November 28, 2011Date Released: 28 November 2011
CASE CCC IN THE NEWS
Explore Your Health Roots at the Holidays With a Family Health Tree
MARK YOUR CALENDARSCancer Center Seminar Series: Nanoparticle-Mediated p53 Gene Delivery for Cancer Therapy
Friday, December 2
Please join us Friday, December 2 at the next Cancer Center Seminar Series featuring Vinod Labhasetwar, PhD. Dr. Labhasetwar, Professor of Biomedical Engineering and Taussig Cancer Institute at CWRU/Cleveland Clinic, will present Modeling the Genesis and Progression of Human Melanoma in the Mouse.
Mutation of the p53 tumor suppressor gene is the most common genetic alteration in human cancers and results in more aggressive disease and increased resistance to conventional cancer therapies. In this presentation, Dr. Labhasetwar will describe the characteristics of biodegradable nanoparticles (NPs) as a sustained gene delivery system in cancer therapy. He will present data on the in vivo efficacy of p53 gene-loaded NPs (p53NPs) in prostate and breast cancer models. It was demonstrated that tumors treated with p53NPs show upregulation of thrombospondin-1, a potent antiangiogenic factor, and a decrease in microvessel density compared to controls (saline, p53 DNA alone, and control NPs). The mechanisms by which p53NPs inhibit tumor growth are disruption of tumor angiogenesis, apoptosis of cancer cells, and inhibition of the progression of tumor metastasis. It was also shown that p53NPs sensitize cancer cells with p53 mutation to cancer chemotherapeutic agents. The efficacy of NPs has been attributed to safe and sustained gene transfection. Dr. Labhasetwar laboratory’s recent investigations include biophysical interaction of NPs with cell membrane lipids and understanding how these interactions influence cellular uptake of NPs, their pharmacokinetics of biodistribution and tumor localization. A summary of these studies will be presented.Laser Capture Microdissection Service Replacement System Demonstrations
Molecular Machines and Industries (MMI) will be on campus to demo their Laser Capture Microdissection (LCM) system November 29-December 1. This is the last opportunity to pick up LCM slides and have them prepped in time for next week's LCM demo. Patrick Leahy, Director of the Laser Capture Microdissection Service, has a few brand-specific frame slides for those wishing to try out the instrument on their own samples. The Leica LMD 6500 system will be demonstrated the week of December 5.
Please contact Patrick Leahy at (216)368-0761 or email@example.com for more information.Weekly Seminar Series on Applied Biostatistics in Clinical Research
Registration is now open for the Weekly Seminar Series on Applied Biostatistics in Clinical Research. The course will be held Wednesdays, January 1-March 7, 2012 from 4-5:30 pm in SOM E301.
The course is targeted to faculty, fellows, and others involved in clinical research at CWRU and its affiliated hospitals, and is meant to provide an introductory overview. Emphasis is non-mathematical, focusing on understanding what methods to use in what situations, and on how to interpret the results. It is not a credited course, and there will not be a formal examination. Individuals are welcome to attend some or all lectures, depending on their particular interest. There is no registration fee, and handouts of slides will be provided.
Please contact course instructor Dr. Mark Schluchter with any questions.
FUNDING OPPORTUNITIESAACI Translational Cancer Research Fellowship
The Case CCC is accepting nominations for the AACI Translational Cancer Research Fellowship. The intent of the fellowship is to provide additional support to individuals who are engaged in any area of clinical and/or translational cancer research in order to further the development of their careers and enhance their future success in an academic discipline. The AACI fellowship will provide a one-year non-renewable grant to support post-doctoral training to individuals who have completed at least one year of training in any field of oncology and have at least one year of training remaining at an AACI member institution.
Interested candidates should forward a letter of support from their mentor and their biosketch to Gillian Todd by Monday, December 12. We may nominate ONE candidate from CWRU/UH, and ONE from the Cleveland Clinic.
Internal Deadline: December 12
The Case CCC is accepting nominations for the Damon Runyon Clinical Investigator Award, which supports young physician-scientists conducting patient-oriented cancer research. The goal is to increase the number of physicians capable of moving seamlessly between the laboratory and the patient's bedside in search of breakthrough treatments. The Clinical Investigator Award program is specifically intended to provide outstanding young physicians with the resources and training structure essential to becoming successful clinical investigators.
Interested candidates should forward a one-page letter of intent of proposal and their biosketch to Gillian Todd by Wednesday, December 14.
Internal Deadline: December 14
The Fight Colorectal Cancer-AACR Career Development Award, in memory of Lisa Dubow is open to junior faculty who are in the first 4 years of a faculty appointment at the start of the grant term on July 1, 2012. Research projects are restricted to translational or clinical cancer research that has an ultimate goal of developing or improving therapeutic interventions for patients with metastatic colorectal cancer.
Deadline: January 17, 2012
ANNOUNCEMENTSTake the Clinical Research Education Needs Assessment Survey
In support of the Clinical and Translational Science Collaborative's (CTSC) goal of strengthening the training and career pathways for all clinical and translational research team members, a survey has been developed. We invite you to take the survey, which will help to assess interest in a certificate program in clinical research fundamentals that would demonstrate standard competency among our partner institutions. Your responses will be anonymous; please be candid. Results will help CTSC's leadership identify and respond to the educational needs of the research community. If you have not done so already, please complete the survey.
**All events are open to anyone interested in attending
Pathology Research Seminar Series
Physiology and Biophysics Seminar
Skeletal Research Center
Cancer Biology Staff Candidate Seminar
Hematology and Oncology Division Research Conference
Center for AIDS Research
Immunology Research in Progress Seminar Series
Hematology/Oncology Fellows Conference
Taussig Cancer Institute Grand Rounds Topic: TBD
Cancer Center Seminar Series
Cancer Center Research in Progress Seminar
Case CCC Calendar
UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS
ADDITIONAL UPCOMING SEMINARS & EVENTS
Office of Cancer Centers Learning Series Webinar: Opportunity for CTSU Support for Collaborative Multi-Center Phase 2 Trials Led by NCI-Designated Cancer Centers and SPOREs
PREVIOUSLY ANNOUNCED OPPORTUNITIES
Robert Wood Johnson Foundation Community Health Leaders
Oncology Nursing Society Foundation Connie Henke Yarbro Excellence in Cancer Nursing Mentorship Award
NIH BULLETIN – Notices and Funding Opportunities
The NIH Operates Under a Continuing Resolution (NOT-OD-12-017)
Notice of Intent to Publish a Funding Opportunity Announcement for the NHLBI Centers for Accelerated Innovations (NOT-HL-11-157)
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