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2011 Articles

October 17, 2011

Date Released: 17 October 2011
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Stan Gerson, MD
Director, Case CCC

Weatherhead Institute of Family Medicine and Community Health

Please note the School of Medicine announcement of the new Weatherhead Institute for Family Medicine and Community Health to be located at CWRU. The gift of Al and Celia Weatherhead will propel our remarkable Department of Family Medicine into an even greater international leader in research of disease prevention and early detection. The Department of Family Medicine is at the heart of our Program in Cancer Prevention and Control, and this support to the department will provide a solid foundation for further expansion of the cancer research component of the mission of this new Institute. We are fortunate that these resources will enrich the department and its investigative and outreach units.

Case CCC Part of Newly Awarded Consortium Contract to Determine Clinical Benefit of New Cancer Drugs

The Case CCC, in partnership with The Ohio State University, Georgetown University, and Roswell Park, is pleased to announce the receipt of an N01 consortium contract to conduct Phase 2 and early clinical trials of NCI Cancer Therapy Evaluation Program (CTEP) agents to determine their clinical benefit.

OSU, which previously held an N01, will serve as the lead site on this contract. The Case CCC team will be led by Dr. Neal Meropol, along with UH Site PI Dr. Afshin Dowlati and Cleveland Clinic Site PI Dr. Robert Dreicer.

Only seven centers in the United States received an N01 contract. Along with the U01 previously awarded to Afshin Dowlati, this award places us in a small group of NCI-designated cancer centers with this dual recognition as a center focused on innovative therapeutics.

NIH-funded Study Shows Increased Prostate Cancer Risk from Vitamin E Supplements

Last week, the NCI released an announcement on new findings related to the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Researchers saw a 17 percent increase of prostate cancers in men who took the daily allotted 400 international units (IUs) of vitamin E versus men who took a placebo. These results were published in the October 12, 2011 issue of the Journal of the American Medical Association.

Dr. Eric Klein, chair of the Glickman Urological and Kidney Institute at the Cleveland Clinic and study co-chair for SELECT, recommends that men who participated in SELECT stop taking the dosage of vitamin E and continue seeing their primary care physician or urologist. [more]


Researchers Discover That Same Gene Has Opposite Effects in Prostate, Breast Cancers
EurekAlert - Oct 17, 2011
Researchers from Cleveland Clinic's Lerner Research Institute, including Charis Eng, M.D., Ph.D., Chair, Genomic Medicine Institute; Robert Silverman, Ph.D., and Warren Heston, Ph.D., both of the Department of Cancer Biology;...

Vitamin E May Increase Risk of Prostate Cancer
TIME - Oct 12, 2011
"This finding was surprising, because all the evidence previously suggested that vitamin E may be protective against prostate cancer," says the Cleveland Clinic's Dr. Eric Klein, lead author of the new study published in the Journal of the American Medical Association.

Beating Cancer: FAQ From the On-line Chat
WBIR (NBC - Knoxville) - Oct 8, 2011
Dr. Robert Shenk, breast surgeon at Seidman Cancer Center at University Hospitals Case Medical Center and Dr. Robert Abouassaly, urologist and prostate cancer expert at the Urology Institute at University Hospitals Case Medical Center were on-hand answering questions and providing medical expertise.

Video: What the Future Holds for Breast Cancer Treatment
NBC -KARE 11 (Minneapolis-St. Paul) - Oct 7, 2011
Dr. Robert Shenk from University Hospitals Case Medical Center shares information about the diagnosis and treatment of breast cancer and future innovations such as vaccines to prevent breast cancer or its recurrence.


Cancer Center Seminar Series: Flushing Oral Oncology Drugs Down the Toilet


Friday, October 21
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, October 21 at the next Cancer Center Seminar Series featuring Mark J. Ratain, MD. Dr. Ratain will present Flushing Oral Oncology Drugs Down the Toilet.

Dr. Ratain has been a faculty member in the Department of Medicine at The University of Chicago since 1986, and is currently the Leon O. Jacobson Professor of Medicine, the Director of the Center for Personalized Therapeutics, and Chief Hospital Pharmacologist. In addition, he serves as the Associate Director for Clinical Sciences in the University's Comprehensive Cancer Center.

The Cancer Genome Atlas Program: Comprehensive Cancer Genomics Data on 5,000+ Cases Across 24 Cancer Subtypes

The NCI Office of Cancer Centers presents the next webinar in its Learning Series, The Cancer Genome Atlas Program: Comprehensive Cancer Genomics Data on 5,000+ Cases Across 24 Cancer Subtypes, on Tuesday, November 1 from 2-3:30 pm. This presentation will address The Cancer Genome Atlas (TCGA) program, which aims to complete the comprehensive genomic characterization of more than 11,000 tumors by the end of 2014.

This presentation will review the status of TCGA in general, a description of tumor types, sample criteria and biospecimen processing, and provide a summary of the discoveries from the most well developed projects. It will also provide information for how different groups can become more involved as collaborators and users of this immense, high-quality, comprehensive dataset.

The featured speakers are: Kenna Shaw, PhD, Deputy Director of The Cancer Genome Atlas Program Office, who will discuss the current projects and discoveries of the TCGA program, and Jill Barnholtz-Sloan, PhD, Associate Professor at Case Western Reserve University/University Hospitals, who will provide information about her work for the TCGA program.

Pre-registration is required.

Graft vs. Host Disease Conference

The Case CCC and the Meredith A. Cowden Foundation are bringing a national educational conference on Graft vs. Host Disease (GvHD) to Cleveland on Friday, November 4, 7:30 am to 5 pm, at the Renaissance Cleveland Hotel. The conference will unite leading specialists in hematology, oncology, bone marrow transplantation and immunology from more than a dozen of the nation's top cancer research centers and educational institutions to present information on cutting-edge research and treatments. Registration (includes CME credits), is $100 for physicians and pharmacists, $75 for nurses and other healthcare professionals and $25 for students. Please make every effort to register and attend.


AACR-FNAB Career Development Award for Translational Cancer Research

The AACR–FNAB Career Development Award for Translational Cancer Research is open to junior faculty who are in the first 4 years of a faculty appointment (at the start of the grant term). Research projects are restricted to translational cancer research focused on any individualized therapeutic area. Proposed project must have implications for individualized cancer treatment and must make use of human biopsies or samples, such as needle biopsies or circulating cancer cells. In vivo primary tumor explants meet these criteria, but xenografts from established cell lines do not.

Deadline: November 1

Doris Duke Clinical Scientist Development Award

The Doris Duke Clinical Scientist Development Awardprovides grants to junior physician-scientists to facilitate their transition to independent clinical research careers. CWRU may nominate TWO candidates for this award.

Internal Deadline: November 2

AACR–Conquer Cancer Foundation of ASCO Young Investigator Translational Cancer Research Award

The AACR–Conquer Cancer Foundation of ASCO Young Investigator Translational Cancer Research Award provides funding to promising investigators to encourage and promote quality research in clinical oncology. The purpose of this award is to fund physician–scientists during the transition from a fellowship program to a faculty appointment. The Award is open to physicians or physicians holding a combined MD/PhD. Applicants must be working in an oncology laboratory or clinical research setting in an academic medical institution. Research projects are restricted to translational cancer research.

Deadline: November 15

Connie Henke Yarbro Excellence in Cancer Nursing Mentorship Award

The Oncology Nursing Society (ONS) Foundation is accepting nominations for the Connie Henke Yarbro Excellence in Cancer Nursing Mentorship Award. The purpose of this award is to recognize and support excellence in the mentorship of oncology nurses.

Nominees may be any oncology nurse (ONS member or non-member) or ONS Chapter or SIG that meet the following qualifications:

  • be a registered nurse with at least two years experience in oncology nursing or a Chapter or SIG that has been active for at least two years.
  • have provided mentoring outside what is expected within work or employment responsibilities
  • demonstrate excellence in the mentorship of others in the practice of oncology nursing in the academic, clinical or research setting.

Deadline: January 15, 2012

Case CCC Clinical Trials Protocol Specific Research Support Funding

The Case CCC is encouraging investigators to submit Letters of Intent for the Protocol Specific Research Support (PSRS) funding for Year 2011. The budgeted funds are for the conduct of early phase clinical trials and restricted to support research nurses and data managers directly involved in the conduct of these clinical trials. Studies developed jointly between UH and CCF with planned accrual at both institutions will be prioritized. Please direct questions and requests for information about the funding process to Katarzyna Karelus, Administrative Director, Case CCC Clinical Research Office, at (216) 844-4176 or


Lazarus Appointed Director of Novel Cell Therapies

Dr. Hillard Lazarus was recently appointed the first Director of Novel Cell Therapies for UHCMC and Seidman Cancer Center. In this position, Dr. Lazarus will work with the Cell Therapy Integrated Service, a cell production facility where he will continue to serve as medical director, and with hospital and cancer leadership developing new cell therapies, in the disciplines of cancer, hematology, neurology, genitourinary diseases, orthopedics, and cardiology.

Miller Named CWRU VP of Research

Dr. Robert Miller was recently named as CWRU Vice President of Research. Dr. Miller has served as vice dean for research at the School of Medicine since 2007.

Clinical Research Education Needs Assessment Survey

CWRU, Cleveland Clinic, UH and MetroHealth Medical Center have partnered to form the Clinical and Translational Science Collaborative (CTSC). One of the goals of the CTSC is to strengthen the training and career pathways for all clinical and translational research team members, including research assistants, study coordinators, data managers, and study recruiters. The CTSC asks that you participate in a survey to assess interest in a certificate program in clinical research fundamentals. A certificate would demonstrate standard competency among the partner institutions. All responses will be anonymous; candid comments are welcome. The survey will be active through November 18.

Laser Capture Microdissection Service Replacement System Demonstrations

The Laser Capture Microdissection (LCM) Service is in the process of vetting LCM systems with a view towards purchasing a replacement for the Arcturus Veritas system. Two comparable replacement systems are being considered: Molecular Medical Instruments (MMI) and Leica LMD6500. Each vendor will be offering onsite demonstrations in the coming weeks. The MMI demonstration will be November 2-3, and Leica is tentatively set for the week of November 7. Investigators are encouraged to bring their own prepared slides for processing during the demonstration period. Please contact Patrick Leahy, Director of the LCM Service, at (216)368-0761 or with any questions or for more information.



**All events are open to anyone interested in attending

October 17

Special Seminar
Joshua Mendell, MD, PhD
Professor, Molecular Biology
UT Southwestern Medical Center
Topic: MicroRNAs in Normal Physiology and Disease
10 am WRB 1-413

Pathology Research Seminar
Laxminarayana Devireddy, DVM, PhD
Assistant Professor, Pathology
Topic: Mitochondrial Iron Transport Pathways
12 pm WRB 1-413

Physiology and Biophysics Seminar
R. John Solaro, PhD
Distinguished University Professor and Head, Physiology and Biophysics
University of Illinois at Chicago
Topic: Signaling to and from Cardiac Sarcomeres
4 pm SOM E501

Special Seminar
Joshua Mendell, MD, PhD
Professor, Molecular Biology
UT Southwestern Medical Center
Topic: MicroRNA Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities
4 pm WRB 1-413

October 18

Immunology Seminar Series
Dana Philpott, PhD
Assistant Professor, Immunology
University of Toronto
Topic: Nod-like Receptors in Immunity and Infection
12 pm WRB 1-413

Cytokine Signaling, Inflammation, and Cancer Focus Group Meeting
6 pm College Club of Cleveland

October 19

Hematology and Oncology Division Research Conference canceled

Immunology Visiting Professor Seminar Series
Dana Philpott, PhD
Assistant Professor, Immunology
University of Toronto
Topic: Nod Proteins in Immunity and Infection
12 pm NC1-202

Nuclear Receptor Signaling and Hormone Responsive Cancers Focus Group Meeting
12:30 pm WRB 3-136

October 20

TGFβ Focus Group Meeting
1 pm WRB 2-136

Molecular and Microbiology Seminar
Nick Cianciola, PhD
Carlin Lab, Molecular and Microbiology
Topic: Early Adenovirus Protein Regulates Cholesterol Homeostasis
Xuehuo Zeng, PhD
Carlin Lab, Molecular and Microbiology
Topic: Autophagy Modifies Adenovirus Infectious Route
1 pm SOM W203

October 21

Hematology/Oncology Fellows Conference
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
William Pao, MD, PhD
Associate Professor, Medicine, Cancer Biology, & Pathology/Microbiology/Immunology
Director, Div. of Hem/Onc and Personalized Cancer Medicine
Vanderbilt University
Topic: Next Generation Cancer Medicine
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Mark J. Ratain, MD
Leon O. Jacobson Professor of Medicine
Director, Center for Personalized Therapeutics
Associate Director for Clinical Sciences
The University of Chicago Comprehensive Cancer Center
Topic: Flushing Oral Oncology Drugs Down the Toilet
12 pm BRB 105

Cancer Center Research in Progress Seminar
Chris Ryder
Graduate Student, Distelhorst Lab, Div. of Hem/Onc
Topic: Acidosis Causes Bcl-2 Family Addiction: The Role of Acid-Sensing GPCR TDAG8
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Graft Versus Host Disease Conference
November 4
Renaissance Cleveland Hotel, 24 Public Square, Cleveland


8th International Conference of the Society for Integrative Oncology: Innovating Integrative Oncology: New Science, New Solutions
November 10-12
InterContinental Hotel Cleveland


DOD LCRP Concept Award
Pre-Application Deadline: October 19
Deadline: November 9

AACR-FNAB Fellows Grant for Translational Pancreatic Cancer Research
Deadline: October 31

Oncology Nursing Society Oncology Nursing Health Policy and Advocacy Award
Deadline: October 31

Pancreatic Cancer Action Network-AACR Career Development Awards
Deadline: October 31

Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant
Deadline: October 31

Pancreatic Cancer Action Network-AACR Fellowship
Deadline: October 31

DeGregorio Family Foundation for Gastric and Esophageal Cancer Research and Education
Deadline: November 1

Leukemia & Lymphoma Society Specialized Center of Research Program
Deadline: November 1

Patient-Centered Outcomes Research Institute (PCORI) Pilot Projects Grants Program
LOI Deadline: November 1
Application Deadline: December 1

University-Community Partnerships to Improve Urban Health Outcomes
Deadline: November 1

Friends of Jose Carreras International Leukemia Foundation (FJCILF) E.D. Thomas Postdoctoral Fellowship
Deadline: November 2

Cellular Molecular Imaging of Cancer Pilot Funding: Cancer Microenvironment
Deadline: November 7

Robert Wood Johnson Foundation Health Policy Fellows program
Deadline: November 9

NCI Provocative Questions Project
Deadline: November 14

Rita Allen Foundation Scholars Program
Internal Deadline: November 14

Burroughs Wellcome Fund Collaborative Research Travel Grants
Deadline: December 1

Kimmel Scholar Award
Deadline: December 1

Kimmel Translational Science Award
Deadline: December 1

American Medical Association Seed Grant Research Program
Deadline: December 5

HHMI Medical Research Fellows Program
Deadline: January 11, 2012

Robert Wood Johnson Foundation Executive Nurse Fellows
Deadline: January 18, 2012

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Request for Information (RFI): To Solicit Input on Partnerships between Extramural and NIH Intramural Investigators Utilizing the NIH Clinical Center (NOT-OD-12-005) National Institutes of Health

Administrative Supplements to NCI-funded Research Projects: Funding to Advance Research on Cancers in Women (NOT-CA-12-001)

Notice of Availability of Administrative Supplements for U.S. - Russia Collaborative HIV/AIDS Research (NOT-MH-12-001)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


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