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2011 Articles

March 21, 2011

Date Released: 21 March 2011
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NCI Cooperative Group Reorganization

There has been intense interest in discussion over efforts of the National Cancer Institute to re-organize cooperative groups. This affects all of us in the Cancer Center because it will alter the way we conduct early translational and clinical trial research with cancer patients.

At the February 2011 cancer directors retreat, a number of issues came forward regarding the intentions of the National Cancer Institute in this effort. As a result, a formal committee was put together with a number of cancer center directors and created a proposal: Building an Integrated National Cancer Clinical Trials Program: A Proposal for Re-Organization from NCI Cancer Center Directors. In addition, we at the Case Comprehensive Cancer Center met to discuss our approach and comments about the trial's efforts amongst the cooperative groups, and prepared a response: Case CCC Cooperative Group White Paper.

There is ongoing dialogue about these restructuring efforts, and I would like our members to be well-informed. I will be participating in a discussion at the AACR Annual Meeting, and value receiving your comments before April 2.

Stan Gerson, MD
Director, Case Comprehensive Cancer Center


New Biomarker for Fatal Brain Disease Identified
Daily News & Analysis - Mar 10, 2011
The research team included Neena Singh and colleagues at Case Western Reserve University School of Medicine. The finding provides a basis for developing a test to diagnosis sCJD while patients are still alive. Presently, the only definitive diagnostic ...

UH Oncologist Uses Avastin in Breast Cancer Study
Plain Dealer - Mar 8, 2011
Joseph Baar, director of breast cancer research and the Breast Cancer Survivor Program at University Hospitals Case Medical Center. In December, the Food and Drug Administration proposed that the label for the drug Avastin be changed to reflect that it ...

When Optimism Is Unrealistic
New York Times - Mar 3, 2011
"You have oncology, a field of medicine that is strongly evidence-based and research-intensive, and you have a population of patients who are experiencing an immediate threat to their lives," said Dr. Neal J. Meropol, a researcher who has done ...

CWRU Positions Regenerative Medicine Center for Future Growth
Newswise (press release) - Mar 3, 2011
"Being part of the School of Medicine gives the NCRM academic credentials," a potential draw in recruiting additional faculty to the school, who will be able to apply for secondary faculty appointments within the Center, says Stan Gerson, MD, ...


Cancer Imaging Program (CIP) Microenvironment Focus Group "Mini Talk"

There will be a Cancer Imaging Program (CIP) Microenvironment Focus Group "Mini Talk" on Monday, March 28 at 2 pm in Wearn B37, featuring Drs. Ann-Marie Broome, ZR Lu, and Horst von Recum. All interested parties are encouraged to attend.

Case CCC Scientific Series

The next installment of the Case CCC Scientific Series is scheduled for Thursday, April 21 from 4-6:30 pm in Wolstein Auditorium (WRB 1-413). Drs. Anton Gorbachev, Neetu Gupta and Alex Huang will discuss the topic of Immunology. Presentations will be followed by a short receptions. All are encouraged to attend.

Case CCC Annual Scientific Retreat

The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon.


CTSC Quarterly Core Utilization Pilot Funding

The CTSC announces the April 1 quarterly competition for core utilization pilot funding of up to $10,000 to support activities provided by any of the CTSC Core facilities. CWRU, UH, and MetroHealth are supporting this program, and investigators whose primary appointments are based at these sites are eligible for this competition. Details and instructions will be posted online. Contact the CTSC research conciergewith questions. Investigators at Cleveland Clinic have access to internal pilot funds through the RPC program. Find information online. Contact Charlotte Bhasin with questions.

Deadline: April 1


Message from AACR: Request for Public Comment on Human Subjects Protection

The Presidential Commission for the Study of Bioethical Issues is requesting public comment on the federal and international standards for protecting the health and well-being of participants in scientific studies supported by the federal government. In order to receive consideration, comments must be received May 2, 2011.

The Commission is charged with identifying and promoting policies and practices that assure the ethically responsible conduct of scientific research, healthcare delivery, and technological innovation. In undertaking these duties, the Commission seeks to identify and examine specific bioethical, legal, and social issues related to potential scientific and technological advances; examine diverse perspectives and possibilities for international collaboration on these issues; and recommend legal, regulatory, or policy actions as appropriate. The Commission has begun a review of the current rules and standards for protecting human subjects in scientific studies supported by the federal government.

Additional information can be found at Click here to view a copy of the announcement. If you decide to submit comments, AACI would appreciate if you could send a copy of your comments that we will maintain in our files for future reference. Copies can be sent to Janie Hofacker, Director of Programs at AACI at

March 8, 2011

Featured Article: Ovarian Cancer Study Raises Questions about Developing Markers for Early Detection

Surgical Biopsy Is Overused for Evaluating Suspicious Breast Imaging Findings

Adding Radiation to Chemotherapy Improves Outcomes in Early-Stage Hodgkin Lymphoma

Trastuzumab after Chemotherapy Is Effective in HER2-Positive Breast Cancer

Denosumab Reduces Risk of Bone Side Effects in Advanced Prostate Cancer

High Rates of Human Papillomavirus Infection Found in Men

Reenergizing the Agenda for Cancer Communication

In Depth
PSA Velocity Does Not Improve Prostate Cancer Detection

The Epithelial-Mesenchymal Transition in Cancer: A Potentially Fatal Transformation?

Featured Clinical Trial: Optimizing Adjuvant Therapy for Resected Pancreatic Cancer

Radically Reducing Radiation Exposure during Routine Medical Imaging

Legislative Update





**All events are open to anyone interested in attending

March 21

March 22

Immunology Seminar
Scott Sieg, PhD
Assistant Professor, Medicine
Topic: Beta Defensin-3: A Link to Adaptive Immunity
12 pm WRB 1413

Taussig Cancer Institute Core Curriculum Series
Roy Silverstein, MD
Professor, Cell Biology
CWRU/ Cleveland Clinic
Topic: Platelet Function
12 pm R3-002 Cleveland Clinic

March 23

Hematology and Oncology Division Research Conference
Shigemi Matsuyama, PhD
Assistant Professor, Medicine- Hem/Onc
Topic: Regulation of Bax-mediated Cell Death by Non-Bcl-2 Family Member Proteins and Their Roles in Tumorigenesis and Age-related Diseases
8 am Lerner Tower B-151

National Center for Regenerative Medicine Lunch and Learn
Jed Johnson, PhD
Nanofiber Solutions
Topic: Next Generation 3D Cell Culture
12 pm Lerner Research Institute NE1-205

March 24

Stem Cell Biology and Regenerative Medicine Seminar
Viviane Tabar, MD
Department of Neurosurgery
Memorial Sloan Kettering Cancer Center
Topic: Glioblastoma Stem-Like Cells Give Rise to Tumor Endothelium
1 pm NE1-205 Cleveland Clinic

Cell Death Regulation Program Meeting
Scott Welford, PhD
Assistant Professor, Radiology Oncology
Topic: How Does Normal Tissue Hypoxia Affect Tumor Initiation?
Shideng Bao, PhD
Associate Professor, Stem Cell Biology and Regenerative Medicine
CWRU/Cleveland Clinic
Topic: Regulation of DNA Damage Checkpoint Activation in Glioblastoma Stem Cells
Alex Almasan, PhD
Associate Professor, Cancer Biology and Radiation Oncology
CWRU/Cleveland Clinic
Topic: DNA Damage Signals Outside the Nucleus: From Autophagy to Senescence
4-6 pm NA5-17 Cleveland Clinic

March 25

Hematology/Oncology Fellows
Santosh Rao, MD
Fellow, Div. of Hem/Onc
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Arti Hurria, MD
Associate Professor, Medical Oncology
City of Hope 
Topic: Research in Geriatric Oncology: Meeting the Needs of an Aging Population
8 am R3/002-003 Cleveland Clinic

BME Seminar Series
Manoj Monga, MD
Staff, Urology
Cleveland Clinic
Topic: Instrumentation in Endourology: From Bedside to Benchtop
11 am NA1-142 Cleveland Clinic

Cancer Center Seminar Series
Zhenghong Lee, PhD
Associate Professor, Radiology and Biomedical Engineering
Topic: PET Imaging of Hepatocellular Carcinoma
12 pm BRB 105

Cancer Center Research in Progress Seminar
Kristy Miskimen, PhD
Post Doctoral Scholar, Jackson Lab
Topic: The FAM83 Family of Oncogenes: Similar, Yet Non-Redundant Roles in Tumorigenesis
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Breast Cancer Detection and Management: Issues for 2011
May 20
Hilton Cleveland East

Case CCC Annual Scientific Retreat
July 8-9
Details to follow


4th Annual Biospecimen Research Network (BRN) Symposium: Advancing Cancer Research Through Biospecimen Science
March 28-29
Bethesda North Marriott Hotel & Conference Center in Bethesda, Maryland

Fourth Annual Translational to Clinical (T2C) Wound Care Conference
April 8-9
Ohio Union, Ohio State University, Columbus

Midwest Blood Club 9th Annual Symposium
April 21-22
Cincinnati Children's Hospital Medical Center

2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29
Omni Shoreham in Washington, DC
Abstract Deadline: December 16

Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation
May 1-4
Westin Hotel Cincinnati

4th International Symposium on Cancer Metastasis and the Lymphovascular System
May 12-14
New York City
Abstract Submission Deadline: March 15

International Society for Stem Cell Research (ISSCR) Annual Meeting
June 15-18
Toronto, Canada

Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland

8th International Conference of the Society for Integrative Oncology
November 10-12
InterContinental Hotel Cleveland


Multiple Myeloma Research Foundation 2011 Research Fellow Award Program
Deadline: March 29 

National CENter for ReGenerAtive Medicine UnderGraduate StudEnt (ENGAGE) Summer Program
Deadline: March 31

ACS Research Scholar Grants
Deadline: April 1

Avon Foundation Breast Cancer Research Program
Cycle 2 LOI Deadline: May 6
Cycle 2 Full Proposal Deadline: July 5

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice: Modification of the Fellowship Biographical Sketch in NIH Grant Application Form SF424 (R&R) to Permit a Description of Factors that may have Resulted in a Break in Training or Reduced Productivity Modification of the Fellowship Biographical Sketch (NOT-OD-11-050)

Delays in Grant Application Submission due to Recent Seismic Events on the Pacific Rim (NOT-OD-11-054)

Nanoscience and Nanotechnology in Biology and Medicine (R01) (PA-11-148)

Nanoscience and Nanotechnology in Biology and Medicine (R21) (PA-11-149)

Biomarkers of Infection-Associated Cancers (R01) (PA-11-158)

Biomarkers of Infection-Associated Cancers (R21) (PA-11-159)

Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01) (PA-11-160)

Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R21) (PA-11-161)

The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R01) (PA-11-162)

The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R21) (PA-11-163)

The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R03) (PA-11-164)

Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01) (PAR-11-146)

Quantitative Imaging for Evaluation of Responses to Cancer Therapies (U01) (PAR-11-150)

Strategic Partnering to Evaluate Cancer Signatures [SPECS II] (U01)(PAR-11-151)

The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01) (PAR-11-152)

Basic Cancer Research in Cancer Health Disparities (U01) (PAR-11-156)

Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (UM1) (PAR-11-167)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


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