued to lead this global diagnostics company during its entire 40-year history. He revolutionized the practice of hematology and laboratory medicine, and pioneered the fields of flow cytometry and monoclonal antibodies. Please plan on attending what promises to be a fascinating lecture.

NCRM Annual Scientific Retreat

The National Center for Regenerative Medicine (NCRM) Annual Scientific Retreat will be Monday, November 14 from 8 am-4:30 pm in Dively 202. Anyone within the CWRU community with an interest in regenerative medicine is encouraged to attend, including faculty, researchers, postdocs, graduate and undergraduate students, lab staff, and clinicians. The day will include a scientific poster session. Cash prizes will be awarded for top posters submitted by graduate students and postdocs. Please send poster title and abstract to Susan Halloway. There is no fee to attend, butregistration is required.


2012 NIH Director's Transformative Research Awards

The NIH has announced the funding opportunity for the 2012 NIH Director's Transformative Research Awards. The awards are aimed at "exceptionally innovative, high risk, original and/or unconventional research".

LOI Deadline: December 12
Application Deadline: January 12, 2012

L'Oréal USA Fellowships For Women In Science

The L'Oréal USA Fellowships For Women In Science is a national awards program that annually recognizes and rewards five US-based women postdoctoral researchers at the beginning of their scientific careers who are pursuing careers in the life and physical/material sciences, as well as mathematics, engineering and computer science. The recipients of this fellowship program participate in a week of events that include an awards ceremony, professional development workshops, media training and networking opportunities.

Deadline: December 15

Lymphatic Research Foundation Postdoctoral Fellowship Awards Program

The Lymphatic Research Foundation (LRF) Postdoctoral Fellowship Program is designed to support postdoctoral scientists in academic, medical or research institutions throughout the world. The awards will support investigators who have recently received their doctorates, a critical point in career development when young scientists choose their lifelong research focus. The goal of the Fellowship Program is to expand and strengthen the pool of outstanding junior investigators in the field of lymphatic research.

Deadline: January 10, 2012

CTSC Annual Pilot Funding Competition

The Clinical and Translational Science Collaborative (CTSC) of CWRU and the Case Coulter Translational Research Partnership (CCTRP) is accepting letters of intent for 2012 CTSC Annual Pilot Grant Funding. The grant will fund up to $50,000 to support innovative translational research projects focused upon the invention, preclinical development and/or first in man studies of novel therapeutic agents, biomedical devices and diagnostics designed to address unmet clinical needs.

Investigators in the basic science and clinical departments at CWRU, Cleveland Clinic, MetroHealth Medical Center, UH and the Louis Stokes Cleveland VA Medical Center are eligible. The PI is required to be a faculty member from one of the five CTSC partner institutions and eligible to be a PI for an NIH grant.

Mandatory LOI Deadline: January 15


Lazarus Honored By Two Organizations

Dr. Hillard LazarusCongratulations to Dr. Hillard Lazarus, who was named Man of the Year by the Northern Ohio Leukemia and Lymphoma Society.

Dr. Lazarus was also recently recognized by his alma mater, Carnegie Mellon, with the 2011 Alumni Distinguished Achievement Award.

CWRU Interdisciplinary Alliance Investment Grant Awardees

The following projects led by Cancer Center members were selected to receive CWRU Interdisciplinary Alliance Investment Grants:

  • Controlled Assembly of Core Shell Viral Nanoparticles for Image-Guided Therapy: Anna Samia, PhD and Nicole Steinmetz, PhD, Materials Alliance
  • Establishing Evolutionary Medicine at Case Western Reserve UniversityEric Arts, PhD, Origins Alliance
  • Promoting Health Across BoundariesKurt Stange, MD, PhD, Human Health Alliance
  • Impact of Drug Abuse on Infectious DiseaseAlan Levine, PhD, Infectious Disease Alliance
  • Planning the Technology and Health Institute at Case (THINC) : Jeff Duerk, PhD, Human Health Alliance

The proposals were scored on overall quality and innovation, extent of interdisciplinary research and/or education, significance relative to the university's mission, vision and core values and feasibility and sustainability.


October 18, 2011

Featured Article: Chemotherapy That is Less Toxic to the Heart May Be an Option for Some Women with HER2-Positive Breast Cancer

Higher-Dose Radiation Does Not Improve Survival in Some Lung Cancer Patients

BRCA Gene Mutations May Influence Survival, Treatment Response in Ovarian Cancer

Newer Cancer Drugs May Cause Thyroid to Function Abnormally

Bacterium Linked to Colorectal Cancer in Two Independent Studies

In Depth
Vitamin E Supplements Tied to Increased Risk of Prostate Cancer

After DES: Tracking the Harms of a Prenatal Drug Exposure

Profiles in Cancer Research: Dr. Samuel Achilefu

Featured Clinical Trial: Bortezomib and Chemotherapy for Systemic Light-Chain Amyloidosis

Cancer Center Profile: Purdue University Center for Cancer Research

AHRQ Update




**All events are open to anyone interested in attending

October 24

David Satcher Lecture Series
Robert Abouassaly, MD
Assistant Professor, Urology
Topic: Racial Disparities in the Diagnosis, Treatment and Outcomes of Prostate Cancer
12 pm RB&C Amphitheater

Pathology Research Seminar Series 
Chenjian Li, PhD
Aidekman Family Endowed Chair, Neurology
Mount Sinai School of Medicine
Topic: Tales of Two Kinases: LRRK2 and PINK1 for Parkinson's Disease
12 pm WRB 1-413

Tumor Microenvironment and Metastasis Focus Group Meeting
1:30 pm WRB 3-136

October 25

Cancer Biology Special Seminar canceled

October 26

Hematology and Oncology Division Research Conference
Simon Lo, MD 
Associate Professor, Radiation Oncology
Director, Neurologic Radiation Oncology & Gamma Knife Radiosurgery
Topic: Local Therapy for Oligio Metastases
8 am Lerner B-151

Immunology Invited Speaker Seminar Series
Jeffrey Rathmell, PhD
Associate Professor, Pharmacology and Cancer Biology
Duke University
Topic: Lymphocyte Metabolism in Immunity, Suppression, and Leukemia
12 pm NC1-202

Nuclear Receptor Signaling and Hormone Responsive Cancers Focus Group
12:30 pm WRB 3-136

October 27

Molecular and Microbiology Seminar
Jennifer Cenker
McDonald Lab, Molecular and Microbiology
Topic: Factors Influencing the Spread of HIV in Macrophage Cultures
Ángel Reyes-Rodriguez
McDonald Lab, Molecular and Microbiology
Topic: Dendritic Cell Mediated HIV Trans-infection in Lymphoid Tissue
1 pm SOM W203

October 28

Hematology/Oncology Fellows Conference
Teresa Gula, MD
Fellow, Div. of Hem/Onc
Topic: Polycythemia Vera
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Matthew Ellis, MB, BChir, PhD
Professor, Medicine- Oncology
Washington University in St. Louis
Topic: Estrogen Receptor Positive Breast Cancer: Where Next?
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Robert C. Bast, Jr., MD
Vice President for Translational Research
Professor, Experimental Therapeutics- Cancer Medicine
University of Texas MD Anderson Cancer Center
Topic: Autophagy, Tumor Dormancy and Taxane Sensitivity in Human Ovarian Cancer
12 pm BRB 105

Cancer Center Research in Progress Seminar
Philip Woost, PhD
Senior Research Associate, Jacobberger Lab, Div. of General Medical Sciences-Oncology
Topic: High Resolution Kinetics of Phosphoprotein Signaling in Unfractionated Bone Marrow
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Graft Versus Host Disease Conference
November 4
Renaissance Cleveland Hotel, 24 Public Square, Cleveland


8th International Conference of the Society for Integrative Oncology: Innovating Integrative Oncology: New Science, New Solutions
November 10-12
InterContinental Hotel Cleveland


AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research
Deadline: October 31

Oncology Nursing Society Oncology Nursing Health Policy and Advocacy Award
Deadline: October 31

Pancreatic Cancer Action Network-AACR Career Development Awards
Deadline: October 31

Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant
Deadline: October 31

Pancreatic Cancer Action Network-AACR Fellowship
Deadline: October 31

AACR–FNAB Career Development Award for Translational Cancer Research
Deadline: November 1

DeGregorio Family Foundation for Gastric and Esophageal Cancer Research and Education
Deadline: November 1

Leukemia & Lymphoma Society Specialized Center of Research Program
Deadline: November 1

Patient-Centered Outcomes Research Institute (PCORI) Pilot Projects Grants Program
LOI Deadline: November 1
Application Deadline: December 1

University-Community Partnerships to Improve Urban Health Outcomes
Deadline: November 1

Doris Duke Clinical Scientist Development Award
Internal Deadline: November 2

Friends of Jose Carreras International Leukemia Foundation (FJCILF) E.D. Thomas Postdoctoral Fellowship
Deadline: November 2

Cellular Molecular Imaging of Cancer Pilot Funding: Cancer Microenvironment
Deadline: November 7

Robert Wood Johnson Foundation Health Policy Fellows program
Deadline: November 9

NCI Provocative Questions Project
Deadline: November 14

Rita Allen Foundation Scholars Program
Internal Deadline: November 14

AACR–Conquer Cancer Foundation of ASCO Young Investigator Translational Cancer Research Award
Deadline: November 15

Burroughs Wellcome Fund Collaborative Research Travel Grants
Deadline: December 1

Kimmel Scholar Award
Deadline: December 1

Kimmel Translational Science Award
Deadline: December 1

American Medical Association Seed Grant Research Program
Deadline: December 5

HHMI Medical Research Fellows Program
Deadline: January 11, 2012

Oncology Nursing Society Foundation Connie Henke Yarbro Excellence in Cancer Nursing Mentorship Award
Deadline: January 15, 2012

Robert Wood Johnson Foundation Executive Nurse Fellows
Deadline: January 18, 2012

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

National Cancer Institute Program Project (P01) Applications (PAR-12-005)

Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R21)(PA-11-074)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


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