March 28, 2011Date Released: 28 March 2011
MESSAGE FROM THE DIRECTORNCI Cooperative Group Reorganization
There has been intense interest in discussion over efforts of the National Cancer Institute to re-organize cooperative groups. This affects all of us in the Cancer Center because it will alter the way we conduct early translational and clinical trial research with cancer patients.
At the February 2011 cancer directors retreat, a number of issues came forward regarding the intentions of the National Cancer Institute in this effort. As a result, a formal committee was put together with a number of cancer center directors and created a proposal: Building an Integrated National Cancer Clinical Trials Program: A Proposal for Re-Organization from NCI Cancer Center Directors. In addition, we at the Case Comprehensive Cancer Center met to discuss our approach and comments about the trial's efforts amongst the cooperative groups, and prepared a response: Case CCC Cooperative Group White Paper.
There is ongoing dialogue about these restructuring efforts, and I would like our members to be well-informed. I will be participating in a discussion at the AACR Annual Meeting, and value receiving your comments before April 2.
Stan Gerson, MD
MESSAGE FROM THE DIRECTORRuth Keri PhD, Appointed Associate Director for Basic Research, Case Comprehensive Cancer Center
After a national search, I am delighted to announce the appointment of Ruth Keri, PhD, to the position of Associate Director for Basic Research, Case Comprehensive Cancer Center. Dr. Keri is an associate professor in the departments of pharmacology, genetics and oncology at CWRU. She received her PhD in the department of pharmacology here in 1992, working at the time on identifying the regulatory mechanisms underlying pituitary gonadotropin hormone gene expression using novel transgenic mouse models. Her interest in the effects of reproductive hormones led to her long-standing interest in breast cancer, and a more recent interest in human breast cancer. She has done a remarkable job linking basic and animal model research to human disease, and in developing the key translational teams that are required for such complex research activities. She serves on a number of NIH and DOD scientific review panels, has been identified as a key investigator in breast cancer, and is recognized as a top educator in the department of pharmacology.
Recently, Dr. Keri's research activities have been to interrogate the role of HER2/c-neu/erbB2 in tumor progression and the impact of a variety of inhibitors on the signaling pathways activated by this receptor, to understand the role of FOXA1 in normal mammary ductal morphogenesis and breast tumor phenotypes, to understand the function of a Kruppel-like factor in epithelial to mesenchymal transition and metastasis, and to evaluate the role of LMO4 in breast-cancer proliferation.
In her position as associate director, Ruth will work with the Cancer Center leadership to develop the priorities and scientific direction of the Center, and will work with the leaders of all programs involved in basic laboratory investigation with an orientation towards promoting translational and disease-based research amongst investigator teams. Dr. Keri will be central to the development of a strategic plan for the Cancer Center, moving us into current preparations for our renewal application due in May of 2012.
Please feel free to contact Dr. Keri regarding any of these initiatives or about her own research. I am sure you will hear more from her soon as she begins to participate in program and scientific focus area meetings.
Stan Gerson, MD
CASE CCC IN THE NEWS
Studies Link Missing Gene to Drug-Resistant Cancers
Please join us in welcoming the newest members of the Case CCC:
Stanley Hazen, PhD
Steve Huang, MD, PhD
Gary Landreth, PhD
Gordon McLennan, MD
Vincent Tuohy, PhD
MARK YOUR CALENDARSCase CCC Scientific Series
The next installment of the Case CCC Scientific Series is scheduled for Thursday, April 21 from 4-6:30 pm in Wolstein Auditorium (WRB 1-413). Drs. Anton Gorbachev, Neetu Gupta and Alex Huang will discuss the topic of Immunology. Presentations will be followed by a short receptions. All are encouraged to attend.2nd Annual Department of Medicine Research Day
Department of Medicine faculty and trainees are invited to participate in the 2nd Annual Department of Medicine Research Day, Monday, May 16 from 12-5 pm in the Wolstein Research Building auditorium and lobby.
The mission of Research Day is twofold. First is to recognize and showcase the wide range of research in the Department by our young investigators at all levels of training. Second, is to provide an opportunity for departmental faculty to share ideas and knowledge and to stimulate discussion about opportunities for collaboration.
All Department of Medicine faculty and trainees are encouraged to attend this important event. In addition, young researchers (faculty within 5 years of appointment, fellows, residents and post-doctoral and graduate students) are invited to submit abstracts for poster presentation. Visit theevent webpage for details.Case CCC Annual Scientific Retreat
The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon.
FUNDING OPPORTUNITIESUniting Against Lung Cancer
Uniting Against Lung Cancer is accepting applications for the2011 Legacy Program for Advances in Lung Cancer Research.In 2011, the program is prioritizing innovative, high risk/high reward research, with an aim towards jumpstarting new projects leading to improved treatments and a cure for lung cancer, including non-small cell and small cell lung cancer. Proposals do not require large amounts of preliminary data, but must have a clear hypothesis and research plan to be completed within the two year grant term. This funding is intended primarily as seed money for promising and potentially transformative new projects, rather than funding well-developed clinical projects that already receive considerable support. However, high risk/high reward add-on studies leveraging larger ongoing projects, or pre-existing data-sets, clinical samples, etc. are of interest. Investigators at all levels will be funded through the Legacy Program and are encouraged to apply.
Deadline: August 17
NCI CANCER BULLETINMarch 22
**All events are open to anyone interested in attending
Pathology Research Seminar
Cancer Imaging Program (CIP) Microenvironment Focus Group "Mini Talk"
Physiology and Biophysics Seminar
Cellular and Molecular Biology of Disease: A Symposium Series
Cancer Biology Invited Speaker Seminar
Cellular and Molecular Biology of Disease: A Symposium Series
Hematology and Oncology Division Research Conference
13th Lerner Lecture
Cancer Center Research in Progress Seminar canceled- AACR
Cancer Center Seminar Series canceled-AACR
Taussig Cancer Institute Grand Rounds
Case CCC Calendar
UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS
Breast Cancer Detection and Management: Issues for 2011
Case CCC Annual Scientific Retreat
ADDITIONAL UPCOMING SEMINARS & EVENTS
4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
Fourth Annual Translational to Clinical (T2C) Wound Care Conference
Midwest Blood Club 9th Annual Symposium
2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation
4th International Symposium on Cancer Metastasis and the Lymphovascular System
Race for the Place
International Society for Stem Cell Research (ISSCR) Annual Meeting
Cancer Health Disparities Summit 2011
8th International Conference of the Society for Integrative Oncology
PREVIOUSLY ANNOUNCED OPPORTUNITIES
Multiple Myeloma Research Foundation 2011 Research Fellow Award Program
Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
NIH BULLETIN – Notices and Funding Opportunities
Re-Issuance of Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (Parent T32) and Short-Term Institutional Research Training Grants (Parent T35) (NOT-OD-11-060)
Clarification, Institutional Clinical and Translational Science Award (U54), RFA-RM-10-020 (NOT-RM-11-012)
Research on Ethical Issues in Biomedical, Social and Behavioral Research (R01) (PA-11-180)
Research on Ethical Issues in Biomedical, Social, and Behavioral Research (R21) (PA-11-182)
Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (Parent T32) (PA-11-184)
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