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2011 Articles

June 20, 2011

Date Released: 20 June 2011
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Register Today!

Registration is open for the Case CCC annual scientific retreat, July 8-9 at Corporate College East. All Cancer Center members are encouraged to attend. Please click here to let us know whether or not you are able to attend.

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Registration | Agenda | Retreat Homepage

The Cancer Center has a block of rooms for a reduced rate at the Marriott Cleveland East, which is across from Corporate College East. Click here to reserve a room at your own expense of $114 per night.


Oncologists Confront "Financial Toxicity" of Cancer Care
American Medical News - Jun 19, 2011
Though the impact is less severe for those with private group insurance and public insurance, the number of patients in each category is significant, said Neal Meropol, MD, chief of the Division of Hematology and Oncology at University Hospitals Case ...

Researchers Discover Gene That Controls Inflammation in Obese
Medical Daily - Jun 18, 2011
If they learn to control levels of the factor in defense cells called macrophages, "We have a shot at a novel treatment for obesity and its complications, such as diabetes, heart disease and cancer," said Mukesh K. Jain, MD, Ellery Sedgwick Jr. Chair, ...

Cleveland Center to Provide Lung Cancer Screening CT
Health Imaging & IT - Jun 16, 2011
"CT lung cancer screening can be likened to a mammogram for lung cancer and has the potential to do what mammography has done for breast cancer-to make the disease more treatable by detecting tumors at earlier stages," said Stan Gerson, MD, ...


DOD Lung Cancer Research Program

Applications for the FY11 Lung Cancer Research Program (LCRP) are being solicited by the Assistant Secretary of Defense for Health Affairs, Defense Health Program. The vision of the FY11 LCRP is to eradicate deaths from lung cancer to better the health and welfare of the military and the American public. As such, the LCRP will support and integrate research from multiple disciplines for early detection, diagnosis, prevention, cure, and control of lung cancer.

DOD LCRP Early Investigator Synergistic Idea Award
Supports collaborations between two independent investigators early in their careers who address an innovative and high impact lung cancer research question from synergistic and complementary perspectives. This award is designed to promote collaborations between a clinician and laboratory scientist.
Pre-Application (Preproposal) Deadline: August 3
Application Deadline: November 9

DOD LCRP Investigator Initiated Translational Research Award
Supports translational research that will accelerate the movement of promising ideas in lung cancer into clinical applications. Must include preliminary data that is relevant to lung cancer and the proposed project. This award does not support clinical trials, but may support correlative studies that are associated with an existing clinical trial and projects that develop endpoints for clinical trials.
Pre-Application (Preproposal) Deadline: August 3
Application Deadline: November 9

DOD LCRP Promising Clinician Research Award
Supports a research project performed by promising physician-researchers. This award is intended to prepare physicians with clinical duties and/or responsibilities for an independent and active career in lung cancer research. Previous experience in lung cancer research is allowed, but not required.
Pre-Application (Preproposal) Deadline: August 3
Application Deadline: November 9

Pilot Project Grants: American Cancer Society IRG Awards

The Case CCC is currently accepting applications for American Cancer Society Institutional Research Grant (IRG) awards. Pilot funding is available for projects in basic, clinical, prevention and control, behavioral, health services, and epidemiology cancer research with awards up to $30,000 for one-year cancer research projects that provide the basis for future independent grants.

Instructions, frequently asked questions, and application forms are available at Contact Terri Daso, Cancer Center Administration (844-7252, for more information.

LOI Deadline: June 13
Application Deadline: July 5, 2011

Case CCC Clinical Trials Funding Opportunity

The Case Comprehensive Cancer Center is announcing the availability of Protocol Specific Research Support (PSRS) funding for Year 2011. The budgeted funds are for the conduct of early phase clinical trial and restricted to support research nurses and data managers directly involved in the conduct of these clinical trials. Studies developed jointly between UH and CCF with planned accrual at both institutions will be prioritized. Please direct questions and requests for information about the funding process to Katarzyna Karelus, Administrative Director, Case Comprehensive Cancer Center Clinical Research Office, at (216) 368-6287 or


An article co-authored by Aruna Basu, Hansjuerg Alder, Amer Khiyami, Patrick Leahy, Carlo M. Croce and Subrata Haldarwas highlighted on the cover of the February 11, 2011 issue of Genes and Cancer. Their article, "MicroRNA-375 and MicroRNA-221 Potential Noncoding RNAs Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer", suggests that anticancer agent BITC might target the expression of miR-221 and miR-375 to switch hyperproliferative pancreatic cancer cells to a hypoproliferative state.


June 14, 2011

Featured Article: New Therapies Offer Much-Needed Options for Patients with Melanoma

Ovarian Cancer Screening Method Fails to Reduce Deaths from the Disease

Longer Imatinib Treatment for GIST Improves Survival

High-Dose Methotrexate Extends Event-Free Survival for Children with Leukemia

Combining Chemotherapy with Bevacizumab Improves Outcomes for Ovarian Cancer Patients

Experimental Drug Shrinks Tumors in Rare Sarcoma

International Study Tests Additional Radiation Therapy for Breast Cancer

Patient Navigation Leads to Fewer Missed Oncology Appointments

In Depth
Exemestane Substantially Reduces Breast Cancer Risk

Perfect Match: Unraveling the Origin of XMRV

Featured Clinical Trial: Combining Second-Line Targeted Therapies for Advanced Kidney Cancer

Cancer Advocates at ASCO: Connecting for a Cause

FDA Update




**All events are open to anyone interested in attending

June 20

June 21

June 22

Special Presentation: Hematology and Oncology Research Conference
Neelesh Sharma, MD, PhD
Assistant Professor, Medical Oncology
Roswell Park Cancer Institute
Topic: Clinical Evaluation of cMET Inhibitors
8 am Lerner B-151

Immunology Invited Speaker Seminar Series
Mohamed Oukka, PhD
Assistant Professor, Pediatrics
Adjunct Assistant Professor, Immunology
University of Washington
Topic: Interleukin 23 in Immunity and Autoimmunity
12 pm NC1-202 Cleveland Clinic

June 23

June 24

Hematology/Oncology Fellows Seminar canceled

Taussig Cancer Institute Grand Rounds
Mikkael Sekeres, MD
Associate Professor, Hematology & Medical Oncology
CWRU/Cleveland Clinic
Topic: The Cleveland Clinic Leukemia Program: 2011
David Peereboom, MD
Associate Professor, Hematology & Medical Oncology
CWRU/Cleveland Clinic
Topic: Brain Tumor Clinical Research Program
8 am R3/002-003 Cleveland Clinic

World Health Interest Group Special Seminar
Adam J. Gehring, PhD
Assistant Principal Investigator, A*Star Brenner Center for Molecular Medicine
Singapore Institute for Clinical Sciences
Topic: Engineering Virus-Specific T Cell Immunity to Target Chronic Hepatitis B Virus Infection and Virus-Induced Cancer
9 am BRB 1033

Pathology Graduate Student Defense Seminar
Yi Liu
Graduate Student, Harding Lab, Pathology
Topic: Negative Regulation of Type I Interferon Induction in Dendritic Cells
1:30 pm WRB 5-136

Cancer Center Research in Progress Seminar
Marvin Nieman, PhD
Assistant Professor, Medicine
Topic: Thrombin Mediated Protease Activated Receptor Dimers
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


ASCO Review 2011
June 30
InterContinental Hotel and Bank of America Conference Center

Case CCC Annual Scientific Retreat
July 8-9


Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland

8th International Conference of the Society for Integrative Oncology: Innovating Integrative Oncology: New Science, New Solutions
November 10-12
InterContinental Hotel Cleveland


AACR-Aflac, Inc. Career Development Award for Pediatric Cancer Research 
Application Deadline: June 20

Society of Surgical Oncology Clinical Investigator Award in Breast Cancer Research
Deadline: July 8

Chordoma Foundation Investigator-Initiated Projects
LOI Deadline: July 15
Application Deadline: August 15

James S. McDonnell Foundation 21st Century Science Initiative 2011
Deadline: July 15

International Myeloma Foundation Brian D. Novis Research Grant program
Deadline: August 1

Mesothelioma Applied Research Foundation
Deadline: August 5

Damon Runyon Fellowship Award
Application Deadline: August 15

Uniting Against Lung Cancer 2011 Legacy Program for Advances in Lung Cancer Research
Deadline: August 17

AACR Team Science Award
Deadline: September 6

Pezcoller Foundation-AACR International Award for Cancer Research
Deadline: September 12

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Notice of Intent to Publish a Request for Applications for The Electronic Medical Records and Genomics (eMERGE) Network - Pediatric Study Investigators (U01) (NOT-HG-11-023)

Correction to RFA-MD-11-006: Limited Competition: NIMHD Endowment Program for Increasing Research and Institutional Resources Capacity (S21) (NOT-MD-11-009)

Notice of Changes in Key Dates for RFA-RR-11-004, Limited Competition for Competitive Revision Applications to Accelerating and Enhancing Collaborative Translational Science (UL1) (NOT-RR-11-007)

Spatial Uncertainty: Data, Modeling, and Communication (R01) (PA-11-238)

Spatial Uncertainty: Data, Modeling, and Communication (R21)(PA-11-239)

Spatial Uncertainty: Data, Modeling, and Communication (R03) (PA-11-240)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


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