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2011 Articles

April 4, 2011

Date Released: 4 April 2011
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Annual Report to the Nation on the Status of Cancer, 1975-2007, Featuring Tumors of the Brain and Other Nervous System

According to the recently released Annual Report to the Nation on the Status of Cancer, there has been a decrease in the rate of deaths from all cancers. Lung cancer continues to take more lives than any other cancer, despite a continued decrease in lung cancer deaths in men and a first-time decrease in in women. New cancer diagnoses for adults have also dropped slightly, though childhood cancer incidence rates have increased.

The Report also includes a special section on brain tumors and other nervous system cancers. Of special note, researchers found non-malignant tumors were about twice as common as malignant tumors in adults. Brain tumors were much more common among adults than children, but if a child was diagnosed with a brain tumor it was more likely to be malignant.

The Report appeared online March 31 in the "Journal of the National Cancer Institute", and will be available in print on May 4. A summary of report highlights is available on the NCI website.

Stan Gerson, MD
Director, Case Comprehensive Cancer Center


Komen Founder and CEO Wraps up Cleveland Visit with UH Tour, City Club Speech
Plain Dealer (blog) - Apr 1, 2011
In 2010 UH oncologist Dr. Cynthia Owusu received a three-year, $500000 grant from the national Komen group to fund a study aimed at improving outcomes for older women with newly diagnosed breast cancer. Wanting to put a face with the name, ...

Case Western Reserve's Medical School Wins $1.6 Million Cancer Research Grant
Crain's Cleveland Business - Mar 31, 2011
With the support of the five-year grant, Dr. Alex Y. Huang, an assistant professor at CWRU and a hematologist and oncologist at Rainbow Babies & Children's Hospital, will lead a team of researchers examining why the immune system doesn't fend off these ...


Case CCC Scientific Series

The next installment of the Case CCC Scientific Series is scheduled for Thursday, April 21 from 4-6:30 pm in Wolstein Auditorium (WRB 1-413). Drs. Anton Gorbachev, Neetu Gupta and Alex Huang will discuss the topic of Immunology. Presentations will be followed by a short receptions. All are encouraged to attend.

Case CCC Annual Scientific Retreat

The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon.


Strategic Partnering to Evaluate Cancer Signatures [SPECS II]

The cancer center leadership encourages consideration of this grant opportunity especially in the context of our disease based research initiative and strategic plan. Please direct comments to Dr. Stan Gerson and he will facilitate dialogue with other cancer center member investigators.

This message is to alert you to a new funding opportunity announcement: Strategic Partnering to Evaluate Cancer Signatures [SPECS II] (PAR-11-151). There will be one receipt date in 2011 for this competition. Please note this is a re-issue of PAR-10-126. New in 2011: electronic application submission and a cap on requested budgets.

This FOA encourages the submission of grant applications for support of the clinical application of multi-analyte molecular signatures derived from comprehensive molecular annotation of tumors. The NCI invites investigators to form strategic partnerships that will bring together the multi-disciplinary expertise and resources needed to determine how the information derived from comprehensive molecular analyses can be used to improve patient care and, ultimately, patient outcomes.


George Stark Named Honored with American Society for Biochemistry and Molecular Biology's (ASBMB) 2011 Herbert Tabor/Journal of Biological Chemistry Lectureship

Congratulations to Dr. George Stark who was awarded the 2011 Herbert Tabor/Journal of Biological Chemistry Lectureship by the American Society for Biochemistry and Molecular Biology (ASBMB). Dr. Stark will present his award lecture the ASBMB's annual meeting on April 9 in Washington, DC.

AACR Annual Meeting

The following Cancer Center members will be participating in the upcoming American Association for Cancer Research (AACR) Annual Meeting, April 2-6:

Jill Barnholtz-Sloan, PhD
Presentation, "How do I utilize ancestry estimates in my own study of cancer risk?"
Session Chair, Methods Workshop: Population Stratification and Use of Genetic Ancestry to Assess Risk for Cancer
Sat Apr 2, 8-10 am; Room W414 C/D, Orange County Convention Center

Chair, Minisymposium: Host and Lifestyle Factors in Cancer Risk
Sun Apr 3, 3:15-5:15 pm; Room W205, Orange County Convention Center

Jorge A. Garcia, MD
Presentation, "Bisphosphonates or RANK-ligand inhibitors: Options to reduce skeletal related events in Castraton-resistant Prostate cancer"
New Concepts in Organ Site Research Session: NC24. Novel Therapeutic Strategies for the Treatment of Bone Metastases
Tues Apr 5, 10:55-11:15 am; Room W224 A/B/E/F, Orange County Convention Center

Donna Hansel, MD, PhD
Presentation, Career Conversations: Choosing the Right Postdoctoral
Fellowship/Clinical Fellowship for Research Careers in Academia, Industry, and Government
Tues Apr 5, 1-2 pm; AACR Central, Associate Member Resource and Career Center, Exhibit Hall A4-C

Michael Kattan, PhD
Presentation, "Analysis and modeling"
Methods Workshop: Design and Analysis of Cancer Prognosis Studies: Interface of Molecular Epidemiology and Clinical Research
Sat Apr 2, 2:30-2:50 pm; Room W209, Orange County Convention Center

Sanford Markowitz, MD, PhD
Presentation, "DNA methylation markers for early cancer detection"
Educational Session: Epigenetic Regulation and Cancer
Sat Apr 2, 9-9:25 am; West Hall F5, Orange County Convention Center

Jeremy Rich, MD
Presentation, "The tumor microenvironment informs the tumor hierarchy"
Session Chair, Educational Session: The Cancer Stem Cell Niche
Sat Apr 2, 3:15-5:15 pm; West Hall F3/F4, Orange County Convention Center

Session Chair, New Concepts in Organ Site Research: Stem Cells in the Brain: At the Crossroads of Development and Disease
Tues Apr 5, 1-3 pm Room W311 E-H, Orange County Convention Center

Brian Rini, MD
Presentation, "Clinical applications of genomic classification of RCC"
Session Chair, New Concepts in Organ Site Research Sessions: Molecular Insights in Renal Cell Carcinoma
Sun Apr 3, 1-3 pm Room W315, Orange County Convention Center

A full listing of all Cancer Center member presentations and abstracts is available on our website.



**All events are open to anyone interested in attending

April 4

Pathology Research Seminar
Marco Sardiello, PhD
Assistant Professor, Molecular and Human Genetics
Baylor University
Topic: Network Approaches to Study and Treat Neuronal Ceroid Lipofuscinoses
12 pm WRB 1-413

April 5

Immunology Seminar
Eric Meffre, PhD
Associate Professor, Immunobiology
Yale University
Topic: The Regulation of Early B Cell Tolerance Checkpoints in Humans
12 pm WRB 1-413

April 6

Hematology and Oncology Division Research Conference
Scott Sommers, MD
Fellow, Div. of Hem/Onc
Topic: Spontaneous Autologous GVHD in Plasma Cell Myeloma Autograft Recipients: Flow Cytometric Analysis of Hematopoietic Progenitor Cell Grafts
8 am Lerner Tower B-151

April 7

Aging-Cancer-Energetics Seminar
Mary Step, PhD
Assistant Professor, Family Medicine
Topic: A Communication Process Approach to Understanding Age-Related Patterns in Decision-Making
4 pm BRB 732

April 8

Hematology/Oncology Fellows
Brad Clifford, MD
Fellow, Div. of Hem/Onc
Topic: TBD
8 am Wearn 137

Taussig Cancer Institute Grand Rounds
Thomas Buchholz, MD
Professor, Radiation Oncology
MD Anderson Cancer Center
Topic: Radiation for Breast Cancer Treated with Neoadjuvant Chemotherapy
8 am R3/002-003 Cleveland Clinic

Cancer Center Seminar Series
Donna Hansel, MD, PhD
Associate Professor, Anatomic Pathology
CWRU/Cleveland Clinic
Topic: Bladder Cancer on the Move: mTOR and Migration
12 pm BRB 105

LRI Graduate Student Association Seminar
Vincent Tuohy, PhD
Professor, Immunology
CWRU/Cleveland Clinic
Topic: Developing Immune Protection Against Adult Diseases
3 pm Bunts Auditorium Cleveland Clinic

Cancer Center Research in Progress Seminar
Peng Zhang
Graduate Student, Wang Lab
Topic: Identification of Cas as a Substrate of PTPN14
4 pm WRB 3-136

Case CCC Calendar

LRI Calendar


Breast Cancer Detection and Management: Issues for 2011
May 20
Hilton Cleveland East

Case CCC Annual Scientific Retreat
July 8-9
Details to follow


Fourth Annual Translational to Clinical (T2C) Wound Care Conference
April 8-9
Ohio Union, Ohio State University, Columbus

Midwest Blood Club 9th Annual Symposium
April 21-22
Cincinnati Children's Hospital Medical Center

2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29
Omni Shoreham in Washington, DC

Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation
May 1-4
Westin Hotel Cincinnati

4th International Symposium on Cancer Metastasis and the Lymphovascular System
May 12-14
New York City

2nd Annual Department of Medicine Research Day
May 16
12-5 pm
Wolstein Research Building auditorium and lobby

Race for the Place
June 5
Beachwood Place Mall

International Society for Stem Cell Research (ISSCR) Annual Meeting
June 15-18
Toronto, Canada

Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland

8th International Conference of the Society for Integrative Oncology
November 10-12
InterContinental Hotel Cleveland



Avon Foundation Breast Cancer Research Program
Cycle 2 LOI Deadline: May 6
Cycle 2 Full Proposal Deadline: July 5

Uniting Against Lung Cancer 2011 Legacy Program for Advances in Lung Cancer Research
Deadline: August 17

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Genetic Screens to Enhance Zebrafish Research (R01) (PAR-11-130)

Enhancing Zebrafish Research with Research Tools and Techniques (R01) (PAR-11-131)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


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